Mephedrone

Closure of psx:substance/mephedrone/section/comparative-pharmacology.full@1: 48 upstream, 23 downstream.

psx:substance/mephedrone/section/comparative-pharmacology.full@1
├─ informed_by  claim/75277482-2a8d-4d1f-804f-87c77a6a9a61  Claim in comparative-pharmacology — inconclusive  working
├─ informed_by  claim/595a7a7f-83cf-447c-811f-b165c8b8203d  Claim in comparative-pharmacology — inconclusive  working
├─ informed_by  claim/c2474ea4-fdb3-45ce-8bfb-94683bceedc8  Claim in comparative-pharmacology — inconclusive  working
├─ informed_by  claim/eae55f18-923a-42b3-b3ef-42d7b181076b  Claim in comparative-pharmacology — inconclusive  working
├─ informed_by  claim/10e5d521-0686-4059-8f71-2ed2f9c9ccbe  Claim in comparative-pharmacology — inconclusive  working
  ├─ used  src/doi:10.1038/npp.2011.304  The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue
  ├─ used  src/doi:10.1111/j.1476-5381.2011.01499.x  Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats
  ├─ used  src/doi:10.1007/164_2018_178  Neuropharmacology of Synthetic Cathinones
      ├─ used  src/doi:10.1111/j.1476-5381.2012.02145.x  Pharmacological characterization of designer cathinones in vitro
      ├─ used  src/doi:10.1093/jat/bkw120  GC-MS Quantification Method for Mephedrone in Plasma and Urine: Application to Human Pharmacokinetics
      ├─ used  src/doi:10.1038/npp.2016.75  Human Pharmacology of Mephedrone in Comparison with MDMA
      ├─ used  src/doi:10.1007/s00213-010-2070-x  Mephedrone (4-methylmethcathinone; 'meow meow'): chemical, pharmacological and clinical issues
      ├─ used  src/url:ef3c1c9e5932c845  Mephedrone Legal Status by Jurisdiction (Erowid)
      ├─ used  src/doi:10.3389/fphar.2019.01588  Mephedrone and Alcohol Interactions in Humans
      ├─ used  src/doi:10.1016/j.neuropharm.2023.109704  Mephedrone induces partial release at human dopamine transporters but full release at human serotonin transporters
      ├─ used  src/doi:10.1002/cpt.1417  Dose-Response Pharmacological Study of Mephedrone and Its Metabolites: Pharmacokinetics, Serotoninergic Effects, and Impact of CYP2D6 Genetic Variation
      ├─ used  src/doi:10.1016/j.toxlet.2011.10.010  Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat
      ├─ used  src/doi:10.1136/bcr.04.2010.2925  The serotonin syndrome as a result of mephedrone toxicity
      ├─ used  src/doi:10.1111/j.1360-0443.2011.03502.x  Mephedrone: use, subjective effects and health risks
      ├─ used  src/doi:10.1124/jpet.111.184119  4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse
      ├─ used  src/doi:10.1016/j.forsciint.2014.04.017  A 3-year review of new psychoactive substances in casework
      ├─ used  src/doi:10.1016/j.forsciint.2025.112553  Chemsex-related deaths in the United Kingdom (2017-2022): A review of the Forensic Toxicology data
      ├─ used  src/url:f0071bcdab06c69f  SMILES and physical properties of mephedrone (CID 45266826)
      ├─ used  src/doi:10.1021/acschemneuro.7b00212  Stereoselective Differences between the Reinforcing and Motivational Effects of Cathinone-Derived 4-Methylmethcathinone (Mephedrone) in Self-Administering Rats
      ├─ used  src/doi:10.1016/j.neuint.2018.09.008  Polytox synthetic cathinone abuse: role for organic cation transporter 3
      ├─ used  src/doi:10.1093/jat/bkaa134  Pharmacokinetics of Mephedrone and Its Metabolites in Whole Blood and Plasma after Controlled Intranasal Administration to Healthy Human Volunteers
      ├─ used  src/doi:10.3390/ph14020100  Acute Pharmacological Effects of Oral and Intranasal Mephedrone: An Observational Study in Humans
      ├─ used  src/doi:10.1002/dta.1369  In vitro metabolism studies on mephedrone and analysis of forensic cases
      ├─ used  src/doi:10.1208/s12248-017-0132-2  Pharmacokinetics of Mephedrone and Its Metabolites in Human by LC-MS/MS
      ├─ used  src/doi:10.1111/j.1476-5381.2012.01998.x  Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone
      ├─ used  src/doi:10.1111/adb.12038  Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats
      ├─ used  src/doi:10.1007/s00213-013-3223-5  Abuse-related and abuse-limiting effects of methcathinone and the synthetic bath salts cathinone analogs MDPV, methylone and mephedrone on intracranial self-stimulation in rats
      ├─ used  src/doi:10.1016/j.pbb.2012.10.006  Long-term cognitive and neurochemical effects of bath salt designer drugs methylone and mephedrone
      ├─ used  src/doi:10.1093/ijnp/pyu106  Manganese-enhanced magnetic resonance imaging reveals differential long-term neuroadaptation after methamphetamine and mephedrone
      ├─ used  src/doi:10.1007/7854_2016_21  Neurotoxicology of Synthetic Cathinone Analogs
      ├─ used  src/doi:10.1111/j.1476-5381.2012.02236.x  Differential effects of cathinone compounds and MDMA on body temperature in the rat, and pharmacological characterization of mephedrone-induced hypothermia
      ├─ used  src/doi:10.1371/journal.pone.0044652  Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats
      ├─ used  src/doi:10.1016/j.drugalcdep.2012.07.003  Changes in ambient temperature differentially alter the thermoregulatory, cardiac and locomotor stimulant effects of 4-methylmethcathinone (mephedrone)
      ├─ used  src/doi:10.1007/s13181-010-0018-5  Recreational use of mephedrone (4-methylmethcathinone, 4-MMC) with associated sympathomimetic toxicity
      ├─ used  src/doi:10.1016/j.jemermed.2013.04.017  Bath salts intoxication: a case series
      ├─ used  src/doi:10.1124/jpet.122.001478  Neurochemical and Cardiovascular Effects of 4-Chloro Ring-Substituted Synthetic Cathinones in Rats
      ├─ used  src/doi:10.1016/j.pbb.2020.172871  Synthetic psychoactive cathinones: hypothermia and reduced lethality compared to methamphetamine and MDMA
      ├─ used  src/pmid:20406541  Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin
      ├─ used  src/pmid:26502870  Mephedrone related fatalities: a review
      ├─ used  src/doi:10.1007/s00204-020-02693-7  Designer drugs: mechanism of action and adverse effects
      ├─ used  src/doi:10.1016/j.drugpo.2014.07.004  Self-reported prevalence of dependence of MDMA compared to cocaine, mephedrone and ketamine among a sample of recreational poly-drug users
      ├─ derived_from  gen/25618495-032d-4439-b758-e10a0e03004e  Generation — pipeline-v5
      └─ generated_by  pub/e4b45656-8984-4967-a869-d24533e60737  Publication — backfill
    ├─ used  version/1  Revision 1
    ├─ used  claim/f6d79fa1-1ac6-464f-85d6-1b447e81d106  Claim in summary — inconclusive  working
    ├─ used  claim/38285fde-8f81-4936-8c23-a674f4cbd417  Claim in pharmacology — inconclusive  working
    ├─ used  claim/0cd49946-34d6-4a7b-aa87-b6ae6b6d1e57  Claim in neuroscience — inconclusive  working
    ├─ used  claim/5d9aab9d-fa3b-48e2-924a-028a01d60700  Claim in neuroscience — inconclusive  working
    ├─ used  claim/b3cccd3f-80a2-4328-870a-c7bd2a56562a  Claim in safety — inconclusive  working
    ├─ used  claim/30f4b24f-6655-4959-98c7-4b306a1835db  Claim in chemistry — inconclusive  working
    ├─ used  claim/ff80795c-9262-41b9-b9d9-7b93a8d1ce5c  Claim in receptor-pharmacology — inconclusive  working
    ├─ used  claim/c681b68b-4e81-4d58-897a-a67f16c43916  Claim in summary — inconclusive  working
    ├─ used  claim/814a91de-6f64-49c4-8901-9e7949137b76  Claim in neuroscience — inconclusive  working
    ├─ used  claim/4a0c8cc6-66e6-4129-a372-06c8e13f092c  Claim in neuroscience — inconclusive  working
    ├─ used  claim/6336a170-5467-4490-9647-3f51b1d0627a  Claim in neuroscience — inconclusive  working
    ├─ used  claim/57121ffe-05a2-484c-a3ac-ade4f2984d6e  Claim in pharmacology — inconclusive  working
      ├─ derived_from  issue/notice@6092867e67a3  Issued notice
      ├─ derived_from  issue/info_card@29319cdac70f  Issued info_card
      ├─ derived_from  issue/emergency@47cf1475db8d  Issued emergency
      ├─ derived_from  issue/info_card@1e3038aebd82  Issued info_card
      ├─ informed_by  section/summary.full@1
      ├─ informed_by  section/pharmacology.full@1
      ├─ informed_by  section/neuroscience.full@1
      ├─ informed_by  section/safety.full@1
      ├─ informed_by  section/chemistry.full@1
      └─ informed_by  section/receptor-pharmacology.full@1
… closure truncated at 200 nodes

indented by distance from this node, not by parentage