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psx:substance/jwh-073/claim/ec69acd3-e9d3-428b-8eb2-ecd105f6b008

claim2026-05-11workinginconclusive

derived from · upstream

feeds · downstream

Closure of psx:substance/jwh-073/claim/ec69acd3-e9d3-428b-8eb2-ecd105f6b008: 39 upstream, 160 downstream.

psx:substance/jwh-073/claim/ec69acd3-e9d3-428b-8eb2-ecd105f6b008
├─ used  src/doi:10.3389/fpsyt.2022.953909  Synthetic cannabinoid JWH-073 alters both acute behavior and in vivo/vitro electrophysiological responses in mice
  ├─ informed_by  claim/71a761d4-8de9-43f4-98ff-04f68d9ce848  Claim in neuroscience — inconclusive  working
  ├─ informed_by  claim/4e729bcc-edef-443c-931f-710fc11d8dd0  Claim in neuroscience — inconclusive  working
  ├─ informed_by  claim/b6dfaf52-6650-44ac-8aa7-c04822da792f  Claim in neuroscience — inconclusive  working
  ├─ informed_by  claim/20ea1778-ed4c-4a43-9bb3-a5853ca33e10  Claim in neuroscience — inconclusive  working
    ├─ used  src/url:1528a771c440257c  Ki binding affinity values for JWH-073 at CB1 (8.9 nM) and CB2 (38 nM) receptors
    ├─ used  src/url:f0137df1499b0984  JWH-073 Discovery - John W. Huffman, Clemson University
    ├─ used  src/doi:10.1002/jms.1811  Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds
    ├─ used  src/url:7f2c1eb247d220c0  Permanent Scheduling of Five Synthetic Cannabinoids Including JWH-073
    ├─ used  src/doi:10.1016/j.neuropharm.2017.11.020  Methodology for controlled administration of smoked synthetic cannabinoids JWH-018 and JWH-073
    ├─ used  src/doi:10.1016/j.pnpbp.2016.01.007  Effect of JWH-250, JWH-073 and their interaction on tetrad, sensorimotor, neurological and neurochemical responses in mice
    ├─ used  src/doi:10.1016/j.bcp.2012.01.004  Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity
    ├─ used  src/doi:10.3109/15563650.2011.584316  Three cases of spice exposure
    ├─ used  src/doi:10.1111/j.1360-0443.2012.04078.x  Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings
    ├─ used  src/doi:10.3109/15563650.2015.1110590  A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment
    ├─ used  src/doi:10.1093/jat/bkv013  Detection Times of Carboxylic Acid Metabolites of the Synthetic Cannabinoids JWH-018 and JWH-073 in Human Urine
    ├─ used  src/pmid:15582455  Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors
    ├─ used  src/doi:10.1016/j.lfs.2013.09.011  Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids
    ├─ used  src/url:6c7f1f14eed0882f  DEA Temporary Scheduling of Five Synthetic Cannabinoids Including JWH-073
    ├─ used  src/doi:10.1016/j.jmgm.2023.108620  Influence of structural characteristics on the binding of synthetic cannabinoids from the JWH family to the CB1 receptor: A computational study
    ├─ used  src/url:972c9b9ad6e5df8e  JWH-073 SMILES and Chemical Structure
    ├─ used  src/doi:10.1016/j.taap.2013.03.012  Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors
    ├─ used  src/doi:10.1097/FBP.0b013e328308f1e6
    ├─ used  src/doi:10.3389/fnins.2018.00703  Behavioral and Pharmacokinetic Profile of Indole-Derived Synthetic Cannabinoids JWH-073 and JWH-210 as Compared to the Phytocannabinoid Delta9-THC in Rats
    ├─ used  src/doi:10.1124/dmd.111.040709  Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases
    ├─ used  src/doi:10.1093/jat/bku178  A sensitive GC-EIMS method for simultaneous detection and quantification of JWH-018 and JWH-073 carboxylic acid and hydroxy metabolites in urine
    ├─ used  src/doi:10.1016/j.forsciint.2013.03.053  Monitoring of urinary metabolites of JWH-018 and JWH-073 in legal cases
    ├─ used  src/doi:10.1016/j.ajem.2011.05.013  Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation
    ├─ used  src/doi:10.3402/jchimp.v5.27540  Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting high
    ├─ used  src/doi:10.1111/1556-4029.12216  K2 toxicity: fatal case of psychiatric complications following AM2201 exposure
    ├─ used  src/doi:10.1124/jpet.113.206003  Differential drug-drug interactions of the synthetic Cannabinoids JWH-018 and JWH-073: implications for drug abuse liability and pain therapy
    ├─ used  src/doi:10.1177/0269881114565142  The adverse health effects of synthetic cannabinoids with emphasis on psychosis-like effects
    ├─ used  src/pmid:27535976  Stratification of Cannabinoid 1 Receptor (CB1R) Agonist Efficacy: Manipulation of CB1R Density through Use of Transgenic Mice
    ├─ used  src/doi:10.3390/molecules25246057  QSAR Model for Predicting the Cannabinoid Receptor 1 Binding Affinity and Dependence Potential of Synthetic Cannabinoids
    ├─ used  src/doi:10.1007/s00204-013-1029-1  Toxicological profiles of selected synthetic cannabinoids showing high binding affinities to the cannabinoid receptor subtype CB1
    ├─ used  src/doi:10.1007/s11920-016-0694-1  Adverse Effects of Synthetic Cannabinoids: Management of Acute Toxicity and Withdrawal
    ├─ used  src/doi:10.1111/j.1521-0391.2012.00240.x  "Spice" and "K2" herbal highs: a case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humans
    ├─ derived_from  gen/c2937a50-9204-4bbc-895f-d19b4c680e77  Generation — pipeline-v5
    └─ generated_by  pub/e3d4b86a-9067-4dc3-bfea-be56a6c2dc22  Publication — backfill
├─ informed_by  section/neuroscience.full@1
  ├─ used  version/1  Revision 1
  ├─ used  claim/97ca6a7d-0d21-4bc3-84a6-f1256ed0058e  Claim in pharmacology — inconclusive  working
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  ├─ used  claim/0b0b786a-606b-4604-9ab9-6af5e9d4f535  Claim in neuroscience — inconclusive  working
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  ├─ used  claim/c9c31a89-2a8d-426f-ad99-c7a5c0130f3a  Claim in neuroscience — inconclusive  working
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  ├─ used  claim/f033a5cf-f0fd-41c9-b564-89fa60ea8021  Claim in neuroscience — inconclusive  working
    ├─ derived_from  issue/notice@6cc1eca3752c  Issued notice
    ├─ derived_from  issue/info_card@d5b12ec04bf0  Issued info_card
    ├─ derived_from  issue/emergency@207cf682e28a  Issued emergency
    ├─ derived_from  issue/info_card@83349dee8ef1  Issued info_card
    ├─ derived_from  issue/emergency@7386375eac13  Issued emergency
    ├─ informed_by  section/pharmacology.full@1
    ├─ informed_by  section/summary.full@1
      ├─ used  claim/4fc90df8-d9a6-4841-acc1-ee5fb61cc139  Claim in summary — inconclusive  working
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      ├─ used  claim/97e793de-28af-45a1-94d2-cedc79617d77  Claim in pharmacology — inconclusive  working
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      ├─ used  claim/59216528-617b-45aa-80dc-539d768ccac5  Claim in clinical-evidence — inconclusive  working
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      ├─ used  claim/88d64416-fbd1-40a3-a9da-cd3e12c8569a  Claim in clinical-evidence — inconclusive  working
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      ├─ used  claim/74398c28-2134-4a75-8ff7-0f171ffe7a94  Claim in pharmacology — inconclusive  working
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      ├─ used  claim/87d3ed3a-3c04-4831-8592-35550c4173dc  Claim in receptor-pharmacology — inconclusive  working
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      ├─ used  claim/9cc6e8ab-f1ad-41fc-a8b8-b310041942d2  Claim in receptor-pharmacology — inconclusive  working
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      ├─ used  claim/11be676d-5049-415f-ac4c-3ec37afb9211  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/7563fb70-e631-4769-827e-39c9adff6750  Claim in safety — inconclusive  working
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      ├─ used  claim/ddf16811-74bb-44e2-936a-3da088c515d9  Claim in receptor-pharmacology — inconclusive  working
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      ├─ used  claim/41aabb4d-14c2-4662-841a-6af7cb901aa5  Claim in pharmacokinetic-detail — inconclusive  working
      ├─ used  claim/34abac85-59b5-44f3-9333-ef5b379ece76  Claim in comparative-pharmacology — inconclusive  working
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      ├─ used  claim/55670596-5714-47d4-bbc0-7046a411f096  Claim in clinical-evidence — inconclusive  working
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      ├─ used  claim/e2e5cef4-8452-4022-ae8a-3822c0903a53  Claim in chemistry — inconclusive  working
      ├─ used  claim/baa78ba2-a7b2-40a5-8083-5df8b5c33f36  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/98d74ef3-ed39-4061-ab86-61818f05cb8a  Claim in comparative-pharmacology — inconclusive  working
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      ├─ used  claim/ea7aacba-d101-4892-8e7a-b930d9634d71  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/ac26fe68-ff94-460d-a0f2-ea4b561001c1  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/c7b644fe-0d03-40f7-9b6c-6bb950743704  Claim in pharmacology — inconclusive  working
      ├─ used  claim/1972d818-3930-4bb3-a784-9b21261ce90f  Claim in pharmacology — inconclusive  working
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      ├─ used  claim/eda2632f-bde8-4d8d-ada9-330e44d70aa6  Claim in pharmacology — inconclusive  working
      ├─ used  claim/38ea6577-a0b5-4b89-a98a-148f77d37ba1  Claim in pharmacokinetic-detail — inconclusive  working
      ├─ used  claim/e4760d31-dbae-4033-b704-ef6017fa8af2  Claim in pharmacology — inconclusive  working
      ├─ used  claim/9c3f50c4-b91e-4b2a-98e7-9336642ede7b  Claim in pharmacokinetic-detail — inconclusive  working
      ├─ used  claim/16be9e5e-788e-4a26-af4e-371e9f23cf0b  Claim in pharmacology — inconclusive  working
      ├─ used  claim/b3ba2eee-3f75-40e6-99cb-3add6369ec1e  Claim in pharmacology — inconclusive  working
      ├─ used  claim/5bd8ced1-02cb-4814-9c1b-f96c9fed442d  Claim in pharmacokinetic-detail — inconclusive  working
      ├─ used  claim/7d84d7fb-0288-498c-8bcc-140112b45516  Claim in pharmacokinetic-detail — inconclusive  working
      ├─ used  claim/40afe19b-e453-412a-8b99-7f1cf770e1ae  Claim in pharmacokinetic-detail — inconclusive  working
      ├─ used  claim/99a7f7b8-40b5-4157-8b8e-7e7c1b222e98  Claim in pharmacokinetic-detail — inconclusive  working
      ├─ used  claim/8951f1af-ce10-43e1-804f-826ea6cb298d  Claim in pharmacology — inconclusive  working
      ├─ used  claim/96245069-9310-46eb-8023-489561192f83  Claim in pharmacology — inconclusive  working
      ├─ used  claim/0779f838-f89a-43b3-b725-e07fda8ec598  Claim in pharmacology — inconclusive  working
      ├─ used  claim/a51e7945-1ad1-4d33-956d-e3d23bd5f4eb  Claim in pharmacokinetic-detail — inconclusive  working
      ├─ used  claim/e0096852-efa0-47cf-a4b6-bf2f84451cf3  Claim in pharmacokinetic-detail — inconclusive  working
      ├─ used  claim/b90469a1-429d-4901-99d6-7815217b338b  Claim in pharmacology — inconclusive  working
      ├─ used  claim/d69aa8dd-8ee4-4c89-bf69-9400fd524bca  Claim in safety — inconclusive  working
      ├─ used  claim/3d573356-93cf-416c-814d-9f1902b59a78  Claim in safety — inconclusive  working
      ├─ used  claim/077f306a-a940-4beb-a26e-f4ba952e0c35  Claim in safety — inconclusive  working
      ├─ used  claim/8d19ece3-ab2b-403e-b220-f0d4d1e73173  Claim in clinical-evidence — inconclusive  working
      ├─ used  claim/8164d75b-6396-4e80-8044-6b2abcfe69d3  Claim in safety — inconclusive  working
      ├─ used  claim/eb4c6990-747d-40c0-9ec4-1a2ec81c4232  Claim in safety — inconclusive  working
      ├─ used  claim/bc70b700-76d2-4100-a3ea-c5ca983577cf  Claim in clinical-evidence — inconclusive  working
      ├─ used  claim/c2de30dd-b083-44ae-9abc-55b2abd15d5a  Claim in safety — inconclusive  working
      ├─ used  claim/800d0a41-cd74-437a-8e24-af381413ac5e  Claim in safety — inconclusive  working
      ├─ used  claim/21e1e305-3e68-4f9a-8ae2-086242159257  Claim in safety — inconclusive  working
      ├─ used  claim/28a5a575-3dc5-4033-ae6f-70594ca1df50  Claim in safety — inconclusive  working
      ├─ used  claim/c89e7fbd-3ec8-4689-9122-0b6e9aa866bc  Claim in safety — inconclusive  working
      ├─ used  claim/d84400bc-b408-4a4a-a0ce-b3cfa55ded55  Claim in safety — inconclusive  working
      ├─ used  claim/8ee1d4ea-f18c-4649-ac5a-14adef7c2d8a  Claim in safety — inconclusive  working
      ├─ used  claim/600e454d-52c7-4055-a594-4380b632b847  Claim in clinical-evidence — inconclusive  working
      ├─ used  claim/86bf2933-12a6-4b7d-ae0b-3febc8593ecf  Claim in safety — inconclusive  working
      ├─ used  claim/cf1dcaef-4b09-40ac-944f-4e744ce8188c  Claim in safety — inconclusive  working
      ├─ used  claim/db67142c-eb2f-43c1-88fc-292774f13c97  Claim in clinical-evidence — inconclusive  working
      ├─ used  claim/571680dd-6c9c-473a-8d3a-8e03ed3bbb1d  Claim in safety — inconclusive  working
      ├─ used  claim/125d5a16-c91e-4e67-b2b1-6e7d48e18c03  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/3faae5e9-03db-46ae-8bfa-f2a5fbeccd33  Claim in comparative-pharmacology — inconclusive  working
      └─ used  claim/b124ed16-ddcc-4cde-ba7e-0de4b918d021  Claim in safety — inconclusive  working
… closure truncated at 200 nodes

indented by distance from this node, not by parentage

1Provenance card

the boundary, as counts

Sources

3326 with DOI

1 strong · 23 moderate · 9 weak

Compilations

12026-05-11T14:14:27.789Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

29last ruled 2026-06-04

0 awaiting a ruling

Issued documents

52026-10-19T20:32:24.016Z

notice · info card · emergency

Searches

181 with no results

queries and counts on the build

Claims checked

18815 supported

15 supported · 173 not

Correspondence

0received

consent field ships in Phase 4

Edges

471

derivations recorded for this entity

Complete over 33 sources, 1 compilation, and 29 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/jwh-073/archive

2Build

one panel per compilation run

generation run 2026-05-11

59 min completedmodel pipeline-v5plan not recordedrun/28857926…

research

citationsRegistryrecordresearchOutputworking

draft

articleDraftworking

audit

articleAuditedworking

verify

verificationResultworking

simplify

articleSimplifiedworking

publish

runMetarecordrunSummaryrecord

Selection

results seen90
selected by the model43
consumed as sources33

Verification

claims checked188
supported12
partially supported3
not supported0
inconclusive173
  • record
  • seen / partial
  • working

The model's own caveats

  • sparse_evidence
  • sparse_evidence
  • structural_inference

Reproduce

inputs
33 source keys (listed under Sources)
plan
not recorded — template version, prompt hash and git SHA are written from 2026-09 onward
model
pipeline-v5
streams
none — agent transcripts are persisted from 2026-09 onward
18 searches — query, source, results, what was kept and why
18 searches for this run
#sourcequeryseenkeptrationale
1OpenAlexJWH-073 synthetic cannabinoid106—
2PubMedJWH-073 synthetic cannabinoid toxicity case report44—
3PubMedJWH-073 cannabinoid pharmacology receptor binding77—
4PubChemJWH-07311—
5PubMednaphthoylindole cannabinoid receptor binding affinity structure activity44—
6PubMedJWH-073 metabolism pharmacokinetics human urine55—
7ClinicalTrials.gov · absenceJWH-073 synthetic cannabinoid0——
8PubMedsynthetic cannabinoid spice K2 dependence withdrawal abuse55—
9WebJWH-073 DEA Schedule I scheduling date United States 2011102—
10ErowidJWH-073 experience reports subjective effects4——
11WebJWH-073 legal status UK Australia Canada EU101—
12PubMedCooper controlled administration JWH-073 JWH-018 smoked human11—
13PubMedJWH-073 metabolism pharmacokinetics human urine52—
14PubMedJWH-073 JWH-210 pharmacokinetic behavioral profile THC rats11—
15Cayman ChemicalJWH-073 physical properties11—
16WebJWH-073 discovery synthesis history John Huffman Clemson University101—
17PubMedJWH-073 carboxylic acid metabolite detection times human urine21—
18WebJWH-073 Ki binding affinity CB1 CB2 nM values pharmacology101—
188 claims by section — every cited sentence, checked against its source
safety68 · 12 ok

  • Claim in safety — inconclusiveinconclusiveworking →

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  • Full agonism permits dose-dependent escalation of effects without the ceiling imposed by partial agonist pharmacology, producing a steeper dose-toxicity gradient.supported

    SCRAs are full agonists, more potent than THC, contain no CBD — higher psychosis-inducing potential than cannabis. 0269881114565142

  • Claim in safety — inconclusiveinconclusiveworking →

  • JWH-073 induced membrane damage in buccal epithelial (TR146) and breast cancer (MCF-7) cell lines at concentrations ≥75–100 µMpartially supported

    JWH-018 causes cell membrane damage at ≥75-100 µM; anti-estrogenic effects; no estrogenic activity; no cytokine release effects in PBMCs at realistic concentrations. s00204-013-1029-1

  • Claim in safety — inconclusiveinconclusiveworking →

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  • Population-level data identify tachycardia as the single most common adverse presentation (37–77% of synthetic cannabinoid emergency cases).supported

    Most common: tachycardia (37-77%), agitation (16-41%), nausea (13-94%). 15563650.2015.1110590

  • Synthetic cannabinoid receptor agonists, including JWH-073, carry psychotomimetic risk exceeding that of Δ9-THCsupported

    SCRAs are full agonists, more potent than THC, contain no CBD — higher psychosis-inducing potential than cannabis. 0269881114565142

  • Three factors converge to elevate this risk: full CB1 agonism (producing greater receptor activation than the partial agonist THC), higher potency (lower doses needed for equivalent receptor occupancy), and absence of cannabidiol (CBD), which in natural cannabis may moderate psychosis risk.supported

    SCRAs are full agonists, more potent than THC, contain no CBD — higher psychosis-inducing potential than cannabis. 0269881114565142

  • Claim in safety — inconclusiveinconclusiveworking →

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  • Psychosis-like conditions occur more frequently with synthetic cannabinoid receptor agonists than with natural cannabis, particularly in inexperienced users and those with pre-existing psychiatric vulnerability. anxiety, paranoia, and confusion appear to be dose-dependent, though the absence of controlled human data prevents quantification of incidence at specific dose levels.supported

    SCRAs are full agonists, more potent than THC, contain no CBD — higher psychosis-inducing potential than cannabis; reviews general toxicity profile and psychosis risk of synthetic cannabinoids. 0269881114565142

  • Claim in safety — inconclusiveinconclusiveworking →

  • Claim in safety — inconclusiveinconclusiveworking →

  • Physical and psychological-dependence on JWH-073 and related synthetic cannabinoids is documented in clinical literaturesupported

    Review of SC pharmacology, adverse effects of acute intoxication and withdrawal from daily use. Withdrawal symptom relief reported with benzodiazepines and quetiapine. s11920-016-0694-1

  • Physical and psychological-dependence on JWH-073 and related synthetic cannabinoids is documented in clinical literaturesupported

    Case series and systematic review; SC effects similar to marijuana; cases of dependence; SC effectively alleviates cannabis withdrawal. j.1521-0391.2012.00240.x

  • Claim in safety — inconclusiveinconclusiveworking →

  • Some symptom relief has been reported with benzodiazepines (for agitation) and quetiapine (for psychosis)supported

    Withdrawal symptom relief reported with benzodiazepines and quetiapine. s11920-016-0694-1

  • Users may substitute synthetic cannabinoid products to manage cannabis withdrawal.supported

    SC effectively alleviates cannabis withdrawal. j.1521-0391.2012.00240.x

  • Claim in safety — inconclusiveinconclusiveworking →

  • Claim in safety — inconclusiveinconclusiveworking →

  • History of psychosis or schizophrenia (absolute): full CB1 agonism at synthetic cannabinoid potency carries markedly elevated risk of precipitating acute psychotic episodes. The absence of CBD moderation in synthetic cannabinoid products removes a potential protective factor present in cannabis.supported

    SCRAs are full agonists, more potent than THC, contain no CBD — higher psychosis-inducing potential than cannabis. 0269881114565142

  • Claim in safety — inconclusiveinconclusiveworking →

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  • A systematic review of approximately 4,000 synthetic cannabinoid cases identified at least 26 deaths across the broader class, though JWH-073-specific mortality cannot be isolated from aggregate reporting.supported

    Systematic review of ~4000 SC cases including ~26 deaths; major complications: cardiovascular events, AKI, seizures, psychosis. 15563650.2015.1110590

pharmacology34 · 0 ok

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summary18 · 2 ok

  • Claim in summary — inconclusiveinconclusiveworking →

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  • The compound entered recreational markets in early 2009 as a replacement for JWH-018 following the latter's prohibition in Germany, and was permanently placed in Schedule I under the US Controlled Substances Act in March 2012partially supported

    Monitoring of 140+ Spice products; JWH-018 identified in December 2008; product compositions changed repeatedly due to prohibition. jms.1811

  • Claim in summary — inconclusiveinconclusiveworking →

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  • Full CB1 agonist status confers a higher ceiling for toxicity than Δ9-THC, and case reports document seizures, cardiotoxicity, and multi-organ dysfunction associated with synthetic cannabinoid products containing JWH-073. tolerance develops through CB1 receptor desensitization and downregulation; physical and psychological-dependence are documented at moderate severitypartially supported

    Systematic review of ~4000 SC cases including ~26 deaths; major complications: cardiovascular events, AKI, seizures, psychosis. 15563650.2015.1110590

  • Claim in summary — inconclusiveinconclusiveworking →

comparative-pharmacology12 · 1 ok

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  • This difference confers several clinically important properties to JWH-073:supported

    SCRAs are full agonists, more potent than THC, contain no CBD — higher psychosis-inducing potential than cannabis. 0269881114565142

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neuroscience12 · 0 ok

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pharmacokinetic-detail12 · 0 ok

  • Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →

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receptor-pharmacology12 · 0 ok

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clinical-evidence10 · 0 ok

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chemistry6 · 0 ok

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history4 · 0 ok

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3Sources

33 consumed · sorted by year · feeds = sections resting on it

Sources 1 to 30
yearsourcetierstatusfeeds
2024Influence of structural characteristics on the binding of synthetic cannabinoids from the JWH family to the CB1 receptor: A computational studyChaturvedi K, Anthony CS, Pandey P, Doerksen RJ, Godfrey M · Journal of Molecular Graphics and Modellingdoi:10.1016/j.jmgm.2023.108620moderateconsumed3 sections
2024JWH-073 SMILES and Chemical StructurePubChem/ChemSpiderurl:972c9b9ad6e5df8eweakconsumedcited only
2022Synthetic cannabinoid JWH-073 alters both acute behavior and in vivo/vitro electrophysiological responses in miceBarbieri M, Tirri M, Bilel S, Arfe R, Corli G, Marchetti B, Caruso L, Soukupova M, Cristofori V, Serpelloni G, Marti M · Frontiers in Psychiatrydoi:10.3389/fpsyt.2022.953909moderateconsumed3 sections
2020QSAR Model for Predicting the Cannabinoid Receptor 1 Binding Affinity and Dependence Potential of Synthetic CannabinoidsLee W, Park SJ, Hwang JY, et al. · Moleculesdoi:10.3390/molecules25246057moderateconsumed1 section
2018Behavioral and Pharmacokinetic Profile of Indole-Derived Synthetic Cannabinoids JWH-073 and JWH-210 as Compared to the Phytocannabinoid Delta9-THC in RatsUttl L, Szczurowska E, Hajkova K, et al. · Frontiers in Neurosciencedoi:10.3389/fnins.2018.00703moderateconsumed2 sections
2018Methodology for controlled administration of smoked synthetic cannabinoids JWH-018 and JWH-073Cooper ZD, Poklis JL, Liu F · Neuropharmacologydoi:10.1016/j.neuropharm.2017.11.020moderateconsumed4 sections
2016A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatmentTait RJ, Caldicott D, Mountain D, Hill SL, Lenton S · Clinical Toxicologydoi:10.3109/15563650.2015.1110590strongconsumed2 sections
2016Adverse Effects of Synthetic Cannabinoids: Management of Acute Toxicity and WithdrawalCooper ZD · Current Psychiatry Reportsdoi:10.1007/s11920-016-0694-1moderateconsumed1 section
2016Effect of JWH-250, JWH-073 and their interaction on tetrad, sensorimotor, neurological and neurochemical responses in miceOssato A, Canazza I, Trapella C, Vincenzi F, De Luca MA, Rimondo C, Varani K, Borea PA, Serpelloni G, Marti M · Progress in neuro-psychopharmacology & biological psychiatrydoi:10.1016/j.pnpbp.2016.01.007moderateconsumed4 sections
2016Stratification of Cannabinoid 1 Receptor (CB1R) Agonist Efficacy: Manipulation of CB1R Density through Use of Transgenic MiceGrim TW, Morales AJ, Gonek MM, et al. · Journal of Pharmacology and Experimental Therapeuticspmid:27535976moderateconsumed1 section
2015A sensitive GC-EIMS method for simultaneous detection and quantification of JWH-018 and JWH-073 carboxylic acid and hydroxy metabolites in urinePaul BD, Bosy T · Journal of Analytical Toxicologydoi:10.1093/jat/bku178moderateconsumed2 sections
2015Detection Times of Carboxylic Acid Metabolites of the Synthetic Cannabinoids JWH-018 and JWH-073 in Human UrineHegstad S, Westin AA, Spigset O · Journal of Analytical Toxicologydoi:10.1093/jat/bkv013moderateconsumed2 sections
2015Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting highSherpa D, Paudel BM, Subedi BH, Chow RD · Journal of Community Hospital Internal Medicine Perspectivesdoi:10.3402/jchimp.v5.27540weakconsumed1 section
2015The adverse health effects of synthetic cannabinoids with emphasis on psychosis-like effectsvan Amsterdam J, Brunt T, van den Brink W · Journal of psychopharmacologydoi:10.1177/0269881114565142moderateconsumed2 sections
2014Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoidsWiley JL, Marusich JA, Huffman JW · Life sciencesdoi:10.1016/j.lfs.2013.09.011moderateconsumed2 sections
2013Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findingsHermanns-Clausen M, Kneisel S, Szabo B, Auwaerter V · Addictiondoi:10.1111/j.1360-0443.2012.04078.xmoderateconsumed3 sections
2013Differential drug-drug interactions of the synthetic Cannabinoids JWH-018 and JWH-073: implications for drug abuse liability and pain therapyBrents LK, Zimmerman SM, Saffell AR, Prather PL, Fantegrossi WE · Journal of Pharmacology and Experimental Therapeuticsdoi:10.1124/jpet.113.206003moderateconsumed2 sections
2013Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptorsRajasekaran M, Brents LK, Franks LN, Moran JH, Prather PL · Toxicology and Applied Pharmacologydoi:10.1016/j.taap.2013.03.012moderateconsumed2 sections
2013K2 toxicity: fatal case of psychiatric complications following AM2201 exposurePatton AL, Chimalakonda KC, Moran CL, et al. · Journal of Forensic Sciencesdoi:10.1111/1556-4029.12216weakconsumed2 sections
2013Monitoring of urinary metabolites of JWH-018 and JWH-073 in legal casesJang M, Yang W, Choi H, Chang H, Lee S, Kim E, Chung H · Forensic Science Internationaldoi:10.1016/j.forsciint.2013.03.053moderateconsumedcited only
2013Toxicological profiles of selected synthetic cannabinoids showing high binding affinities to the cannabinoid receptor subtype CB1Koller VJ, Zlabinger GJ, Auwärter V, Fuchs S, Knasmueller S · Archives of toxicologydoi:10.1007/s00204-013-1029-1moderateconsumed1 section
2012"Spice" and "K2" herbal highs: a case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humansGunderson EW, Haughey HM, Ait-Daoud N, Joshi AS, Hart CL · The American journal on addictionsdoi:10.1111/j.1521-0391.2012.00240.xmoderateconsumed1 section
2012Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmationYoung AC, Schwarz E, Medina G, et al. · American Journal of Emergency Medicinedoi:10.1016/j.ajem.2011.05.013weakconsumed2 sections
2012Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activityBrents LK, Gallus-Zawada A, Radominska-Pandya A, Vasiljevik T, Prisinzano TE, Fantegrossi WE, Moran JH, Prather PL · Biochemical Pharmacologydoi:10.1016/j.bcp.2012.01.004moderateconsumed6 sections
2012Permanent Scheduling of Five Synthetic Cannabinoids Including JWH-073DEA/Federal Registerurl:7f2c1eb247d220c0weakconsumedcited only
2011Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferasesChimalakonda KC, Bratton SM, Le VH, Yiew KH, Dineva A, Moran CL, James LP, Moran JH, Radominska-Pandya A · Drug Metabolism and Dispositiondoi:10.1124/dmd.111.040709moderateconsumed2 sections
2011DEA Temporary Scheduling of Five Synthetic Cannabinoids Including JWH-073DEA/Federal Registerurl:6c7f1f14eed0882fweakconsumedcited only
2011Ki binding affinity values for JWH-073 at CB1 (8.9 nM) and CB2 (38 nM) receptorsCayman Chemical product page citing Huffman JW researchurl:1528a771c440257cweakconsumedcited only
2011Three cases of spice exposureSimmons J, Cookman L, Kang C, Skinner C · Clinical Toxicologydoi:10.3109/15563650.2011.584316weakconsumed3 sections
2010JWH-073 Discovery - John W. Huffman, Clemson UniversityVarious web sourcesurl:f0137df1499b0984weakconsumedcited only
Show all 34 sources — 4 more
Sources 31 to 34
yearsourcetierstatusfeeds
2010Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compoundsDresen S, Ferreirós N, Pütz M, Westphal F, Zimmermann R · Journal of Mass Spectrometrydoi:10.1002/jms.1811moderateconsumed1 section
2008Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- miceBreivogel CS, Lambert JM, Gerfin S, Huffman JW, Razdan RK · Behavioural Pharmacologydoi:10.1097/fbp.0b013e328308f1e6moderateconsumedcited only
2005Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptorsHuffman JW, Zengin G, Wu MJ, et al. · Bioorganic & Medicinal Chemistrypmid:15582455moderateconsumed3 sections
—Searched ClinicalTrials.gov for "JWH-073 synthetic cannabinoid" — no resultsabsenceno results—

4Docket

one filing per activity — decisions, correspondence, reports

  1. 0012026-05-11revisionRevision 1

    Initial LLM generation (v5 pipeline, wiki, prose phase)

    psx:substance/jwh-073/version/1
  2. 0022026-06-04proposal27 value proposals approved together

    one review action inferred from a shared reviewer and instant — the graph records one activity per proposal

    27 items in this filing

    • contraindication · cardiovascular
    • contraindication · other
    • contraindication · age
    • contraindication · neurological
    • contraindication · pregnancy_breastfeeding
    • dose_tier · threshold
    • dose_tier · light
    • dose_tier · common
    • dose_tier · strong
    • dose_tier · heavy
    • timeline · smoked · onset
    • timeline · smoked · come_up
    • timeline · smoked · peak
    • timeline · smoked · resolution
    • timeline · smoked · afterglow
    • toxicity
    • dependence · full
    • withdrawal
    • tolerance
    • dosage · smoked
    • duration · smoked · onset
    • duration · smoked · come_up
    • duration · smoked · peak
    • duration · smoked · offset
    • duration · smoked · total
    • duration · smoked · aftereffects
    psx:substance/jwh-073/proposal/contraindication/64c6eef0-56c2-46df-8996-60767e89b367
  3. 0032026-06-04publicationPublication — backfill
    psx:substance/jwh-073/pub/e3d4b86a-9067-4dc3-bfea-be56a6c2dc22

5Issued documents

what the notice, info card and emergency page said, by hash

Issued documents
documentcontent hashissuedfrom versionsuperseded
emergency7386375eac1334714f070b93…2026-10-19 20:32Revision 1current
info_card83349dee8ef1e167cf5be2f9…2026-10-19 20:32Revision 1current
emergency207cf682e28a91d88136b9a2…2026-09-04 04:30Revision 1superseded2026-10-19
info_cardd5b12ec04bf0c2a518dab6f6…2026-09-04 04:30Revision 1superseded2026-10-19
notice6cc1eca3752c8ad4ae4d5c0c…2026-09-04 04:30Revision 1current