4-HO-MiPT
4-hydroxy-N-methyl-N-isopropyltryptamine
Lethal interactions
By drug class
- MAOIslethal2 mechanismsconfidence high
Dangerous interactions
19 dangerous interactions recorded for this substance.
See the full interactions tableContraindications
Cardiovascular
- cardiovascular diseaserelative
Pre-existing coronary artery disease, uncontrolled hypertension, or heart failure increase risk. No cardiac safety data exist for 4-HO-MiPT.
Neurological
- epilepsyrelative
Seizure disorders including epilepsy represent a relative contraindication. Seizure threshold reduction cannot be verified against published literature for 4-HO-MiPT specifically.
Psychiatric
- psychotic disordersabsolute
Personal history of schizophrenia, schizoaffective disorder, or other primary psychotic disorders is an absolute contraindication.
- bipolar disorderrelative
Bipolar I and II disorder increase the risk of mood episode precipitation regardless of current mood state.
- family history of psychotic disordersrelative
Family history of schizophrenia or other psychotic disorders in first-degree relatives indicates elevated genetic risk.
Pregnancy & Breastfeeding
- pregnancyabsolute
Pregnancy is an absolute contraindication by precautionary principle. No safety data exist.
Other
- concurrent lithium useabsolute
Concurrent lithium use is absolutely contraindicated. Risk consistently reported across the psychedelic class.
- concurrent tramadol useabsolute
Concurrent tramadol use is absolutely contraindicated due to serotonin syndrome risk.
- concurrent MAOI useabsolute
Concurrent use of any MAO inhibitor is absolutely contraindicated.