2C-E
4-ethyl-2,5-dimethoxyphenethylamine
Lethal interactions
By drug class
- MAOIslethal2 mechanismsconfidence high
Dangerous interactions
18 dangerous interactions recorded for this substance.
See the full interactions tableContraindications
Cardiovascular
- hypertensionrelative
Uncontrolled hypertension is a relative contraindication. 2C-E produces measurable increases in blood pressure and heart rate at common doses.
- cardiac arrhythmiasrelative
Pre-existing cardiac arrhythmias or structural heart disease represent relative contraindications given documented cardiovascular stimulation and the cardiac arrest fatality.
Neurological
- epilepsyabsolute
Epilepsy and seizure disorders represent absolute contraindications. Seizures are documented in the 2C-class toxidrome.
Psychiatric
- psychotic disordersabsolute
Personal or family history of schizophrenia, schizoaffective disorder, or other psychotic disorders represents an absolute contraindication. 2C-E's 5-HT2A agonism can trigger psychotic decompensation in vulnerable individuals.
- bipolar disorderabsolute
Personal or family history of bipolar disorder represents an absolute contraindication due to risk of manic episode precipitation.
Pregnancy & Breastfeeding
- pregnancy and breastfeedingabsolute
Pregnancy and breastfeeding are absolute contraindications due to complete absence of reproductive safety data.
Other
- MAOI useabsolute
concurrent MAOI therapy, within 14 days of MAOI discontinuation
Concurrent or recent MAOI use is an absolute contraindication due to high risk of serotonin syndrome.
- tramadol useabsolute
Concurrent tramadol use is classified as dangerous. The combination of SERT inhibition (tramadol) with 5-HT2A agonism and weak SERT inhibition (2C-E) creates substantial serotonin syndrome risk.