Proscaline
3,5-dimethoxy-4-propoxyphenethylamine
Lethal interactions
By drug class
- MAOIslethal2 mechanismsconfidence high
Dangerous interactions
17 dangerous interactions recorded for this substance.
See the full interactions tableContraindications
Cardiovascular
- uncontrolled hypertensionrelative
Uncontrolled hypertension, recent myocardial infarction, and clinically significant arrhythmias are relative contraindications due to expected cardiovascular stress.
Psychiatric
- bipolar disorderabsolute
Bipolar I disorder is an absolute contraindication. Bipolar II is a relative contraindication requiring careful risk-benefit assessment.
- psychotic disordersabsolute
Personal or family history of psychotic disorders, including schizophrenia and schizoaffective disorder, is an absolute contraindication for proscaline and all 5-HT2A agonist psychedelics.
Pregnancy & Breastfeeding
- pregnancyabsolute
Pregnancy is an absolute contraindication. No teratogenicity or reproductive toxicity data exist for proscaline.
Other
- concurrent MAOI useabsolute
Concurrent use of MAO inhibitors (pharmaceutical or botanical) is contraindicated due to expected potentiation of effects and risk of serotonin syndrome.
- concurrent lithium useabsolute
Concurrent lithium carbonate use is contraindicated due to reported seizure risk when combined with serotonergic psychedelics.