Escaline
Lethal interactions
By drug class
- MAOIslethal2 mechanismsconfidence high
Dangerous interactions
18 dangerous interactions recorded for this substance.
See the full interactions tableContraindications
Cardiovascular
- severe cardiovascular diseaseabsolute
Absolute contraindication in individuals with uncontrolled hypertension, coronary artery disease, heart failure, or recent myocardial infarction. Tachycardia was documented in Shulgin's bioassays; mescaline produces dose-dependent cardiovascular stimulation in controlled trials.
Neurological
- epilepsyrelative
Relative contraindication in individuals with seizure disorders. Limited class-level evidence.
Psychiatric
- psychotic disordersabsolute
Absolute contraindication in individuals with personal or family history of schizophrenia, schizoaffective disorder, or other psychotic spectrum conditions.
- bipolar disorderrelative
Relative contraindication. Risk of manic episode precipitation is documented at class level for serotonergic psychedelics. No escaline-specific data.
Pregnancy & Breastfeeding
- pregnancy and breastfeedingabsolute
Absolute contraindication during pregnancy and breastfeeding. No safety data exist. Precautionary principle applies.
Other
- concurrent MAOI useabsolute
Absolute contraindication. MAOIs include prescription antidepressants (phenelzine, tranylcypromine, moclobemide) and plant-derived preparations (harmine, harmaline).
- concurrent tramadol useabsolute
Absolute contraindication. Serotonin syndrome risk from dual serotonergic activation.
- concurrent lithium useabsolute
Absolute contraindication. Case reports of seizures with classic psychedelics + lithium.