Diphenhydramine

6Node page

what any key link opens

psx:substance/diphenhydramine/proposal/timeline/ea9c6fe2-3e53-4d2a-be46-6d86091aa8df

proposal2026-04-24recordapproved

derived from · upstream

none recorded

feeds · downstream

derived_fromvalue/timeline/oral/come_up@1psx:substance/diphenhydramine/value/timeline/oral/come_up@1

psx:substance/diphenhydramine/proposal/timeline/ea9c6fe2-3e53-4d2a-be46-6d86091aa8df
└─ derived_from  value/timeline/oral/come_up@1

indented by distance from this node, not by parentage

1Provenance card

the boundary, as counts

Sources

4119 with DOI

8 strong · 19 moderate · 14 weak

Compilations

12026-04-24T13:01:15.584Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09 · 1 other run

Decisions

35last ruled 2026-06-04

0 awaiting a ruling

Issued documents

52026-10-19T20:31:32.665Z

notice · info card · emergency

Searches

310 with no results

queries and counts on the build

Claims checked

2021 supported

1 supported · 201 not

Correspondence

0received

consent field ships in Phase 4

Edges

525

derivations recorded for this entity

Complete over 41 sources, 1 compilation, and 35 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/diphenhydramine/archive

2Build

one panel per compilation run

generation run 2026-04-24

59 min completedmodel pipeline-v5plan not recordedrun/e7675f9b…

Selection

results seen149

selected by the model62

consumed as sources41

Verification

claims checked202

supported0

partially supported1

not supported0

inconclusive201

record
seen / partial
working

The model's own caveats

taper_unassessed
withdrawal_documented_but_mild
no_guidelines_body_recommendation

Reproduce

inputs: 41 source keys (listed under Sources)
plan: not recorded — template version, prompt hash and git SHA are written from 2026-09 onward
model: pipeline-v5
streams: none — agent transcripts are persisted from 2026-09 onward

31 searches — query, source, results, what was kept and why

31 searches for this run
#	source	query	seen	kept	rationale
1	PubMed	diphenhydramine overdose toxicity fatal death case report	9	5	Critical safety/toxicity data including lethal concentrations
2	PubChem	diphenhydramine	1	1	Primary compound identity verification
3	PubMed	diphenhydramine pharmacology receptor binding histamine muscarinic	10	3	Directly relevant binding affinity and receptor pharmacology data
4	OpenAlex	diphenhydramine pharmacology antihistamine anticholinergic	10	1	IUPHAR histamine receptor review provides authoritative receptor classification context
5	PubMed	diphenhydramine pharmacokinetics bioavailability half-life metabolism human	7	6	Human PK data directly relevant to dosing and duration sections
6	PubMed	diphenhydramine NMDA receptor open channel block	1	1	Novel receptor mechanism beyond H1/muscarinic
7	WebSearch	diphenhydramine discovery George Rieveschl 1943 synthesis history Parke-Davis FDA approval	10	3	Historical discovery narrative not available in PubMed; web sources provide documented institutional history
8	PubMed	diphenhydramine psychotropic effects doses subjective effects volunteers	5	5	Human controlled studies of DPH subjective and psychomotor effects
9	PubMed	anticholinergic drugs dementia risk cumulative burden older adults	8	2	Chronic risk data from anticholinergic exposure relevant to DPH chronic toxicity
10	PubMed	Sanger antiemetic history nausea vomiting antihistamine discovery dimenhydrinate	1	1	Authoritative peer-reviewed history of DPH/dimenhydrinate antiemetic discovery
11	ClinicalTrials.gov	diphenhydramine sleep aid insomnia treatment placebo controlled	10	1	Completed Phase 4 DPH-specific clinical trial for insomnia
12	PubMed	physostigmine anticholinergic toxidrome treatment reversal	8	2	Physostigmine as antidote for DPH-induced anticholinergic toxidrome
13	PubMed	diphenhydramine Benadryl challenge social media TikTok adolescent overdose	1	1	Directly relevant to harm reduction and social media harm context
14	PubMed	diphenhydramine sodium channel blockade cardiac arrhythmia QRS	5	5	Critical safety mechanism data - sodium channel blockade explains cardiac toxicity
15	WebSearch	diphenhydramine legal status OTC prescription UK Australia Canada scheduling	10	3	Legal status by jurisdiction, particularly the recent Australia scheduling change
16	WebSearch	diphenhydramine LD50 rat oral mg/kg lethal dose 50 toxicology	10	2	Animal toxicity data for safety section
17	PubMed	diphenhydramine metabolism CYP2D6 CYP3A4 enzyme inhibition	3	2	CYP enzyme involvement directly relevant to drug interactions section
18	NCBI Bookshelf	diphenhydramine toxicity StatPearls	1	1	Comprehensive toxicity reference with specific dose thresholds and treatment protocols
19	IUPHAR/BPS Guide to Pharmacology	diphenhydramine binding affinity all receptors	1	0	Could not extract specific Ki values from static page; noted for further investigation
20	PubMed	diphenhydramine anticholinergic delirium hallucinations psychosis	3	2	Relevant toxicity and subjective effects data
21	NCBI Bookshelf	diphenhydramine pharmacology StatPearls	1	1	Comprehensive pharmacological reference with specific PK values
22	PubMed	diphenhydramine abuse recreational use misuse substance use disorder	2	1	Confirms recreational use patterns documented in toxicology literature
23	PubMed	antihistamine children death pediatric cough cold safety	7	3	Critical safety data for pediatric use; hallucinations at 46.5% highly relevant to effects section
24	PubMed	antihistamine QT prolongation hERG cardiac first-generation	3	1	Confirms hERG blocking mechanism of first-generation antihistamines including DPH
25	PubMed	diphenhydramine Benadryl challenge social media TikTok adolescent	1	1	Critical harm reduction data and contemporary misuse pattern
26	NCBI Bookshelf	diphenhydramine pharmacology mechanism	1	1	Authoritative reference with specific PK values
27	WebSearch	diphenhydramine Australia Schedule 4 2026 TGA rescheduling	10	2	Critical recent legal status change
28	PubMed	diphenhydramine H1 receptor binding crystal structure	5	2	H1R structural pharmacology context
29	PubMed	restless legs syndrome antihistamine worsening	1	1	Important contraindication for DPH use as sleep aid
30	DOI verification via Crossref	verify DOIs for key citations	3	1	DOI verification for key high-impact citations
31	PubChem CID 3100	diphenhydramine chemical identity SMILES formula	1	1	Chemical identity verification for seed data

202 claims by section — every cited sentence, checked against its source

safety58 · 1 ok

Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Physostigmine, an acetylcholinesterase inhibitor, reverses the syndrome and is associated with fewer intubations and ICU admissions compared to non-antidote therapy in a cohort of 141 patients.partially supported
Retrospective analysis of 815 anticholinergic toxidrome patients; physostigmine associated with lower intubation rate (1.9% vs 8.4%). s13181-014-0452-x
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →
Claim in safety — inconclusiveinconclusiveworking →

pharmacology44 · 0 ok

Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →
Claim in pharmacology — inconclusiveinconclusiveworking →

neuroscience18 · 0 ok

Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →
Claim in neuroscience — inconclusiveinconclusiveworking →

comparative-pharmacology16 · 0 ok

Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →
Claim in comparative-pharmacology — inconclusiveinconclusiveworking →

summary16 · 0 ok

Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →
Claim in summary — inconclusiveinconclusiveworking →

chemistry14 · 0 ok

Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →
Claim in chemistry — inconclusiveinconclusiveworking →

clinical-evidence14 · 0 ok

Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →
Claim in clinical-evidence — inconclusiveinconclusiveworking →

history12 · 0 ok

Claim in history — inconclusiveinconclusiveworking →
Claim in history — inconclusiveinconclusiveworking →
Claim in history — inconclusiveinconclusiveworking →
Claim in history — inconclusiveinconclusiveworking →
Claim in history — inconclusiveinconclusiveworking →
Claim in history — inconclusiveinconclusiveworking →
Claim in history — inconclusiveinconclusiveworking →
Claim in history — inconclusiveinconclusiveworking →
Claim in history — inconclusiveinconclusiveworking →
Claim in history — inconclusiveinconclusiveworking →
Claim in history — inconclusiveinconclusiveworking →
Claim in history — inconclusiveinconclusiveworking →

pharmacokinetic-detail6 · 0 ok

Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →
Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →
Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →
Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →
Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →
Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →

receptor-pharmacology4 · 0 ok

Claim in receptor-pharmacology — inconclusiveinconclusiveworking →
Claim in receptor-pharmacology — inconclusiveinconclusiveworking →
Claim in receptor-pharmacology — inconclusiveinconclusiveworking →
Claim in receptor-pharmacology — inconclusiveinconclusiveworking →

Other runs

brief run2026-09-27completed5 minrun/accbee9e…

3Sources

41 consumed · sorted by year · feeds = sections resting on it

Sources 1 to 30
year	source	tier	status	feeds
2026	Australia TGA Scheduling - Diphenhydramine Schedule 4 (July 1, 2026)Therapeutic Goods Administration (TGA)url:b8e942ad30117904	weak	consumed	cited only
2026	Death due to diphenhydramine toxicity: A 9-year review from the Cook County Medical Examiner's Office and a review of the literature.Macorano E, Tarozzi I, Gitto L · Journal of Forensic Sciencesdoi:10.1111/1556-4029.70239	moderate	consumed	3 sections
2026	Lidocaine for diphenhydramine-induced ventricular tachycardia: A case report.Carroll S, McGee M, Audette M, Tuttle M, Corcoran J, Stanton M, Feldman R · The American Journal of Emergency Medicinedoi:10.1016/j.ajem.2026.01.040	weak	consumed	5 sections
2026	Restless Legs Syndrome: A Review.Winkelman JW, Wipper B · JAMAdoi:10.1001/jama.2025.23247	strong	consumed	1 section
2025	Anticholinergic burden and incident dementia: a Swedish nationwide case-control study.Zhu N, Eriksdotter M, Liabeuf S, Tan ECK, Johnell K, Garcia-Ptacek S, Xu H · Alzheimer's Research & Therapydoi:10.1186/s13195-025-01883-8	moderate	consumed	3 sections
2024	Benadryl: Allergy Relief for Millions - American Chemical SocietyAmerican Chemical Societyurl:736c295bfa3d18f9	weak	consumed	cited only
2024	Diphenhydramine - PubChem CompoundNational Library of Medicinepmid:3100	moderate	consumed	1 section
2024	Diphenhydramine - WikipediaWikipedia contributorsurl:c28d60b998176c0e	weak	consumed	cited only
2024	Diphenhydramine legal status by jurisdiction (Erowid/Wikipedia/ACS sources combined)Variousurl:b060ec4995f7a05b	weak	consumed	cited only
2024	Diphenhydramine Overdose: A Case Report and Topic Review of Prehospital Diagnosis and Treatment.Frank MA, Lund J, Langley DM, Annis M, Peredy TR · Cureusdoi:10.7759/cureus.70719	weak	consumed	2 sections
2023	A TikTok 'Benadryl Challenge' death - A case report and review of the literature.Elkhazeen A, Poulos C, Zhang X, Cavanaugh J, Cain M · Journal of Forensic Sciencesdoi:10.1111/1556-4029.15149	weak	consumed	2 sections
2023	Diphenhydramine - StatPearls (NBK526010)Sicari V, Zabbo CP · StatPearls Publishingurl:5897be19afc8eb58	weak	consumed	cited only
2023	Diphenhydramine Toxicity - StatPearls (NBK557578)Reiter PD, Bhatt M · StatPearls Publishingurl:de86627bfcc84cd5	weak	consumed	cited only
2022	Psilocybin for alcohol use disorder: Rationale and design considerations for a randomized controlled trial.O'Donnell KC, Mennenga SE, Owens LT, et al. · Contemporary Clinical Trialsdoi:10.1016/j.cct.2022.106976	moderate	consumed	1 section
2021	LD50 data for diphenhydramine hydrochloride (MSDS/safety data)Various (MSDS sources)url:bc4c41cd5fbd55d0	weak	consumed	cited only
2020	Adverse events associated with diphenhydramine in children, 2008-2015.Palmer RB, Reynolds KM, Banner W, Bond GR, Kauffman RE, Paul IM, Green JL, Dart RC · Clinical Toxicologydoi:10.1080/15563650.2019.1609683	moderate	consumed	3 sections
2019	A Comparison of Resource Utilization in the Management of Anticholinergic Delirium Between Physostigmine and Nonantidote Therapy.Boley SP, Stellpflug SJ · The Annals of Pharmacotherapydoi:10.1177/1060028019846654	moderate	consumed	1 section
2019	IV Lipid Emulsion Infusion in the Treatment of Severe Diphenhydramine Overdose.Cherukuri SV, Purvis AW, Tosto ST, Velayati A · The American Journal of Case Reportsdoi:10.12659/ajcr.912523	weak	consumed	cited only
2018	A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research.Sanger GJ, Andrews PLR · Frontiers in Pharmacologydoi:10.3389/fphar.2018.00913	strong	consumed	2 sections
2018	Extracorporeal Cardiopulmonary Resuscitation After Diphenhydramine Ingestion.Labarinas S, Meulmester K, Greene S, Thomas J, Virk M, Erkonen G · Journal of Medical Toxicologydoi:10.1007/s13181-018-0672-6	weak	consumed	1 section
2017	Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL · Journal of Clinical Sleep Medicinedoi:10.5664/jcsm.6470	strong	consumed	2 sections
2016	A Literature Review of the Use of Sodium Bicarbonate for the Treatment of QRS Widening.Bruccoleri RE, Burns MM · Journal of Medical Toxicologydoi:10.1007/s13181-015-0483-y	strong	consumed	3 sections
2015	International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.Panula P, Chazot PL, Cowart M, Gutzmer R, Leurs R, et al. · Pharmacological Reviewsdoi:10.1124/pr.114.010249	strong	consumed	5 sections
2015	Open channel block of NMDA receptors by diphenhydramine.Föhr KJ, Zeller K, Georgieff M, Köster S, Adolph O · Neuropharmacologydoi:10.1016/j.neuropharm.2015.08.021	moderate	consumed	3 sections
2015	The Use of Physostigmine by Toxicologists in Anticholinergic Toxicity.Watkins JW, Schwarz ES, Arroyo-Plasencia AM, Mullins ME · Journal of Medical Toxicologydoi:10.1007/s13181-014-0452-x	moderate	consumed	1 section
2013	[Diphenhydramine addiction and detoxification. A systematic review and case report].Erbe S, Bschor T · Psychiatrische Praxisdoi:10.1055/s-0032-1332949	strong	consumed	2 sections
2013	Toxicological identification of diphenhydramine (DPH) in suicide.Eckes L, Tsokos M, Herre S, Gapert R, Hartwig S · Forensic Science, Medicine, and Pathologydoi:10.1007/s12024-012-9383-5	moderate	consumed	1 section
2006	Antimuscarinic actions of antihistamines on the heart.Liu H, Zheng Q, Farley JM · Journal of Biomedical Sciencepmid:16453179	moderate	consumed	3 sections
2006	Sedation and memory: studies with a histamine H-1 receptor antagonist.Turner C, Handford AD, Nicholson AN · Journal of Psychopharmacologypmid:16401664	moderate	consumed	4 sections
2003	Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects.Glass JR, Sproule BA, Herrmann N, Streiner D, Busto UE · Journal of Clinical Psychopharmacologypmid:12826988	moderate	consumed	2 sections

Show all 41 sources — 11 more

Sources 31 to 41
year	source	tier	status	feeds
2003	Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view.Sharma A, Hamelin BA · Current Drug Metabolismpmid:12678691	strong	consumed	4 sections
2003	Pharmacokinetics of diphenhydramine in healthy volunteers with a dimenhydrinate 25 mg chewing gum formulation.Valoti M, Frosini M, Dragoni S, Fusi F, Sgaragli G · Methods and Findings in Experimental and Clinical Pharmacologypmid:12851661	moderate	consumed	1 section
1998	Diphenhydramine toxicity: comparisons of postmortem findings in diphenhydramine-, cocaine-, and heroin-related deaths.Karch SB · The American Journal of Forensic Medicine and Pathologypmid:9662109	weak	consumed	1 section
1997	Lack of sedative and cognitive effects of diphenhydramine and cyclobenzaprine in elderly volunteers.Lines C, Traub M, Raskin S, Mant T, Reines S · Journal of Psychopharmacologypmid:9443520	moderate	consumed	1 section
1995	[An anticholinergic syndrome with hallucinatory psychosis after diphenhydramine poisoning].Lang K, Sigusch H, Müller S · Deutsche Medizinische Wochenschriftpmid:7497894	weak	consumed	2 sections
1991	Trifluoperazine inhibits phosphoinositide hydrolysis as a histamine H1-receptor antagonist.Nakahata N, Ishimoto H, Takahashi A, Ohmori K, Kurita M · European Journal of Pharmacologypmid:1685127	moderate	consumed	2 sections
1990	Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration.Scavone JM, Luna BG, Harmatz JS, von Moltke L, Greenblatt DJ · Biopharmaceutics & Drug Dispositionpmid:2328304	moderate	consumed	1 section
1986	[Pharmacokinetics and bioavailability of diphenhydramine in man].Gielsdorf W, Pabst G, Lutz D, Graf F · Arzneimittel-Forschungpmid:3718600	moderate	consumed	1 section
1986	H1-histamine receptors on human astrocytoma cells.Nakahata N, Martin MW, Hughes AR, Hepler JR, Harden TK · Molecular Pharmacologypmid:2419744	moderate	consumed	1 section
1985	Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines).Paton DM, Webster DR · Clinical Pharmacokineticspmid:2866055	strong	consumed	2 sections
1978	Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings.Moser L, Hüther KJ, Koch-Weser J, Lundt PV · European Journal of Clinical Pharmacologypmid:33053	moderate	consumed	2 sections

4Docket

one filing per activity — decisions, correspondence, reports

0012026-04-24revisionRevision 1
Initial LLM generation (v5 pipeline, wiki)
psx:substance/diphenhydramine/version/1
0022026-06-04proposal32 value proposals approved together
one review action inferred from a shared reviewer and instant — the graph records one activity per proposal
32 items in this filing
- dose_tier · light
- dose_tier · common
- dose_tier · strong
- dose_tier · heavy
- timeline · oral · onset
- timeline · oral · come_up
- timeline · oral · peak
- timeline · oral · plateau
- timeline · oral · resolution
- timeline · oral · afterglow
- toxicity
- dependence · full
- withdrawal
- tolerance
- dosage · oral
- duration · oral · onset
- duration · oral · come_up
- duration · oral · peak
- duration · oral · offset
- duration · oral · total
- duration · oral · aftereffects
- contraindication · age
- contraindication · pregnancy_breastfeeding
- contraindication · other
- contraindication · other
- contraindication · hepatic
- contraindication · age
- contraindication · age
- contraindication · neurological
- contraindication · cardiovascular
- contraindication · respiratory
psx:substance/diphenhydramine/proposal/dose_tier/365f312d-d07b-4880-8c90-d4d66daaa03f
0032026-06-04publicationPublication — backfill
psx:substance/diphenhydramine/pub/fa9daa3e-7f00-4c3f-9988-ab930a59e490
0042026-09-27revisionr1.a1
brief-overview retired 2026-09-30 (founder): Description reads the essential summary for every substance.
psx:substance/diphenhydramine/version/2

5Issued documents

what the notice, info card and emergency page said, by hash

Issued documents
document	content hash	issued	from version	superseded
emergency	202c57e4fe575e44059df0ab…	2026-10-19 20:31	Revision 1	current
info_card	eb1efe8b4354f15f8d577408…	2026-10-19 20:31	Revision 1	current
emergency	e2acd002694f8aad19cda75f…	2026-09-04 04:29	Revision 1	superseded2026-10-19
info_card	348705653ea53dc6ece037d0…	2026-09-04 04:29	Revision 1	superseded2026-10-19
notice	034a58fba8b8cf2dbf968fb5…	2026-09-04 04:29	Revision 1	current

Diphenhydramine

6Node page

derived from · upstream

feeds · downstream

1Provenance card

2Build

generation run 2026-04-24

research→

draft→

audit→

verify→

simplify→

publish

Selection

Verification

The model's own caveats

Reproduce

Other runs

3Sources

4Docket

5Issued documents

research

draft

audit

verify

simplify