Dextropropoxyphene

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psx:substance/dextropropoxyphene/claim/844f6303-3022-4f1a-9e30-b3b8976b2ee0

claim2026-07-17workinginconclusive

derived from · upstream

usedMonoamine oxidase inhibitors, opioid analgesics and serotonin toxicity.psx:substance/dextropropoxyphene/src/pmid:16051647

feeds · downstream

informed_bysection/safety.full@1psx:substance/dextropropoxyphene/section/safety.full@1

psx:substance/dextropropoxyphene/claim/844f6303-3022-4f1a-9e30-b3b8976b2ee0
├─ used  src/pmid:16051647  Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity.
  ├─ informed_by  claim/91b3d04d-6b24-4bff-9df0-c46d6757402c  Claim in safety — inconclusive  working
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  ├─ informed_by  claim/9372f1e2-36db-4944-9b38-b84c70fd0163  Claim in safety — inconclusive  working
  ├─ informed_by  claim/d5f827a8-0382-42ae-88d8-c2f1adb9ce44  Claim in safety — inconclusive  working
  ├─ informed_by  claim/95066fe1-9a8e-4c1f-ba26-d3ac6721d54b  Claim in safety — inconclusive  working
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  ├─ informed_by  claim/b31cbd83-0f7c-4e96-9a73-ce28330861b9  Claim in safety — inconclusive  working
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  ├─ informed_by  claim/6346fe33-5414-4820-a893-2f88f9d15379  Claim in safety — inconclusive  working
  ├─ informed_by  claim/f60dde70-1639-434a-927f-2eefa154f98f  Claim in safety — inconclusive  working
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  ├─ informed_by  claim/0a5fb1cc-8c2e-414d-9de6-814cfaa7e705  Claim in safety — inconclusive  working
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  ├─ informed_by  claim/dcb20893-2f95-49cb-bccb-a8a39a1622c7  Claim in safety — inconclusive  working
  ├─ informed_by  claim/649edb5f-14a7-4b62-9f66-e3dd12794e29  Claim in safety — inconclusive  working
  ├─ informed_by  claim/09ad07c1-f7cd-46e1-864c-8c938cb003cf  Claim in safety — inconclusive  working
  ├─ informed_by  claim/771dfe43-8250-4f6d-919c-7be8564aac74  Claim in safety — inconclusive  working
  ├─ informed_by  claim/00a9a89a-3a44-4a7b-8701-93f4e13e6ea4  Claim in safety — inconclusive  working
  ├─ informed_by  claim/47a6d99c-1cc4-4374-b4b9-ad25be54e6df  Claim in safety — inconclusive  working
  ├─ informed_by  claim/6750049b-84ff-4ec6-9e9b-27060fc9c331  Claim in safety — inconclusive  working
  ├─ informed_by  claim/6936f5a1-7c2d-44ae-8b33-5a0beeb45341  Claim in safety — inconclusive  working
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  ├─ informed_by  claim/bd7516ff-0d0c-4ce8-84ba-b277b07be82e  Claim in safety — inconclusive  working
  ├─ informed_by  claim/a3b3e14a-a354-42d2-8468-1055944dd082  Claim in safety — inconclusive  working
  ├─ informed_by  claim/ad3dfde8-ef58-49bc-bf14-7d0dd5c2d3f9  Claim in safety — inconclusive  working
  ├─ informed_by  claim/89e76371-ed3b-4af1-8937-8fbc1a0f8678  Claim in safety — inconclusive  working
  ├─ informed_by  claim/7bdc417b-dc8d-4c1e-ba3f-1df93a6cd44e  Claim in safety — inconclusive  working
  ├─ informed_by  claim/738bb3ec-6c4a-4e33-aaa0-2b0ceac2ba9e  Claim in safety — inconclusive  working
  ├─ informed_by  claim/e28de135-f217-4d30-9e7a-6b3d4b581e9a  Claim in safety — inconclusive  working
  ├─ informed_by  claim/3cfdaf57-fab3-47cd-943d-bd0908c40282  Claim in safety — inconclusive  working
  ├─ informed_by  claim/70d93191-1cd2-4bc5-a43e-43982c65139f  Claim in safety — inconclusive  working
  ├─ informed_by  claim/6827fb37-e8e2-4c36-8ec5-cdf283a262a6  Claim in safety — inconclusive  working
  ├─ informed_by  claim/da0753ac-1496-4eab-9268-0465906ee516  Claim in safety — inconclusive  working
  ├─ informed_by  claim/3de83d6d-4299-4395-897f-5dd0cb646fc9  Claim in safety — inconclusive  working
  ├─ informed_by  claim/19a6fbb9-9d54-48bd-b627-cc5b58c09a98  Claim in safety — inconclusive  working
  ├─ informed_by  claim/98d76b2f-f73d-4268-9653-98e64fe3cfbb  Claim in safety — inconclusive  working
  ├─ informed_by  claim/803bd090-32b7-4e27-a951-3f526e8ec9e5  Claim in safety — inconclusive  working
  ├─ informed_by  claim/c45337d8-2e3f-4bd8-99d5-77778d48a1fc  Claim in safety — inconclusive  working
  ├─ informed_by  claim/f2c44206-113e-49b6-ade2-3d2eea27b75a  Claim in safety — inconclusive  working
  ├─ informed_by  claim/ef651e4b-bc91-4743-9ece-3f2c882bedf5  Claim in safety — inconclusive  working
  ├─ informed_by  claim/bf1e73f6-40d6-41fe-9e77-4c53ba1e0265  Claim in safety — inconclusive  working
  ├─ informed_by  claim/877be250-4d24-4115-9d72-e1f8dc83021b  Claim in safety — inconclusive  working
  ├─ informed_by  claim/bcb6aeb8-4380-4149-9ce5-58f2502540a6  Claim in safety — inconclusive  working
  ├─ informed_by  claim/350f1c83-f6d9-4a76-a830-a7932203dd27  Claim in safety — inconclusive  working
  ├─ informed_by  claim/5f4909a3-b21c-4c70-8b16-716a85731562  Claim in safety — inconclusive  working
  ├─ informed_by  claim/0218a51e-d2c0-4dba-a029-bdab35ae5549  Claim in safety — inconclusive  working
  ├─ informed_by  claim/905f6e0b-3fe7-4143-b26a-09376af41ab9  Claim in safety — inconclusive  working
  ├─ informed_by  claim/08aebb74-5385-4824-b0f1-0b7e4606d4a5  Claim in safety — inconclusive  working
  ├─ informed_by  claim/ba50a36f-dcdb-405f-bbe0-adfade09685b  Claim in safety — inconclusive  working
  ├─ informed_by  claim/7f98239c-7532-4dac-b09a-12d400c4ed09  Claim in safety — inconclusive  working
  ├─ informed_by  claim/3fe4013d-9c77-447f-b3a1-87ddf8385c2d  Claim in safety — inconclusive  working
  ├─ informed_by  claim/725a90b2-6f85-4b12-8fc4-28929d660480  Claim in safety — inconclusive  working
  ├─ informed_by  claim/edc8d538-574b-431b-9a8f-dd18ffd08e53  Claim in safety — inconclusive  working
  ├─ informed_by  claim/f7829ca3-dedf-40e1-96c2-22719edce653  Claim in safety — inconclusive  working
  ├─ informed_by  claim/d1e448db-5995-4644-bd2f-627c135876e3  Claim in safety — inconclusive  working
  ├─ informed_by  claim/8b7c891e-348b-4786-8cce-5f93e298a4c8  Claim in safety — inconclusive  working
  ├─ informed_by  claim/7b67c13a-dc8a-430c-bbac-397f08b1c115  Claim in safety — inconclusive  working
    ├─ used  src/doi:10.1016/j.yrtph.2010.12.007  Uniform assessment and ranking of opioid mu receptor binding constants for selected opioid drugs
    ├─ used  src/pmid:9437273  Systematic overview of co-proxamol to assess analgesic effects of addition of dextropropoxyphene to paracetamol
    ├─ used  src/pmid:6258941  d-Propoxyphene acts differently from morphine on opioid receptor-effector mechanisms
    ├─ used  src/pmid:2553778  Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine
    ├─ used  src/pmid:10690289  Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents
    ├─ used  src/pmid:20133509  CYP3A5 but not CYP2D6 polymorphism contributes significantly to the variability in dextropropoxyphene disposition
    ├─ used  src/pmid:6480014  Dextropropoxyphene deaths: coroner's report
    ├─ used  src/pmid:17122535  Propoxyphene (dextropropoxyphene): a critical review of a weak opioid analgesic that should remain in antiquity
    ├─ used  src/doi:10.1371/journal.pmed.1001213  Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths: time-series study
    ├─ used  src/url:ab12be4656094f54  Propoxyphene synthesis history - Pohland and Sullivan 1953
    ├─ used  src/pmid:10097357  Suicides may be overreported and accidents underreported among fatalities due to dextropropoxyphene
    ├─ used  src/doi:10.1093/qjmed/hci026  Co-proxamol and suicide: preventing the continuing toll of overdose deaths
    ├─ used  src/pmid:10938209  Middle-aged men--a risk category regarding fatal poisoning due to dextropropoxyphene and alcohol in combination
    ├─ used  src/doi:10.1136/bmj.b2270  Effect of withdrawal of co-proxamol on prescribing and deaths from drug poisoning in England and Wales: time series analysis
    ├─ used  src/doi:10.1186/1472-6904-10-6  Use of analgesics in intentional drug overdose presentations to hospital before and after the withdrawal of distalgesic from the Irish market
    ├─ used  src/doi:10.1111/j.1365-2125.2008.03206.x  Co-proxamol withdrawal has reduced suicide from drugs in Scotland
    ├─ used  src/doi:10.1002/pds.3411  Propoxyphene and the risk of out-of-hospital death
    ├─ used  src/url:908b8b3708835ebc  Dextropropoxyphene legal status and 2010 US withdrawal
    ├─ used  src/pmid:1150913  Propoxyphene bioavailability: an evaluation of ten products
    ├─ used  src/pmid:1277712  Propoxyphene and norpropoxyphene: influence of diet and fluid on plasma levels
    ├─ used  src/pmid:15764408  CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement
    ├─ used  src/pmid:6480016  Pharmacokinetics of dextropropoxyphene and nordextropropoxyphene in elderly hospital patients after single and multiple doses of distalgesic
    ├─ used  src/pmid:15973913  Acute pain management pharmacology for the patient with concurrent renal or hepatic disease
    ├─ used  src/pmid:8764759  A novel approach to the pharmacology of analgesics
    ├─ used  src/doi:10.5055/jom.2018.0466  Dextropropoxyphene effects on QTc-interval prolongation: Frequency and characteristics in relation to plasma levels
    ├─ used  src/pmid:16513452  Profound metoprolol-induced bradycardia precipitated by acetaminophen-propoxyphene
    ├─ used  src/doi:10.1111/j.1472-8206.2008.00661.x  Dextropropoxyphene withdrawal from a French university hospital: impact on analgesic drug consumption
    ├─ used  src/doi:10.1503/cmaj.051528  Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects
    ├─ used  src/pmid:14602  Therapeutic usefulness of propoxyphene napsylate in narcotic addiction
    ├─ used  src/pmid:6122232  Propoxyphene napsylate compared to methadone for opiate dependence
    ├─ used  src/pmid:7312731  Propoxyphene dependence: an update
    ├─ used  src/pmid:6349964  Dextropropoxyphene overdosage. Pharmacological considerations and clinical management
    ├─ used  src/pmid:8335717  Simultaneous determination of dextromoramide, propoxyphene and norpropoxyphene in necropsic whole blood by liquid chromatography
    ├─ used  src/pmid:16138729  Relation of postmortem blood alcohol and drug concentrations in fatal poisonings involving amitriptyline, propoxyphene and promazine
    ├─ used  src/pmid:12774892  Interaction of alcohol and drugs in fatal poisonings
    ├─ used  src/pmid:15676043  A multicentre study of coproxamol poisoning suicides based on coroners' records in England
    ├─ used  src/pmid:3092407  Carbamazepine drug interactions
    ├─ used  src/doi:10.1176/appi.psy.50.2.169  Pharmacokinetic drug interactions of synthetic opiate analgesics
    ├─ derived_from  gen/8f13d2b4-1a32-4a35-9c03-ffe76af0e671  Generation — pipeline-v5
    └─ generated_by  pub/c8622ddf-894b-4a09-8fef-d50dc01f9bdf  Publication — backfill
├─ informed_by  section/safety.full@1
  ├─ used  version/1  Revision 1
  ├─ used  claim/ca0eff91-2c88-4cb6-b59a-f2d0cd92e311  Claim in safety — inconclusive  working
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    ├─ derived_from  issue/notice@88ab1a511225  Issued notice
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      ├─ used  claim/a391b308-ce99-4b12-9722-bec36a5da31a  Claim in receptor-pharmacology — inconclusive  working
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      ├─ used  claim/6a2348a1-410d-4b50-a3e3-f20644c5bb14  Claim in neuroscience — inconclusive  working
      ├─ used  claim/fede25ac-5321-46fa-8927-39613015ff1a  Claim in summary — inconclusive  working
      ├─ used  claim/d5f5e4de-a3a1-4b4f-baf1-df8086feadaf  Claim in pharmacology — inconclusive  working
      ├─ used  claim/477684b1-9eef-4834-9ddd-4b6381709ed6  Claim in pharmacology — inconclusive  working
      ├─ used  claim/d42b018e-df49-4ce8-920c-d8bb4f923740  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/084e15b8-0ccc-451b-b43f-a92d91165744  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/60ac9785-8e65-4491-9956-5647c8474355  Claim in neuroscience — inconclusive  working
      ├─ used  claim/3c0f8ca6-6051-419a-adb5-b4fcecdbb21d  Claim in summary — inconclusive  working
      ├─ used  claim/c916d1e5-3581-4851-8f53-23b8ff2b9988  Claim in pharmacology — inconclusive  working
      ├─ used  claim/2a5e593d-f177-4acc-8853-9c32ec493480  Claim in pharmacology — inconclusive  working
      ├─ used  claim/0e6bf81d-47fc-435d-8b21-fa8978877600  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/63a508ed-6cdb-42b6-920c-e6e472ae1b76  Claim in neuroscience — inconclusive  working
      ├─ used  claim/2fba2686-ba4b-4b4d-9f23-810ad0c842a2  Claim in summary — inconclusive  working
      ├─ used  claim/b7959322-f69b-44be-b1a0-dc1f9e185595  Claim in pharmacology — inconclusive  working
      ├─ used  claim/3658aa7d-ee91-4a19-af63-34b3f3691121  Claim in pharmacology — inconclusive  working
      └─ used  claim/b9382e6f-943d-43c5-8901-9edc21d7beb3  Claim in receptor-pharmacology — inconclusive  working
… closure truncated at 200 nodes

indented by distance from this node, not by parentage

1Provenance card

the boundary, as counts

Sources

3911 with DOI

4 strong · 29 moderate · 6 weak

Compilations

12026-05-09T21:28:12.615Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

29last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:31:27.919Z

notice · info card · emergency

Searches

220 with no results

queries and counts on the build

Claims checked

2542 supported

2 supported · 252 not

Correspondence

0received

consent field ships in Phase 4

Edges

611

derivations recorded for this entity

Complete over 39 sources, 1 compilation, and 29 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/dextropropoxyphene/archive

2Build

one panel per compilation run

generation run 2026-05-09

62 min completedmodel pipeline-v5plan not recordedrun/5217af2c…

Selection

results seen124

selected by the model53

consumed as sources39

Verification

claims checked254

supported2

partially supported0

not supported0

inconclusive252

record
seen / partial
working

The model's own caveats

sparse_evidence
structural_inference

Reproduce

inputs: 39 source keys (listed under Sources)
plan: not recorded — template version, prompt hash and git SHA are written from 2026-09 onward
model: pipeline-v5
streams: none — agent transcripts are persisted from 2026-09 onward

22 searches — query, source, results, what was kept and why

22 searches for this run
#	source	query	seen	kept	rationale
1	PubMed	propoxyphene opioid receptor binding mechanism action	4	1	Direct receptor pharmacology comparison; nicotinic receptor paper was about methadone/analogs, less directly relevant
2	PubChem	dextropropoxyphene	1	1	Primary chemical identity verification
3	PubMed	propoxyphene mu opioid receptor binding affinity Ki	1	1	Only published systematic Ki comparison including propoxyphene at human MOR
4	PubMed	dextropropoxyphene sodium channel block local anesthetic	1	1	Key mechanistic paper on cardiac sodium channel blockade
5	PubMed	dextropropoxyphene propoxyphene pharmacology pharmacokinetics	15	6	Direct relevance to pharmacology, metabolism, and clinical use
6	PubMed	propoxyphene cardiotoxicity norpropoxyphene cardiac arrhythmia QTc	1	1	Already selected; cardiotoxicity covered in Barkin review
7	OpenAlex	propoxyphene cardiotoxicity norpropoxyphene cardiac withdrawal FDA	5	2	Directly relevant to cardiac risk and regulatory decisions
8	ClinicalTrials.gov	dextropropoxyphene propoxyphene	10	1	Only trial specifically about propoxyphene napsylate safety; terminated status is significant
9	OpenAlex	dextropropoxyphene propoxyphene pharmacology	10	0	No propoxyphene-specific landmark papers surfaced; general opioid reviews already covered
10	PubMed	propoxyphene overdose toxicity fatality death	11	8	All directly relevant to toxicity, fatality, and harm reduction
11	PubMed	co-proxamol dextropropoxyphene paracetamol suicide UK withdrawal	6	5	All directly relevant to regulatory history and outcome of withdrawal
12	PubMed	propoxyphene dependence addiction withdrawal abuse	10	3	Dependence, tolerance, and historic opioid utility data
13	WebSearch	propoxyphene dextropropoxyphene legal status UK EU Australia Canada scheduling	10	3	Confirmed multi-jurisdiction regulatory history
14	WebSearch	propoxyphene Pohland 1953 synthesis history Eli Lilly first described	10	3	Key historical facts for history section
15	ClinicalTrials.gov	propoxyphene napsylate	1	1	Only propoxyphene-specific interventional trial found; terminated status relevant to regulatory history
16	DrugCentral	dextropropoxyphene pharmacokinetic parameters	1	4	Specific pharmacokinetic parameters not available from published PubMed articles
17	PubMed	propoxyphene mu opioid receptor binding affinity Ki uniform	1	1	Only published systematic Ki comparison including propoxyphene at human recombinant MOR
18	PubMed	propoxyphene dependence clinical trial addiction withdrawal management	8	3	Characterize dependence, withdrawal, and abuse potential
19	PubMed	propoxyphene pharmacokinetics Tmax half-life plasma concentration oral dose	4	3	All provide specific pharmacokinetic data from human studies
20	Multiple sources	SMILES InChIKey CAS chemical identity verification	3	1	Chemical identity verification complete
21	PubMed	propoxyphene carbamazepine inhibitor drug interaction clinical	1	1	Confirms clinically important drug interaction
22	WebSearch	dextropropoxyphene propoxyphene DEA Schedule IV legal status United States 2010 withdrawal	10	3	Confirmed regulatory history for US market

254 claims by section — every cited sentence, checked against its source

safety102 · 1 ok

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Fatalities from serotonin-syndrome have been documented with structurally related phenylpiperidine/MAOI combinationssupported
Tramadol, meperidine, methadone, dextromethorphan are SRIs involved in serotonin toxicity with MAOIs (including fatalities). pmid:16051647
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pharmacology42 · 0 ok

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history20 · 0 ok

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summary18 · 0 ok

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pharmacokinetic-detail16 · 0 ok

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receptor-pharmacology16 · 1 ok

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Morphine, codeine, oxycodone, and buprenorphine lack this SRI activity and do not produce serotonin toxicity with MAOIs.supported
Morphine, codeine, oxycodone, buprenorphine not SRIs. pmid:16051647
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neuroscience14 · 0 ok

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clinical-evidence12 · 0 ok

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comparative-pharmacology8 · 0 ok

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effects-overview4 · 0 ok

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chemistry2 · 0 ok

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3Sources

39 consumed · sorted by year · feeds = sections resting on it

Sources 1 to 30
year	source	tier	status	feeds
2024	Dextropropoxyphene legal status and 2010 US withdrawalVariousurl:908b8b3708835ebc	weak	consumed	cited only
2024	Propoxyphene synthesis history - Pohland and Sullivan 1953Various secondary sourcesurl:ab12be4656094f54	weak	consumed	cited only
2018	Dextropropoxyphene effects on QTc-interval prolongation: Frequency and characteristics in relation to plasma levelsKeller GA, Villa Etchegoyen C, Fernández N, et al. · Journal of Opioid Managementdoi:10.5055/jom.2018.0466	moderate	consumed	3 sections
2013	Propoxyphene and the risk of out-of-hospital deathRay WA, Murray KT, Kawai V, Graham DJ, Cooper WO, Hall K, Stein CM · Pharmacoepidemiology and Drug Safetydoi:10.1002/pds.3411	moderate	consumed	3 sections
2012	Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths: time-series studyHawton K, Bergen H, Simkin S, Wells C, Kapur N, Gunnell D · PLoS Medicinedoi:10.1371/journal.pmed.1001213	moderate	consumed	3 sections
2011	Uniform assessment and ranking of opioid mu receptor binding constants for selected opioid drugsVolpe DA, McMahon Tobin GA, Mellon RD, et al. · Regulatory Toxicology and Pharmacologydoi:10.1016/j.yrtph.2010.12.007	moderate	consumed	3 sections
2010	CYP3A5 but not CYP2D6 polymorphism contributes significantly to the variability in dextropropoxyphene dispositionYin OQ, Tomlinson B, Chow MS · Journal of Clinical Pharmacologypmid:20133509	moderate	consumed	5 sections
2010	Use of analgesics in intentional drug overdose presentations to hospital before and after the withdrawal of distalgesic from the Irish marketCorcoran P, Reulbach U, Keeley HS, Perry IJ, Hawton K, Arensman E · BMC Clinical Pharmacologydoi:10.1186/1472-6904-10-6	moderate	consumed	cited only
2009	Dextropropoxyphene withdrawal from a French university hospital: impact on analgesic drug consumptionGaubert S, Vié M, Damase-Michel C, Pathak A, Montastruc JL · Fundamental & Clinical Pharmacologydoi:10.1111/j.1472-8206.2008.00661.x	moderate	consumed	2 sections
2009	Effect of withdrawal of co-proxamol on prescribing and deaths from drug poisoning in England and Wales: time series analysisHawton K, Bergen H, Simkin S, Brock A, Griffiths C, Romeri E, Smith KL, Kapur N, Gunnell D · BMJdoi:10.1136/bmj.b2270	moderate	consumed	1 section
2009	Pharmacokinetic drug interactions of synthetic opiate analgesicsArmstrong SC, Wynn GH, Sandson NB · Psychosomaticsdoi:10.1176/appi.psy.50.2.169	moderate	consumed	1 section
2008	Co-proxamol withdrawal has reduced suicide from drugs in ScotlandSandilands EA, Bateman DN · British Journal of Clinical Pharmacologydoi:10.1111/j.1365-2125.2008.03206.x	moderate	consumed	1 section
2006	Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effectsFurlan AD, et al. · Canadian Medical Association Journaldoi:10.1503/cmaj.051528	strong	consumed	cited only
2006	Profound metoprolol-induced bradycardia precipitated by acetaminophen-propoxypheneMarraffa JM, Lang L, Ong G, Lehmann DF · Clinical Pharmacology and Therapeuticspmid:16513452	weak	consumed	2 sections
2006	Propoxyphene (dextropropoxyphene): a critical review of a weak opioid analgesic that should remain in antiquityBarkin RL, Barkin SJ, Barkin DS · American Journal of Therapeuticspmid:17122535	moderate	consumed	9 sections
2005	A multicentre study of coproxamol poisoning suicides based on coroners' records in EnglandHawton K, Simkin S, Gunnell D, Sutton L, Bennewith O, Turnbull P, Kapur N · British Journal of Clinical Pharmacologypmid:15676043	moderate	consumed	1 section
2005	Acute pain management pharmacology for the patient with concurrent renal or hepatic diseaseMurphy EJ · Anaesthesia and Intensive Carepmid:15973913	moderate	consumed	3 sections
2005	Co-proxamol and suicide: preventing the continuing toll of overdose deathsSimkin S, Hawton K, Sutton L, Gunnell D, Bennewith O · QJMdoi:10.1093/qjmed/hci026	moderate	consumed	2 sections
2005	Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity.Gillman PK · British Journal of Anaesthesiapmid:16051647	strong	consumed	4 sections
2005	Relation of postmortem blood alcohol and drug concentrations in fatal poisonings involving amitriptyline, propoxyphene and promazineKoski A, Vuori E, Ojanperä I · Human & Experimental Toxicologypmid:16138729	moderate	consumed	1 section
2004	CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvementSomogyi AA, Menelaou A, Fullston SV · Xenobioticapmid:15764408	moderate	consumed	2 sections
2003	Interaction of alcohol and drugs in fatal poisoningsKoski A, Ojanperä I, Vuori E · Human & Experimental Toxicologypmid:12774892	moderate	consumed	1 section
2000	Middle-aged men--a risk category regarding fatal poisoning due to dextropropoxyphene and alcohol in combinationJonasson U, Jonasson B, Saldeen T · Preventive Medicinepmid:10938209	moderate	consumed	2 sections
1999	Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currentsUlens C, Daenens P, Tytgat J · Cardiovascular Researchpmid:10690289	moderate	consumed	4 sections
1999	Suicides may be overreported and accidents underreported among fatalities due to dextropropoxypheneJonasson B, Jonasson U, Saldeen T · Journal of Forensic Sciencespmid:10097357	moderate	consumed	2 sections
1997	Systematic overview of co-proxamol to assess analgesic effects of addition of dextropropoxyphene to paracetamolLi Wan Po A, Zhang WY · BMJpmid:9437273	strong	consumed	5 sections
1996	A novel approach to the pharmacology of analgesicsRaffa RB · The American Journal of Medicinepmid:8764759	moderate	consumed	1 section
1993	Simultaneous determination of dextromoramide, propoxyphene and norpropoxyphene in necropsic whole blood by liquid chromatographyRop PP, Grimaldi F, Bresson M, Fornaris M, Viala A · Journal of Chromatographypmid:8335717	weak	consumed	1 section
1989	Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaineWhitcomb DC, Gilliam FR, Starmer CF, Grant AO · The Journal of Clinical Investigationpmid:2553778	weak	consumed	5 sections
1986	Carbamazepine drug interactionsBaciewicz AM · Therapeutic Drug Monitoringpmid:3092407	moderate	consumed	1 section

Show all 39 sources — 9 more

Sources 31 to 39
year	source	tier	status	feeds
1984	Dextropropoxyphene deaths: coroner's reportWhittington RM · Human Toxicologypmid:6480014	weak	consumed	3 sections
1984	Pharmacokinetics of dextropropoxyphene and nordextropropoxyphene in elderly hospital patients after single and multiple doses of distalgesicCrome P, Gain R, Ghurye R, Flanagan RJ · Human Toxicologypmid:6480016	moderate	consumed	2 sections
1983	Dextropropoxyphene overdosage. Pharmacological considerations and clinical managementYoung RJ · Drugspmid:6349964	moderate	consumed	1 section
1981	d-Propoxyphene acts differently from morphine on opioid receptor-effector mechanismsNeil A, Terenius L · European Journal of Pharmacologypmid:6258941	moderate	consumed	6 sections
1981	Propoxyphene dependence: an updateCollins GB, Kiefer KS · Postgraduate Medicinepmid:7312731	moderate	consumed	2 sections
1981	Propoxyphene napsylate compared to methadone for opiate dependenceWang RI, Kochar C, Hasegawa AT, Roh BL · Psychopharmacologypmid:6122232	strong	consumed	1 section
1977	Therapeutic usefulness of propoxyphene napsylate in narcotic addictionJasinski DR, Pevnick JS, Clark SC, Griffith JD · Archives of General Psychiatrypmid:14602	moderate	consumed	1 section
1976	Propoxyphene and norpropoxyphene: influence of diet and fluid on plasma levelsWelling PG, Lyons LL, Tse FL, Craig WA · Clinical Pharmacology and Therapeuticspmid:1277712	moderate	consumed	2 sections
1975	Propoxyphene bioavailability: an evaluation of ten productsSlywka GW, Melikian AP, Whyatt PL, Meyer MC · Journal of Clinical Pharmacologypmid:1150913	moderate	consumed	2 sections

4Docket

one filing per activity — decisions, correspondence, reports

0012026-05-09revisionRevision 1
Initial LLM generation (v5 pipeline, wiki, prose phase)
psx:substance/dextropropoxyphene/version/1
0022026-06-04proposal27 value proposals approved together
one review action inferred from a shared reviewer and instant — the graph records one activity per proposal
27 items in this filing
- contraindication · psychiatric
- contraindication · renal
- contraindication · cardiovascular
- contraindication · age
- contraindication · hepatic
- contraindication · respiratory
- contraindication · cardiovascular
- contraindication · other
- contraindication · metabolic
- dose_tier · threshold
- dose_tier · light
- dose_tier · common
- dose_tier · strong
- dose_tier · heavy
- timeline · oral · onset
- timeline · oral · peak
- timeline · oral · afterglow
- toxicity
- dependence · full
- withdrawal
- tolerance
- dosage · oral
- duration · oral · onset
- duration · oral · peak
- duration · oral · total
- duration · oral · aftereffects
psx:substance/dextropropoxyphene/proposal/contraindication/fe13e721-4645-41df-95af-7b91347f79c4
0032026-06-04publicationPublication — backfill
psx:substance/dextropropoxyphene/pub/c8622ddf-894b-4a09-8fef-d50dc01f9bdf

5Issued documents

what the notice, info card and emergency page said, by hash

Issued documents
document	content hash	issued	from version	superseded
info_card	705afe7a476d032f9e73158d…	2026-10-19 20:31	Revision 1	current
emergency	f85b2d2362c98030e2585598…	2026-09-04 04:29	Revision 1	current
info_card	8aae7dadb18151e84d9217ea…	2026-09-04 04:29	Revision 1	superseded2026-10-19
notice	88ab1a511225c678f3289b6e…	2026-09-04 04:29	Revision 1	current

Dextropropoxyphene

6Node page

derived from · upstream

feeds · downstream

1Provenance card

2Build

generation run 2026-05-09

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Selection

Verification

The model's own caveats

Reproduce

3Sources

4Docket

5Issued documents

research

draft

audit

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simplify