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Dextromethorphan

(+)-3-methoxy-17-methylmorphinan

1Provenance card

the boundary, as counts

Sources

4423 with DOI

9 strong · 26 moderate · 9 weak

Compilations

12026-04-24T14:07:56.088Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

31last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:31:26.972Z

notice · info card · emergency

Searches

190 with no results

queries and counts on the build

Claims checked

7359 supported

59 supported · 14 not

Correspondence

0received

consent field ships in Phase 4

Edges

253

derivations recorded for this entity

Complete over 44 sources, 1 compilation, and 31 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/dextromethorphan/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-24srcEffects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates
  3. 2026-09-24srcEfficacy and safety of dextromethorphan/quinidine in treating pseudobulbar affect: A systematic review and network meta-analysis
  4. 2026-09-24srcSodium Phenylbutyrate and Tauroursodeoxycholic Acid in ALS: DXM/quinidine as one of 5 FDA-approved ALS treatments
  5. 2026-09-24srcDextromethorphan-Bupropion for the Treatment of Depression: A Systematic Review of Efficacy and Safety in Clinical Trials
  6. 2026-09-24srcGlutamatergic Modulators for Major Depression from Theory to Clinical Use
  7. 2026-09-24srcThe strong clinical interaction between bupropion and CYP2D6 is primarily mediated through bupropion metabolites and their stereoisomers
  8. 2026-09-24srcTherapeutic effects of add-on low-dose dextromethorphan plus valproic acid in bipolar disorder
  9. 2026-09-24srcThe DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder
  10. 2026-09-24srcDextromethorphan as a potential rapid-acting antidepressant
  11. 2026-09-24srcAntidepressants in the post-ketamine era: Pharmacological approaches targeting the glutamatergic system
  12. 2026-09-24srcDextromethorphan/Bupropion: A Novel Oral NMDA Receptor Antagonist with Multimodal Activity
  13. 2026-09-24srcClassics in Chemical Neuroscience: Dextromethorphan (DXM)
  14. 2026-09-24srcPharmacokinetics and pharmacodynamics of dextromethorphan: clinical and forensic aspects
  15. 2026-09-24srcModulating tonic NMDA receptor currents: mechanistic insights into ketamine, esketamine, and dextromethorphan for major depressive disorder
  16. 2026-09-24srcAbuse liability of dextromethorphan and its combinatory formulation dextromethorphan/bupropion: a pharmacologic perspective
  17. 2026-09-24srcEffects of Dextromethorphan on Nicotine-Induced Reward, Behavioral Sensitization, Withdrawal Signs, and Drug Seeking-Related Behavior in Rats
  18. 2026-09-24srcCombination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial
  19. 2026-09-24srcDextromethorphan Overdose with Refractory Status Epilepticus and Reversible Cranial Nerve Reflex Loss: A Case Report
  20. 2026-09-24srcHigh doses of dextromethorphan induced shock and convulsions in a 19-year-old female: A case report
  21. 2026-09-24srcDextromethorphan/quinidine sulfate for pseudobulbar affect
  22. 2026-09-24srcPolymorphism of human cytochrome P450 2D6 and its clinical significance: Part I
  23. 2026-09-24srcDextromethorphan withdrawal and dependence syndrome
  24. 2026-09-24srcDextromethorphan provides neuroprotection via anti-inflammatory and anti-excitotoxicity effects in cortex following traumatic brain injury
  25. 2026-09-24srcBinding of dimemorfan to sigma-1 receptor and anticonvulsant effects compared with dextromethorphan and dextrorphan
  26. 2026-09-24srcDextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors
  27. 2026-09-24srcDextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys
  28. 2026-09-24srcA qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia
  29. 2026-09-24srcDrugs used in the treatment of opioid tolerance and physical dependence: a review
  30. 2026-09-24srcDextromethorphan psychosis, dependence and physical withdrawal
  31. 2026-09-24srcA qualitative systematic review of peri-operative dextromethorphan in post-operative pain
  32. 2026-09-24srcPost-treatment of dextromethorphan reverses morphine effect on conditioned place preference in rats
  33. 2026-09-24srcA comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder
  34. 2026-09-24srcDextromethorphan as a potential neuroprotective agent with unique mechanisms of action
  35. 2026-09-24srcDextromethorphan poisoning: an evidence-based consensus guideline for out-of-hospital management
  36. 2026-09-24srcAVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for treatment of pseudobulbar affect and neuropathic pain
  37. 2026-09-24srcDextromethorphan and dextrorphan as calcium channel antagonists
  38. 2026-09-24srcPharmacokinetics of dextromethorphan and metabolites in humans: influence of the CYP2D6 phenotype and quinidine inhibition
  39. 2026-09-24srcThe serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease
  40. 2026-09-24srcA clinical trial of dextromethorphan in amyotrophic lateral sclerosis
  41. 2026-09-24srcDextromethorphan ACS Molecule of the Week / Chemical history
  42. 2026-09-24srcDextromethorphan regulation by U.S. jurisdiction (Wikipedia)
  43. 2026-09-24srcDextromethorphan (StatPearls)
  44. 2026-09-24srcIUPHAR/BPS Guide to Pharmacology: Dextromethorphan ligand pharmacology
  45. 2026-09-24srcDextromethorphan physical properties (CAS 125-71-3)
  46. 2026-09-04issueIssued emergency
  47. 2026-09-04issueIssued info_card
  48. 2026-09-04issueIssued notice
  49. 2026-06-04proposal29 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  50. 2026-06-04publicationPublication — backfill
  51. 2026-04-24revisionRevision 1
  52. 2026-04-24genGeneration — pipeline-v5 · with 2 morepipeline-v5
  53. 2026-04-24rungeneration run

The same entries, as forms: six forms.