Dextromethorphan
(+)-3-methoxy-17-methylmorphinan
1Provenance card
the boundary, as counts
Sources
4423 with DOI
9 strong · 26 moderate · 9 weak
Compilations
12026-04-24T14:07:56.088Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09
Decisions
31last ruled 2026-06-04
0 awaiting a ruling
Issued documents
42026-10-19T20:31:26.972Z
notice · info card · emergency
Searches
190 with no results
queries and counts on the build
Claims checked
7359 supported
59 supported · 14 not
Correspondence
0received
consent field ships in Phase 4
Edges
253
derivations recorded for this entity
Complete over 44 sources, 1 compilation, and 31 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/dextromethorphan/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued info_card
- 2026-09-24srcEffects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates
- 2026-09-24srcEfficacy and safety of dextromethorphan/quinidine in treating pseudobulbar affect: A systematic review and network meta-analysis
- 2026-09-24srcSodium Phenylbutyrate and Tauroursodeoxycholic Acid in ALS: DXM/quinidine as one of 5 FDA-approved ALS treatments
- 2026-09-24srcDextromethorphan-Bupropion for the Treatment of Depression: A Systematic Review of Efficacy and Safety in Clinical Trials
- 2026-09-24srcGlutamatergic Modulators for Major Depression from Theory to Clinical Use
- 2026-09-24srcThe strong clinical interaction between bupropion and CYP2D6 is primarily mediated through bupropion metabolites and their stereoisomers
- 2026-09-24srcTherapeutic effects of add-on low-dose dextromethorphan plus valproic acid in bipolar disorder
- 2026-09-24srcThe DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder
- 2026-09-24srcDextromethorphan as a potential rapid-acting antidepressant
- 2026-09-24srcAntidepressants in the post-ketamine era: Pharmacological approaches targeting the glutamatergic system
- 2026-09-24srcDextromethorphan/Bupropion: A Novel Oral NMDA Receptor Antagonist with Multimodal Activity
- 2026-09-24srcClassics in Chemical Neuroscience: Dextromethorphan (DXM)
- 2026-09-24srcPharmacokinetics and pharmacodynamics of dextromethorphan: clinical and forensic aspects
- 2026-09-24srcModulating tonic NMDA receptor currents: mechanistic insights into ketamine, esketamine, and dextromethorphan for major depressive disorder
- 2026-09-24srcAbuse liability of dextromethorphan and its combinatory formulation dextromethorphan/bupropion: a pharmacologic perspective
- 2026-09-24srcEffects of Dextromethorphan on Nicotine-Induced Reward, Behavioral Sensitization, Withdrawal Signs, and Drug Seeking-Related Behavior in Rats
- 2026-09-24srcCombination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial
- 2026-09-24srcDextromethorphan Overdose with Refractory Status Epilepticus and Reversible Cranial Nerve Reflex Loss: A Case Report
- 2026-09-24srcHigh doses of dextromethorphan induced shock and convulsions in a 19-year-old female: A case report
- 2026-09-24srcDextromethorphan/quinidine sulfate for pseudobulbar affect
- 2026-09-24srcPolymorphism of human cytochrome P450 2D6 and its clinical significance: Part I
- 2026-09-24srcDextromethorphan withdrawal and dependence syndrome
- 2026-09-24srcDextromethorphan provides neuroprotection via anti-inflammatory and anti-excitotoxicity effects in cortex following traumatic brain injury
- 2026-09-24srcBinding of dimemorfan to sigma-1 receptor and anticonvulsant effects compared with dextromethorphan and dextrorphan
- 2026-09-24srcDextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors
- 2026-09-24srcDextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys
- 2026-09-24srcA qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia
- 2026-09-24srcDrugs used in the treatment of opioid tolerance and physical dependence: a review
- 2026-09-24srcDextromethorphan psychosis, dependence and physical withdrawal
- 2026-09-24srcA qualitative systematic review of peri-operative dextromethorphan in post-operative pain
- 2026-09-24srcPost-treatment of dextromethorphan reverses morphine effect on conditioned place preference in rats
- 2026-09-24srcA comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder
- 2026-09-24srcDextromethorphan as a potential neuroprotective agent with unique mechanisms of action
- 2026-09-24srcDextromethorphan poisoning: an evidence-based consensus guideline for out-of-hospital management
- 2026-09-24srcAVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for treatment of pseudobulbar affect and neuropathic pain
- 2026-09-24srcDextromethorphan and dextrorphan as calcium channel antagonists
- 2026-09-24srcPharmacokinetics of dextromethorphan and metabolites in humans: influence of the CYP2D6 phenotype and quinidine inhibition
- 2026-09-24srcThe serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease
- 2026-09-24srcA clinical trial of dextromethorphan in amyotrophic lateral sclerosis
- 2026-09-24srcDextromethorphan ACS Molecule of the Week / Chemical history
- 2026-09-24srcDextromethorphan regulation by U.S. jurisdiction (Wikipedia)
- 2026-09-24srcDextromethorphan (StatPearls)
- 2026-09-24srcIUPHAR/BPS Guide to Pharmacology: Dextromethorphan ligand pharmacology
- 2026-09-24srcDextromethorphan physical properties (CAS 125-71-3)
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-06-04proposal29 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-04-24revisionRevision 1
- 2026-04-24genGeneration — pipeline-v5 · with 2 morepipeline-v5
- 2026-04-24rungeneration run
The same entries, as forms: six forms.