Dextroamphetamine
Standing risks
- High dependence, taper carefullyconfidence high
- Physical dependence
- low
- Psychological dependence
- high
Lethal interactions
Specific substances
- Tramadollethal
By drug class
- Ibogainelethal3 mechanismsconfidence medium
- MAOIslethal6 mechanismsconfidence high
Dangerous interactions
33 dangerous interactions recorded for this substance.
See the full interactions tableContraindications
Cardiovascular
- symptomatic cardiovascular diseaseabsolute
Contraindicated in advanced arteriosclerosis, symptomatic cardiovascular disease, and structural cardiac abnormalities. FDA black box warning notes risk of sudden cardiac death.
- moderate-to-severe hypertensionabsolute
Contraindicated in moderate-to-severe hypertension. Cochrane review confirms chronic blood pressure elevation with amphetamine use.
Psychiatric
- psychotic disordersrelative
Personal or family history of psychosis represents elevated risk. Amphetamine can trigger first psychotic episodes or destabilize controlled schizophrenia.
- bipolar disorderrelative
Risk of mania induction in predisposed individuals. Requires careful risk-benefit assessment and mood stabilizer co-prescription if used.
Metabolic
- hyperthyroidismabsolute
Contraindicated in hyperthyroidism due to synergistic sympathomimetic overload.
Pregnancy & Breastfeeding
- pregnancyrelative
Associated with adverse pregnancy outcomes. Amphetamines excreted in breast milk at 3-7x maternal plasma levels — breastfeeding is contraindicated.
Other
- MAOI use within 14 daysabsolute
Concurrent or recent MAOI use is absolutely contraindicated. Minimum 14-day washout required. Applies to phenelzine, tranylcypromine, selegiline, linezolid, methylene blue.
- glaucomaabsolute
Contraindicated in narrow-angle glaucoma. Pupil dilation from noradrenergic activation can precipitate acute glaucoma attack.