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psx:substance/delta-11-thc/claim/b31395e2-16d9-4e8f-92a5-5805fdeb820c

claim2026-07-17workinginconclusive

derived from · upstream

feeds · downstream

Closure of psx:substance/delta-11-thc/claim/b31395e2-16d9-4e8f-92a5-5805fdeb820c: 42 upstream, 124 downstream.

psx:substance/delta-11-thc/claim/b31395e2-16d9-4e8f-92a5-5805fdeb820c
├─ used  src/pmid:1980883  In vitro metabolism of delta-11-tetrahydrocannabinol in the mouse, rat, guinea pig, rabbit, hamster, gerbil and cat.
  ├─ informed_by  claim/d4e9a52e-3245-450b-a98a-c111ec2e9d04  Claim in pharmacokinetic-detail — inconclusive  working
  ├─ informed_by  claim/b9dfe37b-e7ee-4ca2-abce-a920e33dd63a  Claim in pharmacokinetic-detail — inconclusive  working
  ├─ informed_by  claim/cc7cf8ca-7bbe-47e4-bbdf-d45b2ed3b27f  Claim in pharmacokinetic-detail — inconclusive  working
  ├─ informed_by  claim/82aa3704-30c8-4031-b441-254245b2b3b7  Claim in pharmacokinetic-detail — inconclusive  working
    ├─ used  src/pmid:2539557  The conformational analysis of delta 9- and delta 9,11-tetrahydrocannabinols in solution using high resolution nuclear magnetic resonance spectroscopy.
    ├─ used  src/pmid:3033218  Studies on the agonistic activity of delta 9-11-tetrahydrocannabinol in mice, dogs and rhesus monkeys and its interactions with delta 9-tetrahydrocannabinol.
    ├─ used  src/doi:10.1021/jo00804a024  Synthesis of (-)-Δ9(11)-trans-tetrahydrocannabinol
    ├─ used  src/pmid:2738895  The importance of the orientation of the C9 substituent to cannabinoid activity
    ├─ used  src/doi:10.3390/molecules30122597  Potency Analysis of Semi-Synthetic Cannabinoids in Vaping Oils Using Liquid Chromatography Diode Array Detector with Electrospray Ionization Time-of-Flight Mass Spectrometry for Confirmation of Analyte Identity.
    ├─ used  src/pmid:3037218  Cardiovascular effects of delta 9- and delta 9(11)-tetrahydrocannabinol and their interaction with epinephrine.
    ├─ used  src/pmid:5545571  The synthesis of (-)-delta-9(11)-trans-tetrahydrocannabinol.
    ├─ used  src/pmid:1652071  Evaluation of ether and free hydroxyl analogs of delta-8, delta-9, 11-THC as cannabinoid antagonists.
    ├─ used  src/pmid:1659638  Synthesis and pharmacological evaluation of ether and related analogues of delta 8-, delta 9-, and delta 9,11-tetrahydrocannabinol.
    ├─ used  src/doi:10.1002/dta.3519  Hexahydrocannabinol and closely related semi-synthetic cannabinoids: A comprehensive review
    ├─ used  src/url:09566063ee78cb09  Delta(9-11)-Tetrahydrocannabinol | CID 167577
    ├─ used  src/pmid:8388551  Discriminative stimulus effects of delta 9-tetrahydrocannabinol and delta 9-11-tetrahydrocannabinol in rats and rhesus monkeys.
    ├─ used  src/pmid:1653027  Electron impact-induced fragmentation of the trimethylsilyl derivatives of monohydroxy-hexahydrocannabinols.
    ├─ used  src/pmid:9379452  Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis of O,2-propano-delta 8-THC analogs
    ├─ used  src/doi:10.1093/jat/bkac051  Determination of Cross-Reactivity of Contemporary Cannabinoids with THC Direct Immunoassay (ELISA) in Whole Blood.
    ├─ used  src/doi:10.1016/j.phrs.2021.105970  Similarities and differences upon binding of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors
    ├─ derived_from  gen/d34084bd-cadf-49b8-a436-279e8bfc3f11  Generation — pipeline-v5
    ├─ generated_by  pub/15c3dfa2-7b44-4ce0-af6f-61c01d2f78c1  Publication — backfill
      ├─ used  search/fe0546ce-09e6-48b8-bb40-a6bca5bb8929  Searched PubChem for "delta-11-tetrahydrocannabinol"
      ├─ used  search/c0f0ced9-4a52-4d30-88aa-af999356e238  Searched PubMed for "delta-11-tetrahydrocannabinol pharmacology"
      ├─ used  search/fe584727-645c-4278-a4c3-f77953eeac77  Searched OpenAlex for "delta-11-tetrahydrocannabinol"
      ├─ used  search/e129c646-54d5-4d9a-9e77-ef2ef367d200  Searched PubMed for "9,11-tetrahydrocannabinol cannabinoid"
      ├─ used  search/a50a4651-0843-4bef-923c-8dce59d1731e  Searched PubMed for "delta 9,11-THC cannabinoid activity isomer"
      ├─ used  search/90ddf0d7-9509-4e69-b333-0d57ff866d82  Searched ClinicalTrials.gov for "delta-11-tetrahydrocannabinol"
      ├─ used  search/ced4ce2e-2a2a-465b-a0da-6cd4c68cfab2  Searched PubMed for "9,11-tetrahydrocannabinol OR delta-9,11-THC agonist activity mice dogs monkeys 1987"
      ├─ used  search/42feec7e-ab57-4d08-84e1-9dd872220ea7  Searched PubMed for "synthesis delta-9(11)-trans-tetrahydrocannabinol 1971"
      ├─ used  search/70ee8f2d-61eb-4d9e-9f28-08c0953e6776  Searched WebSearch for "delta-9,11-THC delta-11-THC legal status DEA Schedule I controlled substance"
      ├─ used  search/d7e6a9e7-ea54-4254-b759-8c9b434556e5  Searched WebSearch for "delta-9,11-THC UK Misuse of Drugs Act Australia Canada EMCDDA"
      ├─ used  search/10b18949-7851-4229-834d-274b428665d0  Searched WebFetch
      ├─ used  search/7c1b0e38-4a75-4be2-9690-6870588d8e13  Searched PubChem REST API
      ├─ used  search/e7a3a10b-408d-4134-acc9-e91250438a63  Searched Crossref DOI verification for "10.1021/jo00804a024"
      ├─ used  search/3e819ee0-30d3-402f-b795-27e815f9cde7  Searched PubMed for "cannabinoid C9 substituent orientation activity structure 1989"
      ├─ used  search/00d78d86-50e1-4163-a113-0c0f08744966  Searched WebSearch for "delta-11-THC 11-hydroxy-THC confusion nomenclature isomer cannabinoid"
      ├─ used  search/c6d958bd-b912-4afd-a0c4-ef0c4a86c040  Searched PubChem REST API - synonyms
      ├─ used  search/4f63871a-1775-4be5-94cc-641a438eefb2  Searched WebSearch for "delta-11-THC consumer market products effects potency claims"
      ├─ used  search/42163d8f-b9c2-4118-84af-39ed4c0e6a0c  Searched WebSearch for "EMCDDA novel cannabinoid THC isomers early warning Europe scheduling"
      └─ used  search/df69bf85-3047-4832-9e69-2d8fa5665752  Searched Multiple sources for "delta-11-THC vs 11-OH-THC nomenclature confusion"
├─ informed_by  section/pharmacokinetic-detail.full@1
  ├─ used  version/1  Revision 1
  ├─ used  claim/aef8dbea-d074-4bae-9edb-61eac9250173  Claim in pharmacology — inconclusive  working
  ├─ used  claim/9ae567cc-1ab1-40c1-8c48-cdd0c61bdf22  Claim in pharmacology — inconclusive  working
  ├─ used  claim/7dc0c14c-c637-4509-9839-9b2a9ef9e670  Claim in pharmacokinetic-detail — inconclusive  working
  ├─ used  claim/937b8db2-4319-4177-be8e-470dec771397  Claim in pharmacokinetic-detail — inconclusive  working
  ├─ used  claim/a6314839-faf5-4556-98e2-5277ab26da1d  Claim in pharmacokinetic-detail — inconclusive  working
  ├─ used  claim/8394039a-57c4-4ee6-8792-ad21c364aa10  Claim in neuroscience — inconclusive  working
  ├─ used  claim/d66998f1-070c-45cc-a4a1-93166a37b373  Claim in pharmacology — inconclusive  working
  ├─ used  claim/0b5fb88d-f35d-460e-93a1-7433ae22f516  Claim in pharmacology — inconclusive  working
  ├─ used  claim/0cb8b397-ef48-482c-80ef-4a46c31a727e  Claim in pharmacokinetic-detail — inconclusive  working
  ├─ used  claim/08273eac-a7e2-4d4e-870f-f098d1e82ba1  Claim in pharmacokinetic-detail — inconclusive  working
  ├─ used  claim/b7c792c9-4128-40b4-8d67-9cadd508ae80  Claim in neuroscience — inconclusive  working
    ├─ derived_from  issue/notice@6cc1eca3752c  Issued notice
    ├─ derived_from  issue/info_card@f36980593b42  Issued info_card
    ├─ derived_from  issue/emergency@207cf682e28a  Issued emergency
    ├─ derived_from  issue/info_card@690feaf0cb2f  Issued info_card
    ├─ derived_from  issue/emergency@7386375eac13  Issued emergency
    ├─ informed_by  section/pharmacology.full@1
    ├─ informed_by  section/neuroscience.full@1
      ├─ used  claim/be3a9eb3-0d7e-458f-a5f8-a639342605cc  Claim in summary — inconclusive  working
      ├─ used  claim/7e749add-78d8-4a11-a625-a3ab6a130a83  Claim in history — inconclusive  working
      ├─ used  claim/d482e975-1af0-496c-bb8b-8529c65e8a13  Claim in chemistry — inconclusive  working
      ├─ used  claim/907ee443-27d1-4e96-8b90-4e5e80711f56  Claim in chemistry — inconclusive  working
      ├─ used  claim/0c6943b5-d0a1-41a4-8ef0-30b8083f1d75  Claim in summary — inconclusive  working
      ├─ used  claim/1a9410b3-01c2-4db7-8456-efc4437272ad  Claim in history — inconclusive  working
      ├─ used  claim/7d4a6b6e-e934-49f4-8be8-e1f4e191ff41  Claim in chemistry — inconclusive  working
      ├─ used  claim/007a9b4d-ead5-4d25-9ffc-4429a589f074  Claim in chemistry — inconclusive  working
      ├─ used  claim/d85ff27e-c150-4d78-8bb3-3dcfec159556  Claim in summary — inconclusive  working
      ├─ used  claim/bea521d9-a9dd-4bd5-a4f7-a56c23bcf04d  Claim in summary — inconclusive  working
      ├─ used  claim/85327c5a-87c5-4b01-9fc5-ac37be60d956  Claim in pharmacology — inconclusive  working
      ├─ used  claim/8da3304b-635e-452a-8e10-4c9f5f4f7539  Claim in pharmacology — inconclusive  working
      ├─ used  claim/856e7457-e1dc-4cc7-8f33-04db72115734  Claim in pharmacology — inconclusive  working
      ├─ used  claim/9f9c480d-d540-4691-9c85-889e3ba083d1  Claim in safety — inconclusive  working
      ├─ used  claim/c7dec3d8-ce5e-4a19-9003-e9a8960aa8fc  Claim in safety — inconclusive  working
      ├─ used  claim/38be89e2-d27c-4831-a852-8b809b914a1e  Claim in safety — inconclusive  working
      ├─ used  claim/0fb11dce-381c-4551-aad2-77c5e2cde2f4  Claim in history — inconclusive  working
      ├─ used  claim/1bd2c926-0eef-45d6-93f6-ec7065048ae8  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/5e9751f3-d6ee-4646-bd52-4bd56d3c1c9f  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/14062721-7177-4816-8f5d-cd5bece25cc4  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/0d8e4790-021a-4bbd-93ba-6aa9abd76d48  Claim in neuroscience — inconclusive  working
      ├─ used  claim/c31d3344-0513-492d-9f22-4bc96627ffe7  Claim in summary — inconclusive  working
      ├─ used  claim/7b43f256-c50b-4bd7-b25d-4bfc60c126ff  Claim in summary — inconclusive  working
      ├─ used  claim/eef5f111-1f47-4986-9a36-72adb35242a2  Claim in pharmacology — inconclusive  working
      ├─ used  claim/8fe6fc55-71a9-4c0e-b25f-9202cfaf7f12  Claim in pharmacology — inconclusive  working
      ├─ used  claim/0c9caa3f-f399-46c4-8a5c-7f4e05441d5b  Claim in pharmacology — inconclusive  working
      ├─ used  claim/08a5e917-e009-432c-bcb8-71572fa2a51c  Claim in safety — inconclusive  working
      ├─ used  claim/13f11241-5a45-4eb5-b44e-c2daa2a89e89  Claim in safety — inconclusive  working
      ├─ used  claim/049b8d35-62ae-4cf9-ac64-658be9dc6cfa  Claim in safety — inconclusive  working
      ├─ used  claim/8bef2f49-121f-4d76-8bd1-9b66a3bc4cb4  Claim in history — inconclusive  working
      ├─ used  claim/496f199c-b1b0-4e33-af78-cca7bfdf0a3b  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/07a998bd-3d61-4a2e-8dea-636be9c197c3  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/f7211b37-2848-4456-880a-0f463a5cb235  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/2ed5b4c6-df71-4923-979d-b102a4fcaf8c  Claim in neuroscience — inconclusive  working
      ├─ used  claim/0f77ce87-ea96-4444-b81f-df7c6aee99a0  Claim in summary — inconclusive  working
      ├─ used  claim/2674bcc4-eae8-4cf6-9f94-3524c3761b7e  Claim in history — inconclusive  working
      ├─ used  claim/43d6b799-33e4-4068-9b82-e987d7afb9f1  Claim in chemistry — inconclusive  working
      ├─ used  claim/8560da91-275f-4402-b1cb-9218e32846f4  Claim in summary — inconclusive  working
      ├─ used  claim/80eea7f1-b559-4028-a41f-eb4257acb33c  Claim in history — inconclusive  working
      ├─ used  claim/ba15c584-d2d5-4eb2-b0dc-65508122f847  Claim in chemistry — inconclusive  working
      ├─ used  claim/9d295573-e427-4231-9ce3-0feb7b005824  Claim in pharmacology — inconclusive  working
      ├─ used  claim/c20db989-a929-4790-9398-aa3c74a0aca3  Claim in summary — inconclusive  working
      ├─ used  claim/50d9c938-f414-4f2e-a0de-333a71d6ac6b  Claim in history — inconclusive  working
      ├─ used  claim/8c241fe4-510c-47e7-9a41-0a5cebea2ebb  Claim in chemistry — inconclusive  working
      ├─ used  claim/83b1d315-d214-494a-ad75-2de9282b99f4  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/46fbfe75-bf04-4899-bd2c-a058fad59be2  Claim in summary — inconclusive  working
      ├─ used  claim/279d9829-b71b-4586-9935-20004d9708c3  Claim in pharmacology — inconclusive  working
      ├─ used  claim/7816e6f4-57c6-4ab7-a068-b8b180784f47  Claim in history — supported
      ├─ used  claim/253ff06d-28f5-448d-9351-3c945affdf39  Claim in chemistry — inconclusive  working
      ├─ used  claim/e2801cdd-d031-4488-a1f6-a0373549573e  Claim in comparative-pharmacology — supported
      ├─ used  claim/be7ae777-22cd-4a60-981e-ff56d98f5465  Claim in summary — inconclusive  working
      ├─ used  claim/5d5373d5-8e00-4423-b882-8d47bc297a0d  Claim in safety — inconclusive  working
      ├─ used  claim/a7c61737-b47c-47ef-9481-89f1d6c96f4f  Claim in safety — inconclusive  working
      ├─ used  claim/9ee14a11-0f55-4244-8140-3c368541fbc9  Claim in history — inconclusive  working
      ├─ used  claim/bccb31ab-bb07-4a7a-8219-f6f6ed5b32de  Claim in summary — inconclusive  working
      ├─ used  claim/3ab50982-24a3-49ab-985f-d107222b109a  Claim in safety — inconclusive  working
      ├─ used  claim/e69f35ae-3f45-4620-86a1-72e6e5427469  Claim in safety — inconclusive  working
      ├─ used  claim/38a6e438-a4eb-43ac-84f3-ebba9e591a1a  Claim in history — inconclusive  working
      ├─ used  claim/7a06a867-8d13-401a-bef0-2101124cfb15  Claim in summary — inconclusive  working
      ├─ used  claim/5f8f3573-bd61-499a-ae39-cb5cd0844d44  Claim in pharmacology — inconclusive  working
      ├─ used  claim/f4c7024b-0323-4687-91dc-6404e248f103  Claim in pharmacology — inconclusive  working
      ├─ used  claim/94eb16d9-f137-42cb-939e-7ea4b1ed4078  Claim in safety — inconclusive  working
      ├─ used  claim/e66bd479-3497-4727-9473-9a9519296296  Claim in safety — inconclusive  working
      ├─ used  claim/99d7ff5e-f501-4187-8b4f-e1eb7fbcc974  Claim in safety — inconclusive  working
      ├─ used  claim/6f77173b-d29b-4c13-a657-4d2e4f396e5b  Claim in safety — inconclusive  working
      ├─ used  claim/9bcff596-a80d-43e7-8fa6-d4e798fa0ade  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/aaa76126-2879-4c5f-b70d-516cc2353df6  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/c29deca3-5f72-4acf-a9f0-4a75c81aeff9  Claim in summary — inconclusive  working
      ├─ used  claim/be1a0386-41c9-4fd3-a8c2-55c0827cc282  Claim in pharmacology — inconclusive  working
      ├─ used  claim/c4aa9280-37e6-47ae-a2fc-1e1d8a34dd02  Claim in pharmacology — inconclusive  working
      ├─ used  claim/2f4301a6-d465-4f92-a3bd-504222df072a  Claim in safety — inconclusive  working
      ├─ used  claim/9039be8d-16ca-4f2a-86db-79a0a535d51e  Claim in safety — inconclusive  working
      ├─ used  claim/437b427f-397c-4cff-98d0-cb49d3a9d873  Claim in safety — inconclusive  working
      ├─ used  claim/7e7f5e0b-abb9-4b9e-9128-4aee01388a55  Claim in safety — inconclusive  working
      ├─ used  claim/6bbd866d-22a2-4dd2-8075-b905b3523a08  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/60adbe86-cda1-420e-971f-ae52d9d40381  Claim in comparative-pharmacology — inconclusive  working
      ├─ used  claim/cc5fc6cc-4b7b-47d0-b20b-b58a343e0852  Claim in history — inconclusive  working
      ├─ used  claim/a06abf02-9daa-4d13-abb3-be9e9e70a317  Claim in history — inconclusive  working
      ├─ used  claim/b4fec0ce-4103-4839-96d7-378d93abad43  Claim in history — inconclusive  working
      ├─ used  claim/ef59451e-e928-494d-ae4a-8178475d49d6  Claim in history — inconclusive  working
      ├─ used  claim/0653f36b-d9cb-4ef1-aac9-f0ea750604c2  Claim in pharmacology — inconclusive  working
      ├─ used  claim/7c41d26c-2eba-41a4-b1e0-e2c5193c4557  Claim in history — inconclusive  working
      ├─ used  claim/ed497a87-186b-4702-90a7-1e8408628944  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/9df026e0-8291-45fe-899a-e658574b036a  Claim in pharmacology — inconclusive  working
      ├─ used  claim/4e985c03-b840-4864-8223-391560b6a054  Claim in history — inconclusive  working
      ├─ used  claim/f7606514-3f31-461a-89e7-d4d5b7387f97  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/61acd00c-dc57-4e94-8d0b-5b90db0055e0  Claim in history — inconclusive  working
      ├─ used  claim/e2374128-d652-4eb0-8c99-27f35ceb74b2  Claim in history — supported
      ├─ used  claim/e25a838d-34df-41ab-a537-8b7c366b61d2  Claim in pharmacology — inconclusive  working
      ├─ used  claim/9f6ede6d-6ac1-4663-bb93-29be76f62f9b  Claim in pharmacology — inconclusive  working
      ├─ used  claim/08fec200-1f2a-4afc-a662-3bf85be24b7a  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/411633f8-963a-4080-87fc-ff790eef6291  Claim in neuroscience — inconclusive  working
      ├─ used  claim/02d673c3-456c-4bfc-b55e-a15137bd0a11  Claim in pharmacology — inconclusive  working
      ├─ used  claim/92075c39-528c-4b75-ad82-c011679f3769  Claim in pharmacology — inconclusive  working
      ├─ used  claim/7fdfecb7-453e-4b9d-9791-24a9f9285343  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/359284ea-560d-43af-bffb-c889a62d8ff0  Claim in neuroscience — inconclusive  working
      ├─ used  claim/2d83cf88-336a-4a3e-aab0-743f7c8c31b1  Claim in pharmacology — inconclusive  working
      ├─ used  claim/7609d6d7-519a-4158-9e4d-4c8fbc908041  Claim in pharmacology — inconclusive  working
      ├─ used  claim/4785a39b-5f03-4582-8103-cf2f49a04688  Claim in receptor-pharmacology — inconclusive  working
      ├─ used  claim/29488411-282e-4f9d-b90e-159eeecf767b  Claim in receptor-pharmacology — partially_supported
      ├─ used  claim/38e3eae9-8181-413c-a874-57d0d105b251  Claim in safety — inconclusive  working
      ├─ used  claim/77e526a6-2b67-49c2-828d-575c8c95d923  Claim in safety — inconclusive  working
      ├─ used  claim/9b7a983e-2162-4f4d-9657-864de2d77c33  Claim in safety — inconclusive  working
      └─ used  claim/27432193-5077-49ef-98ab-9690a1b017c3  Claim in safety — inconclusive  working
… closure truncated at 200 nodes

indented by distance from this node, not by parentage

1Provenance card

the boundary, as counts

Sources

175 with DOI

1 strong · 15 moderate · 1 weak

Compilations

12026-05-11T12:16:18.815Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

19last ruled 2026-06-04

0 awaiting a ruling

Issued documents

52026-10-19T20:31:19.158Z

notice · info card · emergency

Searches

191 with no results

queries and counts on the build

Claims checked

1204 supported

4 supported · 116 not

Correspondence

0received

consent field ships in Phase 4

Edges

312

derivations recorded for this entity

Complete over 17 sources, 1 compilation, and 19 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/delta-11-thc/archive

2Build

one panel per compilation run

generation run 2026-05-11

55 min completedmodel pipeline-v5plan not recordedrun/c85aadc2…

research

citationsRegistryrecordresearchOutputworking

draft

articleDraftworking

audit

articleAuditedworking

verify

verificationResultworking

simplify

articleSimplifiedworking

publish

runMetarecordrunSummaryrecord

Selection

results seen106
selected by the model20
consumed as sources17

Verification

claims checked120
supported3
partially supported1
not supported0
inconclusive116
  • record
  • seen / partial
  • working

The model's own caveats

1 further caveat recorded as free text — readable on the working page

Reproduce

inputs
17 source keys (listed under Sources)
plan
not recorded — template version, prompt hash and git SHA are written from 2026-09 onward
model
pipeline-v5
streams
none — agent transcripts are persisted from 2026-09 onward
19 searches — query, source, results, what was kept and why
19 searches for this run
#sourcequeryseenkeptrationale
1ClinicalTrials.gov · absencedelta-11-tetrahydrocannabinol00No clinical trials registered for this compound
2PubMeddelta 9,11-THC cannabinoid activity isomer33Key papers on receptor binding, conformation, and cardiovascular effects of delta-9,11-THC
3PubMeddelta-11-tetrahydrocannabinol pharmacology154Direct primary research on delta-11-THC / delta-9,11-THC pharmacology and metabolism
4PubMed9,11-tetrahydrocannabinol cannabinoid152Relevant to semi-synthetic market context and analytical detection of delta-9,11-THC
5PubChemdelta-11-tetrahydrocannabinol11Primary chemical identity source; confirms exocyclic double bond structure
6OpenAlexdelta-11-tetrahydrocannabinol100No directly relevant results for delta-11-THC specifically
7WebFetch—11Establishes legal framework applicable to delta-9,11-THC as a synthetic or semi-synthetic THC isomer
8PubMedsynthesis delta-9(11)-trans-tetrahydrocannabinol 197111First synthesis paper for delta-9,11-THC (1971)
9WebSearchdelta-9,11-THC delta-11-THC legal status DEA Schedule I controlled substance100General legal framework only - no compound-specific ruling found
10PubMed9,11-tetrahydrocannabinol OR delta-9,11-THC agonist activity mice dogs monkeys 198711Most comprehensive animal pharmacology study of delta-9,11-THC
11WebSearchdelta-9,11-THC UK Misuse of Drugs Act Australia Canada EMCDDA100General regulatory framework; no compound-specific rulings for delta-9,11-THC
12WebSearchdelta-11-THC 11-hydroxy-THC confusion nomenclature isomer cannabinoid100Critical flag for generation agent about consumer market misinformation
13PubMedcannabinoid C9 substituent orientation activity structure 198911Key structure-activity paper explaining why delta-9,11-THC is inactive or weakly active at CB1
14PubChem REST API—13Authoritative chemical structure data for the research output
15Crossref DOI verification10.1021/jo00804a02411Confirms first synthesis paper for the compound
16WebSearchEMCDDA novel cannabinoid THC isomers early warning Europe scheduling100Establishes EU regulatory context
17WebSearchdelta-11-THC consumer market products effects potency claims100Establishes contemporary market context and important consumer misinformation flag
18PubChem REST API - synonyms—12Complete chemical registry data for the compound
19Multiple sourcesdelta-11-THC vs 11-OH-THC nomenclature confusion50Critical flag for generation agent: claims of extreme potency are based on compound confusion
120 claims by section — every cited sentence, checked against its source
pharmacology24 · 0 ok

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safety22 · 0 ok

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history18 · 2 ok

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  • Simultaneously, Reggio and colleagues at the University of North Carolina used molecular mechanics calculations to classify Δ-9,11-THC as an "inactive cannabinoid" based on its carbocyclic ring conformation, while Kriwacki and Makriyannis at the University of Connecticut characterized its solution conformation by NMR and similarly described it as "biologically inactive"supported

    Molecular mechanics calculations show that carbocyclic ring conformation determines orientation relative to phenyl group hydroxyl. pmid:2738895

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  • This regulatory framework inadvertently created a commercial pathway for semi-synthetic cannabinoids — compounds produced by isomerizing hemp-derived cannabidiol (CBD) into various THC isomerssupported

    Current large-scale manufacture of HHC is based on hemp-derived CBD extract, converted by cyclization into delta8/delta9-THC mixture, followed by catalytic hydrogenation to afford a mixture of (9R)-HHC and (9S)-HHC epimers. dta.3519

summary14 · 0 ok

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comparative-pharmacology10 · 1 ok

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  • Reggio et al. (1989) demonstrated that the chair conformation misaligns the C9 substituent relative to the phenolic hydroxyl, disrupting a geometric relationship proposed as critical for cb1-receptor binding.supported

    Molecular mechanics calculations show that carbocyclic ring conformation determines orientation relative to phenyl group hydroxyl. pmid:2738895

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pharmacokinetic-detail10 · 0 ok

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chemistry8 · 0 ok

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receptor-pharmacology8 · 1 ok

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  • Reggio et al. (1997) synthesized O,2-propano-bridged analogs of Δ-9,11-THC and found modest CB2 selectivity in these derivatives, but the parent compound itself was not characterized at CB2.partially supported

    HHC analogs evaluated for CB1 and CB2 receptor affinity. O,2-propano-9-beta-OH-11-nor-HHC: Ki(CB1) = 26 nM, Ki(CB2) = 5.8 nM. pmid:9379452

neuroscience6 · 0 ok

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3Sources

17 consumed · sorted by year · feeds = sections resting on it

Sources
yearsourcetierstatusfeeds
2025Potency Analysis of Semi-Synthetic Cannabinoids in Vaping Oils Using Liquid Chromatography Diode Array Detector with Electrospray Ionization Time-of-Flight Mass Spectrometry for Confirmation of Analyte Identity.Zhang S, Alam MM, Chandler BD, Lanorio JP, Deskins C, Song L · Molecules (Basel, Switzerland)doi:10.3390/molecules30122597moderateconsumed4 sections
2024Delta(9-11)-Tetrahydrocannabinol | CID 167577PubChem (NCBI)url:09566063ee78cb09weakconsumedcited only
2024Hexahydrocannabinol and closely related semi-synthetic cannabinoids: A comprehensive reviewUjváry I · Drug Testing and Analysisdoi:10.1002/dta.3519moderateconsumed1 section
2022Determination of Cross-Reactivity of Contemporary Cannabinoids with THC Direct Immunoassay (ELISA) in Whole Blood.Moody MT, Ringel MM, Mathews CM, Midthun KM · Journal of analytical toxicologydoi:10.1093/jat/bkac051moderateconsumed1 section
2021Similarities and differences upon binding of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptorsRaïch I, Rivas-Santisteban R, Lillo A, et al. · Pharmacological Researchdoi:10.1016/j.phrs.2021.105970strongconsumedcited only
1997Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis of O,2-propano-delta 8-THC analogsReggio PH, Wang T, Brown AE, et al. · Journal of Medicinal Chemistrypmid:9379452moderateconsumed1 section
1993Discriminative stimulus effects of delta 9-tetrahydrocannabinol and delta 9-11-tetrahydrocannabinol in rats and rhesus monkeys.Wiley JL, Barrett RL, Britt DT, Balster RL, Martin BR · Neuropharmacologypmid:8388551moderateconsumed3 sections
1991Electron impact-induced fragmentation of the trimethylsilyl derivatives of monohydroxy-hexahydrocannabinols.Harvey DJ, Brown NK · Biological mass spectrometrypmid:1653027moderateconsumed2 sections
1991Synthesis and pharmacological evaluation of ether and related analogues of delta 8-, delta 9-, and delta 9,11-tetrahydrocannabinol.Compton DR, Prescott WR, Martin BR, Siegel C, Gordon PM, Razdan RK · Journal of medicinal chemistrypmid:1659638moderateconsumed3 sections
1990Evaluation of ether and free hydroxyl analogs of delta-8, delta-9, 11-THC as cannabinoid antagonists.Compton DR, Prescott WR, Siegel CS, Gordon PM, Razdan RK, Martin BR · NIDA research monographpmid:1652071moderateconsumed1 section
1990In vitro metabolism of delta-11-tetrahydrocannabinol in the mouse, rat, guinea pig, rabbit, hamster, gerbil and cat.Harvey DJ, Brown NK · Comparative biochemistry and physiology. C, Comparative pharmacology and toxicologypmid:1980883moderateconsumed3 sections
1989The conformational analysis of delta 9- and delta 9,11-tetrahydrocannabinols in solution using high resolution nuclear magnetic resonance spectroscopy.Kriwacki RW, Makriyannis A · Molecular pharmacologypmid:2539557moderateconsumed3 sections
1989The importance of the orientation of the C9 substituent to cannabinoid activityReggio PH, Greer KV, Cox SM · Journal of Medicinal Chemistrypmid:2738895moderateconsumed5 sections
1987Cardiovascular effects of delta 9- and delta 9(11)-tetrahydrocannabinol and their interaction with epinephrine.Estrada U, Brase DA, Martin BR, Dewey WL · Life sciencespmid:3037218moderateconsumed4 sections
1987Studies on the agonistic activity of delta 9-11-tetrahydrocannabinol in mice, dogs and rhesus monkeys and its interactions with delta 9-tetrahydrocannabinol.Beardsley PM, Scimeca JA, Martin BR · The Journal of pharmacology and experimental therapeuticspmid:3033218moderateconsumed7 sections
1971Synthesis of (-)-Δ9(11)-trans-tetrahydrocannabinolPitt CG, Wildes JW, Martin NH, Wall ME · The Journal of Organic Chemistrydoi:10.1021/jo00804a024moderateconsumed3 sections
1971The synthesis of (-)-delta-9(11)-trans-tetrahydrocannabinol.Wildes JW, Martin NH, Pitt CG, Wall ME · The Journal of organic chemistrypmid:5545571moderateconsumed1 section
—Searched ClinicalTrials.gov for "delta-11-tetrahydrocannabinol" — no resultsabsenceno results—

4Docket

one filing per activity — decisions, correspondence, reports

  1. 0012026-05-11revisionRevision 1

    Initial LLM generation (v5 pipeline, wiki, prose phase)

    psx:substance/delta-11-thc/version/1
  2. 0022026-05-11proposalduration · oral · totalrejectedworking →
  3. 0032026-05-11proposalduration · inhaled · totalrejectedworking →
  4. 0042026-06-04proposal15 value proposals approved together

    one review action inferred from a shared reviewer and instant — the graph records one activity per proposal

    15 items in this filing

    • contraindication · psychiatric
    • contraindication · pregnancy_breastfeeding
    • contraindication · other
    • toxicity
    • dependence · full
    • withdrawal
    • tolerance
    • dose_tier · threshold
    • dose_tier · light
    • dose_tier · common
    • dose_tier · strong
    • dose_tier · heavy
    • dosage · oral
    • dosage · inhaled
    psx:substance/delta-11-thc/proposal/contraindication/c5745268-4fe1-4f94-b280-2d1d1c448418
  5. 0052026-06-04publicationPublication — backfill
    psx:substance/delta-11-thc/pub/15c3dfa2-7b44-4ce0-af6f-61c01d2f78c1

5Issued documents

what the notice, info card and emergency page said, by hash

Issued documents
documentcontent hashissuedfrom versionsuperseded
emergency7386375eac1334714f070b93…2026-10-19 20:31Revision 1current
info_card690feaf0cb2f68edf0cae33b…2026-10-19 20:31Revision 1current
emergency207cf682e28a91d88136b9a2…2026-09-04 04:29Revision 1superseded2026-10-19
info_cardf36980593b42f5efaa843758…2026-09-04 04:29Revision 1superseded2026-10-19
notice6cc1eca3752c8ad4ae4d5c0c…2026-09-04 04:29Revision 1current