Cocoa

6Node page

what any key link opens

psx:substance/cocoa/import/curiosity-v1

import2026-03-17recordimported

derived from · upstream

none recorded

feeds · downstream

derived_fromRevision 1psx:substance/cocoa/version/1

psx:substance/cocoa/import/curiosity-v1
└─ derived_from  version/1  Revision 1

indented by distance from this node, not by parentage

1Provenance card

the boundary, as counts

Sources

3824 with DOI

9 strong · 25 moderate · 4 weak

Compilations

12026-05-13T08:52:52.271Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

20last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:31:13.284Z

notice · info card · emergency

Searches

200 with no results

queries and counts on the build

Claims checked

1436 supported

6 supported · 137 not

Correspondence

0received

consent field ships in Phase 4

Edges

375

derivations recorded for this entity

Complete over 38 sources, 1 compilation, and 20 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/cocoa/archive

2Build

one panel per compilation run

generation run 2026-05-13

56 min completedmodel pipeline-v5plan not recordedrun/73845b2f…

Selection

results seen108

selected by the model46

consumed as sources38

Verification

claims checked143

supported4

partially supported2

not supported0

inconclusive137

record
seen / partial
working

The model's own caveats

sparse_evidence
taper_not_applicable

Reproduce

inputs: 38 source keys (listed under Sources)
plan: not recorded — template version, prompt hash and git SHA are written from 2026-09 onward
model: pipeline-v5
streams: none — agent transcripts are persisted from 2026-09 onward

20 searches — query, source, results, what was kept and why

20 searches for this run
#	source	query	seen	kept	rationale
1	PubMed	cocoa theobromine pharmacology mechanism receptor	6	4	Core mechanistic pharmacology papers for theobromine and caffeine in cocoa
2	PubMed	Theobroma cacao alkaloids theobromine caffeine phytochemistry	1	1	Key review on caffeine/theobromine biosynthesis in Theobroma and related plants
3	PubMed	cocoa flavanols polyphenols health effects cardiovascular	10	3	High-quality RCTs and systematic reviews on cocoa health effects
4	PubChem	theobromine, caffeine, phenethylamine, anandamide	4	4	Core active constituents of cocoa confirmed
5	OpenAlex	Theobroma cacao cocoa phytochemistry constituents methylxanthines flavonoids	10	4	High-citation papers covering cocoa phytochemistry and health effects
6	WebSearch	Theobroma cacao POWO accepted taxonomy family Malvaceae native range synonyms	10	2	Confirms botanical taxonomy
7	PubMed	cocoa chocolate heavy metal cadmium lead contamination safety	8	4	Safety-critical contaminant data: cadmium in cocoa major documented concern
8	POWO (Plants of the World Online)	Theobroma cacao taxonomy	1	1	Authoritative taxonomy source
9	PubMed	chocolate phenylethylamine tyramine biogenic amine content analysis	1	1	Confirms phenylethylamine/tyramine presence in chocolate via fermentation
10	PubMed	Theobroma cacao genetics cultivar criollo forastero trinitario genotype	1	1	Key paper on cultivar genetics and domestication history
11	PubMed	cocoa cacao Maya evidence residue history	1	1	Foundational archaeological evidence of earliest Maya cacao use, Nature publication
12	ClinicalTrials.gov	cocoa flavanols cognitive function randomized	6	4	Active clinical research base on cocoa cognitive/neurological effects
13	OpenAlex	Theobroma cacao history ethnobotany Maya Aztec Mesoamerica chocolate	10	3	Key ethnobotanical and archaeological literature on cacao origin and indigenous use
14	WebSearch	Theobroma cacao Linnaeus 1753 history European introduction colonial Mexico	10	2	Historical context for ethnobotany section
15	PubMed	theobromine cough antitussive effect clinical trial	1	1	Pharmacological effect of theobromine beyond CNS/cardiovascular — antitussive clinical RCT
16	Multiple PubMed + OpenAlex sources	Theobromine/caffeine quantitative data in cocoa	5	3	Quantitative alkaloid data for alkaloid profile section
17	PubMed	di Tomaso Beltramo Piomelli chocolate brain cannabinoid	1	3	Key papers on endocannabinoid-mimic hypothesis for chocolate — relevant to psychoactive effects discussion
18	OpenAlex	cocoa blood pressure meta-analysis systematic review	8	1	Highest quality evidence on cocoa cardiovascular effects — Cochrane review
19	PubMed	caffeine pregnancy birth outcomes systematic review	4	1	Safety: pregnancy contraindication data for caffeine in cocoa
20	OpenAlex	theobromine pharmacology cardiovascular respiratory stimulant mechanism	10	2	Foundational pharmacology reviews on theobromine mechanism

143 claims by section — every cited sentence, checked against its source

safety50 · 2 ok

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At 125-200 mg/kg/day, fetal weight decreases and skeletal malformations were observed, while dietary exposure at 63 mg/kg/day or less showed no fetotoxicity or teratogenicity.supported
Developmental variations at 125-200 mg/kg. No teratogenicity at dietary levels. Highest test doses 38x human maximum consumption. pmid:3744189
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A meta-analysis of 60 studies found that each 100 mg increment in daily caffeine intake was associated with a 14% increase in spontaneous abortion risk, a 19% increase in stillbirth risk, and a 10% increase in small-for-gestational-age birth risksupported
Meta-analysis of 60 publications: per 100mg caffeine increment associated with 14% increased spontaneous abortion risk, 19% stillbirth, 7% low birth weight, 10% SGA. s10654-014-9944-x
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alkaloid-profile26 · 0 ok

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neuroscience20 · 3 ok

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At physiologically relevant concentrations (30 uM), theobromine facilitates synaptic transmission via A1R blockade and impairs long-term potentiation via A2AR blockade in hippocampal neuronssupported
Theobromine (30 uM) facilitated synaptic transmission while decreasing LTP magnitude. A1R antagonist eliminated theobromine-dependent facilitation; A2AR antagonist abrogated LTP impairment. ijms231810510
This dual action also confers neuroprotection against amyloid-beta1-42-induced neuronal loss in vitro. Caffeine shares these receptor targets but is present in cocoa at approximately one-tenth the concentration of theobrominepartially supported
Theobromine prevented LTP deficits and neuronal loss in Abeta1-42 exposed hippocampal preparations. ijms231810510
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The proposed mechanism is peripheral inhibition of capsaicin-induced sensory nerve depolarization of the vagus nerve, a pathway distinct from adenosine receptor antagonism.supported
Theobromine directly inhibits capsaicin-induced sensory nerve depolarization of guinea-pig and human vagus nerve suggestive of an inhibitory effect on afferent nerve activation. Actions of theobromine appear to be peripherally mediated. pmid:15548587
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preparations20 · 0 ok

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summary13 · 1 ok

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Theobromine exerts its primary central and peripheral effects through antagonism of adenosine A1 and A2A receptors and inhibition of phosphodiesterases, increasing intracellular cAMPpartially supported
A1R antagonist eliminated theobromine-dependent facilitation; A2AR antagonist abrogated LTP impairment. ijms231810510
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history12 · 0 ok

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botanical-overview2 · 0 ok

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3Sources

38 consumed · sorted by year · feeds = sections resting on it

Sources 1 to 30
year	source	tier	status	feeds
2026	Chromatographic Profiling of Artisanal Chocolates: Volatile Composition and Methylxanthines as Markers of Cocoa Content.Altissimo J et al. · Journal of Food Sciencedoi:10.1111/1750-3841.70979	moderate	consumed	3 sections
2026	Dark chocolate, heavy metals, and neurodevelopment in children.Avasarala J · Food and Chemical Toxicologydoi:10.1016/j.fct.2025.115799	moderate	consumed	1 section
2026	Simulated gastrointestinal digestion of cocoa powder (INFOGEST): methylxanthine bioaccessibility and antioxidant properties.Rivera-Manzorro L et al. · Food & Functiondoi:10.1039/d5fo05193b	moderate	consumed	1 section
2025	Severe hypernatremia in a dog following activated charcoal treatment for chocolate ingestion.Genareo C, Durkan S · Canadian Veterinary Journalpmid:41030422	weak	consumed	1 section
2024	Theobroma cacao — Plants of the World OnlineRoyal Botanic Gardens Kewurl:3785f4fea644a5a3	weak	consumed	cited only
2024	Theobroma cacao (L.) — First described by Linnaeus, Species Plantarum, 1753; European Introduction timelineVarious (Wikipedia, Kew, Oxford)url:30f9ffb844cf77a0	weak	consumed	cited only
2023	Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial (COSMOS-Mind).Baker LD, Manson JE, Rapp SR, Sesso HD, Gaussoin SA, Shumaker SA, Espeland MA · Alzheimer's & Dementiadoi:10.1002/alz.12767	strong	consumed	3 sections
2023	Flavan-3-ol-methylxanthine interactions: Modulation of flavan-3-ol bioavailability in volunteers with a functional colon and an ileostomyOttaviani JI, Fong RY, Borges G, et al. · Free Radical Biology & Medicinedoi:10.1016/j.freeradbiomed.2023.01.003	strong	consumed	cited only
2023	Profile of Bioactive Components of Cocoa (Theobroma cacao L.) By-Products from Ecuador.Llerena W et al. · Foodsdoi:10.3390/foods12132583	moderate	consumed	1 section
2023	Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis.Di Pede G, Mena P et al. · Molecular Aspects of Medicinedoi:10.1016/j.mam.2022.101146	strong	consumed	2 sections
2022	Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: COSMOS randomized clinical trial.Sesso HD, Manson JE, et al. · American Journal of Clinical Nutritiondoi:10.1093/ajcn/nqac055	strong	consumed	2 sections
2022	Theobromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and DamageValada P, Alcada-Morais S, Cunha RA, Lopes JP · International Journal of Molecular Sciencesdoi:10.3390/ijms231810510	moderate	consumed	2 sections
2021	Pre-clinical and cellular toxicity evaluation of 7-methylxanthine.Singh H et al. · Drug and Chemical Toxicologydoi:10.1080/01480545.2019.1635615	moderate	consumed	1 section
2020	Cocoa-laden cadmium threatens human health and cacao economy: A critical view.Maddela NR et al. · Science of the Total Environmentdoi:10.1016/j.scitotenv.2020.137645	moderate	consumed	1 section
2020	Perspective on Cadmium and Lead in Cocoa and Chocolate.Abt E, Robin LP · Journal of Agricultural and Food Chemistrydoi:10.1021/acs.jafc.9b08295	moderate	consumed	2 sections
2020	The History of Cacao and Its Diseases in the Americas.Diaz-Valderrama JR, Leiva S, Aime MC · Phytopathologydoi:10.1094/phyto-05-20-0178-rvw	moderate	consumed	2 sections
2019	Identification and quantification of free and bound phenolic compounds in high-molecular weight melanoidin fractions derived from two different types of cocoa beans.Oracz J, Nebesny E, Zyzelewicz D · Food Research Internationaldoi:10.1016/j.foodres.2018.08.028	moderate	consumed	2 sections
2019	Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative DiseaseCamandola S, Plick N, Mattson MP · Neurochemical Researchdoi:10.1007/s11064-018-2492-0	moderate	consumed	1 section
2019	Sub-Chronic Consumption of Dark Chocolate Enhances Cognitive Function and Releases Nerve Growth Factors: A Parallel-Group Randomized TrialSumiyoshi E, Matsuzaki K, Sugimoto N, Tanabe Y, Hara T, Katakura M, Miyamoto M, Mishima S, Shido O · Nutrientsdoi:10.3390/nu11112800	strong	consumed	cited only
2017	Effect of cocoa on blood pressure.Ried K, Fakler P, Stocks N · Cochrane Database of Systematic Reviewsdoi:10.1002/14651858.cd008893.pub3	strong	consumed	1 section
2017	Effect of the solid state fermentation of cocoa shell on the secondary metabolites, antioxidant activity, and fatty acids.Lessa OA et al. · Food Science and Biotechnologydoi:10.1007/s10068-017-0196-x	moderate	consumed	cited only
2016	Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks.Monteiro JP, Alves MG, Oliveira PF, Silva BM · Moleculesdoi:10.3390/molecules21080974	moderate	consumed	1 section
2015	Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregationRull G, Mohd-Zain ZN, Shiel J, Lundberg MH, Collier DJ, Johnston A, Warner TD, Corder R · Vascular Pharmacologydoi:10.1016/j.vph.2015.02.010	strong	consumed	1 section
2015	The cardiovascular benefits of dark chocolate.Kerimi A, Williamson G · Vascular Pharmacologydoi:10.1016/j.vph.2015.05.011	moderate	consumed	3 sections
2015	The relevance of theobromine for the beneficial effects of cocoa consumption.Martinez-Pinilla E, Onatibia-Astibia A, Franco R · Frontiers in Pharmacologydoi:10.3389/fphar.2015.00030	moderate	consumed	3 sections
2014	Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose-response meta-analysis.Greenwood DC, Thatcher NJ, Ye J, Garrard L, et al. · European Journal of Epidemiologydoi:10.1007/s10654-014-9944-x	strong	consumed	1 section
2008	Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering.Ashihara H, Sano H, Crozier A · Phytochemistrypmid:18068204	moderate	consumed	1 section
2008	Clinical benefit and preservation of flavonols in dark chocolate manufacturing.McShea A, Ramiro-Puig E, Munro SB, Casadesus G, Castell M · Nutrition Reviewsdoi:10.1111/j.1753-4887.2008.00114.x	moderate	consumed	2 sections
2005	Theobromine inhibits sensory nerve activation and coughUsmani OS, Belvisi MG, Patel HJ, Crispino N, Birrell MA, Korbonits M, Korbonits D, Barnes PJ · FASEB Journalpmid:15548587	strong	consumed	1 section
2003	Cacao domestication II: progenitor germplasm of the Trinitario cacao cultivar.Motamayor JC, Risterucci AM, Heath M, Lanaud C · Hereditypmid:12939635	moderate	consumed	cited only

Show all 38 sources — 8 more

Sources 31 to 38
year	source	tier	status	feeds
2002	Cacao usage by the earliest Maya civilization.Hurst WJ, Tarka SM, Powis TG, Valdez F, Hester TR · Naturepmid:12124611	moderate	consumed	2 sections
2000	Caffeine as a model drug of dependence: recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome, and caffeine negative reinforcement.Griffiths RR, Chausmer AL · Japanese Journal of Psychopharmacologypmid:11326548	moderate	consumed	1 section
2000	Cannabinoid mimics in chocolate utilized as an argument in court.Tytgat J, Van Boven M, Paulie Daenens P · International Journal of Legal Medicinepmid:10876983	weak	consumed	2 sections
1999	HPLC method for the quantification of procyanidins in cocoa and chocolate samples.Adamson GE et al. · Journal of Agricultural and Food Chemistrypmid:10552788	moderate	consumed	1 section
1996	Brain cannabinoids in chocolate.di Tomaso E, Beltramo M, Piomelli D · Naturepmid:8751435	moderate	consumed	2 sections
1996	Marijuana and chocolate.James JS · AIDS Treatment Newspmid:11363932	moderate	consumed	2 sections
1986	Evaluation of the teratogenic potential of cocoa powder and theobromine in New Zealand White rabbitsTarka SM, Applebaum RS, Borzelleca JF · Food and Chemical Toxicologypmid:3744189	moderate	consumed	1 section
1986	Human coffee drinking: reinforcing and physical dependence producing effects of caffeine.Griffiths RR, Bigelow GE, Liebson IA · Journal of Pharmacology and Experimental Therapeuticspmid:3772801	moderate	consumed	1 section

4Docket

one filing per activity — decisions, correspondence, reports

0012026-03-17importImported from Curiosity v1
imported 2026-03; original sourcing not recoverable
psx:substance/cocoa/import/curiosity-v1
0022026-03-17publicationPublication — backfill
psx:substance/cocoa/pub/8e690ee9-7a71-4302-8601-db8d6c031224
0032026-03-17revisionRevision 1
no edit summary recorded
psx:substance/cocoa/version/1
0042026-05-13revisionRevision 2
Initial LLM generation (plant pipeline v1, wiki, prose phase)
psx:substance/cocoa/version/2
0052026-06-04proposal15 value proposals approved together
one review action inferred from a shared reviewer and instant — the graph records one activity per proposal
15 items in this filing
- contraindication · age
- contraindication · other
- contraindication · hepatic
- contraindication · psychiatric
- contraindication · cardiovascular
- dose_tier · threshold
- dose_tier · light
- dose_tier · common
- dose_tier · strong
- dose_tier · heavy
- toxicity
- dependence · full
- withdrawal
- tolerance
psx:substance/cocoa/proposal/contraindication/1fa6ea56-15bc-488e-9837-7bfe1d012c7d
0062026-06-04publicationPublication — backfill
psx:substance/cocoa/pub/67ed14d7-b116-41bc-a1b8-75fb27bd0f1c

5Issued documents

what the notice, info card and emergency page said, by hash

Issued documents
document	content hash	issued	from version	superseded
info_card	0d2fd79fa4115ab6d7c5b8c9…	2026-10-19 20:31	Revision 2	current
emergency	777b5863d801327b008f5610…	2026-09-04 04:29	Revision 2	current
info_card	7cc1504b4e1fc009fd9b9f12…	2026-09-04 04:29	Revision 2	superseded2026-10-19
notice	fb6e5e61c98289464444fa49…	2026-09-04 04:29	Revision 2	current

Cocoa

6Node page

derived from · upstream

feeds · downstream

1Provenance card

2Build

generation run 2026-05-13

research→

draft→

audit→

verify→

simplify→

publish

Selection

Verification

The model's own caveats

Reproduce

3Sources

4Docket

5Issued documents

research

draft

audit

verify

simplify