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Psychedex

6Node page

what any key link opens

psx:substance/amt/proposal/dependence/58472f00-411a-467b-afa7-3765aa9ef119

proposal2026-04-24recordapproved

derived from · upstream

none recorded

feeds · downstream

Closure of psx:substance/amt/proposal/dependence/58472f00-411a-467b-afa7-3765aa9ef119: 0 upstream, 1 downstream.

psx:substance/amt/proposal/dependence/58472f00-411a-467b-afa7-3765aa9ef119
└─ derived_from  value/dependence@1

indented by distance from this node, not by parentage

1Provenance card

the boundary, as counts

Sources

2214 with DOI

3 strong · 13 moderate · 6 weak

Compilations

0no compilation run

Decisions

32last ruled 2026-06-04

0 awaiting a ruling

Issued documents

62026-10-19T20:30:37.413Z

notice · info card · emergency

Searches

171 with no results

queries and counts on the build

Claims checked

5444 supported

44 supported · 10 not

Correspondence

0received

consent field ships in Phase 4

Edges

196

derivations recorded for this entity

Complete over 22 sources and 32 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/amt/archive

3Sources

22 consumed · sorted by year · feeds = sections resting on it

Sources
yearsourcetierstatusfeeds
2025A systematic study of changes in monoamine neurotransmitters in the rat brain following acute administration of alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT).Li K, Li N, Chen Y, Li X, Qiao Y, Wang D, Di B, Xu P · Neuroscience researchdoi:10.1016/j.neures.2025.04.006moderateconsumed3 sections
2025Dual Modulation of 5-HT2A Receptors and SERT by α-Ethyltryptamine and Its Optical Isomers.Silverman JM, Fiorillo M, Younkin J, Jones CB, Maltman JL, Herszenhorn I, et al. · ACS chemical neurosciencedoi:10.1021/acschemneuro.5c00468moderateconsumed5 sections
2025Effects of three tryptamines: alpha-methyltryptamine, 5-methoxy-alpha-methyltryptamine, and 5-methoxy-N,N-diisopropyltryptamine on acute toxicity, locomotor activity, and hallucinogenic behavior in mice.Li K, Li N, Chen Y, Li X, Qiao Y, Wang D, Di B, Xu P · Behavioural pharmacologydoi:10.1097/fbp.0000000000000841moderateconsumedcited only
2024Alpha-methyltryptamine (Indopan) - NCATS Inxight DrugsNCATS/NIHurl:20cb97e3473fcc7cweakconsumedcited only
2024Alpha-methyltryptamine and 5-(2-methylaminopropyl)-benzofuran (5-MAPB) fatal co-intoxication: case report and review of literatureEpain M, Cartiser N, Bevalot F, Bottinelli C, Chatenay C, Fanton L · International Journal of Legal Medicinedoi:10.1007/s00414-024-03236-wweakconsumed1 section
2024Legal Status of Alpha-methyltryptamine - Multiple JurisdictionsVarious (Wikipedia, WebSearch)url:c29bc5afd23f85d7weakconsumedcited only
2023Alpha-methyltryptamine (alpha-MT) Metabolite Profiling in Human Hepatocyte Incubations and Postmortem Urine and BloodMalaca S, Bottinelli C, Fanton L, Cartiser N, Carlier J, Busardo FP · Metabolitesdoi:10.3390/metabo13010092moderateconsumed2 sections
2023Release.org.uk - AMT Drug InformationRelease UKurl:3ad72d5c592d8337weakconsumedcited only
2022Serotonin toxicity of serotonergic psychedelicsMalcolm B, Thomas K · Psychopharmacologydoi:10.1007/s00213-021-05876-xmoderateconsumed2 sections
2022Tolerance and Cross-Tolerance among Psychedelic and Nonpsychedelic 5-HT2A Receptor Agonists in Micede la Fuente Revenga M, Jaster AM, McGinn J, Silva G, Saha S, Gonzalez-Maeso J · ACS Chemical Neurosciencedoi:10.1021/acschemneuro.2c00170moderateconsumed2 sections
2021New psychoactive substances (NPS) and serotonin syndrome onset: A systematic review.Schifano F, Chiappini S, Miuli A, Corkery JM, Scherbaum N, Napoletano F, Arillotta D, Zangani C, Catalani V, Vento A, Pettorruso M, Martinotti G, Massimo DG, Guirguis A · Experimental neurologydoi:10.1016/j.expneurol.2021.113638strongconsumed2 sections
2020Designer drugs: mechanism of action and adverse effectsLuethi D, Liechti ME · Archives of Toxicologydoi:10.1007/s00204-020-02693-7strongconsumed2 sections
20195-Methoxy-alpha-methyltryptamine (5-MeO-AMT), a tryptamine derivative, induces head-twitch responses in mice through the activation of serotonin receptor 2a in the prefrontal cortex.Abiero A, Botanas CJ, Sayson LV, Custodio RJ, de la Pena JB, Kim M, Lee HJ, Seo JW, Ryu IS, Chang CM, Yang JS, Lee YS, Jang CG, Kim HJ, Cheong JH · Behavioural brain researchdoi:10.1016/j.bbr.2018.07.020moderateconsumed3 sections
2017In vitro monoamine oxidase inhibition potential of alpha-methyltryptamine analog new psychoactive substances for assessing possible toxic risks.Wagmann L, Brandt SD, Kavanagh PV, Maurer HH, Meyer MR · Toxicology lettersdoi:10.1016/j.toxlet.2017.03.007moderateconsumed4 sections
2015Recreational use, analysis and toxicity of tryptamines.Tittarelli R, Mannocchi G, Pantano F, Romolo FS · Current neuropharmacologydoi:10.2174/1570159x13666141210222409moderateconsumedcited only
2015The hallucinogenic world of tryptamines: an updated review.Araújo AM, Carvalho F, Bastos Mde L, Guedes de Pinho P, Carvalho M · Archives of toxicologydoi:10.1007/s00204-015-1513-xstrongconsumed3 sections
2014AMT Drug Information - DrugWiseDrugWise UKurl:3c1fc77ba0385127weakconsumedcited only
2014Patterns of presentation and clinical toxicity after reported use of alpha methyltryptamine in the United Kingdom. A report from the UK National Poisons Information Service.Kamour A, James D, Spears R, Cooper G, Lupton DJ, Eddleston M, Thompson JP, Vale AJ, Thanacoody HK, Hill SL, Thomas SH · Clinical toxicology (Philadelphia, Pa.)doi:10.3109/15563650.2014.885983moderateconsumed1 section
2005Fatality due to acute alpha-methyltryptamine intoxication.Boland DM, Andollo W, Hime GW, Hearn WL · Journal of analytical toxicologypmid:16105268weakconsumed2 sections
2004Schedules of controlled substances: placement of alpha-methyltryptamine and 5-methoxy-N,N-diisopropyltryptamine into schedule I of the Controlled Substances Act. Final rule.DEA Deputy Administrator · Federal Registerpmid:15455477moderateconsumed2 sections
2003Schedules of controlled substances: temporary placement of alpha-methyltryptamine and 5-methoxy-N,N-diisopropyltryptamine into Schedule I. Final rule.DEA Deputy Administrator · Federal Registerpmid:12678045moderateconsumed2 sections
1986The effects of monoamine oxidase inhibitors on the ejaculatory response induced by 5-methoxy-N,N-dimethyltryptamine in the rat.Rényi L · British journal of pharmacologypmid:3091132moderateconsumed1 section
—Searched ClinicalTrials.gov for "alpha-methyltryptamine AMT tryptamine" — no resultsabsenceno results—

4Docket

one filing per activity — decisions, correspondence, reports

  1. 0012026-04-24revisionRevision 1

    Initial LLM generation (v5 pipeline, wiki)

    psx:substance/amt/version/1
  2. 0022026-06-04proposal30 value proposals approved together

    one review action inferred from a shared reviewer and instant — the graph records one activity per proposal

    30 items in this filing

    • dose_tier · light
    • dose_tier · common
    • dose_tier · strong
    • dose_tier · heavy
    • timeline · oral · onset
    • timeline · oral · come_up
    • timeline · oral · peak
    • timeline · oral · plateau
    • timeline · oral · resolution
    • timeline · oral · afterglow
    • toxicity
    • dependence · full
    • withdrawal
    • tolerance
    • dosage · oral
    • duration · oral · onset
    • duration · oral · come_up
    • duration · oral · peak
    • duration · oral · offset
    • duration · oral · total
    • duration · oral · aftereffects
    • contraindication · psychiatric
    • contraindication · psychiatric
    • contraindication · cardiovascular
    • contraindication · cardiovascular
    • contraindication · other
    • contraindication · hepatic
    • contraindication · pregnancy_breastfeeding
    • contraindication · neurological
    psx:substance/amt/proposal/dose_tier/5daefdb4-dcbe-401b-b597-53e14f0c8e12
  3. 0032026-06-04publicationPublication — backfill
    psx:substance/amt/pub/793ed85a-cf09-4c5b-a475-4376fad1f033

5Issued documents

what the notice, info card and emergency page said, by hash

Issued documents
documentcontent hashissuedfrom versionsuperseded
emergencyc15c760aabf6f0fcf5b6fc6b…2026-10-19 20:30Revision 1current
info_cardedd9e6b4fbffd1631569c3d6…2026-10-19 20:30Revision 1current
noticea5727d1128c1dace6c07efd9…2026-10-19 20:30Revision 1current
emergency3f0909c25c714d225b4bb3e3…2026-09-04 04:28Revision 1superseded2026-10-19
info_card46bc1bb853c085bd0b8092e6…2026-09-04 04:28Revision 1superseded2026-10-19
notice76ddbaed5b3762d419832d3d…2026-09-04 04:28Revision 1superseded2026-10-19