4-HO-DPT
4-hydroxy-N,N-dipropyltryptamine
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4-HO-DPT (4-hydroxy-N,N-dipropyltryptamine) is an emerging synthetic psychedelic of the tryptamine class. It is the 4-hydroxylated structural analog of DPT, with lower potency and longer duration than psilocin. 4-HO-DPT is a presumed 5-HT₂A receptor agonist,[1] producing its effects by disrupting serotonergic filtering of sensory and cognitive input.
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First synthesized by Repke, Ferguson, and Bates in 1977 as part of a series of psilocin analogs,[2] the compound received no pharmacological evaluation in the original publication. Shulgin later documented it in TiHKAL,[3] reporting only a possible threshold effect at 20 mg and noting synthetic difficulty — effectively shelving investigation for two decades. It appeared on research chemical vendor sites substantially later than most substituted tryptamines and remains one of the least explored members of the 4-hydroxytryptamine series.
Subjective effects include geometric visual patterns, color enhancement, sensory intensification, and altered thought patterns. The experience is described as more visually elaborate and less emotionally confrontational than psilocin, with a sensory-dominant character that distinguishes it from the introspective depth of shorter-chain 4-hydroxytryptamines. Nausea during onset, anxiety at higher doses, and dysphoric reactions in unsupported settings are common unsought effects.
4-HO-DPT produces no physical dependence; tolerance develops rapidly through downregulation[4] and resets within approximately seven days. The primary risk is psychological — acute anxiety, paranoia, and dysphoric reactions scale with dose and are amplified by unsupported settings or psychiatric vulnerability. No controlled human study of any kind has been published; virtually all quantitative parameters remain uncharacterized.
History[edit]
Discovery
4-HO-DPT was first synthesized by David B. Repke, William J. Ferguson, and Dale K. Bates at Kansas State University in 1977, reported in a paper describing synthetic routes to psilocin analogs.[2] No pharmacological data were included — the work was purely synthetic. Alexander Shulgin independently prepared the compound and documented it in TiHKAL (1997),[3] but his self-administered 20 mg oral dose produced only a possible threshold effect, and he described the compound as "difficult to make" — effectively discouraging further investigation.
Parent Compound Clinical History
4-HO-DPT itself has never appeared in a clinical trial, but its parent compound DPT has a modest therapeutic history. Soskin, Grof, and Richards published a double-blind study in 1973 using intramuscular DPT as a psycholytic therapy adjunct for alcoholism,[5] with Soskin extending the work in 1975.[6] These studies were part of the broader psycholytic therapy movement spanning the 1950s through 1970s.[7]
Modern Status
4-HO-DPT appeared on grey-market research chemical vendor sites substantially later than most substituted tryptamines, consistent with the synthesis difficulty Shulgin noted. Chapman (2017) confirmed the chemical identity of commercially available material via NMR spectroscopy,[8] and Sammeta et al. (2020) resolved the first crystal structure.[9] The compound remains emerging — it has attracted far less community attention than more accessible analogs like 4-HO-MET or 4-HO-MiPT.
The name Procin follows the informal naming convention used for 4-hydroxytryptamines: psilocin (DMT), metocin (MET), miprocin (MiPT), and so on. The "-cin" suffix signals 4-hydroxy substitution, while "pro-" references the propyl chains. Despite this systematic naming, Procin has seen minimal adoption compared to the alphanumeric designation 4-HO-DPT, reflecting the compound's limited circulation and community engagement.
Chemistry[edit]
Structural Class
4-HO-DPT belongs to the 4-hydroxytryptamine series — the same structural family as psilocin (4-HO-DMT). The core scaffold is an indole ring system linked through an ethyl bridge to a terminal amine. A hydroxyl group at the 4-position of the indole ring provides the pharmacophore shared with psilocin,[10] while two n-propyl chains on the amine nitrogen distinguish it from psilocin's two methyl groups.
The compound sits in a homologous series of increasing N-alkyl chain length: 4-HO-DMT (dimethyl), 4-HO-DET (diethyl), 4-HO-DPT (dipropyl), 4-HO-DiBT (dibutyl). Lengthening the alkyl chains progressively shifts receptor selectivity, enhancing 5-HT₂A preference over 5-HT₂C.[1]
Molecular Properties
| Molecular formula | C₁₆H₂₄N₂O |
| Molecular weight | 260.37 g/mol |
Stereochemistry
4-HO-DPT contains no chirality center. The molecule is achiral, and no stereoisomer considerations apply to its pharmacology.
Physical Properties
The freebase is a solid with a melting point of 96–97 °C, first reported by Repke et al. (1977)[2] and independently confirmed by Shulgin.[3] The hydrochloride salt has been characterized by X-ray crystallography,[9] and the fumarate salt by NMR.[8]
By structural analogy with psilocin, the 4-hydroxyl group likely renders the compound susceptible to oxidative degradation — darkening upon air exposure — though this has not been confirmed experimentally for 4-HO-DPT specifically.inferred No published data exist on aqueous solubility or plasma stability.
Pharmacology[edit]
Mechanism of Action
4-HO-DPT acts primarily through agonism at the 5-HT₂A receptor, the principal molecular target for serotonergic psychedelic effects. No binding affinity data specific to this compound have been published — classification rests on structural analogy and class-level evidence showing that all tested 4-hydroxy-N,N-dialkyltryptamines activate 5-HT₂A, serotonin₂B, and 5-HT₂C receptors.[1]
The parent compound DPT is a confirmed 5-HT₂A full agonist,[11] and the 4-hydroxyl group on the indole ring enhances rather than diminishes this activity.[12] Psychedelic effects are mediated through 5-HT₂A–Gq protein coupling, where Gq efficacy predicts psychedelic potential more reliably than other signaling pathways.[4]
The N,N-dipropyl substitution confers approximately 129-fold selectivity for 5-HT₂A over 5-HT₂C relative to psilocin,[10] with concurrently enhanced activity at 5-HT₂B.[1] DPT also shows secondary activity at 5-HT₁A receptors, where it functions as a modulator rather than a primary driver of effects.[13]
Pharmacokinetics
No human pharmacokinetic studies have been published for 4-HO-DPT. Metabolism, bioavailability, plasma half-life, and elimination pathways are entirely uncharacterized.
By class analogy with psilocin, oral bioavailability is expected to be meaningful, and the 4-hydroxyl group likely undergoes liver processing as a primary metabolic pathway. Tryptamines are generally broken down by MAO-A (MAO-A).inferred
The onset difference between oral (45–60 minutes) and insufflated (15–45 minutes) routes reported by users[10] is consistent with first-pass liver metabolism slowing oral absorption, as observed across the tryptamine class.
Neuroscience[edit]
Where It Acts
No direct neuroimaging or electrophysiology data exist for 4-HO-DPT. Based on its 5-HT₂A agonism, the compound is expected to disrupt thalamocortical gating — the brain's mechanism for filtering sensory information before it reaches conscious awareness.[14] This disruption allows a flood of sensory and associative signals into cortical processing areas, producing the perceptual and cognitive changes characteristic of psychedelic states.
Serotonergic psychedelics also reliably reduce connectivity within the default mode network, the brain system underpinning self-referential thought. This network dissolution correlates with the subjective experience of ego softening or dissolution.
Why It Matters
The REBUS model (Relaxed Beliefs Under Psychedelics) proposes that compounds like 4-HO-DPT relax the brain's high-level assumptions, allowing raw sensory input greater influence over conscious experience. The compound's enhanced 5-HT₂A selectivity could theoretically produce a more perceptually dominated experience than psilocin — but this remains speculative.inferred
5-HT₂A agonists as a class also promote structural neuroplasticity — encouraging new neural connections through signaling cascades that increase dendritic complexity. Whether 4-HO-DPT's specific selectivity profile alters this process relative to psilocin is unknown.
Several unanswered questions distinguish 4-HO-DPT from better-characterized relatives. Does its enhanced 5-HT₂A/2C selectivity ratio translate to measurably different patterns of neural activity compared to psilocin? What explains its longer duration — is it receptor residence time, slower metabolism, or both?
Subjective Effects[edit]
4-HO-DPT's experiential character is reported as distinctly sensory-dominant among the 4-hydroxytryptamine series. The high 5-HT₂A/2C selectivity conferred by its bulky N,N-dipropyl groups[1] may underlie this perceptual emphasis, producing elaborate visual phenomena while leaving emotional and introspective depth less pronounced than shorter-chain relatives. Set, setting, and dose remain the primary modulators of experience quality; insufflation produces faster onset and a compressed duration relative to oral administration.
Within its structural family, 4-HO-DPT sits at lower milligram potency and longer duration than psilocin. User reports suggest a more visually ornate and less emotionally confrontational character than either psilocin or 4-HO-DET — though this positioning rests entirely on uncontrolled reports rather than comparative studies, and the compound's limited availability means community characterization remains shallow.
Effect Grid
Full psychedelic experience with clear visual, cognitive, and emotional components. Visual drifting, geometric patterning, color enhancement, and symmetrical texture repetition are characteristic. Internal hallucinations may emerge with eyes closed. Music enhancement is prominent — auditory textures feel richer and more spatially defined.
Emotional enhancement and time alteration are reliable features. Thought acceleration and conceptual thinking shift perception of ordinary ideas. Analysis enhancement and pattern recognition enhancement color the cognitive landscape. Nausea is possible during onset, typically resolving as effects build. Body load includes spontaneous body sensations and possible muscle relaxation.
Set and setting meaningfully shape the experience. The insufflated route (15–25 mg) produces faster onset and a more compressed arc than oral administration (60–90 mg). Users report a sensory-dominant character — more visually elaborate and less emotionally confrontational than psilocin at equivalent intensity.
Modeled from the effect's dose-dependence curve — not per-substance measurements.
Geometry · Music enhancement · Tracers · Visual breathing · Visual drifting · Brightness alteration · Environmental patterning · Touch enhancement · Visual diffraction · Visual haze / noise · Visual morphing · After-images · Auditory distortion · Auditory enhancement · Depth perception distortion · Light sensitivity · Peripheral vision distortion · Perspective distortion · Sound sensitivity · Spatial disorientation · Symmetrical texture repetition · Vestibular distortion · Visual melting · Auditory misinterpretation · Peripheral misidentification · Proprioceptive distortion · Synesthesia · Visual acuity enhancement · Visual processing acceleration · Visual magnification · Dreaming enhancement · Olfactory enhancement · Taste enhancement · Flashbacks · External hallucinations · Internal hallucinations · Object transformations · Visual recursion · Object activation · Auditory hallucinations · Environmental orbism / cubism · Perspective hallucinations · Visual scenery slicing
Visual drifting · Brightness alteration · Environmental patterning · Touch enhancement · Visual diffraction · Visual haze / noise · Visual morphing · After-images · Auditory distortion · Auditory enhancement · Depth perception distortion · Light sensitivity · Peripheral vision distortion · Perspective distortion · Sound sensitivity · Spatial disorientation · Symmetrical texture repetition · Vestibular distortion · Visual melting · Auditory misinterpretation · Peripheral misidentification · Proprioceptive distortion · Synesthesia · Visual acuity enhancement · Visual processing acceleration · Visual magnification · Dreaming enhancement · Olfactory enhancement · Taste enhancement · Flashbacks · External hallucinations · Internal hallucinations · Object transformations · Visual recursion · Object activation · Auditory hallucinations · Environmental orbism / cubism · Perspective hallucinations · Visual scenery slicing
Spontaneous body sensations · Appetite suppression · Nausea · Stimulation · Tactile euphoria · Tingling / electric sensations · Wakefulness · Bodily heaviness · Body schema distortion · Dizziness · Excessive sweating · Heart rate perception changes · Insomnia · Laughter fits · Physical fatigue · Restlessness · Vibrations / buzzing · Bodily lightness · Bodily pressures · Breathing alteration · Dry mouth · Muscle relaxation · Muscle tension · Sexual arousal enhancement · Trembling · Bruxism · Headache · Involuntary body movements · Kundalini-like energy · Nystagmus (eye wobbles) · Pain suppression · Sedation · Vasoconstriction · Vomiting · Yawning · Diarrhea · Bodily dissociation · Tactile hallucination
Stimulation · Tactile euphoria · Tingling / electric sensations · Wakefulness · Bodily heaviness · Body schema distortion · Dizziness · Excessive sweating · Heart rate perception changes · Insomnia · Laughter fits · Physical fatigue · Restlessness · Vibrations / buzzing · Bodily lightness · Bodily pressures · Breathing alteration · Dry mouth · Muscle relaxation · Muscle tension · Sexual arousal enhancement · Trembling · Bruxism · Headache · Involuntary body movements · Kundalini-like energy · Nystagmus (eye wobbles) · Pain suppression · Sedation · Vomiting · Yawning · Diarrhea · Bodily dissociation · Tactile hallucination
Immersion enhancement · Introspection enhancement · Novelty enhancement · Openness enhancement · Pattern recognition enhancement · Thought connectivity · Cognitive euphoria · Cognitive impairment · Focus suppression · Increased nature relatedness · Multiple thought streams · Thought acceleration · Thought disorganization · Creativity enhancement · Confusion · Humor enhancement · Information processing suppression · Memory fragmentation · Memory suppression · Synchronicity · Thought loops · Analysis enhancement · Analysis suppression · Cognitive dysphoria · Cognitive fatigue · Memory replays · Motivation suppression · Information processing enhancement · Focus enhancement · Language enhancement · Amnesia
Openness enhancement · Pattern recognition enhancement · Thought connectivity · Cognitive euphoria · Cognitive impairment · Focus suppression · Increased nature relatedness · Multiple thought streams · Thought acceleration · Thought disorganization · Creativity enhancement · Confusion · Humor enhancement · Information processing suppression · Memory fragmentation · Memory suppression · Synchronicity · Thought loops · Analysis enhancement · Analysis suppression · Cognitive dysphoria · Cognitive fatigue · Memory replays · Motivation suppression · Information processing enhancement · Focus enhancement · Language enhancement
Catharsis · Empathy enhancement · Anxiety · Dysphoria
Depersonalization · Trust enhancement · Automaticity · Communication suppression · Disinhibition · Flow state · Sociability enhancement · Compulsive behavior reduction · Ego inflation · Social disconnection · Communication enhancement · Boundary dissolution · Ego dissolution · Identity alteration · Cognitive disconnection · Telepathic feelings
Disinhibition · Flow state · Sociability enhancement · Compulsive behavior reduction · Ego inflation · Social disconnection · Communication enhancement · Boundary dissolution · Ego dissolution · Identity alteration · Cognitive disconnection · Telepathic feelings
Time cessation
Transpersonal visions · Death-rebirth sequence · Entity contact · Transpersonal memory access · Near-death experience · Voidness · Cessation
Near-death experience · Voidness · Cessation
Lucidity enhancement · Recursive awareness
Timeline
Subtle alerting and first body awareness. Mild nausea may appear. Mood shifts slightly but no definitive psychedelic effects.
Progressive build of perceptual and cognitive effects. Body load peaks during this phase — nausea is most likely here. Color enhancement and visual acuity changes emerge.
Full expression of visual, cognitive, and emotional effects. Geometry, visual drifting, and music enhancement are prominent. Time alteration and thought acceleration characterize the cognitive state.
Gradual return toward baseline. Residual visual effects (tracers, color shifts) persist while emotional processing continues. Cognitive clarity begins to return.
Mild residual mood elevation and sensory sensitivity. Subtle body awareness may persist.
⚠ Avoid driving or operating heavy machinery for at least 8 hours after oral ingestion.
Safety[edit]
- Acute toxicity
- Low
- Chronic toxicity
- Low
- Withdrawal
- None
- Tolerance buildup
- rapid
- Tolerance reset
- 7 days
- Physical
- None
- Psychological
- Negligible
- Compulsive redosing
- Negligible
- Dose escalation
- Negligible
- Cross-tol.
- psilocin · LSD · mesc
Toxicity
No lethal dose data exist for 4-HO-DPT in any species, and no case reports of fatal or non-fatal overdose have been published.[10] No organ-specific toxicity data — liver, kidney, or neurological — exist for this compound.
Seizure Risk
The parent compound DPT produced seizure-like effects in mice at doses exceeding 20 mg/kg.[11] Human oral doses of 4-HO-DPT (approximately 1–2 mg/kg) fall far below this murine threshold, but the observation represents a dose-dependent safety signal for the compound class at very high exposures.safety citation needed
Heart and Circulation
Tryptamines with bulkier nitrogen substituents — including N,N-dipropyl compounds — show increased activity at serotonin₂B receptors.[1] Chronic 5-HT₂B stimulation is the established mechanism behind heart valve damage associated with fenfluramine. No clinical heart data exist for 4-HO-DPT; the risk is theoretical and most relevant to patterns of frequent repeated use rather than occasional administration.safety citation needed
Tryptamine-associated health problems are "considerable and underestimated".[16] Reviews of novel tryptamine cases have documented fatalities predominantly associated with multiple-drug use, heart events, and dangerously elevated body temperature[17] — none specific to 4-HO-DPT.
Psychological Risks
Consistent with the serotonergic psychedelic class, 4-HO-DPT carries risk of acute psychological distress including anxiety, panic, paranoia, and dysphoric reactions — particularly at high doses, in unsupported settings, or in individuals with pre-existing psychiatric vulnerability.
The risk of HPPD (HPPD) has not been characterized for 4-HO-DPT. HPPD appears rare across serotonergic psychedelics but can be persistent when it occurs.citation needed
Triggering or worsening of psychotic episodes is a class-level risk for all serotonin 2A receptor agonists, particularly in individuals with personal or family history of psychotic spectrum disorders.
Tolerance and Dependence
Tolerance develops rapidly — effectively after a single dose — through 5-HT₂A downregulation.[4] Community consensus estimates a tolerance half-life of approximately 3 days and full reset within 7 days, consistent with class-level data.
A notable finding: daily DPT in mice did not produce tolerance to psychedelic-indicative responses, unlike the phenethylamine hallucinogens DOI and 2C-T-7.[15] This suggests tryptamines may develop tolerance more slowly on consecutive-day dosing, though acute within-session tolerance still occurs.
4-HO-DPT cross-tolerates with all classical serotonergic psychedelics (LSD, psilocin, mescaline, DMT) via shared 5-HT₂A receptor mechanisms. Serotonergic psychedelics are not habit-forming. No physical dependence or withdrawal has been documented for this class. DPT did not produce compulsive redosing in clinical settings.[5]
Drug Interactions
Tramadol — Dangerous
Tramadol blocks serotonin reuptake[18] and lowers seizure threshold. Combined with a serotonergic tryptamine that increases synaptic serotonin levels (as DPT does[19]), this creates dual risk: serotonin syndrome and seizures.[11]
MAO Inhibitors — Dangerous
MAO-A is the primary enzyme that breaks down tryptamines. Blocking it would dramatically elevate 4-HO-DPT blood levels and extend duration, while combined serotonin-raising effects could produce life-threatening serotonin toxicity.[19]safety citation needed
Cannabis — Unknown
THC interacts with serotonin signaling through cannabinoid receptor mechanisms. Cannabis may intensify or alter the subjective experience, potentially increasing anxiety. No controlled data exist for this combination with 4-HO-DPT.
Lithium — Caution
Lithium combined with serotonergic psychedelics is associated with increased seizure risk in published case reports and is recognized as a contraindication in standard psychedelic harm reduction guidelines.safety citation needed
SSRIs and SNRIs
Serotonin reuptake inhibitors may weaken or unpredictably modify psychedelic effects while introducing theoretical serotonin toxicity risk, particularly at high doses of either agent.citation needed
Contraindications
Absolute contraindications:
- MAO inhibitors: Life-threatening serotonin toxicity due to elimination of the primary tryptamine breakdown pathway
- Lithium: Increased seizure risk; replicated across case reports involving psilocybin and LSD
Relative contraindications:
- Personal or family history of psychotic spectrum disorders: 5-HT₂A agonists can trigger or worsen psychotic episodes
- Heart conditions: Theoretical valve damage risk with repeated exposure; possible acute cardiovascular effectssafety citation needed
- Tramadol or other serotonergic medications: Serotonin syndrome risk and seizure threshold reduction
- Pregnancy: No safety data; effects of 5-HT₂A agonism during development are unexploredcitation needed
Harm Reduction[edit]
Forms & Identification
4-HO-DPT circulates primarily as powder in freebase, hydrochloride, or fumarate salt forms. Because the compound has limited market presence and no distinctive physical characteristics, reagent testing alone cannot definitively identify it — only confirm the presence of an indole-class compound. Verifying exact identity requires laboratory analysis or a combination of multiple reagent results cross-referenced against known reaction profiles.
Salt form matters for dosing: a milligram of fumarate salt contains less active compound than a milligram of freebase due to the added weight of the salt counterion. If switching between salt forms, doses are not directly interchangeable.
Guidelines
- Test all material with reagent kits before use. Laboratory analysis services provide definitive identification where available.
- Start with a low dose to establish individual sensitivity, especially given the sparse dosing data for this compound.
- Use a milligram-precision scale (0.001 g). Volumetric dosing in solution improves accuracy for small quantities.
- Avoid redosing during the experience — tolerance onset is rapid and unpredictable dose stacking can produce overwhelming effects.
- Ensure a sober, trusted person is present, especially for first experiences.
- Eat lightly several hours before to reduce nausea during onset.
- Clear the schedule for the full duration plus several hours of recovery. Do not drive or operate machinery.
- Keep the environment comfortable, warm, and controllable — ability to change music, lighting, and room matters.
Set & Setting
As with all serotonergic psychedelics, the quality of a 4-HO-DPT experience is heavily modulated by mindset and environment. Anxiety, unresolved stress, or unfamiliar surroundings increase the likelihood of difficult experiences. A calm, private space with a trusted sitter present — particularly for first experiences or higher doses — substantially reduces psychological risk.
The compound's limited characterization means fewer people have experience guiding or supporting others through its effects. A sitter familiar with psychedelic states in general is preferable to navigating a first experience alone.
Aftercare & integration. The days following a 4-HO-DPT experience may include emotional sensitivity, fatigue, and residual shifts in perception. These typically resolve within 24–48 hours.
Journaling or discussing the experience with a trusted person while memories are fresh can help process unusual or challenging content. For experiences involving difficult emotions, ego dissolution, or disorientation, professional integration support from a therapist familiar with psychedelic experiences is valuable. Allow at least 7 days before considering another psychedelic experience to permit full tolerance reset and emotional processing.
Recovery & Support
Serotonergic psychedelics as a class carry low abuse liability, and compulsive use patterns are rare. If psychedelic use is becoming a way to avoid addressing problems rather than a tool for insight, this pattern is worth examining honestly.
For those experiencing persistent distress, HPPD symptoms, or difficulty reintegrating after psychedelic experiences, professional support is available. The Fireside Project (62-FIRESIDE / 623-473-7433) offers free peer support for psychedelic experiences. MAPS maintains a directory of integration-aware therapists.
Recovery resources, crisis lines, and support pathways → View all
Emergency Response
Recognizing an emergency:
Most difficult psychedelic experiences are distressing but not medically dangerous. Seek immediate help if any of the following occur:
- Loss of contact with reality combined with self-harm risk or dangerous behavior
- Seizures or convulsions
- Chest pain or irregular heartbeat
- Severe uncontrollable overheating (skin hot to touch, confusion)
- Loss of consciousness
Immediate steps:
- 1. Stay with the person. Speak calmly and simply.
- 2. Call emergency services if the person is physically endangering themselves, having seizures, or is unresponsive.
- 3. Move them to a quiet, safe space. Reduce stimulation — dim lights, lower noise.
- 4. Do not restrain them unless there is immediate danger to themselves or others.
- 5. If unconscious, place in the recovery position and monitor breathing.
What to tell the dispatcher:
State the substance name (4-HO-DPT, a synthetic tryptamine), approximate amount and time taken, current symptoms, and the person's age and weight. Good Samaritan laws in many jurisdictions protect people who call for help during drug emergencies.
Legal Status[edit]
4-HO-DPT occupies an ambiguous legal position in most jurisdictions. It is not explicitly scheduled under most national drug control frameworks, but broad structural analog provisions and novel psychoactive substance legislation may apply depending on jurisdiction and context of possession or supply.
| Jurisdiction | Classification | Key provisions |
|---|---|---|
| United States | Not explicitly scheduled | Not listed in CSA Schedules I–V. The Federal Analogue Act (21 U.S.C. § 813) may apply if intended for human consumption, given structural similarity to psilocin (Schedule I). DEA proposed scheduling of 4-OH-DiPT (a different compound) and later withdrew it.[20] |
| United Kingdom | Class A (Misuse of Drugs Act 1971) | Controlled under the tryptamine catch-all clause. Possession and supply are criminal offenses. The Psychoactive Substances Act 2016 also applies. |
| Germany | Controlled (NpSG) | Covered under the Neue-psychoaktive-Stoffe-Gesetz since July 2019. Possession for personal use not criminalized; supply and trade prohibited. |
| Canada | Not scheduled | Not listed in Schedules I–VI of the Controlled Drugs and Substances Act. No analog provision equivalent to the US Federal Analogue Act. |
| Switzerland | Possibly uncontrolled | Not listed under controlled substance categories A–D. Status uncertain; subject to regulatory change. |
| Australia | Status unconfirmed | Several tryptamines are Schedule 9 (Prohibited Substances). Whether 4-HO-DPT falls under existing scheduling entries could not be confirmed.citation needed |
Analog Act Considerations
4-HO-DPT is structurally very similar to psilocin (4-HO-DMT), differing only in the length of the nitrogen-attached alkyl chains. Under the US Federal Analogue Act, a substance "substantially similar" in structure or pharmacological effect to a Schedule I or II substance may be treated as controlled if intended for human consumption. This creates legal risk for possession or distribution of 4-HO-DPT in any context suggesting human use, despite the absence of explicit scheduling.
references
- [1]
- [2] ^abcRepke D, Ferguson W, Bates D (1977) Psilocin analogs. 1. Synthesis of 3-[2-(dialkylamino)ethyl]-and 3-[2-(cycloalkylamino)ethyl] indol-4-ols — Journal of Heterocyclic Chemistry doi:10.1002/jhet.5570140113
- [3]
- [4] ^abcWallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, et al. (2023) Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential — Nature Communications doi:10.1038/s41467-023-44016-1
- [5] ^abSoskin RA, Grof S, Richards WA (1973) Low doses of Dipropyltryptamine in psychotherapy. — Archives of general psychiatry PMID:4575167
- [6]