4-AcO-MET
4-acetoxy-N-methyl-N-ethyltryptamine
Lethal interactions
By drug class
- MAOIslethal2 mechanismsconfidence high
Dangerous interactions
17 dangerous interactions recorded for this substance.
See the full interactions tableContraindications
Cardiovascular
- uncontrolled cardiovascular diseaserelative
Pre-existing cardiovascular conditions (uncontrolled hypertension, significant arrhythmias) constitute relative contraindications due to expected transient cardiovascular stress.
Psychiatric
- psychotic disordersabsolute
Personal or family history of schizophrenia, schizoaffective disorder, or other psychotic disorders constitutes an absolute contraindication for all serotonergic psychedelics.
- bipolar disorderrelative
Bipolar disorder is a relative contraindication. Mania precipitation risk exists but may be manageable with appropriate support.
Pregnancy & Breastfeeding
- pregnancyabsolute
Pregnancy is an absolute contraindication due to complete absence of reproductive safety data.
Other
- lithium co-administrationabsolute
Concurrent lithium use is an absolute contraindication. Case reports document seizures and cardiovascular events.
- MAOI co-administrationabsolute
Concurrent use of monoamine oxidase inhibitors is an absolute contraindication due to serotonin syndrome risk.
- tramadol co-administrationabsolute
Concurrent tramadol use is contraindicated. Classification is mechanism-based; no case reports exist for this specific combination.