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Psychedex

25B-NBOH

4-bromo-2,5-dimethoxy-N-(2-hydroxybenzyl)phenethylamine

1Provenance card

the boundary, as counts

Sources

2826 with DOI

4 strong · 20 moderate · 4 weak

Compilations

12026-05-07T22:01:47.741Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

30last ruled 2026-06-04

0 awaiting a ruling

Issued documents

62026-10-19T20:29:04.145Z

notice · info card · emergency

Searches

143 with no results

queries and counts on the build

Claims checked

8863 supported

63 supported · 25 not

Correspondence

0received

consent field ships in Phase 4

Edges

265

derivations recorded for this entity

Complete over 28 sources, 1 compilation, and 30 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/25b-nboh/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued emergency
  2. 2026-10-19issueIssued info_card
  3. 2026-10-19issueIssued notice
  4. 2026-09-24srcAssessment of the Acute Effects of 2C-B vs. Psilocybin on Subjective Experience, Mood, and Cognition
  5. 2026-09-24srcCharacterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH
  6. 2026-09-24srcPharmacology and Toxicology of N-Benzylphenethylamine (NBOMe) Hallucinogens
  7. 2026-09-24srcPsychedelic experience dose-dependently modulated by cannabis: results of a prospective online survey
  8. 2026-09-24srcSevere 25E-NBOH intoxication associated with MDPHP intake: a case report, metabolism study, and literature review
  9. 2026-09-24src25I-NBOH: a new potent serotonin 5-HT2A receptor agonist identified in blotter paper seizures in Brazil
  10. 2026-09-24srcIdentification of new NBOH drugs in seized blotter papers: 25B-NBOH, 25C-NBOH, and 25E-NBOH
  11. 2026-09-24srcNeurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT2A receptors.
  12. 2026-09-24srcIdentification of psychedelic new psychoactive substances (NPS) showing biased agonism at the 5-HT2AR through simultaneous use of β-arrestin 2 and miniGαq bioassays
  13. 2026-09-24srcSynthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists
  14. 2026-09-24srcLiquid chromatography-tandam mass spectrometry-based pharmacokinetic and metabolic analysis of 4-bromo-2,5-dimethoxyphenethylamine and its metabolites in human plasma
  15. 2026-09-24srcSimultaneous analysis of 2Cs, 25-NBOHs, 25-NBOMes and LSD in seized exhibits using liquid chromatography-tandem mass spectrometry: A targeted approach
  16. 2026-09-24srcMetabolic fate and detectability of 25B-NBOMe and 25C-NBOMe in human and rat urine by GC-MS, LC-MSn, and LC-HR-MS/MS approaches.
  17. 2026-09-24srcMetabolic characterization of 25X-NBOH and 25X-NBOMe phenethylamines based on UHPLC-Q-Exactive Orbitrap MS in human liver microsomes.
  18. 2026-09-24srcReceptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs)
  19. 2026-09-24src2-((2-(4-Iodo-2,5-dimethoxyphenyl)ethylamino)methyl)phenol (25I-NBOH) and 2-(((2-(4-chloro-2,5-dimethoxyphenyl)ethyl)amino)methyl)phenol (25C-NBOH) induce adverse effects on the cardiovascular system
  20. 2026-09-24srcTolerance and Cross-Tolerance among Psychedelic and Nonpsychedelic 5-HT2A Receptor Agonists in Mice
  21. 2026-09-24srcSynthesis and Structure-Activity Relationships of N-Benzyl Phenethylamines as 5-HT2A/2C Agonists
  22. 2026-09-24srcIdentification of 5-HT2A receptor signaling pathways associated with psychedelic potential
  23. 2026-09-24srcPsychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling
  24. 2026-09-24srcBehavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT2A receptor activation
  25. 2026-09-24srcA cluster of 25B-NBOH poisonings following exposure to powder sold as lysergic acid diethylamide (LSD)
  26. 2026-09-24srcLocomotor and discriminative stimulus effects of NBOH hallucinogens in rodents
  27. 2026-09-24srcInteractions between classic psychedelics and serotonergic antidepressants: Effects on the acute psychedelic subjective experience, well-being and depressive symptoms from a prospective survey study
  28. 2026-09-24srcNBOMes-Highly Potent and Toxic Alternatives of LSD
  29. 2026-09-24srcAcute Pharmacological Effects of 2C-B in Humans: An Observational Study
  30. 2026-09-24srcUNODC Substance Details: 25B-NBOH
  31. 2026-09-24src25B-NBOH New Drug Monograph
  32. 2026-09-04issueIssued emergency
  33. 2026-09-04issueIssued info_card
  34. 2026-09-04issueIssued notice
  35. 2026-06-04proposal28 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  36. 2026-06-04publicationPublication — backfill
  37. 2026-05-07revisionRevision 1
  38. 2026-05-07absenceSearched PubMed for "25B-NBOMe 2C-B N-benzyl serotonin receptor Ki pKi binding affinity" — no results
  39. 2026-05-07absenceSearched PubMed for "NBOH discriminative stimulus locomotor head twitch hallucinogen 2025" — no results
  40. 2026-05-07absenceSearched ClinicalTrials.gov for "25B-NBOH" — no results
  41. 2026-05-07genGeneration — pipeline-v5 · with 2 morepipeline-v5
  42. 2026-05-07rungeneration run

The same entries, as forms: six forms.