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1Provenance card

the boundary, as counts

Sources

4627 with DOI

14 strong · 28 moderate · 4 weak

Compilations

12026-05-09T18:33:30.136Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

30last ruled 2026-06-04

1 awaiting a ruling

Issued documents

42026-10-19T20:34:28.134Z

notice · info card · emergency

Searches

251 with no results

queries and counts on the build

Claims checked

12883 supported

83 supported · 45 not

Correspondence

0received

consent field ships in Phase 4

Edges

369

derivations recorded for this entity

Complete over 46 sources, 1 compilation, and 30 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/zopiclone/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-07srcZopiclone as a Potent Positive Control for Assessing the Residual Effects of Hypnotic Drugs on Next Day Driving Performance: A Systematic Review
  3. 2026-09-07srcAssociation of eszopiclone, zaleplon, or zolpidem with complex sleep behaviors resulting in serious injuries, including death
  4. 2026-09-07srcThe Efficacy and Safety of Drug Treatments for Chronic Insomnia in Adults: A Meta-analysis of RCTs
  5. 2026-09-07srcThe Clinical and Forensic Toxicology of Z-drugs
  6. 2026-09-07srcIn the Zzz zone: the effects of Z-drugs on human performance and driving
  7. 2026-09-07srcZopiclone to treat insomnia in older adults: A systematic review
  8. 2026-09-07srcAn accidental poisoning with mitragynine
  9. 2026-09-07srcEfficacy and tolerability of pharmacological treatments for insomnia in adults: A systematic review and network meta-analysis
  10. 2026-09-07srcComparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
  11. 2026-09-07srcStructural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different
  12. 2026-09-07srcThe efficacy and safety of zolpidem and zopiclone to treat insomnia in Alzheimer's disease: a randomized, triple-blind, placebo-controlled trial
  13. 2026-09-07srcAn Insight into Z-Drug Abuse and Dependence: An Examination of Reports to the European Medicines Agency Database of Suspected Adverse Drug Reactions
  14. 2026-09-07srcPharmacobezoar-Related Fatalities: A Case Report and Review.
  15. 2026-09-07srcCase report of acute liver injury caused by the eszopiclone in a patient with chronic liver disease
  16. 2026-09-07srcBenzodiazepine harm: how can it be reduced?
  17. 2026-09-07srcThe European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023
  18. 2026-09-07srcSedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
  19. 2026-09-07srcHypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit
  20. 2026-09-07srcComparative study of effectiveness of cognitive-behavior therapy and zopiclone for chronic insomnia
  21. 2026-09-07srcA comparison of complex sleep behaviors with two short-acting Z-hypnosedative drugs in nonpsychotic patients
  22. 2026-09-07srcZopiclone: Is there cause for concern in addiction services and general practice?
  23. 2026-09-07srcNon-benzodiazepine hypnotic use for sleep disturbance in people aged over 55 years living with dementia: a series of cohort studies
  24. 2026-09-07srcDependence on zopiclone: a case report
  25. 2026-09-07srcRisk predictors for hypnosedative-related complex sleep behaviors: a retrospective, cross-sectional pilot study
  26. 2026-09-07srcClinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.
  27. 2026-09-07srcNext-day effects of ramelteon (8 mg), zopiclone (7.5 mg), and placebo on highway driving performance, memory functioning, psychomotor performance, and mood in healthy adult subjects
  28. 2026-09-07srcEszopiclone versus zopiclone in the treatment of insomnia
  29. 2026-09-07srcMetabolism of anxiolytics and hypnotics: benzodiazepines, buspirone, zopiclone, and zolpidem
  30. 2026-09-07srcPharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition.
  31. 2026-09-07srcMolecular actions of (S)-desmethylzopiclone (SEP-174559), an anxiolytic metabolite of zopiclone
  32. 2026-09-07srcPharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent
  33. 2026-09-07srcNew drugs for insomnia: comparative tolerability of zopiclone, zolpidem and zaleplon
  34. 2026-09-07srcClinically important drug interactions with zopiclone, zolpidem and zaleplon
  35. 2026-09-07srcSchedules of controlled substances: placement of Zopiclone into Schedule IV. Final rule
  36. 2026-09-07srcZopiclone: is it a pharmacologic agent for abuse?
  37. 2026-09-07srcEszopiclone: its use in the treatment of insomnia
  38. 2026-09-07srcActions and interactions of hypnotics on human performance: single doses of zopiclone, triazolam and alcohol
  39. 2026-09-07srcZopiclone, the third generation hypnotic: a clinical overview
  40. 2026-09-07srcZopiclone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as an hypnotic
  41. 2026-09-07srcA sleep laboratory evaluation of the long-term efficacy of zopiclone
  42. 2026-09-07srcCritical factors for pharmacokinetics of zopiclone in the elderly and in patients with liver and renal insufficiency
  43. 2026-09-07srcPharmacokinetics and metabolism of zopiclone
  44. 2026-09-07srcPharmacokinetic and clinical parameters of zopiclone and trimipramine when administered simultaneously to volunteers
  45. 2026-09-07srcPharmacokinetics and metabolism of zopiclone
  46. 2026-09-07srcClinical pharmacokinetics of zopiclone
  47. 2026-09-07src[The effect of Imovane on sleep structure and respiratory indices during sleep in insomnia patients]
  48. 2026-09-04issueIssued emergency
  49. 2026-09-04issueIssued info_card
  50. 2026-09-04issueIssued notice
  51. 2026-07-03proposaldependence · taper
  52. 2026-06-04proposal27 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  53. 2026-06-04publicationPublication — backfill
  54. 2026-05-09revisionRevision 1
  55. 2026-05-09absenceSearched PubMed/OpenAlex/WebSearch for "Cross-reference seed data against published sources" — no results
  56. 2026-05-09genGeneration — pipeline-v5 · with 3 morepipeline-v5
  57. 2026-05-09rungeneration run

The same entries, as forms: six forms.