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the boundary, as counts

Sources

4732 with DOI

18 strong · 21 moderate · 8 weak

Compilations

12026-04-28T02:26:56.300Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

38last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:34:27.206Z

notice · info card · emergency

Searches

250 with no results

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Claims checked

11980 supported

80 supported · 39 not

Correspondence

0received

consent field ships in Phase 4

Edges

361

derivations recorded for this entity

Complete over 47 sources, 1 compilation, and 38 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/zolpidem/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-24srcComparative bioavailability of two zolpidem hemitartrate formulations in healthy human Brazilian volunteers
  3. 2026-09-24srcAre Seniors Dependent on Benzodiazepines? A National Clinical Survey of Substance Use Disorder
  4. 2026-09-24srcThe effects of repeated zolpidem treatment on tolerance, withdrawal-like symptoms, and GABAA receptor mRNAs profile expression in mice: comparison with diazepam
  5. 2026-09-24srcSleep self-intoxication and sleep driving as rare zolpidem-induced complex behaviour
  6. 2026-09-24srcRelationship between plasma exposure of zolpidem and CYP2D6 genotype in healthy Korean subjects
  7. 2026-09-24srcBenzodiazepines and Z-Drugs: An Updated Review of Major Adverse Outcomes Reported on in Epidemiologic Research
  8. 2026-09-24srcProbing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors
  9. 2026-09-24srcReview of Safety and Efficacy of Sleep Medicines in Older Adults
  10. 2026-09-24srcSublingual zolpidem is more effective than oral zolpidem in initiating early onset of sleep
  11. 2026-09-24srcEfficacy and safety of insomnia pharmacotherapies: Convergent evidence from Bayesian network meta-regression and FAERS-based disproportionality analysis
  12. 2026-09-24srcExamination of Zolpidem effects on AhR- and PXR-dependent expression of drug-metabolizing cytochromes P450 in primary cultures of human hepatocytes
  13. 2026-09-24srcAcute effects of zolpidem extended-release on cognitive performance and sleep in healthy males after repeated nightly use
  14. 2026-09-24srcThe efficacy and safety of zolpidem and zopiclone to treat insomnia in Alzheimer's disease: a randomized, triple-blind, placebo-controlled trial
  15. 2026-09-24srcStructural and dynamic mechanisms of GABAA receptor modulators with opposing activities
  16. 2026-09-24srcAssessment of the Abuse Potential of the Orexin Receptor Antagonist, Suvorexant, Compared With Zolpidem in a Randomized Crossover Study
  17. 2026-09-24srcZolpidem and eszopiclone prime a1b2g2 GABAA receptors for longer duration of activity
  18. 2026-09-24srcDrug interaction between St John's wort and zolpidem in healthy subjects
  19. 2026-09-24srcThe European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023
  20. 2026-09-24srcSedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
  21. 2026-09-24srcEffects on sleep stages and microarchitecture of caffeine and its combination with zolpidem or trazodone in healthy volunteers
  22. 2026-09-24srcSex differences in pharmacokinetics predict adverse drug reactions in women
  23. 2026-09-24srcZolpidem for insomnia
  24. 2026-09-24srcComparative tolerability of newer agents for insomnia
  25. 2026-09-24srcZolpidem Versus Trazodone Initiation and the Risk of Fall-Related Fractures among Individuals Receiving Maintenance Hemodialysis
  26. 2026-09-24srcEffects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial
  27. 2026-09-24srcAssociation Between Z Drugs Use and Risk of Cognitive Impairment in Middle-Aged and Older Patients With Chronic Insomnia
  28. 2026-09-24srcCase report: Chronological symptom profile after cessation of overdose zolpidem in a patient with comorbid bipolar disorder
  29. 2026-09-24srcZolpidem withdrawal induced uncoupling of GABA(A) receptors in vitro associated with altered GABA(A) receptor subunit mRNA expression
  30. 2026-09-24srcComparison of the treatment effectiveness between lemborexant and zolpidem tartrate extended-release for insomnia disorder subtypes
  31. 2026-09-24srcSpontaneous Adverse Event Reports Associated with Zolpidem in the United States 2003-2012
  32. 2026-09-24srcClinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.
  33. 2026-09-24srcComparison of lemborexant with placebo and zolpidem tartrate extended release on sleep architecture in older adults
  34. 2026-09-24srcRegional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha1 versus alpha2 and alpha3 subunit-containing GABAA receptors
  35. 2026-09-24srcIndependence of sleep EEG responses to GABAergic hypnotics: biological implications
  36. 2026-09-24srcNew drugs for insomnia: comparative tolerability of zopiclone, zolpidem and zaleplon
  37. 2026-09-24srcNewer hypnotic drugs for the short-term management of insomnia: a systematic review and economic evaluation
  38. 2026-09-24srcZolpidem extended-release
  39. 2026-09-24srcHPLC quantification of zolpidem and prothipendyl in a voluntary intoxication
  40. 2026-09-24srcLow-dose sublingual zolpidem tartrate is associated with dose-related improvement in sleep onset and duration in insomnia characterized by middle-of-the-night awakenings
  41. 2026-09-24srcZolpidem intoxication mimicking narcotic overdose: response to flumazenil
  42. 2026-09-24srcZolpidem dependence and withdrawal seizure--report of two cases
  43. 2026-09-24srcSilencing the brain may be better than stimulating it. The GABA effect
  44. 2026-09-24srcZolpidem dependence, abuse and withdrawal: A case report
  45. 2026-09-24srcZolpidem and rebound insomnia--a double-blind, controlled polysomnographic study in chronic insomniac patients
  46. 2026-09-24srcClinical pharmacokinetics and pharmacodynamics of zolpidem. Therapeutic implications
  47. 2026-09-24srcZolpidem - StatPearls
  48. 2026-09-24srcFDA requires lower recommended doses for certain drugs containing zolpidem (Ambien, Ambien CR, Edluar, Zolpimist)
  49. 2026-09-04issueIssued emergency
  50. 2026-09-04issueIssued info_card
  51. 2026-09-04issueIssued notice
  52. 2026-06-04proposal36 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  53. 2026-06-04publicationPublication — backfill
  54. 2026-04-28revisionRevision 1
  55. 2026-04-28genGeneration — pipeline-v5 · with 2 morepipeline-v5
  56. 2026-04-28rungeneration run

The same entries, as forms: six forms.