Xylazine

1. 2026-10-19issueIssued info_card
2. 2026-10-02srcThe first report from Ankara on the presence of xylazine abuse in blood and urine samples using a validated LC-HRMS method
3. 2026-10-02srcXylazine: A Drug Adulterant of Clinical Concern
4. 2026-10-02srcXylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism
5. 2026-10-02srcNIDA Clinical Trials Network Meeting Report: Managing Patients Exposed to Xylazine-Adulterated Opioids
6. 2026-10-02srcEnhancing fentanyl antinociception and preventing tolerance with alpha-2 adrenoceptor agonists in rats
7. 2026-10-02srcXylazine induced central antinociception mediated by endogenous opioids and mu-opioid receptor, but not delta- or kappa-opioid receptors
8. 2026-10-02srcDetecting Xylazine: Prevalence, Pharmacokinetics, and Analytical Considerations
9. 2026-10-02srcXylazine spreads across the US: A growing component of the increasingly synthetic and polysubstance overdose crisis
10. 2026-10-02srcEmergence of xylazine in accidental overdose deaths, impaired drivers, sexual assaults, and public intoxications within San Francisco
11. 2026-10-02srcalpha(2)-Adrenoceptor agonist xylazine induces peripheral antinociceptive effect by activation of the L-arginine/nitric oxide/cyclic GMP pathway in rat
12. 2026-10-02srcAntagonism of the antinociceptive effects of fentanyl and the veterinary anesthetic xylazine in mice
13. 2026-10-02srcInteractions between cardiorespiratory effects of fentanyl and xylazine and their reversal
14. 2026-10-02srcAlpha2-Adrenergic agonists including xylazine and dexmedetomidine inhibit norepinephrine transporter function in SK-N-SH cells
15. 2026-10-02srcTemporal and spatial patterns of xylazine and medetomidine detected in the DEA NFLIS reports
16. 2026-10-02srcEstablishing a research agenda for the study and assessment of opioid withdrawal
17. 2026-10-02srcXylazine suppresses fentanyl consumption during self-administration and induces a unique sex-specific withdrawal syndrome not altered by naloxone in rats
18. 2026-10-02srcCombined treatment with naloxone and atipamezole reversed brain hypoxia induced by a fentanyl-xylazine mixture in a rat model
19. 2026-10-02srcXylazine Pharmacokinetics in Patients Testing Positive for Fentanyl and Xylazine
20. 2026-10-02srcSelf-reported Xylazine Experiences: A Mixed-methods Study of Reddit Subscribers
21. 2026-10-02srcXylazine-associated Wounds: Clinical Experience From a Low-barrier Wound Care Clinic in Philadelphia
22. 2026-10-02srcMedetomidine-Associated Opioid Overdoses in Chicago, Illinois: A Report of 3 Cases
23. 2026-10-02srcPerformance of Xylazine Qualitative Immunoassays Designed for Drug Checking in Urine Samples
24. 2026-10-02srcXylazine Use in Pregnancy: A Case Report and Narrative Review
25. 2026-10-02srcXylazine Exposure and Association With Early Physiological and Withdrawal Symptoms in People With Opioid Use Disorder
26. 2026-10-02srcXylazine-Associated Wounds: A Scoping Review of Clinical Presentation and Management
27. 2026-10-02srcPrevalence of xylazine in overdose cases: An analysis of Miami-Dade County medical examiner case data
28. 2026-10-02srcCase Series: Magnitude and duration of fentanyl and xylazine detection in the urine of persons with opioid use disorder
29. 2026-10-02srcPoint-Of-Care Drug-Checking: Assessing the Rhode Island Drug Supply Using FTIR Spectroscopy to Detect Fentanyl, Xylazine and Other Substances
30. 2026-10-02srcIncreasing presence of xylazine in heroin and/or fentanyl deaths, Philadelphia, Pennsylvania, 2010-2019
31. 2026-10-02srcXylazine (veterinary sedative) use in Puerto Rico
32. 2026-10-02srcXylazine detected in unregulated opioids and drug administration equipment in Toronto, Canada
33. 2026-10-02srcReducing the harms of xylazine: clinical approaches, research deficits, and public health context
34. 2026-10-02srcPharmacologic Reversal of Xylazine-Induced Unconsciousness in Rats
35. 2026-10-02srcEvidence that xylazine disrupts skin homeostasis by acting on epithelial cells through the kappa opioid receptor
36. 2026-10-02srcPostmortem toxicology findings from the Camden Opioid Research Initiative
37. 2026-10-02srcIllicitly Manufactured Fentanyl-Involved Overdose Deaths with Detected Xylazine - United States, January 2019-June 2022
38. 2026-10-02srcIn Vitro Drug-Drug Interactions between Oxycodone and Commonly Co-Consumed Drugs in Rat and Human Liver Microsomes
39. 2026-10-02srcManagement of Xylazine-Induced Soft-Tissue Necrosis: A Review of 20 Cases
40. 2026-10-02srcXylazine's kappa opioid agonist activity is not shared with other FDA-approved alpha2-adrenergic agonists
41. 2026-10-02srcXylazine-Induced Skin Ulcers in a Person Who Injects Drugs in Philadelphia, Pennsylvania
42. 2026-10-02srcXylazine in the Opioid Epidemic: A Systematic Review of Case Reports and Clinical Implications
43. 2026-10-02srcXylazine-Induced Necrotic Skin Ulcers in a Fentanyl-Injecting Individual in South Florida
44. 2026-10-02srcCross-tolerance between analgesia produced by xylazine and selective opioid receptor subtype treatments
45. 2026-10-02srcSevere intoxication from xylazine inhalation
46. 2026-10-02srcSystemic toxicity after an ocular exposure to xylazine hydrochloride
47. 2026-10-02srcInhibition of glucose-induced insulin release by xylazine
48. 2026-10-02srcXylazine-induced hyperglycemia in cattle: a possible involvement of alpha 2-adrenergic receptors regulating insulin release
49. 2026-10-02srcUK ACMD Amendment Report: Use and Harms of Xylazine, Medetomidine and Detomidine
50. 2026-10-02srcXylazine Toxicity - StatPearls
51. 2026-10-02srcState and Federal Actions to Respond to Xylazine - National Governors Association
52. 2026-09-04issueIssued emergency
53. 2026-09-04issueIssued info_card
54. 2026-09-04issueIssued notice
55. 2026-06-04proposal22 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
56. 2026-06-04publicationPublication — backfill
57. 2026-05-08revisionRevision 1
58. 2026-05-08genGeneration — pipeline-v5 · with 1 morepipeline-v5
59. 2026-05-08rungeneration run
60. 2026-05-08rungeneration run

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