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1Provenance card

the boundary, as counts

Sources

4132 with DOI

20 strong · 9 moderate · 12 weak

Compilations

12026-04-24T19:48:50.759Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09 · 1 other run

Decisions

35last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:34:23.391Z

notice · info card · emergency

Searches

262 with no results

queries and counts on the build

Claims checked

10475 supported

75 supported · 29 not

Correspondence

0received

consent field ships in Phase 4

Edges

322

derivations recorded for this entity

Complete over 41 sources, 1 compilation, and 35 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/tramadol/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-27runbrief run
  3. 2026-09-27revisionr1.a1
  4. 2026-09-07srcOccurrence of the synthetic analgesic tramadol in an African medicinal plant.
  5. 2026-09-07srcOpioids in Breast Milk: Pharmacokinetic Principles and Clinical Implications.
  6. 2026-09-07srcPhysiologically based pharmacokinetic modeling of tramadol to inform dose adjustment and drug-drug interactions according to CYP2D6 phenotypes.
  7. 2026-09-07srcEnantioselective pharmacokinetics of tramadol and its three main metabolites; impact of CYP2D6, CYP2B6, and CYP3A4 genotype.
  8. 2026-09-07srcChanges in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice.
  9. 2026-09-07srcPopulation pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk.
  10. 2026-09-07srcRifampicin markedly decreases the exposure to oral and intravenous tramadol.
  11. 2026-09-07srcTramadol non-medical use in Four European countries: A comparative analysis.
  12. 2026-09-07srcTramadol: Effects on sexual behavior in male rats are mainly caused by its 5-HT reuptake blocking effects.
  13. 2026-09-07srcSerotonin syndrome induced by tramadol intoxication in an 8-month-old infant.
  14. 2026-09-07srcEffects of unconventional recreational drug use in pregnancy.
  15. 2026-09-07srcMechanisms of tramadol-related neurotoxicity in the rat: Does diazepam/tramadol combination play a worsening role in overdose?
  16. 2026-09-07srcSerotonin Syndrome Following Tramadol and Gabapentin Use After Spine Surgery.
  17. 2026-09-07srcTramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice.
  18. 2026-09-07srcRetrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids.
  19. 2026-09-07srcAtypical Withdrawal Symptoms after Abrupt Tramadol Discontinuation: A Case Report.
  20. 2026-09-07srcThe Effectiveness of Tramadol in Pain Relief in Chronic Diseases: A Review Based on Clinical Trials.
  21. 2026-09-07srcCombined on-demand sildenafil citrate and tramadol hydrochloride is an effective and safe treatment for premature ejaculation: A randomized placebo-controlled double-blind clinical trial.
  22. 2026-09-07srcEfficacy and safety of pharmacological treatments in patients with premature ejaculation: an umbrella review of meta-analyses of randomized controlled trials.
  23. 2026-09-07srcA novel tramadol-polycaprolactone implant could palliate heroin conditioned place preference and withdrawal in rats.
  24. 2026-09-07srcSerotonin syndrome after the use of tramadol and ziprasidone in a patient with a deep brain stimulator for Parkinson disease.
  25. 2026-09-07srcTramadol versus codeine and the short-term risk of cardiovascular events in patients with non-cancer pain: A population-based cohort study.
  26. 2026-09-07srcTramadol for management of fibromyalgia pain and symptoms: Systematic review.
  27. 2026-09-07srcAn unconscious man with profound drug-induced hypoglycaemia.
  28. 2026-09-07srcComparative pharmacokinetics of a once-daily tramadol extended-release tablet and an immediate-release reference product following single-dose and multiple-dose administration.
  29. 2026-09-07srcTramadol Therapy and CYP2D6 Genotype
  30. 2026-09-07srcMedical and Psychiatric Effects of Long-Term Dependence on High Dose of tramadol.
  31. 2026-09-07srcPain management discussion forum: serious interaction among frequently used drugs for chronic pain.
  32. 2026-09-07srcDifferent Pharmacokinetics of Tramadol, O-Demethyltramadol and N-Demethyltramadol in Postoperative Surgical Patients From Those Observed in Medical Patients.
  33. 2026-09-07srcUndetected Ultracet dependence in an adolescent with nonmalignant back pain.
  34. 2026-09-07srcMultimechanistic Single-Entity Combinations for Chronic Pain Control: A Narrative Review.
  35. 2026-09-07srcSerotonin Syndrome With Concomitant Antidepressant and Tramadol: A Case Report.
  36. 2026-09-07srcPharmacokinetics of tramadol and bioavailability of enteral tramadol formulations. 4th communication: drops (without ethanol).
  37. 2026-09-07srcAnticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy.
  38. 2026-09-07srcThe effects of the tramadol metabolite O-desmethyl tramadol on muscarinic receptor-induced responses.
  39. 2026-09-07srcInfluence of tramadol on neurotransmitter systems of the rat brain.
  40. 2026-09-07src[Pharmacology of tramadol].
  41. 2026-09-07srcTramadol - Wikipedia
  42. 2026-09-07srcTramadol: new legal classification (UK Derbyshire NHS)
  43. 2026-09-07srcTramadol legal status and global situation - INCB Alert 7, 2018
  44. 2026-09-07srcDEA Classifies Tramadol as a Schedule IV Controlled Substance
  45. 2026-09-04issueIssued emergency
  46. 2026-09-04issueIssued info_card
  47. 2026-09-04issueIssued notice
  48. 2026-06-04proposal32 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  49. 2026-06-04publicationPublication — backfill
  50. 2026-04-24revisionRevision 1
  51. 2026-04-24absenceSearched PubMed for "tramadol atypical withdrawal hallucinations anxiety serotonergic discontinuation" — no results
  52. 2026-04-24absenceSearched PubMed for "tramadol NMDA receptor antagonism local anesthetic sodium channel blocking" — no results
  53. 2026-04-24genGeneration — pipeline-v5 · with 2 morepipeline-v5
  54. 2026-04-24rungeneration run

The same entries, as forms: six forms.