Tianeptine
1Provenance card
the boundary, as counts
Sources
4228 with DOI
11 strong · 20 moderate · 11 weak
Compilations
12026-04-26T02:50:59.475Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09
Decisions
31last ruled 2026-06-04
1 awaiting a ruling
Issued documents
42026-10-19T20:34:19.733Z
notice · info card · emergency
Searches
190 with no results
queries and counts on the build
Claims checked
10276 supported
76 supported · 26 not
Correspondence
0received
consent field ships in Phase 4
Edges
308
derivations recorded for this entity
Complete over 42 sources, 1 compilation, and 31 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/tianeptine/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued info_card
- 2026-09-24srcA double-blind comparison of tianeptine, imipramine and placebo in the treatment of major depressive episodes
- 2026-09-24srcInfluence of anxiety symptoms on improvement of neurocognitive functions in patients with MDD: CAMPION study
- 2026-09-24srcTianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways
- 2026-09-24srcThe antiallodynic effect of intrathecal tianeptine is exerted by increased serotonin and norepinephrine in the spinal dorsal horn
- 2026-09-24srcTianeptine: enantiomeric separations, structural assignment, and biological interactions
- 2026-09-24srcClassics in Chemical Neuroscience: Tianeptine
- 2026-09-24srcNeurotrophic effects of tianeptine on hippocampal neurons: a proteomic approach
- 2026-09-24srcThe same antidepressant elicits contrasting patterns of synaptic changes in the amygdala vs hippocampus
- 2026-09-24srcThe Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor
- 2026-09-24srcAntidepressants for the treatment of adults with MDD in the maintenance phase: a systematic review and network meta-analysis
- 2026-09-24srcMu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine
- 2026-09-24srcTianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain
- 2026-09-24srcThe atypical antidepressant and neurorestorative agent tianeptine is a mu-opioid receptor agonist
- 2026-09-24srcSevere tianeptine withdrawal symptoms managed with medications for opioid use disorder: a case report
- 2026-09-24srcPoison control center experience with tianeptine: an unregulated pharmaceutical product with potential for abuse
- 2026-09-24srcUse of Buprenorphine-Naloxone in the Treatment of Tianeptine Use Disorder
- 2026-09-24srcMicrodose Induction of Buprenorphine in a Patient Using Tianeptine
- 2026-09-24srcTianeptine reduces morphine antinociceptive tolerance and physical dependence
- 2026-09-24srcImprovement in subjective and objective neurocognitive functions in patients with MDD: the CAMPION study
- 2026-09-24srcAnti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways
- 2026-09-24srcTianeptine Misuse, Dependence, and Clinical Management: Three Case Reports and Literature Review
- 2026-09-24srcAdjunctive tianeptine treatment for bipolar disorder: A 24-week randomized, placebo-controlled, maintenance trial
- 2026-09-24srcGas station heroin - tianeptine and its impact: a systematic review and exploratory analysis
- 2026-09-24srcNeonatal Opioid Withdrawal Syndrome Following Prenatal Use of Supplements Containing Tianeptine
- 2026-09-24srcTargeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment--Suppressed Microglia Polarization to M1 Phenotype
- 2026-09-24srcEfficacy of Tianeptine 25-50 mg in Elderly Patients With Recurrent Major Depressive Disorder
- 2026-09-24srcTianeptine as an opiate replacement in a patient on methadone treatment: A case report
- 2026-09-24srcTreatment of concurrent etizolam and tianeptine withdrawal following accidental overdose
- 2026-09-24srcEffects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress
- 2026-09-24srcTianeptine: a review of its use in depressive disorders
- 2026-09-24srcChronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine
- 2026-09-24srcA comparative study of fluoxetine, moclobemide, and tianeptine in the treatment of posttraumatic stress disorder following an earthquake
- 2026-09-24srcFatal intoxication with tianeptine (Stablon)
- 2026-09-24srcNeurobiological and clinical effects of the antidepressant tianeptine
- 2026-09-24srcCardiovascular tolerance to tianeptine
- 2026-09-24srcTianeptine in the combined treatment of combat related posttraumatic stress disorder
- 2026-09-24srcLack of cardiovascular side effects of the new tricyclic antidepressant tianeptine
- 2026-09-24srcThe pharmacokinetics of the antidepressant tianeptine and its main metabolite in healthy humans--influence of alcohol co-administration
- 2026-09-24srcPharmacokinetic and metabolic parameters of tianeptine in healthy volunteers and in populations with risk factors
- 2026-09-24srcPrevention of stress-induced morphological and cognitive consequences
- 2026-09-24srcTianeptine - Wikipedia
- 2026-09-24srcTianeptine Crackdown Continues: New Legislative and Enforcement Efforts Target Tianeptine Products
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-07-03proposaldependence · taper
- 2026-06-04proposal28 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-04-26revisionRevision 1
- 2026-04-26genGeneration — pipeline-v5 · with 3 morepipeline-v5
- 2026-04-26rungeneration run
The same entries, as forms: six forms.