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Psychedex

1Provenance card

the boundary, as counts

Sources

2917 with DOI

14 strong · 10 moderate · 5 weak

Compilations

12026-05-07T13:55:14.771Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

23last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:34:16.652Z

notice · info card · emergency

Searches

211 with no results

queries and counts on the build

Claims checked

9059 supported

59 supported · 31 not

Correspondence

0received

consent field ships in Phase 4

Edges

267

derivations recorded for this entity

Complete over 29 sources, 1 compilation, and 23 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/theobromine/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-07srcCocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study
  3. 2026-09-07srcA comprehensive insight into the molecular effect of theobromine on cardiovascular-related risk factors: A systematic review of in vitro and in vivo studies
  4. 2026-09-07srcTheobromine consumption does not improve fasting and postprandial vascular function in overweight and obese subjects
  5. 2026-09-07srcImpact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease
  6. 2026-09-07srcTheobromine does not affect postprandial lipid metabolism and duodenal gene expression, but has unfavorable effects on postprandial glucose and insulin responses in humans
  7. 2026-09-07srcFlavan-3-ol-methylxanthine interactions: Modulation of flavan-3-ol bioavailability in volunteers with a functional colon and an ileostomy
  8. 2026-09-07srcDifferential contributions of theobromine and caffeine on mood, psychomotor performance and blood pressure
  9. 2026-09-07srcEffects of high flavanol dark chocolate on cardiovascular function and platelet aggregation
  10. 2026-09-07srcThe acute effects on duodenal gene expression in healthy men following consumption of a low-fat meal enriched with theobromine or fat
  11. 2026-09-07srcTheobromine supplementation in combination with a low-calorie diet improves cardiovascular risk factors in overweight and obese subjects with metabolic syndrome: a randomized controlled trial
  12. 2026-09-07srcCocoa phytochemicals: recent advances in molecular mechanisms on health
  13. 2026-09-07srcChanges in endothelial function, arterial stiffness and blood pressure in pregnant women after consumption of high-flavanol and high-theobromine chocolate: a double blind randomized clinical trial
  14. 2026-09-07srcEffect of Theobromine Consumption on Serum Lipoprotein Profiles in Apparently Healthy Humans with Low HDL-Cholesterol Concentrations
  15. 2026-09-07srcTheobromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage
  16. 2026-09-07srcSub-Chronic Consumption of Dark Chocolate Enhances Cognitive Function and Releases Nerve Growth Factors: A Parallel-Group Randomized Trial
  17. 2026-09-07srcEffect of cocoa and theobromine consumption on serum HDL-cholesterol concentrations: a randomized controlled trial
  18. 2026-09-07srcChocolate-Induced Sinus Tachycardia: A Sweet Surprise
  19. 2026-09-07srcCytochrome P450 isoform selectivity in human hepatic theobromine metabolism
  20. 2026-09-07srcTheobromine inhibits sensory nerve activation and cough
  21. 2026-09-07srcMethylxanthines are the psycho-pharmacologically active constituents of chocolate
  22. 2026-09-07srcEvaluation of the teratogenic potential of cocoa powder and theobromine in New Zealand White rabbits
  23. 2026-09-07srcEvaluation of the perinatal, postnatal and teratogenic effects of cocoa powder and theobromine in Sprague-Dawley/CD rats
  24. 2026-09-07srcTeratogenicity of paraxanthine (1,7-dimethylxanthine) in C57BL/6J mice
  25. 2026-09-07srcHigh levels of methylxanthines in chocolate do not alter theobromine disposition
  26. 2026-09-07srcThe toxicology of cocoa and methylxanthines: a review of the literature
  27. 2026-09-07srcTheobromine - Coffee, Tea, Mate, Methylxanthines and Methylglyoxal - NCBI Bookshelf NBK507032
  28. 2026-09-07srcTheobromine - Wikipedia (discovery history)
  29. 2026-09-07srcEFSA Scientific Opinion: Flavouring Group Evaluation 49, Revision 1 - xanthine alkaloids (includes theobromine)
  30. 2026-09-07srcTheobromine poisoning - Wikipedia / Merck Veterinary Manual / ASPCA
  31. 2026-09-04issueIssued emergency
  32. 2026-09-04issueIssued info_card
  33. 2026-09-04issueIssued notice
  34. 2026-06-04proposal21 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  35. 2026-06-04publicationPublication — backfill
  36. 2026-05-07revisionRevision 1
  37. 2026-05-07absenceSearched ClinicalTrials.gov for "theobromine" — no results
  38. 2026-05-07genGeneration — pipeline-v5pipeline-v5
  39. 2026-05-07rungeneration run

The same entries, as forms: six forms.