Tetrahydrocannabihexol Facts
Cannabinoid;
Description
THCH (tetrahydrocannabihexol) — also known as parahexyl — is a cannabinoid of the dibenzopyran class. It is a direct homolog of Δ9-THC, its six-carbon side chain producing stronger cannabinoid receptor binding than conventional THC.[1][2] It activates these receptors more completely than THC, generating a more intense cannabis-type experience.
Subjective effects include sedation, euphoria, appetite enhancement, time alteration, and sensory intensification. The experience resembles cannabis but is steeper — the margin between comfortable and overwhelming narrows because THCH activates receptors more completely than THC can.
Dependence liability is presumed at least equivalent to cannabis; no lethal dose data exist for any species. As a full receptor activator — unlike THC, which is partial — THCH can push effects beyond what plant cannabis reaches, including prolonged unconsciousness documented in real cases.
Dose and duration
No dose or duration recorded for any route.
Body and dependence
- Acute toxicity
- Moderate
- Chronic toxicity
- Low
- Physical dependence
- Low
- Psychological dependence
- Moderate
- Withdrawal
- Moderate
- Compulsive redosing
- Low
Tolerance
- Builds
- Moderate
- Fully resets after
- 21 days
- Carries over to
- Δ9-THC;
Δ8-THC; THCP; THCB; HHC; Synthetic cannabinoids
Effectslikely at a common dose
- Perception
- none likely · 18 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
- Body
- Body high;
Dry mouth; +20 possible, including Abnormal heartbeat, Motor control impairment, Dizziness - Thinking
- Cognitive impairment;
Memory suppression; +32 possible, including Decision impairment, Information processing suppression, Analysis suppression - Feeling
- none likely · 10 possible, including Anxiety, Emotional lability, Paranoia
- Self
- none likely · 14 possible, including Communication suppression, Depersonalization, Derealization
- Time
- Time alteration;
+2 possible, including Temporal disorientation - Awareness
- none likely · 2 possible
Who shouldn't take it
Combinations60 recorded
Seek help immediately if
Natural cannabis rarely causes a medical emergency — "greening out" is: pale/sweaty skin, dizziness, nausea or vomiting, anxiety or panic, rapid heartbeat, feeling faint — and usually passes with rest.
Seek emergency help for these — far more likely with synthetic cannabinoids ("spice" / K2):
- Seizures
- Severe chest pain; very fast or irregular heartbeat
- Unresponsiveness or extreme drowsiness
- Severe agitation, aggression, or psychosis
- Repeated vomiting; difficulty breathing
What to do
- Sit or lie them down somewhere calm, cool, and quiet
- Reassure them — cannabis panic and "greening out" pass with time
- Offer sips of water; a little sugar can help if they feel faint
- Recovery position if nauseated, drowsy, or vomiting
- Stay with them and monitor
- For seizures, chest pain, unresponsiveness, or severe agitation, call emergency services
Natural cannabis "greening out" resolves with rest, calm, and time, with no lasting harm. Synthetic cannabinoids are unpredictable and can cause seizures, cardiac events, kidney injury, and severe agitation that needs emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^Janssens LK, Van Uytfanghe K, Williams JB, Hering KW, Iula DM, Stove CP (2024) Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays - and how this matters for the harm potential of seized drugs — Archives of Toxicology doi:10.1007/s00204-024-03769-4
- [2]^Bow EW, Rimoldi JM (2016) The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation — Perspectives in Medicinal Chemistry doi:10.4137/pmc.s32171