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the boundary, as counts

Sources

4132 with DOI

31 strong · 7 moderate · 3 weak

Compilations

12026-05-07T10:03:51.638Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

33last ruled 2026-10-02

0 awaiting a ruling

Issued documents

42026-10-02T13:10:02.699Z

notice · info card · emergency

Searches

180 with no results

queries and counts on the build

Claims checked

9450 supported

50 supported · 44 not

Correspondence

0received

consent field ships in Phase 4

Edges

297

derivations recorded for this entity

Complete over 41 sources, 1 compilation, and 33 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/salvinorin-a/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-02issueIssued info_card
  2. 2026-10-02srcA Protecting-Group-Free Synthesis of (-)-Salvinorin A.
  3. 2026-10-02srcSalvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors.
  4. 2026-10-02srcKappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents.
  5. 2026-10-02srcLack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, in humans: a placebo-controlled trial.
  6. 2026-10-02srcDose-related effects of salvinorin A in humans: dissociative, hallucinogenic, and memory effects.
  7. 2026-10-02srcDose-related behavioral, subjective, endocrine, and psychophysiological effects of the kappa opioid agonist Salvinorin A in humans.
  8. 2026-10-02srcSalvinorin A moderates postischemic brain injury by preserving endothelial mitochondrial function via AMPK/Mfn2 activation.
  9. 2026-10-02srcFrom local to global-fifty years of research on Salvia divinorum.
  10. 2026-10-02srcSalvinorin A ameliorates pilocarpine-induced seizures by regulating hippocampal microglia polarization.
  11. 2026-10-02srcPharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans.
  12. 2026-10-02srcDiscovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening.
  13. 2026-10-02srcAcute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A.
  14. 2026-10-02srcSignaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses.
  15. 2026-10-02srcInhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors.
  16. 2026-10-02srcImmediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET.
  17. 2026-10-02srcThe translational potential of salvinorin A: systematic review and meta-analysis of preclinical studies.
  18. 2026-10-02srcLigand and G-protein selectivity in the κ-opioid receptor.
  19. 2026-10-02srcThe Acute Effects of the Atypical Dissociative Hallucinogen Salvinorin A on Functional Connectivity in the Human Brain.
  20. 2026-10-02srcSalvinorin, a new trans-neoclerodane diterpene from Salvia divinorum (Labiatae)
  21. 2026-10-02srcSalvia divinorum and Salvinorin A: An Update on Pharmacology and Analytical Methodology
  22. 2026-10-02srcThe Association of Salvia divinorum and Psychotic Disorders: A Review of the Literature and Case Series.
  23. 2026-10-02srcQuite a Profoundly Strange Experience: An Analysis of the Experiences of Salvia divinorum Users.
  24. 2026-10-02srcSalvinorin-A Induces Intense Dissociative Effects, Blocking External Sensory Perception and Modulating Interoception and Sense of Body Ownership in Humans.
  25. 2026-10-02srcNaltrexone but Not Ketanserin Antagonizes the Subjective, Cardiovascular, and Neuroendocrine Effects of Salvinorin-A in Humans.
  26. 2026-10-02srcSalvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating kappa-opioid and cannabinoid receptors.
  27. 2026-10-02srcPotential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents.
  28. 2026-10-02srcTime course of pharmacokinetic and hormonal effects of inhaled high-dose salvinorin A in humans.
  29. 2026-10-02srcIntranasal salvinorin A improves neurological outcome in rhesus monkey ischemic stroke model using autologous blood clot.
  30. 2026-10-02srcUse of Salvia divinorum in a nationally representative sample.
  31. 2026-10-02srcOpioid Receptors in Psychedelia: Indirect Serotonergic Modulation of Direct KOR Activation by Salvinorin A.
  32. 2026-10-02srcSolving an Old Puzzle: Elucidation and Evaluation of the Binding Mode of Salvinorin A at the Kappa Opioid Receptor.
  33. 2026-10-02srcPharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects
  34. 2026-10-02srcSalvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.
  35. 2026-10-02srcSalvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.
  36. 2026-10-02srcPharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates.
  37. 2026-10-02srcN-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy.
  38. 2026-10-02srcToxic psychosis after intake of the hallucinogen salvinorin A.
  39. 2026-10-02srcSalvia divinorum: a psychopharmacological riddle and a mind-body prospect.
  40. 2026-10-02srcSalvinorin A: A Mini Review of Physical and Chemical Properties Affecting Its Translation from Research to Clinical Applications in Humans.
  41. 2026-10-02srcCytotoxic Effects of Salvinorin A, A Major Constituent of Salvia divinorum.
  42. 2026-10-02srcErowid Salvia Divinorum Vault: Legal Status
  43. 2026-10-02publicationPublication — publishagent-psx
  44. 2026-10-02revisionr1.a1
  45. 2026-10-02rulingRuling — psx:substance/salvinorin-a/proposal/article_section_proposals/488e5b61-8d5c-4eb5-84ac-8772920cc0bcfounder
  46. 2026-10-02rulingRuling — psx:substance/salvinorin-a/proposal/article_section_proposals/b592b634-a27c-4c0f-a354-1aaa7e7737a5founder
  47. 2026-09-04issueIssued emergency
  48. 2026-09-04issueIssued info_card
  49. 2026-09-04issueIssued notice
  50. 2026-06-04proposal27 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  51. 2026-06-04publicationPublication — backfill
  52. 2026-05-07revisionRevision 1
  53. 2026-05-07genGeneration — pipeline-v5 · with 3 morepipeline-v5
  54. 2026-05-07rungeneration run

The same entries, as forms: six forms.