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1Provenance card

the boundary, as counts

Sources

3314 with DOI

12 strong · 12 moderate · 9 weak

Compilations

12026-05-12T06:43:04.804Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

37last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:33:48.633Z

notice · info card · emergency

Searches

251 with no results

queries and counts on the build

Claims checked

7861 supported

61 supported · 17 not

Correspondence

0received

consent field ships in Phase 4

Edges

297

derivations recorded for this entity

Complete over 33 sources, 1 compilation, and 37 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/promethazine/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-24srcInterventions for treating hyperemesis gravidarum.
  3. 2026-09-24srcDrugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.
  4. 2026-09-24srcDetection of pharmaceuticals in "dirty sprite" using gas chromatography and mass spectrometry.
  5. 2026-09-24srcPharmacodynamic Drug-Drug interactions of QT-prolonging drugs in hospitalized psychiatric patients.
  6. 2026-09-24srcAn autopsy case of rhabdomyolysis related to vegetamin and genetic analysis of the rhabdomyolysis-associated genes.
  7. 2026-09-24src"Purple Drank" (Codeine and Promethazine Cough Syrup): A Systematic Review of a Social Phenomenon with Medical Implications.
  8. 2026-09-24srcAssociation of H1-antihistamines with torsade de pointes: a pharmacovigilance study of the food and drug administration adverse event reporting system.
  9. 2026-09-24srcPrevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108.
  10. 2026-09-24srcPromethazine overdose: clinical effects, predicting delirium and the effect of charcoal.
  11. 2026-09-24srcA Danish Survey of Antihistamine Use and Poisoning Patterns.
  12. 2026-09-24srcAmerican Geriatrics Society 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults.
  13. 2026-09-24srcComparison of Low-Dose Promethazine and Dexamethasone against Ondansetron Monotherapy Given as Antiemetic Prophylaxis during Myomectomy Under Spinal Anesthesia: A Randomized Clinical Trial.
  14. 2026-09-24srcPromethazine Combined with Metoclopramide for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial.
  15. 2026-09-24srcMechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems
  16. 2026-09-24srcPharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects.
  17. 2026-09-24srcPromethazine as a motion sickness treatment: impact on human performance and mood states.
  18. 2026-09-24srcComparison of treatment strategies for Space Motion Sickness.
  19. 2026-09-24srcInhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes.
  20. 2026-09-24srcStudy of the stability of promethazine enantiomers by liquid chromatography using a vancomycin-bonded chiral stationary phase.
  21. 2026-09-24srcEffects of drug countermeasures for space motion sickness on working memory in humans.
  22. 2026-09-24srcDisabling work-related persistent photosensitivity following photoallergic contact dermatitis from chlorpromazine and olaquindox in a pig breeder.
  23. 2026-09-24srcAntimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay.
  24. 2026-09-24srcBioequivalency and dose proportionality of three tableted promethazine products.
  25. 2026-09-24srcPROMETHAZINE-INDUCED THROMBOPHLEBITIS IN A NIGERIAN MAN: A CASE REPORT.
  26. 2026-09-24srcPoisoning from dermal absorption of promethazine.
  27. 2026-09-24src[Absolute bioavailability of chlorpromazine, promazine and promethazine].
  28. 2026-09-24srcCYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes.
  29. 2026-09-24srcA retrospective study of promethazine and its failure to produce the expected incidence of sedation during space flight.
  30. 2026-09-24srcBoxed Warning Added to Promethazine Labeling for Pediatric Use
  31. 2026-09-24srcFirst chemoenzymatic stereodivergent synthesis of both enantiomers of promethazine and ethopropazine
  32. 2026-09-24srcPromethazine Receptor Binding Data — IUPHAR/BPS Guide to Pharmacology
  33. 2026-09-24srcPromethazine — Wikipedia
  34. 2026-09-24srcPromethazine — StatPearls
  35. 2026-09-04issueIssued emergency
  36. 2026-09-04issueIssued info_card
  37. 2026-09-04issueIssued notice
  38. 2026-08-19revisionr1.a1
  39. 2026-06-04proposal34 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  40. 2026-06-04publicationPublication — backfill
  41. 2026-05-12revisionRevision 1
  42. 2026-05-12absenceSearched PubMed for "promethazine pharmacology receptor binding H1 dopamine muscarinic" — no results
  43. 2026-05-12genGeneration — pipeline-v5 · with 1 morepipeline-v5
  44. 2026-05-12rungeneration run

The same entries, as forms: six forms.