Prolintane Facts
Stimulant;
Description
Prolintane is a synthetic stimulant of the pyrrolidine class. It raises dopamine and norepinephrine by blocking their reuptake, producing the focused wakefulness characteristic of catecholaminergic stimulants.[1]
Subjective effects include wakefulness, sharper focus, mood elevation, appetite suppression, and mild euphoria. The experience is functional rather than euphoric — closer to Methylphenidate than cocaine, a clean, focused alertness without strong stimulant intensity.[2]
Prolintane carries moderate dependence potential, and high doses can produce psychosis, dangerous heart rhythms, and death. The cardiac risk is the most acute: prolintane disrupts an electrical channel in the heart,[3] and combining it with serotonin-affecting substances can trigger a life-threatening overheating and seizure response.
Dose and durationby route · individual sensitivity varies
Starts in 20 – 60 minLasts 4 – 6 hoursAfter-effects 2 – 6 hours
Body and dependence
- Acute toxicity
- Moderate
- Chronic toxicity
- Moderate
- Physical dependence
- Low
- Psychological dependence
- Moderate
- Withdrawal
- Mild
- Compulsive redosing
- Moderate
Tolerance
- Builds
- Moderate
- Fully resets after
- 14 days
- Carries over to
- cocaine;
methylphenidate; pyrovalerone
Effectslikely at a common dose
- Perception
- none likely · 2 possible
- Body
- Appetite suppression;
Wakefulness; Stimulation; Pupil dilation; +13 possible, including Muscle tension, Insomnia, Vasoconstriction - Thinking
- Thought acceleration;
+10 possible, including Compulsive redosing urge - Feeling
- none likely · 6 possible, including Anxiety, Anhedonia, Depression
- Self
- none likely · 6 possible, including Ego inflation, Craving
Who shouldn't take it
Combinations61 recorded
Seek help immediately if
- Chest pain; racing, pounding, or irregular heartbeat
- Very high body temperature; heavy sweating; hot, flushed skin
- Severe agitation, paranoia, panic, or confusion
- Severe headache; muscle rigidity or twitching
- Seizures
- Signs of stroke — face drooping, one-sided weakness, slurred speech
- Difficulty breathing; collapse or unconsciousness
What to do
- Call emergency services for chest pain, overheating, seizure, or unresponsiveness
- Move them to a cool, quiet place and reduce stimulation
- Cool the body — remove excess clothing, apply cool damp cloths, fan them
- Keep them calm; reassure — panic worsens the cardiovascular strain
- If seizing, protect from injury (don't restrain); recovery position afterward
- Monitor breathing and be ready to give rescue breaths / CPR
Most stimulant overdoses settle with cooling, a calm environment, and time. The medical danger is hyperthermia, cardiac events (arrhythmia, heart attack, stroke), and seizures — get help immediately if any appear.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^Kastner N, Islam MN, Dybek M, Roth E, Heisinger S, Holy M, Jäntsch K, Walther D, Stockner T, Baumann MH, Brandt SD, Wallach J, Sitte HH, Kudlacek O (2025) Prolintane analogs as hybrid monoamine transporter ligands: Structural determinants and species differences. — The Journal of Biological Chemistry doi:10.1016/j.jbc.2025.110903
- [2]^Lee W, Lee JW, Kim JM, Hong YK, Kim MS, Choi SO, Kang MS (2022) The abuse potential of prolintane in rodents: Behavioral pharmacology approaches. — Neuropharmacology doi:10.1016/j.neuropharm.2021.108917
- [3]^Jeong S, Yoon KS, Lee JM, Jo ES, Kim D, Choi SO (2023) Neurotoxic and cardiotoxic effects of N-methyl-1-(naphthalen-2-yl)propan-2-amine (methamnetamine) and 1-phenyl-2-pyrrolidinylpentane (prolintane). — Drug and Chemical Toxicology doi:10.1080/01480545.2022.2049289