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1Provenance card

the boundary, as counts

Sources

4132 with DOI

11 strong · 24 moderate · 6 weak

Compilations

12026-04-28T00:29:04.514Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

32last ruled 2026-06-04

1 awaiting a ruling

Issued documents

42026-10-19T20:33:44.857Z

notice · info card · emergency

Searches

210 with no results

queries and counts on the build

Claims checked

9981 supported

81 supported · 18 not

Correspondence

0received

consent field ships in Phase 4

Edges

304

derivations recorded for this entity

Complete over 41 sources, 1 compilation, and 32 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/pregabalin/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-24srcPregabalin for neuropathic pain in adults.
  3. 2026-09-24srcPregabalin for the treatment of fibromyalgia syndrome: Results of a randomized, double-blind, placebo-controlled trial.
  4. 2026-09-24srcGabapentinoid Pharmacology in the Context of Emerging Misuse Liability.
  5. 2026-09-24srcPregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: A case series and literature review.
  6. 2026-09-24srcPathophysiological Roles of Auxiliary Calcium Channel Alpha2delta Subunits.
  7. 2026-09-24srcPregabalin abuse and dependence in Germany: results from a database query.
  8. 2026-09-24srcNeuronal alpha2delta proteins and brain disorders.
  9. 2026-09-24srcMolecular and hormonal changes caused by long-term use of high dose pregabalin on testicular tissue: the role of p38 MAPK, oxidative stress and apoptosis.
  10. 2026-09-24srcEffects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues.
  11. 2026-09-24srcMisuse and abuse of pregabalin and gabapentin: cause for concern?
  12. 2026-09-24srcPregabalin: a review of its use in adults with generalized anxiety disorder.
  13. 2026-09-24srcA Decade of Gabapentinoid Misuse: An Analysis of the European Medicines Agency's 'Suspected Adverse Drug Reactions' Database.
  14. 2026-09-24srcTrends in gabapentinoid prescribing, co-prescribing of opioids and benzodiazepines, and associated deaths in Scotland.
  15. 2026-09-24srcPharmacokinetics of a New, Once-Daily, Sustained-release Pregabalin Tablet in Healthy Male Volunteers.
  16. 2026-09-24srcThe calcium channel agonist (±)-BAY-K-8644 attenuates the ability of gabapentinoids to increase the potency of fentanyl and heroin and decrease the potency of cocaine and d-methamphetamine.
  17. 2026-09-24srcTrends in gabapentinoid prescribing in UK primary care using the Clinical Practice Research Datalink: an observational study.
  18. 2026-09-24srcFatal pregabalin poisoning in Japan: A case report.
  19. 2026-09-24srcEfficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens.
  20. 2026-09-24srcPharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis.
  21. 2026-09-24srcSexual Dysfunctions Induced by Pregabalin.
  22. 2026-09-24srcRisk to heroin users of polydrug use of pregabalin or gabapentin
  23. 2026-09-24srcAnalgesia with Gabapentin and Pregabalin May Involve N-Methyl-d-Aspartate Receptors, Neurexins, and Thrombospondins.
  24. 2026-09-24srcGabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels.
  25. 2026-09-24srcBenefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials.
  26. 2026-09-24srcPregabalin use early in pregnancy and the risk of major congenital malformations.
  27. 2026-09-24srcA meta-epidemiological study on the reported treatment effect of pregabalin in neuropathic pain trials over time.
  28. 2026-09-24srcThe increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin.
  29. 2026-09-24srcPregabalin treatment for peripheral neuropathic pain: a review of safety data from randomized controlled trials conducted in Japan and in the west.
  30. 2026-09-24srcComparative Remission Rates and Tolerability of Drugs for Generalised Anxiety Disorder: A Systematic Review and Network Meta-analysis.
  31. 2026-09-24srcGabapentinoid Abuse in France: Evidence on Health Consequences and New Points of Vigilance.
  32. 2026-09-24srcEpinephrine, Pregabalin, and Crizotinib as Three Medicines with Polish Implications.
  33. 2026-09-24srcPregabalin abuse and dependence during insomnia and protocol for short-term withdrawal management with diazepam.
  34. 2026-09-24srcPharmacokinetics of pregabalin in subjects with various degrees of renal function.
  35. 2026-09-24srcEfficacy of the novel anxiolytic pregabalin in social anxiety disorder: a placebo-controlled, multicenter study.
  36. 2026-09-24srcPregabalin pharmacology and its relevance to clinical practice.
  37. 2026-09-24srcPlacement of pregabalin into Schedule V. Final rule
  38. 2026-09-24srcAlpha2delta subunit voltage-gated calcium channel ligands: Ki values and anti-allodynic effects comparison.
  39. 2026-09-24srcPregabalin for generalized anxiety disorder: an updated systematic review and meta-analysis.
  40. 2026-09-24srcPregabalin for the Treatment of Drug and Alcohol Withdrawal Symptoms: A Comprehensive Review.
  41. 2026-09-24srcReclassification of pregabalin and gabapentin to Schedule 3 drugs from 1 April 2019
  42. 2026-09-24srcPregabalin (Lyrica) FDA Approval History
  43. 2026-09-04issueIssued emergency
  44. 2026-09-04issueIssued info_card
  45. 2026-09-04issueIssued notice
  46. 2026-07-03proposaldependence · taper
  47. 2026-06-04proposal29 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  48. 2026-06-04publicationPublication — backfill
  49. 2026-04-28revisionRevision 1
  50. 2026-04-28genGeneration — pipeline-v5 · with 2 morepipeline-v5
  51. 2026-04-28rungeneration run

The same entries, as forms: six forms.