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1Provenance card

the boundary, as counts

Sources

5445 with DOI

28 strong · 22 moderate · 4 weak

Compilations

12026-04-27T23:28:09.792Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

62last ruled 2026-06-04

1 awaiting a ruling

Issued documents

42026-10-19T20:33:27.325Z

notice · info card · emergency

Searches

241 with no results

queries and counts on the build

Claims checked

2102 supported

2 supported · 208 not

Correspondence

0received

consent field ships in Phase 4

Edges

572

derivations recorded for this entity

Complete over 54 sources, 1 compilation, and 62 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/oxycodone/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-07srcCharacteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns
  3. 2026-09-07srcPhysiologically based pharmacokinetic modelling of oxycodone drug-drug interactions
  4. 2026-09-07srcOxymorphone and Oxycodone Pharmacy Purchases in US Counties: Prelude to the Largest Rural HIV Outbreak in US History
  5. 2026-09-07srcOpioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects
  6. 2026-09-07srcPerinatal oxycodone exposure causes long-term sex-dependent changes in weight trajectory and sensory processing in adult mice
  7. 2026-09-07srcManagement of Opioid-Induced Constipation and Bowel Dysfunction
  8. 2026-09-07srcUpdated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone
  9. 2026-09-07srcEnzalutamide Reduces Oxycodone Exposure in Men with Prostate Cancer
  10. 2026-09-07srcThe impact of the abuse-deterrent reformulation of extended-release OxyContin on prescription pain reliever misuse and heroin initiation
  11. 2026-09-07srcSeparate and combined psychopharmacological effects of alprazolam and oxycodone in healthy volunteers
  12. 2026-09-07srcValidation and characterization of oxycodone physical dependence in C57BL/6J mice
  13. 2026-09-07srcCharacterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases
  14. 2026-09-07srcCharacterization of [3H] oxymorphone binding sites in mouse brain: Quantitative autoradiography in opioid receptor knockout mice
  15. 2026-09-07srcA limited access oral oxycodone paradigm produces physical dependence and mesocorticolimbic region-dependent increases in DeltaFosB expression without preference
  16. 2026-09-07srcOxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain
  17. 2026-09-07srcMinocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users
  18. 2026-09-07srcCannabidiol interactions with oxycodone analgesia in an operant orofacial cutaneous thermal pain assay
  19. 2026-09-07srcDoes co-administration of paroxetine change oxycodone analgesia
  20. 2026-09-07srcDrug-Drug Interaction Between Oxycodone and Diazepam by a Combined in Silico Pharmacokinetic and Pharmacodynamic Modeling Approach
  21. 2026-09-07srcDopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement
  22. 2026-09-07srcImpact of genetic variation in CYP2C19, CYP2D6, and CYP3A4 on oxycodone and its metabolites in a large database of clinical urine drug tests
  23. 2026-09-07srcMorphine and alternative opioids in cancer pain: the EAPC recommendations
  24. 2026-09-07srcRelationship between Nonmedical Prescription-Opioid Use and Heroin Use
  25. 2026-09-07srcTrends in Opioid Analgesic Abuse and Mortality in the United States
  26. 2026-09-07srcLigand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling
  27. 2026-09-07srcEvaluating the effectiveness of reformulated extended-release oxycodone with abuse-deterrent properties on reducing non-oral abuse
  28. 2026-09-07srcDo CYP2D6 genotypes affect oxycodone dose, pharmacokinetics, pain, and adverse effects in cancer?
  29. 2026-09-07srcIn vitro inhibition of methadone and oxycodone cytochrome P450-dependent metabolism: reversible inhibition by H2-receptor agonists and proton-pump inhibitors
  30. 2026-09-07srcAzole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism
  31. 2026-09-07srcRates of opioid misuse, abuse, and addiction in chronic pain
  32. 2026-09-07srcComparing withdrawal- and anxiety-like behaviors following oral and subcutaneous oxycodone administration in C57BL/6 mice
  33. 2026-09-07srcRisk to heroin users of polydrug use of pregabalin or gabapentin
  34. 2026-09-07srcOnce-Daily Oxycodone Prolonged-Release Tablets Are Resistant to Alcohol-Induced Dose Dumping
  35. 2026-09-07srcOpioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel
  36. 2026-09-07srcThe Prescription Opioid and Heroin Crisis: A Public Health Approach to an Epidemic of Addiction
  37. 2026-09-07srcOxycodone/naloxone PR versus oxycodone PR in advanced cancer (ENhANCE trial)
  38. 2026-09-07srcGabapentin, opioids, and the risk of opioid-related death: A population-based nested case-control study
  39. 2026-09-07srcSafety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse
  40. 2026-09-07srcComprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids
  41. 2026-09-07srcDrug and Opioid-Involved Overdose Deaths - United States, 2013-2017
  42. 2026-09-07srcCDC Guideline for Prescribing Opioids for Chronic Pain - United States, 2016.
  43. 2026-09-07srcCDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022
  44. 2026-09-07srcComprehensive Analysis of Strong Opioid Side Effects in Palliative Care Using the SIDER Database
  45. 2026-09-07srcPrescription of Controlled Substances: Benefits and Risks
  46. 2026-09-07srcAltered Mental Status in an Octogenarian: Serotonin Syndrome from Venlafaxine and Oxycodone
  47. 2026-09-07srcOxycodone involvement in drug abuse deaths: a DAWN-based classification scheme applied to an oxycodone postmortem database containing over 1000 cases
  48. 2026-09-07srcDiscriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys
  49. 2026-09-07srcOxycodone: a pharmacological and clinical review
  50. 2026-09-07srcOpioid Overdose Prevention Programs Providing Naloxone to Laypersons - United States, 2014
  51. 2026-09-07srcMu Receptors (StatPearls/NCBI)
  52. 2026-09-07srcPharmacokinetic comparison of intravenous and intranasal administration of oxycodone
  53. 2026-09-07srcOxycodone physicochemical properties (CAS 76-42-6)
  54. 2026-09-07srcOxycodone synthesis history (Freund & Speyer, 1916)
  55. 2026-09-07srcOxycodone pharmacology overview (StatPearls/NCBI Bookshelf)
  56. 2026-09-04issueIssued emergency
  57. 2026-09-04issueIssued info_card
  58. 2026-09-04issueIssued notice
  59. 2026-07-03proposaldependence · taper
  60. 2026-06-04proposal59 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  61. 2026-06-04publicationPublication — backfill
  62. 2026-04-27revisionRevision 1
  63. 2026-04-27absenceSearched PubMed for "oxycodone history synthesis Martin Freund Edmund Speyer 1916" — no results
  64. 2026-04-27genGeneration — pipeline-v5 · with 3 morepipeline-v5
  65. 2026-04-27rungeneration run

The same entries, as forms: six forms.