O-Desmethyltramadol

1. 2026-10-19issueIssued info_card
2. 2026-09-07srcClinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy
3. 2026-09-07srcEmesis and Constipation Induced by Methadone and the Active Metabolite of Tramadol (M1) in Animals
4. 2026-09-07srcPhysical dependence potential of daily tramadol dosing in humans
5. 2026-09-07srcRifampicin markedly decreases the exposure to oral and intravenous tramadol.
6. 2026-09-07srcInterconversion of the (+)-O-desmethyltramadol to the lowest-energy conformer when coupled to µ-opioid receptor: comprehensive analysis using in silico molecular modeling
7. 2026-09-07srcPopulation Pharmacokinetic Model for Tramadol and O-desmethyltramadol in Older Patients
8. 2026-09-07srcPharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-Release Tablets to Elderly and Young Subjects
9. 2026-09-07srcCentrally administered CYP2D inhibitors increase oral tramadol analgesia in rats
10. 2026-09-07srcA suicidal poisoning due to tramadol. A metabolic approach to death investigation
11. 2026-09-07srcDesmetramadol Has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials
12. 2026-09-07srcTramadol-associated seizures in Egypt: Epidemiological, clinical, and radiological study
13. 2026-09-07srcMechanisms of tramadol-related neurotoxicity in the rat: Does diazepam/tramadol combination play a worsening role in overdose?
14. 2026-09-07srcOpioid metabolism
15. 2026-09-07srcChiral Switches of Tramadol Hydrochloride, a Potential Psychedelic Drug-Past and Future
16. 2026-09-07srcTramadol versus methadone for treatment of opiate withdrawal: a double-blind, randomized, clinical trial
17. 2026-09-07srcAtypical Withdrawal Symptoms after Abrupt Tramadol Discontinuation: A Case Report.
18. 2026-09-07srcCharacterizing the Toxicity and Dose-Effect Profile of Tramadol Ingestions in Children
19. 2026-09-07srcOpioid-induced inhibition of the human 5-HT and noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome
20. 2026-09-07srcThe investigation of tramadol dependence with no history of substance abuse: a cross-sectional survey of spontaneously reported cases in Guangzhou City, China
21. 2026-09-07srcInhibition by O-desmethyltramadol of glutamatergic excitatory transmission in adult rat spinal substantia gelatinosa neurons
22. 2026-09-07srcTramadol and its metabolite M1 selectively suppress transient receptor potential ankyrin 1 activity, but not transient receptor potential vanilloid 1 activity
23. 2026-09-07srcEffects of tramadol on substantia gelatinosa neurons in the rat spinal cord: an in vivo patch-clamp analysis
24. 2026-09-07srcPopulation pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6
25. 2026-09-07srcDesmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist
26. 2026-09-07srcO-Desmethyltramadol Enhanced Anti-Cancer Efficacy over Tramadol Through Non-µ-Opioid Receptor and Differential Cellular Contexts of Human Breast Cancer Cells
27. 2026-09-07srcComparison of efficacy between buprenorphine and tramadol in the detoxification of opioid (heroin)-dependent subjects
28. 2026-09-07srcClinical pharmacology of tramadol and tapentadol in dogs and cats
29. 2026-09-07srcAnticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy.
30. 2026-09-07srcTramadol (Ultram) concentrations in death investigation and impaired driving cases and their significance
31. 2026-09-07srcPostmortem urine immunoassay showing false-positive phencyclidine reactivity in a case of fatal tramadol overdose
32. 2026-09-07srcMu receptor binding of some commonly used opioids and their metabolites
33. 2026-09-07srcQuantification in postmortem blood and identification in urine of tramadol and its two main metabolites in two cases of lethal tramadol intoxication
34. 2026-09-07src[Krypton--new, deadly Internet drug. Since October 2009 have nine young persons died in Sweden]
35. 2026-09-07srcUnintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton
36. 2026-09-07srcSchedule of controlled substances: placement of tramadol into schedule IV. Final rule
37. 2026-09-07srcTramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review
38. 2026-09-07srcFatal moclobemide overdose or death caused by serotonin syndrome?
39. 2026-09-07srcInfluence of tramadol on neurotransmitter systems of the rat brain.
40. 2026-09-07srcTramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells
41. 2026-09-07srcACMD Advice on O-desmethyltramadol (UK)
42. 2026-09-07srcNCT04683926: A Randomized Study Investigating Oral Desmetramadol Dose Proportionality and Food Effect In Normal Human Subjects
43. 2026-09-04issueIssued emergency
44. 2026-09-04issueIssued info_card
45. 2026-09-04issueIssued notice
46. 2026-06-04proposal51 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
47. 2026-06-04publicationPublication — backfill
48. 2026-05-08revisionRevision 1
49. 2026-05-08genGeneration — pipeline-v5 · with 2 morepipeline-v5
50. 2026-05-08rungeneration run

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