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1Provenance card

the boundary, as counts

Sources

5338 with DOI

14 strong · 32 moderate · 7 weak

Compilations

12026-04-26T01:48:12.419Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

30last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:33:21.481Z

notice · info card · emergency

Searches

221 with no results

queries and counts on the build

Claims checked

2730 supported

all 273 inconclusive — working grade

Correspondence

0received

consent field ships in Phase 4

Edges

664

derivations recorded for this entity

Complete over 53 sources, 1 compilation, and 30 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/nitrous/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-07srcLife style drug laughing gas (nitrous oxide, N2O) and the dependency criteria according to ICD-10
  3. 2026-09-07srcNitrous oxide added at the end of isoflurane anesthesia hastens early recovery without increasing the risk for postoperative nausea and vomiting: a randomized clinical trial
  4. 2026-09-07srcNitrous Oxide, From the Operating Room to the Emergency Department
  5. 2026-09-07srcNitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial
  6. 2026-09-07srcNitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus
  7. 2026-09-07srcPersistent Brain Connectivity Changes in Healthy Volunteers Following Nitrous Oxide Inhalation
  8. 2026-09-07srcAntidepressant Effects of Nitrous Oxide in Major Depressive Disorder: A Phase 2b Randomized Clinical Trial
  9. 2026-09-07srcNitrous oxide-induced NO-dependent neuronal release of beta-endorphin from the rat arcuate nucleus and periaqueductal gray
  10. 2026-09-07srcNitrous oxide for the treatment of depression: a systematic review and meta-analysis
  11. 2026-09-07srcNitrous oxide abuse in the emergency practice, and Review of toxicity mechanisms and potential markers
  12. 2026-09-07srcA single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats
  13. 2026-09-07srcChronic postsurgical pain after nitrous oxide anesthesia
  14. 2026-09-07srcEfficacy and safety of nitrous oxide for patients with treatment-resistant depression, a randomized controlled trial
  15. 2026-09-07srcBrain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression: Evidence from task-state EEG
  16. 2026-09-07srcEmpirical evidence for the neurocognitive effect of nitrous oxide as an adjunctive therapy in patients with treatment resistant depression
  17. 2026-09-07srcDouble-sidedness of laughing gas on the N-methyl-d-aspartate receptor: A case report of acute psychosis associated with nitrous oxide-induced hyperhomocysteinemia
  18. 2026-09-07srcNitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect
  19. 2026-09-07srcNitrous oxide abuse induced subacute combined degeneration despite patient initiated B12 supplementation
  20. 2026-09-07srcDeletion of mu-opioid receptor in mice does not affect the minimum alveolar concentration of volatile anaesthetics and nitrous oxide-induced analgesia
  21. 2026-09-07srcPast, present, and future of nitrous oxide
  22. 2026-09-07srcNitrous Oxide and Serious Long-term Morbidity and Mortality in the ENIGMA-II Trial
  23. 2026-09-07srcSevere Nausea and Vomiting in the Evaluation of Nitrous Oxide in the Gas Mixture for Anesthesia II Trial
  24. 2026-09-07srcBiologic effects of nitrous oxide: a mechanistic and toxicologic review
  25. 2026-09-07srcNitrous oxide induced subacute combined degeneration of the spine cord: A case report
  26. 2026-09-07srcCommentary on Nitrous Oxide: Weighing the Toxic Neuropsychiatric Effects of Abuse Against Potential Therapeutic Benefits for Psychiatric Disorders
  27. 2026-09-07srcProof-of-concept randomized controlled trial of single-session nitrous oxide treatment for refractory bipolar depression
  28. 2026-09-07srcA phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression
  29. 2026-09-07srcIncreasing recreational nitrous oxide use: Should we worry? A narrative review
  30. 2026-09-07srcNitrous oxide induced subacute combined degeneration with longitudinally extensive myelopathy with inverted V-sign on spinal MRI: a case report and literature review
  31. 2026-09-07srcMini-Review: A Brief History of Nitrous Oxide (N2O) Use in Neuropsychiatry
  32. 2026-09-07srcElucidating Unique Axonal Dysfunction Between Nitrous Oxide Abuse and Vitamin B12 Deficiency
  33. 2026-09-07srcTreatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy
  34. 2026-09-07srcNo Laughing Matter: Presence, Consumption Trends, Drug Awareness, and Perceptions of 'Hippy Crack' (Nitrous Oxide) among Young Adults in England
  35. 2026-09-07srcMechanisms Involved in the Neurotoxicity and Abuse Liability of Nitrous Oxide: A Narrative Review
  36. 2026-09-07srcGlobal Burden Related to Nitrous Oxide Exposure in Medical and Recreational Settings: A Systematic Review and Individual Patient Data Meta-Analysis
  37. 2026-09-07srcPlasma Methionine and Clinical Severity in Nitrous Oxide Consumption
  38. 2026-09-07srcNitrous Oxide Abuse: Clinical Outcomes, Pharmacology, Pharmacokinetics, Toxicity and Impact on Metabolism
  39. 2026-09-07srcA new mechanistic approach for the treatment of chronic neuropathic pain with nitrous oxide integrated from a systems biology narrative review
  40. 2026-09-07srcRole of brain dynorphin in nitrous oxide antinociception in mice
  41. 2026-09-07srcAntinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of alpha2B adrenoceptors
  42. 2026-09-07srcOccupational hazards of inhalational anaesthetics
  43. 2026-09-07srcNitrous oxide (N2O) requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans
  44. 2026-09-07srcEffects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes
  45. 2026-09-07srcProtein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies
  46. 2026-09-07srcAdvances in understanding the actions of nitrous oxide
  47. 2026-09-07srcThe safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial
  48. 2026-09-07srcIncidence and pathogenesis of acute megaloblastic bone-marrow change in patients receiving intensive care
  49. 2026-09-07srcHuman bone marrow biochemical function and megaloblastic hematopoiesis after nitrous oxide anesthesia
  50. 2026-09-07srcThe minimum alveolar concentration of nitrous oxide in man
  51. 2026-09-07srcMegaloblastic haemopoiesis in patients receiving nitrous oxide
  52. 2026-09-07srcAntinociceptive response to nitrous oxide is mediated by supraspinal opiate and spinal alpha 2 adrenergic receptors in the rat
  53. 2026-09-07srcCircular 006/2023: Control of nitrous oxide under the Misuse of Drugs Act 1971
  54. 2026-09-07srcRegulation of Nitrous Oxide: Australia, Belgium, Canada, China
  55. 2026-09-04issueIssued emergency
  56. 2026-09-04issueIssued info_card
  57. 2026-09-04issueIssued notice
  58. 2026-06-04proposal28 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  59. 2026-06-04publicationPublication — backfill
  60. 2026-04-26revisionRevision 1
  61. 2026-04-26absenceSearched cross_reference for "Verify interactions listed as unknown in brief - opioids, alcohol, GHB" — no results
  62. 2026-04-26genGeneration — pipeline-v5pipeline-v5
  63. 2026-04-26rungeneration run

The same entries, as forms: six forms.