Nitrous
1Provenance card
the boundary, as counts
Sources
5338 with DOI
14 strong · 32 moderate · 7 weak
Compilations
12026-04-26T01:48:12.419Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09
Decisions
30last ruled 2026-06-04
0 awaiting a ruling
Issued documents
42026-10-19T20:33:21.481Z
notice · info card · emergency
Searches
221 with no results
queries and counts on the build
Claims checked
2730 supported
all 273 inconclusive — working grade
Correspondence
0received
consent field ships in Phase 4
Edges
664
derivations recorded for this entity
Complete over 53 sources, 1 compilation, and 30 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/nitrous/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued info_card
- 2026-09-07srcLife style drug laughing gas (nitrous oxide, N2O) and the dependency criteria according to ICD-10
- 2026-09-07srcNitrous oxide added at the end of isoflurane anesthesia hastens early recovery without increasing the risk for postoperative nausea and vomiting: a randomized clinical trial
- 2026-09-07srcNitrous Oxide, From the Operating Room to the Emergency Department
- 2026-09-07srcNitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial
- 2026-09-07srcNitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus
- 2026-09-07srcPersistent Brain Connectivity Changes in Healthy Volunteers Following Nitrous Oxide Inhalation
- 2026-09-07srcAntidepressant Effects of Nitrous Oxide in Major Depressive Disorder: A Phase 2b Randomized Clinical Trial
- 2026-09-07srcNitrous oxide-induced NO-dependent neuronal release of beta-endorphin from the rat arcuate nucleus and periaqueductal gray
- 2026-09-07srcNitrous oxide for the treatment of depression: a systematic review and meta-analysis
- 2026-09-07srcNitrous oxide abuse in the emergency practice, and Review of toxicity mechanisms and potential markers
- 2026-09-07srcA single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats
- 2026-09-07srcChronic postsurgical pain after nitrous oxide anesthesia
- 2026-09-07srcEfficacy and safety of nitrous oxide for patients with treatment-resistant depression, a randomized controlled trial
- 2026-09-07srcBrain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression: Evidence from task-state EEG
- 2026-09-07srcEmpirical evidence for the neurocognitive effect of nitrous oxide as an adjunctive therapy in patients with treatment resistant depression
- 2026-09-07srcDouble-sidedness of laughing gas on the N-methyl-d-aspartate receptor: A case report of acute psychosis associated with nitrous oxide-induced hyperhomocysteinemia
- 2026-09-07srcNitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect
- 2026-09-07srcNitrous oxide abuse induced subacute combined degeneration despite patient initiated B12 supplementation
- 2026-09-07srcDeletion of mu-opioid receptor in mice does not affect the minimum alveolar concentration of volatile anaesthetics and nitrous oxide-induced analgesia
- 2026-09-07srcPast, present, and future of nitrous oxide
- 2026-09-07srcNitrous Oxide and Serious Long-term Morbidity and Mortality in the ENIGMA-II Trial
- 2026-09-07srcSevere Nausea and Vomiting in the Evaluation of Nitrous Oxide in the Gas Mixture for Anesthesia II Trial
- 2026-09-07srcBiologic effects of nitrous oxide: a mechanistic and toxicologic review
- 2026-09-07srcNitrous oxide induced subacute combined degeneration of the spine cord: A case report
- 2026-09-07srcCommentary on Nitrous Oxide: Weighing the Toxic Neuropsychiatric Effects of Abuse Against Potential Therapeutic Benefits for Psychiatric Disorders
- 2026-09-07srcProof-of-concept randomized controlled trial of single-session nitrous oxide treatment for refractory bipolar depression
- 2026-09-07srcA phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression
- 2026-09-07srcIncreasing recreational nitrous oxide use: Should we worry? A narrative review
- 2026-09-07srcNitrous oxide induced subacute combined degeneration with longitudinally extensive myelopathy with inverted V-sign on spinal MRI: a case report and literature review
- 2026-09-07srcMini-Review: A Brief History of Nitrous Oxide (N2O) Use in Neuropsychiatry
- 2026-09-07srcElucidating Unique Axonal Dysfunction Between Nitrous Oxide Abuse and Vitamin B12 Deficiency
- 2026-09-07srcTreatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy
- 2026-09-07srcNo Laughing Matter: Presence, Consumption Trends, Drug Awareness, and Perceptions of 'Hippy Crack' (Nitrous Oxide) among Young Adults in England
- 2026-09-07srcMechanisms Involved in the Neurotoxicity and Abuse Liability of Nitrous Oxide: A Narrative Review
- 2026-09-07srcGlobal Burden Related to Nitrous Oxide Exposure in Medical and Recreational Settings: A Systematic Review and Individual Patient Data Meta-Analysis
- 2026-09-07srcPlasma Methionine and Clinical Severity in Nitrous Oxide Consumption
- 2026-09-07srcNitrous Oxide Abuse: Clinical Outcomes, Pharmacology, Pharmacokinetics, Toxicity and Impact on Metabolism
- 2026-09-07srcA new mechanistic approach for the treatment of chronic neuropathic pain with nitrous oxide integrated from a systems biology narrative review
- 2026-09-07srcRole of brain dynorphin in nitrous oxide antinociception in mice
- 2026-09-07srcAntinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of alpha2B adrenoceptors
- 2026-09-07srcOccupational hazards of inhalational anaesthetics
- 2026-09-07srcNitrous oxide (N2O) requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans
- 2026-09-07srcEffects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes
- 2026-09-07srcProtein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies
- 2026-09-07srcAdvances in understanding the actions of nitrous oxide
- 2026-09-07srcThe safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial
- 2026-09-07srcIncidence and pathogenesis of acute megaloblastic bone-marrow change in patients receiving intensive care
- 2026-09-07srcHuman bone marrow biochemical function and megaloblastic hematopoiesis after nitrous oxide anesthesia
- 2026-09-07srcThe minimum alveolar concentration of nitrous oxide in man
- 2026-09-07srcMegaloblastic haemopoiesis in patients receiving nitrous oxide
- 2026-09-07srcAntinociceptive response to nitrous oxide is mediated by supraspinal opiate and spinal alpha 2 adrenergic receptors in the rat
- 2026-09-07srcCircular 006/2023: Control of nitrous oxide under the Misuse of Drugs Act 1971
- 2026-09-07srcRegulation of Nitrous Oxide: Australia, Belgium, Canada, China
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-06-04proposal28 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-04-26revisionRevision 1
- 2026-04-26absenceSearched cross_reference for "Verify interactions listed as unknown in brief - opioids, alcohol, GHB" — no results
- 2026-04-26genGeneration — pipeline-v5pipeline-v5
- 2026-04-26rungeneration run
The same entries, as forms: six forms.