Nicotine
1Provenance card
the boundary, as counts
Sources
4332 with DOI
7 strong · 33 moderate · 3 weak
Compilations
22026-04-25T19:20:50.898Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09
Decisions
60last ruled 2026-06-04
1 awaiting a ruling
Issued documents
42026-10-19T20:33:19.402Z
notice · info card · emergency
Searches
190 with no results
queries and counts on the build
Claims checked
1983 supported
3 supported · 195 not
Correspondence
0received
consent field ships in Phase 4
Edges
530
derivations recorded for this entity
Complete over 43 sources, 2 compilations, and 60 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/nicotine/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued info_card
- 2026-09-24srcNicotine replacement therapy for smoking cessation
- 2026-09-24srcDifferent doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation.
- 2026-09-24srcImpact of Prenatal Nicotine Exposure on Placental Function and Respiratory Neural Network Development.
- 2026-09-24srcNicotine chemistry, metabolism, kinetics and biomarkers.
- 2026-09-24srcThe neuronal pathways mediating the behavioral and addictive properties of nicotine.
- 2026-09-24srcHow much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century.
- 2026-09-24srcDifferential associations of combined vs. isolated cannabis and nicotine on brain resting state networks.
- 2026-09-24srcA randomised, open-label, cross-over clinical study to evaluate the pharmacokinetic profiles of cigarettes and e-cigarettes with nicotine salt formulations in US adult smokers.
- 2026-09-24srcSafety and Efficacy of Monoamine Oxidase Inhibitors in Patients Who Use Psychoactive Substances
- 2026-09-24srcSmokeless tobacco, sport and the heart.
- 2026-09-24srcNicotine and the Developing Human: A Neglected Element in the Electronic Cigarette Debate.
- 2026-09-24srcCardiovascular and Pulmonary Responses to Acute Use of Electronic Nicotine Delivery Systems and Combustible Cigarettes in Long-Term Users.
- 2026-09-24srcNicotine addiction: More than just dopamine.
- 2026-09-24srcRelationship between skin melanin index and nicotine pharmacokinetics in African American smokers.
- 2026-09-24srcAge-dependent effects of tobacco smoke and nicotine on cognition and the brain: A systematic review of the human and animal literature comparing adolescents and adults.
- 2026-09-24srcA review of monoamine oxidase (MAO) inhibitors in tobacco or tobacco smoke.
- 2026-09-24srcNicotinic acetylcholine receptors and nicotine addiction: A brief introduction.
- 2026-09-24srcAcute separate and combined effects of cannabinoid and nicotinic receptor agonists on MMN-indexed auditory deviance detection in healthy humans.
- 2026-09-24srcMonoamine Oxidase Inhibitors Present in Tobacco Modulate Dopamine Balance Via the Dopamine Transporter.
- 2026-09-24srcRecent and projected changes in global climate may increase nicotine absorption and the risk of green tobacco sickness.
- 2026-09-24srcExpression of water-soluble, ligand-binding concatameric extracellular domains of the human neuronal nicotinic receptor alpha4 and beta2 subunits.
- 2026-09-24srcGreen tobacco sickness: mecamylamine, varenicline, and nicotine vaccine as clinical research tools and potential therapeutics.
- 2026-09-24srcTobacco use disorder and cardiovascular health.
- 2026-09-24srcCurrent advances in research in treatment and recovery: Nicotine addiction.
- 2026-09-24srcHuman Tobacco Smokers in Early Abstinence Have Higher Levels of beta2* Nicotinic Acetylcholine Receptors than Nonsmokers.
- 2026-09-24srcChronic Nicotine Exposure Alters the Neurophysiology of Habenulo-Interpeduncular Circuitry.
- 2026-09-24srcNicotinic Acetylcholine Receptors in the Mesolimbic Pathway: Primary Role of Ventral Tegmental Area alpha6beta2* Receptors.
- 2026-09-24srcA Review of Electronic Cigarettes and Liquid Nicotine Poisoning Exposure Cases in the United States.
- 2026-09-24srcCognitive Effects of Nicotine: Recent Progress.
- 2026-09-24srcPhysiologic Functions and Therapeutic Applications of alpha7 Nicotinic Acetylcholine Receptor in Brain Disorders.
- 2026-09-24srcGlobal Burden of Green Tobacco Sickness in Farm Workers: A Systematic Review and Meta-Analysis.
- 2026-09-24srcCaffeine, nicotine, cannabis, and psilocybin: Pharmacology, toxicology, and potential therapeutic uses of four naturally occurring psychoactive substances.
- 2026-09-24srcSubtype-selective up-regulation by chronic nicotine of high-affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography.
- 2026-09-24srcThe comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells.
- 2026-09-24srcMetabolism and disposition kinetics of nicotine.
- 2026-09-24srcCYP2A6 genotype and the metabolism and disposition kinetics of nicotine.
- 2026-09-24srcPopulation pharmacokinetics of nicotine and its metabolites I. Model development.
- 2026-09-24srcPsychiatric and psychological features of nicotine dependence.
- 2026-09-24srcNicotine and sympathetic neurotransmission.
- 2026-09-24srcAgonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.
- 2026-09-24srcNicotine physical properties: CAS 54-11-5, melting point, boiling point, solubility
- 2026-09-24srcNicotine isolation history: Posselt and Reimann 1828
- 2026-09-24srcFDA Tobacco Product Standard for Nicotine Yield: Proposed Rule 2025
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-07-03proposaldependence · taper
- 2026-06-04proposal57 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-04-25revisionRevision 1
- 2026-04-25genGeneration — pipeline-v5pipeline-v5
- 2026-04-25rungeneration run
- 2026-04-25rungeneration run
The same entries, as forms: six forms.