MPT Facts
Psychedelic;
Dose and durationby route · individual sensitivity varies
Oral(mg)
Threshold< 50 mgLightnot recordedCommonnot recordedStrongnot recordedHeavynot recorded
No duration recorded for this route.
Body and dependence
- Acute toxicity
- Low
- Chronic toxicity
- Low
- Physical dependence
- None
- Psychological dependence
- Negligible
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 7 days
- Carries over to
- LSD;
psilocybin; mescaline; DMT; DPT; MiPT
Effectslikely at a common dose
- Perception
- Color alteration;
Color enhancement; Ganzfeld effect; Geometry; Visual drifting; +27 possible, including Visual haze / noise, Spatial disorientation, Vestibular distortion - Body
- Pupil dilation;
+26 possible, including Nausea, Dizziness, Heart rate perception changes - Thinking
- none likely · 34 possible, including Cognitive impairment, Decision impairment, Confusion
- Feeling
- none likely · 9 possible, including Emotional lability, Anxiety, Paranoia
- Self
- none likely · 10 possible, including Derealization, Depersonalization, Communication suppression
- Time
- Time alteration;
+3 possible, including Temporal disorientation - Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 4 possible
Who shouldn't take it
Absolute
Personal or family history of psychotic disorders; Concurrent MAOI use
Relative
Cardiovascular disease; Bipolar disorder; Concurrent lithium use; Concurrent SSRI/SNRI therapy
Combinations61 recorded
Lethal (1)
MAOIs
Dangerous (19)
MDMA, MDA; Alpha-2 adrenergic receptor antagonist; Dopamine agonists; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); NRIs; Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (37)
See full page: psychedex.org/substances/mpt
Not graded (4)
Not listed never means safe.
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
psychedex.org/substances/mpt · Version r1.a1 · Not medical adviceValues as of