MPT Facts
Psychedelic;
Description
MPT (N-methyl-N-propyltryptamine) is a synthetic psychedelic of the tryptamine class. It is presumed to activate serotonin receptors in the brain, though no binding data have been published.[1]
Subjective effects include none on record — no experience report documents any psychoactive response at any dose or by any route. If an active dose exists, MPT's structural position between DMT and DPT suggests effects somewhere between the two, but this is entirely speculative.
No physical dependence data exist, and the toxic dose is entirely unknown.safety citation needed At doses high enough to overwhelm the enzyme that breaks MPT down in the gut, exposure could spike sharply and without warning.[2]
Dose and durationby route · individual sensitivity varies
No duration recorded for this route.
Body and dependence
- Acute toxicity
- Low
- Chronic toxicity
- Low
- Physical dependence
- None
- Psychological dependence
- Negligible
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 7 days
- Carries over to
- LSD;
psilocybin; mescaline; DMT; DPT; MiPT
Effectslikely at a common dose
- Perception
- Color alteration;
Color enhancement; Ganzfeld effect; Geometry; Visual drifting; +27 possible, including Visual haze / noise, Spatial disorientation, Vestibular distortion - Body
- Pupil dilation;
+26 possible, including Nausea, Dizziness, Heart rate perception changes - Thinking
- none likely · 34 possible, including Cognitive impairment, Decision impairment, Confusion
- Feeling
- none likely · 9 possible, including Emotional lability, Anxiety, Paranoia
- Self
- none likely · 10 possible, including Derealization, Depersonalization, Communication suppression
- Time
- Time alteration;
+3 possible, including Temporal disorientation - Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 4 possible
Who shouldn't take it
Combinations61 recorded
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^Kozell LB, Eshleman AJ, Swanson TL, Bloom SH, Wolfrum KM, et al. (2023) Pharmacologic Activity of Substituted Tryptamines at 5-HT2A, 5-HT2C, 5-HT1A Receptors and SERT — Journal of Pharmacology and Experimental Therapeutics doi:10.1124/jpet.122.001454
- [2]^Shen HW, Jiang XL, Yu AM (2011) Nonlinear pharmacokinetics of 5-methoxy-N,N-dimethyltryptamine in mice — Drug Metabolism and Disposition doi:10.1124/dmd.111.039107