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1Provenance card

the boundary, as counts

Sources

5249 with DOI

27 strong · 12 moderate · 13 weak

Compilations

12026-05-08T14:39:16.961Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

30last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:33:06.126Z

notice · info card · emergency

Searches

231 with no results

queries and counts on the build

Claims checked

12867 supported

67 supported · 61 not

Correspondence

0received

consent field ships in Phase 4

Edges

374

derivations recorded for this entity

Complete over 52 sources, 1 compilation, and 30 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/mitragynine/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-07srcKratom Use: An Emerging Perioperative Nursing Concern
  3. 2026-09-07srcClinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom
  4. 2026-09-07srcPrediction of physicochemical and pharmacokinetic properties of botanical constituents by computational models
  5. 2026-09-07srcClinical Pharmacology of the Dietary Supplement Kratom (Mitragyna speciosa)
  6. 2026-09-07srcThe abuse potential of kratom according the 8 factors of the controlled substances act: implications for regulation and research
  7. 2026-09-07srcAssessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats
  8. 2026-09-07srcRespiratory effects of oral mitragynine and oxycodone in a rodent model
  9. 2026-09-07srcAn exploratory study of the safety profile and neurocognitive function after single doses of mitragynine in humans
  10. 2026-09-07srcQuantification of 11 kratom alkaloids including mitragynine and its main metabolites in human plasma using LC-MS/MS
  11. 2026-09-07srcKratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal
  12. 2026-09-07srcFatal combination of mitragynine and quetiapine - a case report with discussion of a potential herb-drug interaction
  13. 2026-09-07srcIntrahepatic cholestasis following abuse of powdered kratom (Mitragyna speciosa)
  14. 2026-09-07srcKratom (Mitragyna Speciosa) Liver Injury: A Comprehensive Review
  15. 2026-09-07srcAn insight review on the neuropharmacological effects, mechanisms of action, pharmacokinetics and toxicity of mitragynine
  16. 2026-09-07srcPatterns of Kratom use and health impact in the US-Results from an online survey
  17. 2026-09-07srcThe Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic alpha2 receptor activity in vitro and in vivo
  18. 2026-09-07srcAn accidental poisoning with mitragynine
  19. 2026-09-07srcMini review: Potential therapeutic values of mitragynine as an opioid substitution therapy
  20. 2026-09-07srcThe medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse
  21. 2026-09-07srcMitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit beta-Arrestin-2
  22. 2026-09-07src7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects
  23. 2026-09-07srcInvestigating Opioid Receptor Activity through Biocatalytic Halogenation and Oxidation of Mitragynine
  24. 2026-09-07srcIn Vitro Pharmacology of Mitragynine at alpha-Adrenoceptors
  25. 2026-09-07srcPhysiologically Based Pharmacokinetic Model for Clinical Translation and Prediction of Drug Interaction of the Major Kratom Alkaloid, Mitragynine
  26. 2026-09-07srcNon-equilibrium snapshots of ligand efficacy at the mu-opioid receptor
  27. 2026-09-07srcInsights into distinct signaling profiles of the muOR activated by diverse agonists
  28. 2026-09-07srcChemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions
  29. 2026-09-07srcMapping partial agonism of mitragynine at the mu-opioid receptor through molecular dynamics and Markov state modelling analysis
  30. 2026-09-07srcSeverity of Pain and Sleep Problems during Kratom (Mitragyna speciosa Korth.) Cessation among Regular Kratom Users
  31. 2026-09-07srcSeverity of Kratom (Mitragyna speciosa Korth.) Psychological Withdrawal Symptoms
  32. 2026-09-07srcMitragynine 'Kratom' related fatality: a case report with postmortem concentrations
  33. 2026-09-07srcSelf-reported Health Diagnoses and Demographic Correlates With Kratom Use: Results From an Online Survey
  34. 2026-09-07srcUse of Kratom, an Opioid-like Traditional Herb, in Pregnancy
  35. 2026-09-07srcA drug fatality involving Kratom
  36. 2026-09-07srcFatality of 33-Year-Old Man Involving Kratom Toxicity
  37. 2026-09-07srcSelf-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth)
  38. 2026-09-07srcTranslating Kratom-Drug Interactions: From Bedside to Bench and Back
  39. 2026-09-07srcFollowing the Roots of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries
  40. 2026-09-07srcCharacteristics of deaths associated with kratom use
  41. 2026-09-07srcUnusual Presentation of Kratom Overdose With Rhabdomyolysis, Transient Hearing Loss, and Heart Failure
  42. 2026-09-07srcChemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa
  43. 2026-09-07srcNeonatal Abstinence Syndrome Due to Maternal Kratom Use
  44. 2026-09-07srcPharmacokinetics of mitragynine in man
  45. 2026-09-07srcKratom Dependence and Treatment Options: A Comprehensive Review of the Literature
  46. 2026-09-07srcNatural drugs, not so natural effects: Neonatal abstinence syndrome secondary to kratom
  47. 2026-09-07srcThe Chemical and Pharmacological Properties of Mitragynine and Its Diastereomers: An Insight Review
  48. 2026-09-07srcHepatotoxicity Induced by the 3Ks: Kava, Kratom and Khat
  49. 2026-09-07srcHuman Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder
  50. 2026-09-07srcClinical Pharmacokinetic Assessment of Kratom (Mitragyna speciosa), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants
  51. 2026-09-07srcNovel case of maternal and neonatal kratom dependence and withdrawal
  52. 2026-09-07srcKratom Legal Status - US DEA 2016 Scheduling Withdrawal; UK PSA 2016; Australia Schedule 9; WHO ECDD 2021 pre-review
  53. 2026-09-07srcMitragynine: first isolated 1921 by Ellen Field; structure established by Beckett et al. 1965; absolute configuration confirmed by Zacharias et al. 1965
  54. 2026-09-04issueIssued emergency
  55. 2026-09-04issueIssued info_card
  56. 2026-09-04issueIssued notice
  57. 2026-06-04proposal28 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  58. 2026-06-04publicationPublication — backfill
  59. 2026-05-08revisionRevision 1
  60. 2026-05-08absenceSearched Multiple sources for "mitragynine Ki MOR KOR DOR binding affinity values" — no results
  61. 2026-05-08genGeneration — pipeline-v5 · with 2 morepipeline-v5
  62. 2026-05-08rungeneration run

The same entries, as forms: six forms.