Mitragynine
1Provenance card
the boundary, as counts
Sources
5249 with DOI
27 strong · 12 moderate · 13 weak
Compilations
12026-05-08T14:39:16.961Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09
Decisions
30last ruled 2026-06-04
0 awaiting a ruling
Issued documents
42026-10-19T20:33:06.126Z
notice · info card · emergency
Searches
231 with no results
queries and counts on the build
Claims checked
12867 supported
67 supported · 61 not
Correspondence
0received
consent field ships in Phase 4
Edges
374
derivations recorded for this entity
Complete over 52 sources, 1 compilation, and 30 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/mitragynine/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued info_card
- 2026-09-07srcKratom Use: An Emerging Perioperative Nursing Concern
- 2026-09-07srcClinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom
- 2026-09-07srcPrediction of physicochemical and pharmacokinetic properties of botanical constituents by computational models
- 2026-09-07srcClinical Pharmacology of the Dietary Supplement Kratom (Mitragyna speciosa)
- 2026-09-07srcThe abuse potential of kratom according the 8 factors of the controlled substances act: implications for regulation and research
- 2026-09-07srcAssessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats
- 2026-09-07srcRespiratory effects of oral mitragynine and oxycodone in a rodent model
- 2026-09-07srcAn exploratory study of the safety profile and neurocognitive function after single doses of mitragynine in humans
- 2026-09-07srcQuantification of 11 kratom alkaloids including mitragynine and its main metabolites in human plasma using LC-MS/MS
- 2026-09-07srcKratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal
- 2026-09-07srcFatal combination of mitragynine and quetiapine - a case report with discussion of a potential herb-drug interaction
- 2026-09-07srcIntrahepatic cholestasis following abuse of powdered kratom (Mitragyna speciosa)
- 2026-09-07srcKratom (Mitragyna Speciosa) Liver Injury: A Comprehensive Review
- 2026-09-07srcAn insight review on the neuropharmacological effects, mechanisms of action, pharmacokinetics and toxicity of mitragynine
- 2026-09-07srcPatterns of Kratom use and health impact in the US-Results from an online survey
- 2026-09-07srcThe Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic alpha2 receptor activity in vitro and in vivo
- 2026-09-07srcAn accidental poisoning with mitragynine
- 2026-09-07srcMini review: Potential therapeutic values of mitragynine as an opioid substitution therapy
- 2026-09-07srcThe medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse
- 2026-09-07srcMitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit beta-Arrestin-2
- 2026-09-07src7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects
- 2026-09-07srcInvestigating Opioid Receptor Activity through Biocatalytic Halogenation and Oxidation of Mitragynine
- 2026-09-07srcIn Vitro Pharmacology of Mitragynine at alpha-Adrenoceptors
- 2026-09-07srcPhysiologically Based Pharmacokinetic Model for Clinical Translation and Prediction of Drug Interaction of the Major Kratom Alkaloid, Mitragynine
- 2026-09-07srcNon-equilibrium snapshots of ligand efficacy at the mu-opioid receptor
- 2026-09-07srcInsights into distinct signaling profiles of the muOR activated by diverse agonists
- 2026-09-07srcChemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions
- 2026-09-07srcMapping partial agonism of mitragynine at the mu-opioid receptor through molecular dynamics and Markov state modelling analysis
- 2026-09-07srcSeverity of Pain and Sleep Problems during Kratom (Mitragyna speciosa Korth.) Cessation among Regular Kratom Users
- 2026-09-07srcSeverity of Kratom (Mitragyna speciosa Korth.) Psychological Withdrawal Symptoms
- 2026-09-07srcMitragynine 'Kratom' related fatality: a case report with postmortem concentrations
- 2026-09-07srcSelf-reported Health Diagnoses and Demographic Correlates With Kratom Use: Results From an Online Survey
- 2026-09-07srcUse of Kratom, an Opioid-like Traditional Herb, in Pregnancy
- 2026-09-07srcA drug fatality involving Kratom
- 2026-09-07srcFatality of 33-Year-Old Man Involving Kratom Toxicity
- 2026-09-07srcSelf-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth)
- 2026-09-07srcTranslating Kratom-Drug Interactions: From Bedside to Bench and Back
- 2026-09-07srcFollowing the Roots of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries
- 2026-09-07srcCharacteristics of deaths associated with kratom use
- 2026-09-07srcUnusual Presentation of Kratom Overdose With Rhabdomyolysis, Transient Hearing Loss, and Heart Failure
- 2026-09-07srcChemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa
- 2026-09-07srcNeonatal Abstinence Syndrome Due to Maternal Kratom Use
- 2026-09-07srcPharmacokinetics of mitragynine in man
- 2026-09-07srcKratom Dependence and Treatment Options: A Comprehensive Review of the Literature
- 2026-09-07srcNatural drugs, not so natural effects: Neonatal abstinence syndrome secondary to kratom
- 2026-09-07srcThe Chemical and Pharmacological Properties of Mitragynine and Its Diastereomers: An Insight Review
- 2026-09-07srcHepatotoxicity Induced by the 3Ks: Kava, Kratom and Khat
- 2026-09-07srcHuman Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder
- 2026-09-07srcClinical Pharmacokinetic Assessment of Kratom (Mitragyna speciosa), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants
- 2026-09-07srcNovel case of maternal and neonatal kratom dependence and withdrawal
- 2026-09-07srcKratom Legal Status - US DEA 2016 Scheduling Withdrawal; UK PSA 2016; Australia Schedule 9; WHO ECDD 2021 pre-review
- 2026-09-07srcMitragynine: first isolated 1921 by Ellen Field; structure established by Beckett et al. 1965; absolute configuration confirmed by Zacharias et al. 1965
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-06-04proposal28 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-05-08revisionRevision 1
- 2026-05-08absenceSearched Multiple sources for "mitragynine Ki MOR KOR DOR binding affinity values" — no results
- 2026-05-08genGeneration — pipeline-v5 · with 2 morepipeline-v5
- 2026-05-08rungeneration run
The same entries, as forms: six forms.