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1Provenance card

the boundary, as counts

Sources

4629 with DOI

7 strong · 34 moderate · 5 weak

Compilations

12026-05-09T13:32:12.008Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

46last ruled 2026-06-04

1 awaiting a ruling

Issued documents

42026-10-19T20:33:01.751Z

notice · info card · emergency

Searches

271 with no results

queries and counts on the build

Claims checked

9771 supported

71 supported · 26 not

Correspondence

0received

consent field ships in Phase 4

Edges

325

derivations recorded for this entity

Complete over 46 sources, 1 compilation, and 46 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/midazolam/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-10-02srcComparison between midazolam and propofol in acute phase for ventilated patients with sepsis.
  3. 2026-10-02srcMidazolam: The First Water-soluble Benzodiazepine; Pharmacology, Pharmacokinetics and Efficacy in Insomnia and Anesthesia
  4. 2026-10-02srcAbsolute Bioavailability of Microdosed Midazolam After Buccal Administration Is Dependent on Buccal Exposure Time.
  5. 2026-10-02srcMidazolam and other benzodiazepines.
  6. 2026-10-02srcA Two-way Randomized Cross-over Pharmacokinetic and Pharmacodynamic Study of an Innovative Oral Solution of Midazolam (ADV6209).
  7. 2026-10-02srcBenzodiazepines for the Treatment of Seizure Clusters.
  8. 2026-10-02srcThe Role of GABA Receptors in Anesthesia and Sedation: An Updated Review.
  9. 2026-10-02srcTolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABAA receptor subtypes.
  10. 2026-10-02srcBenzodiazepine exposure induces transcriptional down-regulation of GABAA receptor alpha1 subunit gene via L-type voltage-gated calcium channel activation.
  11. 2026-10-02srcIntranasal Versus Buccal Versus Intramuscular Midazolam for the Home and Emergency Treatment of Acute Seizures in Pediatric Patients: A Randomized Controlled Trial.
  12. 2026-10-02srcRefractory symptoms and end of life midazolam use in cancer patients, a single center experience.
  13. 2026-10-02srcSensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.
  14. 2026-10-02srcPreclinical evidence for a novel pharmacotherapeutic approach for treating benzodiazepine addiction.
  15. 2026-10-02srcIntramuscular Midazolam for treatment of Status Epilepticus.
  16. 2026-10-02srcA critical evaluation of midazolam nasal spray for the treatment of patients with seizure clusters.
  17. 2026-10-02srcClinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU (PADIS 2018)
  18. 2026-10-02srcPharmacogenomics of commonly used intravenous anesthetics.
  19. 2026-10-02srcTreatment of high dose of intravenous midazolam abuse: a case report.
  20. 2026-10-02srcTermination of seizures in the paediatric age group, best benzodiazepine and route of administration: A network meta-analysis
  21. 2026-10-02srcEffects of midazolam on high-frequency oscillations in amygdala and hippocampus of epilepsy patients.
  22. 2026-10-02srcSodium oxybate versus midazolam for end-of-life continuous deep sedation: a randomised controlled trial.
  23. 2026-10-02srcDexmedetomidine in combination with midazolam after pediatric cardiac surgery.
  24. 2026-10-02srcGABAA receptor beta1 subunit gene polymorphisms are associated with the sedative and amnesic effects of midazolam.
  25. 2026-10-02srcMidazolam: A Review of its Pharmacological Properties and Therapeutic Use
  26. 2026-10-02srcPharmacokinetics of midazolam, 1'-OH-midazolam, 4-OH-midazolam, 1'-OH-midazolam-beta-D-glucuronide, and 4-OH-midazolam-beta-D-glucuronide in serum and urine from patients undergoing cardiac surgery.
  27. 2026-10-02srcRemimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent
  28. 2026-10-02srcThe history of benzodiazepines
  29. 2026-10-02srcEvidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults
  30. 2026-10-02srcNE contribution to rebooting unconsciousness caused by midazolam.
  31. 2026-10-02srcPharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition.
  32. 2026-10-02srcFlumazenil's reversal of myoclonic-like movements associated with midazolam in term newborns.
  33. 2026-10-02srcFlumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog.
  34. 2026-10-02srcChronic benzodiazepine administration: from the patient to the gene.
  35. 2026-10-02srcEffect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam.
  36. 2026-10-02srcFlumazenil. A reappraisal of its pharmacological properties and therapeutic efficacy as a benzodiazepine antagonist.
  37. 2026-10-02srcAlcohol after sedation with i.v. midazolam-fentanyl: effects on psychomotor functioning.
  38. 2026-10-02srcAmnesia of the Operating Room in the B-Unaware and BAG-RECALL Clinical Trials.
  39. 2026-10-02srcMidazolam: pharmacology and uses.
  40. 2026-10-02srcUse of midazolam hydrochloride in anesthesia.
  41. 2026-10-02srcPharmacokinetics of midazolam in anaesthetized cirrhotic patients.
  42. 2026-10-02srcPharmacokinetics of midazolam used as an intravenous induction agent for patients over 80 years of age.
  43. 2026-10-02srcSafety aspects of midazolam.
  44. 2026-10-02srcEffect of age, gender, and obesity on midazolam kinetics.
  45. 2026-10-02srcProlonged sedation due to accumulation of conjugated metabolites of midazolam.
  46. 2026-10-02srcMidazolam - Wikipedia
  47. 2026-10-02srcMidazolam FDA Approval History (Versed 1985, Nayzilam 2019)
  48. 2026-09-04issueIssued emergency
  49. 2026-09-04issueIssued info_card
  50. 2026-09-04issueIssued notice
  51. 2026-07-03proposaldependence · taper
  52. 2026-06-04proposal43 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  53. 2026-06-04publicationPublication — backfill
  54. 2026-05-09revisionRevision 1
  55. 2026-05-09absenceSearched PubMed for "midazolam history synthesis discovery imidazobenzodiazepine" — no results
  56. 2026-05-09genGeneration — pipeline-v5 · with 3 morepipeline-v5
  57. 2026-05-09rungeneration run

The same entries, as forms: six forms.