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1Provenance card

the boundary, as counts

Sources

3929 with DOI

13 strong · 22 moderate · 4 weak

Compilations

22026-05-03T19:42:41.679Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

46last ruled 2026-06-04

1 awaiting a ruling

Issued documents

42026-10-19T20:32:58.908Z

notice · info card · emergency

Searches

00 with no results

queries and counts on the build

Claims checked

8570 supported

70 supported · 15 not

Correspondence

0received

consent field ships in Phase 4

Edges

267

derivations recorded for this entity

Complete over 39 sources, 2 compilations, and 46 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/methylphenidate/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-24srcEvaluating Dopamine Reward Pathway in ADHD.
  3. 2026-09-24srcMethylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).
  4. 2026-09-24srcEthylphenidate as a selective dopaminergic agonist and methylphenidate-ethanol transesterification biomarker.
  5. 2026-09-24srcDrug Regimen Individualization for Attention-Deficit/Hyperactivity Disorder: Guidance for Methylphenidate and Dexmethylphenidate Formulations.
  6. 2026-09-24srcIncreased Plasma Concentrations of 6-oxo-Methylphenidate in CES1 G134E Carriers Following a Single Oral Dose of Methylphenidate.
  7. 2026-09-24srcDirect comparison of the acute subjective, emotional, autonomic, and endocrine effects of MDMA, methylphenidate, and modafinil in healthy subjects.
  8. 2026-09-24srcOverdose of drugs for attention-deficit hyperactivity disorder: clinical presentation, mechanisms of toxicity, and management.
  9. 2026-09-24srcIs Methylphenidate Beneficial and Safe in Pharmacological Cognitive Enhancement?
  10. 2026-09-24srcClinically Relevant Doses of Methylphenidate Significantly Occupy Norepinephrine Transporters in Humans In Vivo
  11. 2026-09-24srcCatecholamine influences on dorsolateral prefrontal cortical networks.
  12. 2026-09-24srcUnderstanding the risk of using medications for attention deficit hyperactivity disorder with respect to physical growth and cardiovascular function.
  13. 2026-09-24srcThe Pharmacokinetics and Pharmacogenomics of Psychostimulants.
  14. 2026-09-24srcEffects of methylphenidate and MDMA on appraisal of erotic stimuli and intimate relationships.
  15. 2026-09-24srcThe World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder.
  16. 2026-09-24srcComparative efficacy and tolerability of medications for ADHD in children, adolescents, and adults: a systematic review and network meta-analysis
  17. 2026-09-24srcCentral nervous system stimulants in recreational and medical use.
  18. 2026-09-24srcLong-term efficacy and safety outcomes with OROS-MPH in adults with ADHD.
  19. 2026-09-24srcMethylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system.
  20. 2026-09-24srcComparative Effects of Methylphenidate, Modafinil, and MDMA on Response Inhibition Neural Networks in Healthy Subjects.
  21. 2026-09-24srcEthanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers.
  22. 2026-09-24srcThe impact of human CES1 genetic variation on enzyme activity assessed by ritalinic acid/methylphenidate ratios.
  23. 2026-09-24srcPlasma concentrations of methylphenidate enantiomers in adults with ADHD and substance use disorder.
  24. 2026-09-24srcPotential for Underestimation of d-Methylphenidate Bioavailability Using Chiral Derivatization/Gas Chromatography.
  25. 2026-09-24srcCardiovascular adverse events associated with norepinephrine-dopamine reuptake inhibitors: a pharmacovigilance study of the FDA Adverse Event Reporting System.
  26. 2026-09-24srcMethylphenidate and Psychotic Symptoms in Children and Adolescents: A Disproportionality Analysis on the WHO Safety Database (VigiBase).
  27. 2026-09-24srcEchocardiographic Evaluation of the Effect of Long-Term Methylphenidate Use on Cardiovascular Functions.
  28. 2026-09-24srcDifferentiating Between Methylphenidate Use and Misuse: Clinical Insights From University Students and Academic Staff.
  29. 2026-09-24srcBrief psychosis induced by methylphenidate in a child with attention deficit disorder: a case report and literature review.
  30. 2026-09-24srcA Rare Phenomenon, Recurrent Acute Dystonia after Withdrawal of Methylphenidate-immediate Release Form: A Pediatric Case with ADHD.
  31. 2026-09-24srcA 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group.
  32. 2026-09-24srcTherapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain.
  33. 2026-09-24srcEffect of stimulants on 24-h ambulatory blood pressure in children with ADHD: a double-blind, randomized, cross-over trial.
  34. 2026-09-24srcInfluence of ethanol and gender on methylphenidate pharmacokinetics and pharmacodynamics.
  35. 2026-09-24srcMethylphenidate poisoning: an evidence-based consensus guideline for out-of-hospital management.
  36. 2026-09-24srcInfluence of ethanol on the pharmacokinetics of methylphenidate's metabolites ritalinic acid and ethylphenidate.
  37. 2026-09-24srcMethylphenidate — PubChem Compound CID 4158
  38. 2026-09-24srcAffinities of methylphenidate derivatives for dopamine, norepinephrine and serotonin transporters.
  39. 2026-09-24srcMethylphenidate — Wikipedia
  40. 2026-09-24srcMethylphenidate and tramadol drug interaction
  41. 2026-09-04issueIssued emergency
  42. 2026-09-04issueIssued info_card
  43. 2026-09-04issueIssued notice
  44. 2026-07-03proposaldependence · taper
  45. 2026-06-04proposal43 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  46. 2026-06-04publicationPublication — backfill
  47. 2026-05-03revisionRevision 1
  48. 2026-05-03genGeneration — pipeline-v5pipeline-v5
  49. 2026-05-03rungeneration run
  50. 2026-04-24rungeneration run

The same entries, as forms: six forms.