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MDMA

3,4-methylenedioxy-N-methylamphetamine

1Provenance card

the boundary, as counts

Sources

4832 with DOI

23 strong · 20 moderate · 5 weak

Compilations

22026-04-20T22:45:36.694Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09 · 1 other run

Decisions

59last ruled 2026-06-04

1 awaiting a ruling

Issued documents

42026-10-19T20:32:40.411Z

notice · info card · emergency

Searches

250 with no results

queries and counts on the build

Claims checked

10910 supported

10 supported · 99 not

Correspondence

0received

consent field ships in Phase 4

Edges

339

derivations recorded for this entity

Complete over 48 sources, 2 compilations, and 59 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/mdma/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-10-02srcPotential Psychiatric Uses for MDMA
  3. 2026-10-02srcSerotonin transporter availability, neurocognitive function and their correlation in abstinent 3,4-methylenedioxymethamphetamine users
  4. 2026-10-02srcMDMA-assisted psychotherapy for the treatment of PTSD: A systematic review and meta-analysis of randomized controlled trials
  5. 2026-10-02srcReduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study
  6. 2026-10-02srcMDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials [RETRACTED]
  7. 2026-10-02srcMDMA-Assisted Therapy for Post-Traumatic Stress Disorder: Regulatory Challenges and a Path Forward
  8. 2026-10-02srcSafety and Efficacy of Monoamine Oxidase Inhibitors in Patients Who Use Psychoactive Substances
  9. 2026-10-02srcMDMA impairs cognitive function during withdrawal via activation of the arachidonic acid cascade in the hippocampus
  10. 2026-10-02srcEfficacy of MDMA-assisted therapy for PTSD: A systematic review and meta-analysis
  11. 2026-10-02srcAdverse events associated with classic psychedelics and MDMA: a real-world population-based study using WHO pharmacovigilance database (VigiBase)
  12. 2026-10-02srcPlasma oxytocin concentrations following MDMA or intranasal oxytocin in humans
  13. 2026-10-02srcMeta-analysis of executive functioning in ecstasy/polydrug users
  14. 2026-10-02srcPharmacokinetic and pharmacodynamic effects of methylphenidate and MDMA administered alone or in combination
  15. 2026-10-02srcEffects of MDMA and Intranasal oxytocin on social and emotional processing
  16. 2026-10-02srcMDMA Impairs Both the Encoding and Retrieval of Emotional Recollections
  17. 2026-10-02srcEffects of MDMA on attention to positive social cues and pleasantness of affective touch
  18. 2026-10-02srcAcute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants
  19. 2026-10-02srcMDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study
  20. 2026-10-02srcMDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial
  21. 2026-10-02srcMemory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities
  22. 2026-10-02srcRediscovering MDMA (ecstasy): the role of the American chemist Alexander T. Shulgin
  23. 2026-10-02srcResidual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs
  24. 2026-10-02srcAmphetamine, MDMA, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor
  25. 2026-10-02srcThe pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")
  26. 2026-10-02srcThe safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study
  27. 2026-10-02srcA randomized, controlled pilot study of MDMA-assisted psychotherapy for treatment of resistant, chronic PTSD
  28. 2026-10-02srcAcute effects of MDMA on trust, cooperative behaviour and empathy: A double-blind, placebo-controlled experiment
  29. 2026-10-02srcCharacterization of 3,4-methylenedioxymethamphetamine (MDMA) enantiomers in vitro and in the MPTP-lesioned primate: R-MDMA reduces severity of dyskinesia, whereas S-MDMA extends duration of ON-time
  30. 2026-10-02srcHallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine
  31. 2026-10-02srcSex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans
  32. 2026-10-02srcThe harmful health effects of recreational ecstasy: a systematic review of observational evidence
  33. 2026-10-02srcIntracranial Pressure-Guided Therapy in MDMA-Induced Cerebral Edema: A Case Report
  34. 2026-10-02srcHuman pharmacology of 3,4-methylenedioxymethamphetamine ("ecstasy"): psychomotor performance and subjective effects
  35. 2026-10-02srcThe serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of MDMA ('Ecstasy') in healthy volunteers
  36. 2026-10-02srcAcute liver failure following the use of ecstasy (MDMA)
  37. 2026-10-02srcWhich neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies
  38. 2026-10-02srcThe 'ecstasy' hangover: hyponatremia due to 3,4-methylenedioxymethamphetamine
  39. 2026-10-02srcStudy of the behavioural responses related to the potential addictive properties of MDMA in mice
  40. 2026-10-02srcHuman pharmacology of MDMA: pharmacokinetics, metabolism, and disposition
  41. 2026-10-02srcPharmacological characterization of ecstasy synthesis byproducts with recombinant human monoamine transporters
  42. 2026-10-02srcContribution of cytochrome P450 2D6 to 3,4-methylenedioxymethamphetamine disposition in humans: use of paroxetine as a metabolic inhibitor probe
  43. 2026-10-02srcMDMA in humans: factors which affect the neuropsychobiological profiles of recreational ecstasy users, the integrative role of bioenergetic stress
  44. 2026-10-02src3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings
  45. 2026-10-02srcThe origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents
  46. 2026-10-02srcThe origin of MDMA ("ecstasy")--separating the facts from the myth
  47. 2026-10-02srcMethylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity
  48. 2026-10-02srcMDMA scheduling history and DEA Schedule I placement
  49. 2026-10-02srcAustralia TGA rescheduling MDMA to Schedule 8 for PTSD treatment
  50. 2026-09-27runbrief run
  51. 2026-09-27revisionr1.a1
  52. 2026-09-04issueIssued emergency
  53. 2026-09-04issueIssued info_card
  54. 2026-09-04issueIssued notice
  55. 2026-07-03proposaldependence · taper
  56. 2026-06-04proposal33 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  57. 2026-06-04publicationPublication — backfill
  58. 2026-04-20proposalduration · oral · aftereffects
  59. 2026-04-20proposalduration · oral · total
  60. 2026-04-20proposalduration · oral · offset
  61. 2026-04-20proposalduration · oral · peak
  62. 2026-04-20proposalduration · oral · come_up
  63. 2026-04-20proposalduration · oral · onset
  64. 2026-04-20proposaldosage · oral
  65. 2026-04-20proposaltolerance
  66. 2026-04-20proposalwithdrawal
  67. 2026-04-20proposaldependence · full
  68. 2026-04-20proposaltoxicity
  69. 2026-04-20proposaltimeline · oral · afterglow
  70. 2026-04-20proposaltimeline · oral · resolution
  71. 2026-04-20proposaltimeline · oral · plateau
  72. 2026-04-20proposaltimeline · oral · peak
  73. 2026-04-20proposaltimeline · oral · come_up
  74. 2026-04-20proposaltimeline · oral · onset
  75. 2026-04-20proposaldose_tier · heavy
  76. 2026-04-20proposaldose_tier · strong
  77. 2026-04-20proposaldose_tier · common
  78. 2026-04-20proposaldose_tier · light
  79. 2026-04-20proposaldose_tier · threshold
  80. 2026-04-20revisionRevision 1
  81. 2026-04-20genGeneration — pipeline-v5pipeline-v5
  82. 2026-04-20rungeneration run
  83. 2026-04-20rungeneration run

The same entries, as forms: six forms.