MDMA
3,4-methylenedioxy-N-methylamphetamine
1Provenance card
the boundary, as counts
Sources
4832 with DOI
23 strong · 20 moderate · 5 weak
Compilations
22026-04-20T22:45:36.694Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09 · 1 other run
Decisions
59last ruled 2026-06-04
1 awaiting a ruling
Issued documents
42026-10-19T20:32:40.411Z
notice · info card · emergency
Searches
250 with no results
queries and counts on the build
Claims checked
10910 supported
10 supported · 99 not
Correspondence
0received
consent field ships in Phase 4
Edges
339
derivations recorded for this entity
Complete over 48 sources, 2 compilations, and 59 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/mdma/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued info_card
- 2026-10-02srcPotential Psychiatric Uses for MDMA
- 2026-10-02srcSerotonin transporter availability, neurocognitive function and their correlation in abstinent 3,4-methylenedioxymethamphetamine users
- 2026-10-02srcMDMA-assisted psychotherapy for the treatment of PTSD: A systematic review and meta-analysis of randomized controlled trials
- 2026-10-02srcReduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study
- 2026-10-02srcMDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials [RETRACTED]
- 2026-10-02srcMDMA-Assisted Therapy for Post-Traumatic Stress Disorder: Regulatory Challenges and a Path Forward
- 2026-10-02srcSafety and Efficacy of Monoamine Oxidase Inhibitors in Patients Who Use Psychoactive Substances
- 2026-10-02srcMDMA impairs cognitive function during withdrawal via activation of the arachidonic acid cascade in the hippocampus
- 2026-10-02srcEfficacy of MDMA-assisted therapy for PTSD: A systematic review and meta-analysis
- 2026-10-02srcAdverse events associated with classic psychedelics and MDMA: a real-world population-based study using WHO pharmacovigilance database (VigiBase)
- 2026-10-02srcPlasma oxytocin concentrations following MDMA or intranasal oxytocin in humans
- 2026-10-02srcMeta-analysis of executive functioning in ecstasy/polydrug users
- 2026-10-02srcPharmacokinetic and pharmacodynamic effects of methylphenidate and MDMA administered alone or in combination
- 2026-10-02srcEffects of MDMA and Intranasal oxytocin on social and emotional processing
- 2026-10-02srcMDMA Impairs Both the Encoding and Retrieval of Emotional Recollections
- 2026-10-02srcEffects of MDMA on attention to positive social cues and pleasantness of affective touch
- 2026-10-02srcAcute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants
- 2026-10-02srcMDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study
- 2026-10-02srcMDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial
- 2026-10-02srcMemory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities
- 2026-10-02srcRediscovering MDMA (ecstasy): the role of the American chemist Alexander T. Shulgin
- 2026-10-02srcResidual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs
- 2026-10-02srcAmphetamine, MDMA, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor
- 2026-10-02srcThe pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")
- 2026-10-02srcThe safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study
- 2026-10-02srcA randomized, controlled pilot study of MDMA-assisted psychotherapy for treatment of resistant, chronic PTSD
- 2026-10-02srcAcute effects of MDMA on trust, cooperative behaviour and empathy: A double-blind, placebo-controlled experiment
- 2026-10-02srcCharacterization of 3,4-methylenedioxymethamphetamine (MDMA) enantiomers in vitro and in the MPTP-lesioned primate: R-MDMA reduces severity of dyskinesia, whereas S-MDMA extends duration of ON-time
- 2026-10-02srcHallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine
- 2026-10-02srcSex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans
- 2026-10-02srcThe harmful health effects of recreational ecstasy: a systematic review of observational evidence
- 2026-10-02srcIntracranial Pressure-Guided Therapy in MDMA-Induced Cerebral Edema: A Case Report
- 2026-10-02srcHuman pharmacology of 3,4-methylenedioxymethamphetamine ("ecstasy"): psychomotor performance and subjective effects
- 2026-10-02srcThe serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of MDMA ('Ecstasy') in healthy volunteers
- 2026-10-02srcAcute liver failure following the use of ecstasy (MDMA)
- 2026-10-02srcWhich neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies
- 2026-10-02srcThe 'ecstasy' hangover: hyponatremia due to 3,4-methylenedioxymethamphetamine
- 2026-10-02srcStudy of the behavioural responses related to the potential addictive properties of MDMA in mice
- 2026-10-02srcHuman pharmacology of MDMA: pharmacokinetics, metabolism, and disposition
- 2026-10-02srcPharmacological characterization of ecstasy synthesis byproducts with recombinant human monoamine transporters
- 2026-10-02srcContribution of cytochrome P450 2D6 to 3,4-methylenedioxymethamphetamine disposition in humans: use of paroxetine as a metabolic inhibitor probe
- 2026-10-02srcMDMA in humans: factors which affect the neuropsychobiological profiles of recreational ecstasy users, the integrative role of bioenergetic stress
- 2026-10-02src3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings
- 2026-10-02srcThe origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents
- 2026-10-02srcThe origin of MDMA ("ecstasy")--separating the facts from the myth
- 2026-10-02srcMethylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity
- 2026-10-02srcMDMA scheduling history and DEA Schedule I placement
- 2026-10-02srcAustralia TGA rescheduling MDMA to Schedule 8 for PTSD treatment
- 2026-09-27runbrief run
- 2026-09-27revisionr1.a1
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-07-03proposaldependence · taper
- 2026-06-04proposal33 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-04-20proposalduration · oral · aftereffects
- 2026-04-20proposalduration · oral · total
- 2026-04-20proposalduration · oral · offset
- 2026-04-20proposalduration · oral · peak
- 2026-04-20proposalduration · oral · come_up
- 2026-04-20proposalduration · oral · onset
- 2026-04-20proposaldosage · oral
- 2026-04-20proposaltolerance
- 2026-04-20proposalwithdrawal
- 2026-04-20proposaldependence · full
- 2026-04-20proposaltoxicity
- 2026-04-20proposaltimeline · oral · afterglow
- 2026-04-20proposaltimeline · oral · resolution
- 2026-04-20proposaltimeline · oral · plateau
- 2026-04-20proposaltimeline · oral · peak
- 2026-04-20proposaltimeline · oral · come_up
- 2026-04-20proposaltimeline · oral · onset
- 2026-04-20proposaldose_tier · heavy
- 2026-04-20proposaldose_tier · strong
- 2026-04-20proposaldose_tier · common
- 2026-04-20proposaldose_tier · light
- 2026-04-20proposaldose_tier · threshold
- 2026-04-20revisionRevision 1
- 2026-04-20genGeneration — pipeline-v5pipeline-v5
- 2026-04-20rungeneration run
- 2026-04-20rungeneration run
The same entries, as forms: six forms.