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psx:substance/lorazepam/gen/6b85ecf5-6d5a-4b14-acb2-48df0c20acc8

gen2026-05-09pipeline-v5recordgenerated

derived from · upstream

feeds · downstream

  • derived_fromRevision 1psx:substance/lorazepam/version/1

Closure of psx:substance/lorazepam/gen/6b85ecf5-6d5a-4b14-acb2-48df0c20acc8: 60 upstream, 139 downstream.

psx:substance/lorazepam/gen/6b85ecf5-6d5a-4b14-acb2-48df0c20acc8
├─ used  search/22f5050d-307f-45e4-ac27-89e322a91a39  Searched PubMed for "lorazepam pharmacology mechanism GABA receptor binding affinity"
├─ used  search/2f625c90-d389-4552-a4cf-91e661aed1d6  Searched PubChem for "lorazepam"
├─ used  search/5116f799-6394-47ed-afdf-e849e096c50a  Searched PubMed for "lorazepam pharmacokinetics bioavailability half-life metabolism"
├─ used  search/a731354c-2855-4d08-86e3-c23e1786e2b0  Searched OpenAlex for "lorazepam benzodiazepine pharmacology clinical"
├─ used  search/c4f783bd-c95d-4093-ae79-1e33a1054281  Searched PubMed for "lorazepam GABA-A receptor binding affinity benzodiazepine site"
├─ used  search/c40cf227-140a-442f-9c57-fc9ce8d0ffee  Searched PubMed for "lorazepam status epilepticus treatment efficacy"
├─ used  search/a4ac7811-ef69-4165-ad61-755a5edb1153  Searched PubMed for "Greenblatt lorazepam pharmacokinetics plasma distribution elimination"
├─ used  search/e440308e-b89a-4c95-b61a-1055f1d1671c  Searched PubMed for "benzodiazepine tolerance dependence mechanism GABA receptor downregulation"
├─ used  search/0d1dd4f0-60fa-41f4-a9de-761396f24041  Searched PubMed for "lorazepam amnestic anterograde amnesia memory impairment cognitive effects"
├─ used  search/bb7f2bd1-116d-47b1-a894-2a501c05ea7f  Searched PubMed for "benzodiazepine withdrawal treatment diazepam taper discontinuation"
├─ used  search/d4c66b14-1b8d-478b-9bcc-91cd1bee9d2a  Searched ClinicalTrials.gov for "lorazepam anxiety treatment"
├─ used  search/bd8a3ad3-14df-4952-bd22-e785a7db3949  Searched PubMed for "lorazepam alcohol withdrawal delirium treatment"
├─ used  search/523287a5-d4db-47a0-8898-5f5b18e17875  Searched PubMed for "lorazepam GABAA subunit selectivity alpha1 alpha2"
├─ used  search/59c71372-15bb-4125-901b-39e84f9bfebd  Searched WebSearch for "lorazepam history discovery synthesis Wyeth Laboratories approval FDA 1977"
├─ used  search/2813fd15-f5cc-4215-9ebf-09c7274d72a5  Searched WebSearch for "lorazepam scheduling legal status UK US Canada Australia"
├─ used  search/8af57ffe-34c8-491d-af27-0d00257fec64  Searched StatPearls/NCBI
├─ used  search/2f12b76e-ec8f-40dc-85f6-ef6057660dff  Searched PubChem REST API
├─ used  search/ca62d5e1-f1ac-449e-8632-e0342fdda814  Searched PubMed for "lorazepam propylene glycol toxicity ICU continuous infusion"
├─ used  search/1f76dcc4-83c3-4266-b748-75edb9e8ecd3  Searched PubMed for "lorazepam pregnancy teratogenicity fetal risk neonatal"
├─ used  search/5f0c75e5-647c-448e-bcc3-3a27000739c6  Searched PubMed for "lorazepam versus midazolam RAMPART prehospital status epilepticus"
  ├─ used  src/pmid:6111408  Clinical pharmacokinetics of oxazepam and lorazepam
  ├─ used  src/url:df9d4ba508cef4cc  Lorazepam - StatPearls
  ├─ used  src/doi:10.1007/s11606-025-10025-7  The Enduring Impact of Ghostwriting on the Treatment of Alcohol Withdrawal
  ├─ used  src/doi:10.5698/1535-7597-16.1.48  Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults
  ├─ used  src/pmid:11547716  A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus
  ├─ used  src/doi:10.2165/11599020-000000000-00000  GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam.
  ├─ used  src/pmid:12388665  RWJ-51204, a new nonbenzodiazepine anxiolytic (comparison with lorazepam as full agonist)
  ├─ used  src/pmid:2746493  Kinetic and dynamic study of intravenous lorazepam: comparison with intravenous diazepam
  ├─ used  src/pmid:6108079  Pharmacokinetic study of lorazepam overdosage
  ├─ used  src/doi:10.3390/pharmacy12050152  Clinical Outcomes of Benzodiazepine Prescribing for People Receiving Opioid Agonist Treatment: A Systematic Review
  ├─ used  src/pmid:1374467  Effects of lorazepam tolerance and withdrawal on GABAA receptor-operated chloride channels
  ├─ used  src/doi:10.3390/ijms27031430  Benzodiazepine Dependence: Clinical and Molecular Aspects, Preventive Strategies and Therapeutic Approaches.
  ├─ used  src/doi:10.1159/000506868  Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications
  ├─ used  src/url:e573c4005a76a816  Lorazepam - Wikipedia
  ├─ used  src/doi:10.1111/j.1528-1167.2011.03235.x  RAMPART: a double-blind randomized clinical trial of IM midazolam versus IV lorazepam for prehospital status epilepticus
  ├─ used  src/pmid:3958  Lorazepam - PubChem Compound CID 3958
  ├─ used  src/url:de89389c1fd88c84  Lorazepam - Chemical Properties (PubChem CID 3958 REST API)
  ├─ used  src/pmid:16422667  Osmol gap as a surrogate marker for serum propylene glycol concentrations in patients receiving lorazepam for sedation
  ├─ used  src/pmid:16809358  GABAA receptor subtype specific enhancement of inhibition in human motor cortex
  ├─ used  src/pmid:6121043  Pharmacokinetic comparison of sublingual lorazepam with intravenous, intramuscular, and oral lorazepam
  ├─ used  src/pmid:13960  Clinical pharmacokinetics of lorazepam. II. Intramuscular injection
  ├─ used  src/pmid:6132698  Lorazepam and oxazepam kinetics in women on low-dose oral contraceptives
  ├─ used  src/pmid:36252  Lorazepam kinetics in the elderly
  ├─ used  src/doi:10.1038/npp.2012.265  Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in benzodiazepine-experienced monkeys
  ├─ used  src/doi:10.1002/cpdd.134  The effects of the nonselective benzodiazepine lorazepam and the α2/α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels
  ├─ used  src/doi:10.1016/j.jceh.2022.03.003  Management of Alcohol Withdrawal Syndrome in Patients with Alcoholic Liver Disease
  ├─ used  src/pmid:10660854  Prolonged sedation requiring mechanical ventilation after routine doses of clorazepam - lorazepam preferred in hepatic impairment
  ├─ used  src/doi:10.1002/ams2.582  Comparison of diazepam and lorazepam for the emergency treatment of adult status epilepticus: a systemic review and meta-analysis
  ├─ used  src/doi:10.1111/ejn.15732  Termination of seizures in the paediatric age group, best benzodiazepine and route of administration: A network meta-analysis
  ├─ used  src/pmid:16305452  Sedation in PACU: the role of benzodiazepines
  ├─ used  src/doi:10.1097/ccm.0000000000003299  Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU (PADIS 2018)
  ├─ used  src/doi:10.1345/aph.1M313
  ├─ used  src/pmid:10468312  Effects of tiapride on electroencephalograms and cognitive functions in the elderly
  ├─ used  src/doi:10.1038/s41380-018-0100-y  Diazepam-induced loss of inhibitory synapses mediated by PLCδ/Ca2+/calcineurin signalling downstream of GABAA receptors.
  ├─ used  src/pmid:1381457  Effects of lorazepam tolerance and withdrawal on GABAA receptor operated chloride channels in mice selected for differences in ethanol withdrawal severity
  ├─ used  src/pmid:16525857  Dose-dependent retrograde facilitation of verbal memory in healthy elderly after acute oral lorazepam administration
  ├─ used  src/pmid:7881198  The effects of benzodiazepine use during pregnancy and lactation.
  ├─ used  src/pmid:2824007  Lorazepam and FG 7142 induce tolerance to the DMCM antagonistic effect of benzodiazepine receptor ligands
  ├─ generated_by  pub/0aac5353-3baf-4d3c-b916-7cfe0d7cfd9b  Publication — backfill
  └─ invalidated_by  pub/0b349203-6936-4370-b5e9-840dcb4756fe  Publication — publish
├─ derived_from  version/1  Revision 1
  ├─ derived_from  issue/notice@5e0b2fa53726  Issued notice
  ├─ derived_from  issue/info_card@1e472eaff3a9  Issued info_card
  ├─ derived_from  issue/emergency@dcd2ca271fbe  Issued emergency
  ├─ revised_from  version/2  r1.a1
    ├─ used  claim/db1206bf-3425-4145-b8c5-3a30b67f2aba  Claim in pharmacology — inconclusive  working
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    ├─ used  claim/d4f3146e-bcc3-4a16-94ec-2eadfb5afc83  Claim in summary — partially_supported
    ├─ used  claim/cf3ba2b6-e3a5-4972-bfd5-38b15a7869cf  Claim in neuroscience — supported
    ├─ used  claim/14c06572-b01f-4c94-9039-bafa2701fc4d  Claim in safety — supported
    ├─ used  claim/08ad554d-5bcc-49ff-a558-00d550850d74  Claim in safety — partially_supported
    ├─ used  claim/c962b2eb-5653-4462-a80f-eb9d5545f907  Claim in safety — inconclusive  working
    ├─ used  claim/9759c7b0-9623-4f4d-99d7-5bc4d2b25b4d  Claim in safety — inconclusive  working
    ├─ used  claim/c8317111-f688-4b55-9ca6-83e540def0aa  Claim in safety — supported
    ├─ used  claim/0ba1ca69-0967-48ee-bf0c-a65d538d17ca  Claim in neuroscience — partially_supported
    ├─ used  claim/e314c9c0-c6e5-42b3-bbed-0470006cb653  Claim in neuroscience — inconclusive  working
    ├─ used  claim/321cc625-2a4b-45a6-8198-f10ea41cadaa  Claim in summary — inconclusive  working
    ├─ used  claim/fe6568e1-255e-4a09-89eb-aa1c692c2755  Claim in comparative-pharmacology — inconclusive  working
    ├─ used  claim/8100cda8-bc59-48cc-8476-3ab4eaa1f32b  Claim in safety — inconclusive  working
    ├─ used  claim/cdcca60b-9c51-4b33-84aa-d8c888411112  Claim in safety — inconclusive  working
    ├─ used  claim/61a38e28-aabc-488f-8cf0-911c3238dd96  Claim in summary — inconclusive  working
    ├─ used  claim/9c6e7407-cee1-4f49-8ebd-2e8c7390e535  Claim in comparative-pharmacology — inconclusive  working
    ├─ used  claim/5901ff67-9467-41c5-9ae3-76c7591f82d6  Claim in clinical-evidence — inconclusive  working
    ├─ used  claim/19ec858c-155a-4a1a-a77e-4b268db3a0b8  Claim in comparative-pharmacology — inconclusive  working
    ├─ used  claim/20044450-f9a7-4cbb-a129-c2083bb15538  Claim in clinical-evidence — inconclusive  working
    └─ used  claim/7d51f4b8-d586-40f3-a47d-b38a6535adda  Claim in comparative-pharmacology — inconclusive  working
… closure truncated at 200 nodes

indented by distance from this node, not by parentage

1Provenance card

the boundary, as counts

Sources

3815 with DOI

16 strong · 17 moderate · 5 weak

Compilations

12026-05-09T12:23:15.751Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

41last ruled 2026-10-02

1 awaiting a ruling

Issued documents

42026-10-02T13:09:09.604Z

notice · info card · emergency

Searches

200 with no results

queries and counts on the build

Claims checked

22414 supported

14 supported · 210 not

Correspondence

0received

consent field ships in Phase 4

Edges

563

derivations recorded for this entity

Complete over 38 sources, 1 compilation, and 41 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/lorazepam/archive

2Build

one panel per compilation run

generation run 2026-05-09

69 min completedmodel pipeline-v5plan not recordedrun/99c429a6…

research

citationsRegistryrecordresearchOutputworking

draft

articleDraftworking

audit

articleAuditedworking

verify

verificationResultworking

simplify

articleSimplifiedworking

publish

runMetarecordrunSummaryrecord

Selection

results seen119
selected by the model41
consumed as sources38

Verification

claims checked224
supported10
partially supported4
not supported1
inconclusive209
  • record
  • seen / partial
  • working

The model's own caveats

  • taper_protocol_proposed
  • note
  • note

Reproduce

inputs
38 source keys (listed under Sources)
plan
not recorded — template version, prompt hash and git SHA are written from 2026-09 onward
model
pipeline-v5
streams
none — agent transcripts are persisted from 2026-09 onward
20 searches — query, source, results, what was kept and why
20 searches for this run
#sourcequeryseenkeptrationale
1PubMedlorazepam pharmacology mechanism GABA receptor binding affinity1——
2PubChemlorazepam11Primary chemical identity verification
3PubMedlorazepam pharmacokinetics bioavailability half-life metabolism101PMID 6133404 directly reports lorazepam IV/IM pharmacokinetics: t1/2 14.1 hrs, Vd 1.24 L/kg, IM bioavailability 88.8%
4PubMedGreenblatt lorazepam pharmacokinetics plasma distribution elimination76Greenblatt series is definitive source for lorazepam pharmacokinetics in humans
5OpenAlexlorazepam benzodiazepine pharmacology clinical102PADIS guidelines and AES status epilepticus guidelines directly reference lorazepam clinical use
6PubMedlorazepam status epilepticus treatment efficacy94Evidence base for lorazepam in status epilepticus
7PubMedlorazepam GABA-A receptor binding affinity benzodiazepine site92Directly study lorazepam effects on GABA-A receptor chloride channel coupling during tolerance
8PubMedbenzodiazepine tolerance dependence mechanism GABA receptor downregulation73Molecular mechanisms of BZD tolerance relevant to lorazepam dependence section
9PubMedlorazepam amnestic anterograde amnesia memory impairment cognitive effects22—
10PubMedlorazepam pregnancy teratogenicity fetal risk neonatal11—
11WebSearchlorazepam scheduling legal status UK US Canada Australia102—
12PubChem REST API—11—
13PubMedlorazepam GABAA subunit selectivity alpha1 alpha284—
14WebSearchlorazepam history discovery synthesis Wyeth Laboratories approval FDA 1977102—
15PubMedlorazepam versus midazolam RAMPART prehospital status epilepticus21—
16StatPearls/NCBI—11—
17PubMedbenzodiazepine withdrawal treatment diazepam taper discontinuation81—
18PubMedlorazepam alcohol withdrawal delirium treatment83—
19PubMedlorazepam propylene glycol toxicity ICU continuous infusion42—
20ClinicalTrials.govlorazepam anxiety treatment102—
224 claims by section — every cited sentence, checked against its source
pharmacology56 · 2 ok

  • Claim in pharmacology — inconclusiveinconclusiveworking →

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  • Lorazepam is a positive allosteric modulator (PAM) of ionotropic gaba-a-receptor (gaba type A) receptorssupported

    Reviews GABA-A receptor subunit pharmacology; α1 mediates sedation/amnesia, α2 mediates anxiolysis, α subunits involved in anticonvulsant activity; 1,4-BZDs like clonazepam compared to 1,5-BZD clobazam 11599020-000000000-00000

  • Claim in pharmacology — inconclusiveinconclusiveworking →

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  • Each α subunit mediates distinct pharmacological effects: α1 subunits contribute to sedation, hypnosis, anterograde amnesia, and anticonvulsant activity; α2 and α3 subunits mediate anxiolysis and muscle relaxation; α5 subunits modulate learning and memory.supported

    α1 mediates sedation/amnesia, α2 mediates anxiolysis, α subunits involved in anticonvulsant activity 11599020-000000000-00000

  • Claim in pharmacology — inconclusiveinconclusiveworking →

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safety54 · 5 ok

  • Claim in safety — inconclusiveinconclusiveworking →

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  • Third-trimester and peripartum use is associated with "floppy infant syndrome" (neonatal hypotonia, respiratory depression, reluctance to suck, apneic spells) and neonatal withdrawal symptoms persisting hours to months after birthsupported

    late trimester use associated with floppy infant syndrome and neonatal withdrawal pmid:7881198

  • Claim in safety — inconclusiveinconclusiveworking →

  • Claim in safety — inconclusiveinconclusiveworking →

  • Claim in safety — inconclusiveinconclusiveworking →

  • Rebound anxiety and insomnia following discontinuation — even after short-term therapeutic use — are well-documented and contribute to the cycle of dependence.supported

    management requires gradual tapering with long-acting BZD ijms27031430

  • Tolerance develops within days of continuous use for the anxiolytic, anticonvulsant, and sedative effects of lorazepampartially supported

    prolonged use causes tolerance via GABA-A subunit downregulation and compensatory glutamatergic sensitization ijms27031430

  • Claim in safety — inconclusiveinconclusiveworking →

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  • Standard management involves substitution with a long-acting benzodiazepine (typically Diazepam) and gradual dose tapersupported

    management requires gradual tapering with long-acting BZD ijms27031430

  • Claim in safety — inconclusiveinconclusiveworking →

  • Claim in safety — inconclusiveinconclusiveworking →

  • Claim in safety — inconclusiveinconclusiveworking →

  • Pregnancy, especially first and third trimester (FDA Category D — fetal risk documented)partially supported

    late trimester use associated with floppy infant syndrome and neonatal withdrawal pmid:7881198

  • Claim in safety — inconclusiveinconclusiveworking →

summary26 · 2 ok

  • Claim in summary — inconclusiveinconclusiveworking →

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  • Level A evidence supports IV lorazepam as first-line treatment for convulsive status epilepticus, and the landmark PHTSE trial demonstrated superiority over placebo for prehospital seizure terminationsupported

    IM midazolam, IV lorazepam, IV diazepam and IV phenobarbital established as efficacious for SE (Level A). 1535-7597-16.1.48

  • Claim in summary — inconclusiveinconclusiveworking →

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  • Co-administration with opioids carries an FDA Black Box Warning: concurrent benzodiazepine–opioid use increases overdose mortality by 40–334%. tolerance to anxiolytic and anticonvulsant effects develops within days of continuous use, driven by GABA-A receptor uncoupling and compensatory glutamatergic sensitizationpartially supported

    prolonged use causes tolerance via GABA-A subunit downregulation and compensatory glutamatergic sensitization ijms27031430

  • Claim in summary — inconclusiveinconclusiveworking →

neuroscience22 · 3 ok

  • Claim in neuroscience — inconclusiveinconclusiveworking →

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  • (5) Compensatory glutamatergic sensitization: As a homeostatic counterregulation to sustained GABAergic enhancement, excitatory glutamatergic systems are upregulated. This glutamatergic rebound-effect contributes to the hyperexcitability observed during withdrawal, including seizure susceptibility.supported

    prolonged use causes tolerance via GABA-A subunit downregulation and compensatory glutamatergic sensitization ijms27031430

  • Claim in neuroscience — inconclusiveinconclusiveworking →

  • Claim in neuroscience — inconclusiveinconclusiveworking →

  • Claim in neuroscience — inconclusiveinconclusiveworking →

  • (2) α1 subunit downregulation: Sustained benzodiazepine exposure activates L-type voltage-gated calcium channels, triggering a PKA/CREB-ICER signaling cascade that downregulates transcription of the GABA-A α1 subunit.partially supported

    prolonged use causes tolerance via GABA-A subunit downregulation and compensatory glutamatergic sensitization ijms27031430

  • Claim in neuroscience — inconclusiveinconclusiveworking →

  • (4) PLCδ/Ca²⁺/calcineurin-mediated receptor internalization: GABA-A receptors undergo calcineurin-dependent endocytosis and inhibitory synapse disassembly via the PLCδ/Ca²⁺ signaling pathway.supported

    Prolonged diazepam exposure disrupts inhibitory GABAergic synapses via GABAR internalization through PLCδ/Ca2+/calcineurin pathway s41380-018-0100-y

clinical-evidence18 · 1 ok

  • Claim in clinical-evidence — inconclusiveinconclusiveworking →

  • Claim in clinical-evidence — inconclusiveinconclusiveworking →

  • Claim in clinical-evidence — inconclusiveinconclusiveworking →

  • Claim in clinical-evidence — inconclusiveinconclusiveworking →

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  • Claim in clinical-evidence — inconclusiveinconclusiveworking →

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  • Claim in clinical-evidence — inconclusiveinconclusiveworking →

  • IV lorazepam holds Level A evidence as an established first-line treatment for adult convulsive status epilepticus (SE), per American Epilepsy Society guidelines.supported

    IM midazolam, IV lorazepam, IV diazepam and IV phenobarbital established as efficacious for SE (Level A). 1535-7597-16.1.48

  • Claim in clinical-evidence — inconclusiveinconclusiveworking →

  • Claim in clinical-evidence — inconclusiveinconclusiveworking →

  • Claim in clinical-evidence — not_supportednot supportedworking →

  • Claim in clinical-evidence — inconclusiveinconclusiveworking →

pharmacokinetic-detail16 · 0 ok

  • Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →

  • Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →

  • Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →

  • Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →

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  • Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →

  • Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →

  • Claim in pharmacokinetic-detail — inconclusiveinconclusiveworking →

history10 · 1 ok

  • Claim in history — inconclusiveinconclusiveworking →

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  • The 2001 Prehospital Treatment of Status Epilepticus (PHTSE) trial, published in the New England Journal of Medicine, demonstrated that both lorazepam and diazepam were superior to placebo for prehospital seizure termination, establishing Level A evidence for IV lorazepam in this indicationsupported

    IM midazolam, IV lorazepam, IV diazepam and IV phenobarbital established as efficacious for SE (Level A). 1535-7597-16.1.48

receptor-pharmacology10 · 0 ok

  • Claim in receptor-pharmacology — inconclusiveinconclusiveworking →

  • Claim in receptor-pharmacology — inconclusiveinconclusiveworking →

  • Claim in receptor-pharmacology — inconclusiveinconclusiveworking →

  • Claim in receptor-pharmacology — inconclusiveinconclusiveworking →

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  • Claim in receptor-pharmacology — inconclusiveinconclusiveworking →

  • Claim in receptor-pharmacology — inconclusiveinconclusiveworking →

  • Claim in receptor-pharmacology — inconclusiveinconclusiveworking →

comparative-pharmacology8 · 0 ok

  • Claim in comparative-pharmacology — inconclusiveinconclusiveworking →

  • Claim in comparative-pharmacology — inconclusiveinconclusiveworking →

  • Claim in comparative-pharmacology — inconclusiveinconclusiveworking →

  • Claim in comparative-pharmacology — inconclusiveinconclusiveworking →

  • Claim in comparative-pharmacology — inconclusiveinconclusiveworking →

  • Claim in comparative-pharmacology — inconclusiveinconclusiveworking →

  • Claim in comparative-pharmacology — inconclusiveinconclusiveworking →

  • Claim in comparative-pharmacology — inconclusiveinconclusiveworking →

chemistry4 · 0 ok

  • Claim in chemistry — inconclusiveinconclusiveworking →

  • Claim in chemistry — inconclusiveinconclusiveworking →

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  • Claim in chemistry — inconclusiveinconclusiveworking →

3Sources

38 consumed · sorted by year · feeds = sections resting on it

Sources 1 to 30
yearsourcetierstatusfeeds
2026Benzodiazepine Dependence: Clinical and Molecular Aspects, Preventive Strategies and Therapeutic Approaches.Navarrete F, Marín-Mayor M, Martínez-Hostyn L, Rubio G, Manzanares J · International journal of molecular sciencesdoi:10.3390/ijms27031430moderateconsumed3 sections
2026The Enduring Impact of Ghostwriting on the Treatment of Alcohol WithdrawalWeintraub SJ · Journal of general internal medicinedoi:10.1007/s11606-025-10025-7moderateconsumed3 sections
2024Clinical Outcomes of Benzodiazepine Prescribing for People Receiving Opioid Agonist Treatment: A Systematic ReviewMatheson C, Vucic C, Dumbrell J, Robertson R, et al. · Pharmacy (Basel, Switzerland)doi:10.3390/pharmacy12050152strongconsumed2 sections
2024Lorazepam - Chemical Properties (PubChem CID 3958 REST API)PubChemurl:de89389c1fd88c84weakconsumedcited only
2024Lorazepam - PubChem Compound CID 3958PubChem · PubChempmid:3958moderateconsumed1 section
2024Lorazepam - StatPearlsGhiasi N, Bhansali RK, Marwaha R · StatPearls [Internet]url:df9d4ba508cef4ccweakconsumedcited only
2024Lorazepam - WikipediaWikipedia contributorsurl:e573c4005a76a816weakconsumedcited only
2022Management of Alcohol Withdrawal Syndrome in Patients with Alcoholic Liver DiseaseChand PK, Panda U, Mahadevan J, Murthy P · Journal of clinical and experimental hepatologydoi:10.1016/j.jceh.2022.03.003moderateconsumed3 sections
2022Termination of seizures in the paediatric age group, best benzodiazepine and route of administration: A network meta-analysisHasan SU, Pervez A, Bhatty S, Shamim S, et al. · The European journal of neurosciencedoi:10.1111/ejn.15732strongconsumed1 section
2020Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic MedicationsCosci F, Chouinard G · Psychotherapy and Psychosomaticsdoi:10.1159/000506868strongconsumed3 sections
2020Comparison of diazepam and lorazepam for the emergency treatment of adult status epilepticus: a systemic review and meta-analysisKobata H, Hifumi T, Hoshiyama E, Yamakawa K, Nakamura K, Soh M, Kondo Y, Yokobori S · Acute medicine & surgerydoi:10.1002/ams2.582strongconsumedcited only
2018Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU (PADIS 2018)Devlin JW, Skrobik Y, Gélinas C, et al. · Critical Care Medicinedoi:10.1097/ccm.0000000000003299strongconsumedcited only
2018Diazepam-induced loss of inhibitory synapses mediated by PLCδ/Ca2+/calcineurin signalling downstream of GABAA receptors.Nicholson MW, Sweeney A, Pekle E, et al. · Molecular psychiatrydoi:10.1038/s41380-018-0100-ymoderateconsumed1 section
2016Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and AdultsGlauser TA, Shinnar S, Gloss D, Alldredge BK, Arya R · Epilepsy currentsdoi:10.5698/1535-7597-16.1.48strongconsumed4 sections
2015The effects of the nonselective benzodiazepine lorazepam and the α2/α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levelsTe Beek ET, Chen X, Jacobs GE, Nahon KJ, de Kam ML, Lappalainen J, Cross AJ, van Gerven JM, Hay JL · Clinical pharmacology in drug developmentdoi:10.1002/cpdd.134strongconsumedcited only
2013Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in benzodiazepine-experienced monkeysShinday NM, Sawyer EK, Fischer BD, Platt DM, et al. · Neuropsychopharmacologydoi:10.1038/npp.2012.265moderateconsumed1 section
2012GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam.Sankar R · CNS drugsdoi:10.2165/11599020-000000000-00000moderateconsumed4 sections
2011RAMPART: a double-blind randomized clinical trial of IM midazolam versus IV lorazepam for prehospital status epilepticusSilbergleit R, Lowenstein D, Durkalski V, Conwit R · Epilepsiadoi:10.1111/j.1528-1167.2011.03235.xstrongconsumed2 sections
2009Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusionsHorinek EL, Kiser TH, Fish DN, MacLaren R · The Annals of pharmacotherapydoi:10.1345/aph.1m313moderateconsumedcited only
2006Dose-dependent retrograde facilitation of verbal memory in healthy elderly after acute oral lorazepam administrationPomara N, Facelle TM, Roth AE, Willoughby LM, Greenblatt DJ, Sidtis JJ · Psychopharmacologypmid:16525857strongconsumed1 section
2006GABAA receptor subtype specific enhancement of inhibition in human motor cortexDi Lazzaro V, Pilato F, Dileone M, Ranieri F, Ricci V, Profice P, Bria P, Tonali PA, Ziemann U · The Journal of physiologypmid:16809358strongconsumed3 sections
2006Osmol gap as a surrogate marker for serum propylene glycol concentrations in patients receiving lorazepam for sedationBarnes BJ, Gerst C, Smith JR, Terrell AR, Mullins ME · Pharmacotherapypmid:16422667moderateconsumed2 sections
2005Sedation in PACU: the role of benzodiazepinesArcangeli A, Antonelli M, Mignani V, Sandroni C · Current drug targetspmid:16305452moderateconsumed1 section
2002RWJ-51204, a new nonbenzodiazepine anxiolytic (comparison with lorazepam as full agonist)Dubinsky B, Vaidya AH, et al. · The Journal of pharmacology and experimental therapeuticspmid:12388665moderateconsumed3 sections
2001A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticusAlldredge BK, Gelb AM, Isaacs SM, Corry MD, Allen F, et al. · The New England journal of medicinepmid:11547716strongconsumed2 sections
1999Effects of tiapride on electroencephalograms and cognitive functions in the elderlyPatat A, Alberini H, Bonhomme D, Soubrane C, Allain H, Gandon JM · International clinical psychopharmacologypmid:10468312strongconsumed2 sections
1999Prolonged sedation requiring mechanical ventilation after routine doses of clorazepam - lorazepam preferred in hepatic impairmentGuglielminotti J, Maury E, et al. · Intensive care medicinepmid:10660854weakconsumed2 sections
1994The effects of benzodiazepine use during pregnancy and lactation.McElhatton PR · Reproductive toxicologypmid:7881198moderateconsumed1 section
1992Effects of lorazepam tolerance and withdrawal on GABAA receptor operated chloride channels in mice selected for differences in ethanol withdrawal severityAllan AM, Baier LD, Zhang X · Life sciencespmid:1381457moderateconsumed2 sections
1992Effects of lorazepam tolerance and withdrawal on GABAA receptor-operated chloride channelsAllan AM, Baier LD, Zhang X · The Journal of pharmacology and experimental therapeuticspmid:1374467moderateconsumed3 sections
Show all 38 sources — 8 more
Sources 31 to 38
yearsourcetierstatusfeeds
1989Kinetic and dynamic study of intravenous lorazepam: comparison with intravenous diazepamGreenblatt DJ, Ehrenberg BL, Gunderman J, Scavone JM, Tai NT, Harmatz JS, Shader RI · The Journal of pharmacology and experimental therapeuticspmid:2746493strongconsumed4 sections
1987Lorazepam and FG 7142 induce tolerance to the DMCM antagonistic effect of benzodiazepine receptor ligandsPetersen EN, Jensen LH · Brain research bulletinpmid:2824007moderateconsumed1 section
1983Lorazepam and oxazepam kinetics in women on low-dose oral contraceptivesAbernethy DR, Greenblatt DJ, Ochs HR, Weyers D, Divoll M, Harmatz JS, Shader RI · Clinical pharmacology and therapeuticspmid:6132698strongconsumed1 section
1982Pharmacokinetic comparison of sublingual lorazepam with intravenous, intramuscular, and oral lorazepamGreenblatt DJ, Divoll M, Harmatz JS, Shader RI · Journal of pharmaceutical sciencespmid:6121043strongconsumed1 section
1981Clinical pharmacokinetics of oxazepam and lorazepamGreenblatt DJ · Clinical pharmacokineticspmid:6111408strongconsumed5 sections
1980Pharmacokinetic study of lorazepam overdosageAllen MD, Greenblatt DJ, LaCasse Y, Shader RI · The American journal of psychiatrypmid:6108079weakconsumed3 sections
1979Lorazepam kinetics in the elderlyGreenblatt DJ, Allen MD, Locniskar A, Harmatz JS, Shader RI · Clinical pharmacology and therapeuticspmid:36252moderateconsumed3 sections
1977Clinical pharmacokinetics of lorazepam. II. Intramuscular injectionGreenblatt DJ, Joyce TH, Comer WH, Knowles JA, Shader RI, Kyriakopoulos AA, MacLaughlin DS, Ruelius HW · Clinical pharmacology and therapeuticspmid:13960moderateconsumed1 section

4Docket

one filing per activity — decisions, correspondence, reports

awaiting ruling — 1

  • dependence · taper2026-07-03
  1. 0012026-05-09revisionRevision 1

    Initial LLM generation (v5 pipeline, wiki, prose phase)

    psx:substance/lorazepam/version/1
  2. 0022026-06-04proposal34 value proposals approved together

    one review action inferred from a shared reviewer and instant — the graph records one activity per proposal

    34 items in this filing

    • contraindication · respiratory
    • contraindication · other
    • contraindication · respiratory
    • contraindication · other
    • contraindication · age
    • contraindication · pregnancy_breastfeeding
    • contraindication · psychiatric
    • contraindication · age
    • contraindication · hepatic
    • contraindication · other
    • contraindication · other
    • dose_tier · threshold
    • dose_tier · light
    • dose_tier · common
    • dose_tier · strong
    • dose_tier · heavy
    • timeline · oral · onset
    • timeline · oral · come_up
    • timeline · oral · peak
    • timeline · oral · plateau
    • timeline · oral · resolution
    • timeline · oral · afterglow
    • toxicity
    • dependence · full
    • withdrawal
    • tolerance
    • dosage · oral
    • duration · oral · onset
    • duration · oral · come_up
    • duration · oral · peak
    • duration · oral · offset
    • duration · oral · total
    • duration · oral · aftereffects
    psx:substance/lorazepam/proposal/contraindication/73ebb704-a43a-462e-be5a-3b05dc3f832b
  3. 0032026-06-04publicationPublication — backfill
    psx:substance/lorazepam/pub/0aac5353-3baf-4d3c-b916-7cfe0d7cfd9b
  4. 0042026-10-02rulingRuling — psx:substance/lorazepam/proposal/article_section_proposals/3e232eb7-29b9-4359-ab4d-08e719c69148founder
    psx:substance/lorazepam/ruling/harm-reduction-headings/3e232eb7-29b9-4359-ab4d-08e719c69148
  5. 0052026-10-02rulingRuling — psx:substance/lorazepam/proposal/article_section_proposals/52c42611-f6f3-489c-b36a-1aebb09d601afounder
    psx:substance/lorazepam/ruling/harm-reduction-headings/52c42611-f6f3-489c-b36a-1aebb09d601a
  6. 0062026-10-02revisionr1.a1

    no edit summary recorded

    psx:substance/lorazepam/version/2
  7. 0072026-10-02publicationPublication — publishagent-psx
    psx:substance/lorazepam/pub/0b349203-6936-4370-b5e9-840dcb4756fe

5Issued documents

what the notice, info card and emergency page said, by hash

Issued documents
documentcontent hashissuedfrom versionsuperseded
info_cardaa4553fac7108e5fc8a3d1c2…2026-10-02 13:09Revision 2current
emergencydcd2ca271fbe095dc7fb6211…2026-09-04 04:30Revision 1current
info_card1e472eaff3a937fa2c74197d…2026-09-04 04:30Revision 1superseded2026-10-02
notice5e0b2fa53726c91a2b579816…2026-09-04 04:30Revision 1current