Kratom
1Provenance card
the boundary, as counts
Sources
5040 with DOI
12 strong · 22 moderate · 16 weak
Compilations
22026-05-14T02:50:21.731Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09 · 1 other run
Decisions
24last ruled 2026-06-04
0 awaiting a ruling
Issued documents
42026-10-19T20:32:26.876Z
notice · info card · emergency
Searches
00 with no results
queries and counts on the build
Claims checked
9571 supported
71 supported · 24 not
Correspondence
0received
consent field ships in Phase 4
Edges
318
derivations recorded for this entity
Complete over 50 sources, 2 compilations, and 24 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/kratom/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued info_card
- 2026-09-27runbrief run
- 2026-09-27revisionr2.a1
- 2026-09-07srcClinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom
- 2026-09-07srcSimultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra-performance liquid chromatography-tandem mass spectrometry
- 2026-09-07srcChanging trends in the use of kratom (Mitragyna speciosa) in Southeast Asia
- 2026-09-07srcPXR mediated induction of CYP3A4, CYP1A2, and P-gp by Mitragyna speciosa and its alkaloids
- 2026-09-07srcDrug-drug interactions of plant alkaloids derived from herbal medicines on the phase II UGT enzymes: an introductory review
- 2026-09-07srcThe abuse potential of kratom according the 8 factors of the controlled substances act: implications for regulation and research
- 2026-09-07srcRespiratory effects of oral mitragynine and oxycodone in a rodent model
- 2026-09-07srcQuantification of 11 kratom alkaloids including mitragynine and its main metabolites in human plasma using LC-MS/MS
- 2026-09-07srcThe Impact of Diverse Kratom Products on Use Patterns, Dependence, and Toxicity
- 2026-09-07srcOral Pharmacokinetics in Beagle Dogs of the Mitragynine Metabolite, 7-Hydroxymitragynine
- 2026-09-07srcKratom (Mitragyna Speciosa) Liver Injury: A Comprehensive Review
- 2026-09-07srcExploring the cognitive effects of kratom: A review
- 2026-09-07srcKratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users
- 2026-09-07srcPatterns of Kratom use and health impact in the US-Results from an online survey
- 2026-09-07srcKratom addiction per DSM-5 SUD criteria, and kratom physical dependence: Insights from dosing amount versus frequency
- 2026-09-07srcKratom alkaloids and O-desmethyltramadol in urine of a Krypton herbal mixture consumer
- 2026-09-07srcMitragyna speciosa use in the northern states of Malaysia: a cross-sectional study
- 2026-09-07srcMitragyna speciosa Korth toxicity: Experimental findings and future prospects
- 2026-09-07srcThe medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse
- 2026-09-07srcThe neuropharmacology of kratom, a novel psychoactive natural product.
- 2026-09-07srcEffects of unconventional recreational drug use in pregnancy.
- 2026-09-07srcPhysiologically Based Pharmacokinetic Model for Clinical Translation and Prediction of Drug Interaction of the Major Kratom Alkaloid, Mitragynine
- 2026-09-07srcSeverity of Pain and Sleep Problems during Kratom (Mitragyna speciosa Korth.) Cessation among Regular Kratom Users
- 2026-09-07srcSeverity of Kratom (Mitragyna speciosa Korth.) Psychological Withdrawal Symptoms
- 2026-09-07srcFrom kratom to 7-hydroxymitragynine: evolution of a natural remedy into a public-health threat.
- 2026-09-07srcA case of fatal overdose involving both hydromorphone and kratom
- 2026-09-07srcMitragynine (Kratom)-Withdrawal behaviour and cognitive impairments can be ameliorated by an epigenetic mechanism
- 2026-09-07srcKratom (Mitragyna speciosa): A Case Review of Use Before and During Pregnancy
- 2026-09-07srcInteractive Effects of mu-Opioid and Adrenergic-alpha2 Receptor Agonists in Rats.
- 2026-09-07srcTreatment of obsessive compulsive disorder and Kratom dependence with buprenorphine and supportive care.
- 2026-09-07srcFollowing the Roots of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries
- 2026-09-07srcDeath from Kratom toxicity and the possible role of intralipid
- 2026-09-07srcSerotonin release mediates analgesia via opioidergic system and withdrawal symptoms in chronic kratom extract-treated mice
- 2026-09-07srcChemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa
- 2026-09-07srcPharmacokinetics of mitragynine in man
- 2026-09-07srcCurrent perspectives on the impact of Kratom use
- 2026-09-07srcSearching for a Signal: Self-Reported Kratom Dose-Effect Relationships Among a Sample of US Adults With Regular Kratom Use Histories
- 2026-09-07srcEvaluation of the effects of Mitragyna speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay
- 2026-09-07srcKratom induced severe cholestatic liver injury histologically mimicking primary biliary cholangitis: A case report.
- 2026-09-07src7-Hydroxymitragynine and Nicotine Pouch Withdrawal Syndrome: A Case Report
- 2026-09-07srcUnintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton
- 2026-09-07srcPharmacology of kratom: an emerging botanical agent with stimulant, analgesic and opioid-like effects
- 2026-09-07srcDEA Withdrawal of Notice of Intent to Temporarily Place Mitragynine and 7-Hydroxymitragynine Into Schedule I
- 2026-09-07srcThailand Legalizes Kratom - Narcotics Act Amendment B.E. 2564 (2021)
- 2026-09-07srcWHO Expert Committee on Drug Dependence - Kratom (Mitragyna speciosa) critical review 2021
- 2026-09-07srcDEA Notice of Intent to Temporarily Place Mitragynine and 7-Hydroxymitragynine Into Schedule I (Aug 31, 2016)
- 2026-09-07srcMitragyna speciosa Korth. - Plants of the World Online (POWO), Kew
- 2026-09-07srcKratom legal status: Australia Schedule 9, UK Psychoactive Substances Act 2016, International
- 2026-09-07srcKratom Regulation: Federal Status and State Approaches - Congressional Research Service
- 2026-09-07srcFDA and Kratom - FDA enforcement, import alerts, and regulatory position
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-07-09revisionRevision 3
- 2026-06-04proposal17 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-05-14revisionRevision 2
- 2026-05-14genGeneration — pipeline-v5 · with 2 morepipeline-v5
- 2026-05-14rungeneration run
- 2026-05-13rungeneration run
- 2026-03-17importImported from Curiosity v1
- 2026-03-17publicationPublication — backfill
- 2026-03-17revisionRevision 1
The same entries, as forms: six forms.