Ketamine
1Provenance card
the boundary, as counts
Sources
4942 with DOI
23 strong · 21 moderate · 5 weak
Compilations
22026-04-20T09:52:08.318Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09 · 1 other run
Decisions
62last ruled 2026-06-04
0 awaiting a ruling
Issued documents
42026-10-19T20:32:25.864Z
notice · info card · emergency
Searches
250 with no results
queries and counts on the build
Claims checked
19923 supported
23 supported · 176 not
Correspondence
0received
consent field ships in Phase 4
Edges
545
derivations recorded for this entity
Complete over 49 sources, 2 compilations, and 62 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/ketamine/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued info_card
- 2026-09-27runbrief run
- 2026-09-27revisionr1.a1
- 2026-09-24srcWhat urologists need to know about ketamine-induced uropathy: A systematic review
- 2026-09-24srcChronic ketamine abuse is associated with orexin-A reduction and ACTH elevation
- 2026-09-24srcOral ketamine may offer a solution to the ketamine conundrum
- 2026-09-24srcPopulation pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing
- 2026-09-24srcKetamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy
- 2026-09-24srcKetamine-Induced Apoptosis in Normal Human Urothelial Cells: A Direct, N-Methyl-d-Aspartate Receptor-Independent Pathway Characterized by Mitochondrial Stress
- 2026-09-24srcMechanisms of ketamine and its metabolites as antidepressants
- 2026-09-24srcIs persistent ketamine use a valid model of the cognitive and oculomotor deficits in schizophrenia?
- 2026-09-24srcSub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors
- 2026-09-24srcEvaluation of sigma receptors in the antidepressant-like effects of ketamine in vitro and in vivo
- 2026-09-24srcAntidepressant-like effects of ketamine, norketamine and dehydronorketamine in forced swim test: Role of activity at NMDA receptor
- 2026-09-24srcCYP 450 enzymes influence (R,S)-ketamine brain delivery and its antidepressant activity
- 2026-09-24srcDrug-induced liver injury following a repeated course of ketamine treatment for chronic pain in CRPS type 1 patients: a report of 3 cases
- 2026-09-24srcSimilar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia
- 2026-09-24srcPlasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression
- 2026-09-24srcNMDAR inhibition-independent antidepressant actions of ketamine metabolites
- 2026-09-24srcDisruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology
- 2026-09-24srcThe clinical toxicology of ketamine
- 2026-09-24srcReal-World Safety of Esketamine Nasal Spray: A Comprehensive Analysis of Esketamine and Respiratory Depression
- 2026-09-24srcKetamine-induced biliary dilatation: from Hong Kong to New York
- 2026-09-24srcChiral Pharmacokinetics and Metabolite Profile of Prolonged-release Ketamine Tablets in Healthy Human Subjects
- 2026-09-24srcHistory of anaesthesia [Ketamine history editorial]
- 2026-09-24srcChronic ketamine exposure induces permanent impairment of brain functions in adolescent cynomolgus monkeys
- 2026-09-24srcCharacteristics and circumstances of death related to the self-administration of ketamine
- 2026-09-24srcKetamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)
- 2026-09-24srcEsketamine Nasal Spray: Mechanism of Action, Clinical, and Translational Science
- 2026-09-24srcPossible pathophysiology of ketamine-related cystitis and associated treatment strategies
- 2026-09-24srcRifampicin has a profound effect on the pharmacokinetics of oral S-ketamine and less on intravenous S-ketamine
- 2026-09-24srcmTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
- 2026-09-24srcSynaptic Dysfunction in Depression: Potential Therapeutic Targets
- 2026-09-24srcA Case of Hepatotoxicity Induced by Therapeutic Ketamine Use for Sedation
- 2026-09-24srcAcute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications
- 2026-09-24srcAntidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial
- 2026-09-24srcAttenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism
- 2026-09-24srcGender differences in subjective discontinuation symptoms associated with ketamine use
- 2026-09-24srcActivation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions
- 2026-09-24srcKetamine: 50 Years of Modulating the Mind
- 2026-09-24srcS-Ketamine Oral Thin Film-Part 1: Population Pharmacokinetics
- 2026-09-24srcNorketamine, the Main Metabolite of Ketamine, Induces Mitochondria-Dependent and ER Stress-Triggered Apoptotic Death in Urothelial Cells
- 2026-09-24srcKetamine-Induced Cystitis: A Comprehensive Review of the Urologic Effects of This Psychoactive Drug
- 2026-09-24srcHepatobiliary Complications Associated With Ketamine Use: Clinical Insights and Future Directions
- 2026-09-24srcKetamine-Induced Cholangiopathy With Concomitant Hemorrhagic Cystitis
- 2026-09-24srcAntidepressant effects of ketamine in depressed patients
- 2026-09-24srcEffects of ketamine in normal and schizophrenic volunteers
- 2026-09-24srcPostmortem blood ketamine distribution in two fatalities
- 2026-09-24srcDopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics
- 2026-09-24srcA randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
- 2026-09-24srcInteraction of the chiral forms of ketamine with opioid, phencyclidine, sigma and muscarinic receptors
- 2026-09-24srcNorketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-06-04proposal59 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-04-20revisionRevision 1
- 2026-04-20genGeneration — pipeline-v5 · with 1 morepipeline-v5
- 2026-04-20rungeneration run
- 2026-04-20rungeneration run
The same entries, as forms: six forms.