Isotonitazene

1. 2026-10-19issueIssued info_card
2. 2026-09-24srcReport on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene.
3. 2026-09-24srcHuman metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene.
4. 2026-09-24srcIn vitro structure-activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids.
5. 2026-09-24srcThe emergence of nitazenes: a new chapter in the synthetic opioid crisis.
6. 2026-09-24srcFatal intoxications with nitazenes: postmortem findings, toxicology, and in vitro characterization at the mu-opioid receptor of six nitazene analogues.
7. 2026-09-24srcAlkoxy chain length governs the potency of 2-benzylbenzimidazole 'nitazene' opioids associated with human overdose.
8. 2026-09-24srcNew Synthetic Opioids: Clinical Considerations and Dangers.
9. 2026-09-24srcComparative neuropharmacology of structurally distinct non-fentanyl opioids appearing on recreational drug markets worldwide.
10. 2026-09-24srcIsotonitazene: Fatal intoxication in three cases involving this unreported novel psychoactive substance in Switzerland.
11. 2026-09-24srcPostmortem distribution of isotonitazene and its three metabolites in the first lethal case observed in France.
12. 2026-09-24srcNitazene-related deaths in Norway 2021-2024.
13. 2026-09-24srcDetection of N-desethyl etonitazene in a drug checking sample: Chemical analysis and pharmacological characterization.
14. 2026-09-24srcPharmacological characterization of novel synthetic opioids: Isotonitazene, metonitazene, and piperidylthiambutene as potent mu-opioid receptor agonists.
15. 2026-09-24srcNavigating nitazenes: A pharmacological and toxicological overview of new synthetic opioids with a 2-benzylbenzimidazole core.
16. 2026-09-24srcThe synthetic opioid isotonitazene induces locomotor activity and reward effects through modulation of the central dopaminergic system in mice.
17. 2026-09-24srcIsotonitazene, a synthetic opioid from an emerging family: The nitazenes.
18. 2026-09-24srcNitazenes: review of comparative pharmacology and antagonist action.
19. 2026-09-24srcIs nitazene-related mortality underestimated? Findings from an in vivo and ex vivo rat study and pharmacoepidemiological analysis of coroner-reported deaths.
20. 2026-09-24srcAcute Intoxications and Fatalities Associated With Benzimidazole Opioid (Nitazene Analog) Use: A Systematic Review.
21. 2026-09-24srcProliferation of Novel Synthetic Opioids in Postmortem Investigations After Core-Structure Scheduling for Fentanyl-Related Substances.
22. 2026-09-24srcSlow dissociation kinetics of fentanyls and nitazenes correlates with reduced sensitivity to naloxone reversal at the mu-opioid receptor.
23. 2026-09-24srcPharmacologic Characterization of Substituted Nitazenes at mu, kappa, and delta Opioid Receptors Suggests High Potential for Toxicity
24. 2026-09-24srcNitazenes: The Emergence of a Potent Synthetic Opioid Threat.
25. 2026-09-24srcSchedules of Controlled Substances: Temporary Placement of Isotonitazene in Schedule I
26. 2026-09-24srcACMD advice on nitazene and related compounds
27. 2026-09-24srcSchedules of Controlled Substances: Placement of Isotonitazene in Schedule I
28. 2026-09-24srcCommission on Narcotic Drugs: Decision to place isotonitazene under international control
29. 2026-09-24srcWHO Expert Committee on Drug Dependence: 43rd Report - Critical review of isotonitazene
30. 2026-09-04issueIssued emergency
31. 2026-09-04issueIssued info_card
32. 2026-09-04issueIssued notice
33. 2026-06-04proposal29 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
34. 2026-06-04publicationPublication — backfill
35. 2026-05-08revisionRevision 1
36. 2026-05-08genGeneration — pipeline-v5 · with 2 morepipeline-v5
37. 2026-05-08rungeneration run
38. 2026-05-08rungeneration run

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