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1Provenance card

the boundary, as counts

Sources

4226 with DOI

5 strong · 33 moderate · 4 weak

Compilations

12026-04-26T03:53:45.177Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

32last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:32:19.117Z

notice · info card · emergency

Searches

244 with no results

queries and counts on the build

Claims checked

9876 supported

76 supported · 22 not

Correspondence

0received

consent field ships in Phase 4

Edges

307

derivations recorded for this entity

Complete over 42 sources, 1 compilation, and 32 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/ibogaine/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-24srcAscending Single-Dose, Double-Blind, Placebo-Controlled Safety Study of Noribogaine in Opioid-Dependent Patients
  3. 2026-09-24srcAscending-dose study of noribogaine in healthy volunteers: pharmacokinetics, pharmacodynamics, safety, and tolerability
  4. 2026-09-24srcInfluence of CYP2D6 activity on the pharmacokinetics and pharmacodynamics of a single 20 mg dose of ibogaine in healthy volunteers
  5. 2026-09-24srchERG Blockade by Iboga Alkaloids
  6. 2026-09-24srcAnti-addiction Drug Ibogaine Prolongs the Action Potential in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
  7. 2026-09-24srcMystical experiences during magnesium-Ibogaine are associated with improvements in PTSD symptoms in veterans
  8. 2026-09-24srcEffects of low dose ibogaine on subjective mood state and psychological performance
  9. 2026-09-24srcA systematic literature review of clinical trials and therapeutic applications of ibogaine
  10. 2026-09-24srcThe therapeutic effects of psychedelics for opioid use disorder: A systematic review of clinical studies
  11. 2026-09-24srcEfficient Access to the Iboga Skeleton: Optimized Procedure to Obtain Voacangine from Voacanga africana Root Bark
  12. 2026-09-24srcOxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models
  13. 2026-09-24srcMagnesium-ibogaine therapy in veterans with traumatic brain injuries
  14. 2026-09-24srcIbogaine and addiction in the animal model, a systematic review and meta-analysis
  15. 2026-09-24srcToxicokinetics of ibogaine and noribogaine in a patient with prolonged multiple cardiac arrhythmias after ingestion of internet purchased ibogaine
  16. 2026-09-24srcPsychedelic Therapy: A Primer for Primary Care Clinicians-Ibogaine
  17. 2026-09-24srcSafety of ibogaine administration in detoxification of opioid-dependent individuals: a descriptive open-label observational study
  18. 2026-09-24srcNoribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration
  19. 2026-09-24srcThe pharmacokinetics and pharmacodynamics of ibogaine in opioid use disorder patients
  20. 2026-09-24srcIbogaine, an anti-addictive drug: pharmacology and time to go further in development
  21. 2026-09-24srcEffect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation
  22. 2026-09-24srcIbogaine/Noribogaine in the Treatment of Substance Use Disorders: A Systematic Review of the Current Literature
  23. 2026-09-24srcHow toxic is ibogaine?
  24. 2026-09-24srcIbogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence
  25. 2026-09-24srcDrug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites
  26. 2026-09-24srcIbogaine's potential role in supporting reward system recovery across diagnostic boundaries
  27. 2026-09-24srcThe anti-addiction drug ibogaine and the heart: a delicate relation
  28. 2026-09-24srcTreatment of acute opioid withdrawal with ibogaine
  29. 2026-09-24srcDevelopment of novel medications for drug addiction. The legacy of an African shrub
  30. 2026-09-24srcA dose-response study of ibogaine-induced neuropathology in the rat cerebellum
  31. 2026-09-24src18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of action
  32. 2026-09-24srcMechanisms of action of ibogaine: relevance to putative therapeutic effects and development of a safer iboga alkaloid congener
  33. 2026-09-24srcMechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies
  34. 2026-09-24srcGlial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption
  35. 2026-09-24srcReceptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity
  36. 2026-09-24srcIbogaine block of the NMDA receptor: in vitro and in vivo studies
  37. 2026-09-24srcIbogaine neurotoxicity: a re-evaluation
  38. 2026-09-24srcIbogaine and cocaine abuse: pharmacological interactions at dopamine and serotonin receptors
  39. 2026-09-24srcEvidence for roles of kappa-opioid and NMDA receptors in the mechanism of action of ibogaine
  40. 2026-09-24srcThe olivocerebellar projection mediates ibogaine-induced degeneration of Purkinje cells
  41. 2026-09-24srcMechanisms of antiaddictive actions of ibogaine
  42. 2026-09-24srcIbogaine legal status and scheduling history
  43. 2026-09-24srcState-by-State Ibogaine Legislation tracker
  44. 2026-09-04issueIssued emergency
  45. 2026-09-04issueIssued info_card
  46. 2026-09-04issueIssued notice
  47. 2026-06-04proposal30 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  48. 2026-06-04publicationPublication — backfill
  49. 2026-04-26revisionRevision 1
  50. 2026-04-26absenceSearched web for "ibogaine physical properties CAS LD50" — no results
  51. 2026-04-26absenceSearched PubMed for "ibogaine LD50 lethal dose toxicity animal" — no results
  52. 2026-04-26absenceSearched PubChem web for "ibogaine CAS melting point logP LD50" — no results
  53. 2026-04-26absenceSearched PubMed for "ibogaine LD50 lethal dose toxicity animal study mouse rat" — no results
  54. 2026-04-26genGeneration — pipeline-v5pipeline-v5
  55. 2026-04-26rungeneration run

The same entries, as forms: six forms.