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1Provenance card

the boundary, as counts

Sources

2824 with DOI

1 strong · 16 moderate · 11 weak

Compilations

12026-05-07T20:30:20.453Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

56last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:32:15.010Z

notice · info card · emergency

Searches

200 with no results

queries and counts on the build

Claims checked

7454 supported

54 supported · 20 not

Correspondence

0received

consent field ships in Phase 4

Edges

265

derivations recorded for this entity

Complete over 28 sources, 1 compilation, and 56 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/hxe/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-07srcStudies on the Stability and Microbial Biotransformation of Five Deschloroketamine Derivatives as Prerequisite for Wastewater-Based Epidemiology Screening
  3. 2026-09-07src1,2-Diarylethylamine- and Ketamine-Based New Psychoactive Substances
  4. 2026-09-07srcKetamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn
  5. 2026-09-07srcSalting-out-assisted liquid-liquid extraction as a suitable approach for determination of methoxetamine in large sets of tissue samples
  6. 2026-09-07srcBifunctional Modulation of NMDA and Opioid Receptors in Ketamine Reinforcement and Misuse: Implications for Substance Use Disorder Treatment
  7. 2026-09-07srcDetailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue-Behavioural, pharmacokinetic and metabolic studies in the Wistar rat
  8. 2026-09-07srcEmerging new psychoactive ketamine analogues: patterns of use and health risks identified by the French Addictovigilance Network
  9. 2026-09-07srcNew insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat
  10. 2026-09-07srcKetamine-snorting associated cystitis
  11. 2026-09-07srcDerivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors
  12. 2026-09-07srcMethoxetamine: A foe or friend?
  13. 2026-09-07srcIn vitro and in vivo metabolic study of three new psychoactive β-keto-arylcyclohexylamines
  14. 2026-09-07srcAnalytical findings of an acute intoxication after inhalation of methoxetamine
  15. 2026-09-07srcFatal intoxication with methoxetamine
  16. 2026-09-07srcKetamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
  17. 2026-09-07srcMethoxetamine toxicity reported to the National Poisons Information Service: clinical characteristics and patterns of enquiries (including the period of the introduction of the UK's first Temporary Class Drug Order)
  18. 2026-09-07srcKetamine-associated urinary tract dysfunction: an underrecognized clinical entity
  19. 2026-09-07srcRedefining Ketamine Pharmacology for Antidepressant Action: Synergistic NMDA and Opioid Receptor Interactions
  20. 2026-09-07srcThe ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor
  21. 2026-09-07srcAcute methoxetamine and amphetamine poisoning with fatal outcome: a case report
  22. 2026-09-07srcMethoxetamine associated reversible cerebellar toxicity: three cases with analytical confirmation
  23. 2026-09-07srcCharacterization of 3-Hydroxyeticyclidine (3-HO-PCE) Metabolism in Human Liver Microsomes and Biological Samples Using High-Resolution Mass Spectrometry
  24. 2026-09-07srcEvaluation of urinary bladder fibrogenesis in a mouse model of long-term ketamine injection
  25. 2026-09-07srcBilateral hydronephrosis and cystitis resulting from chronic ketamine abuse
  26. 2026-09-07srcKetamine dependence
  27. 2026-09-07srcHydroxetamine (HXE) Toxicology Report
  28. 2026-09-07srcGovernment bans methoxetamine (mexxy) — GOV.UK with ACMD generic arylcyclohexylamine catch-all recommendation
  29. 2026-09-07srcSchedules of Controlled Substances: Placement of Methoxetamine (MXE) in Schedule I
  30. 2026-09-04issueIssued emergency
  31. 2026-09-04issueIssued info_card
  32. 2026-09-04issueIssued notice
  33. 2026-06-04proposal54 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  34. 2026-06-04publicationPublication — backfill
  35. 2026-05-07revisionRevision 1
  36. 2026-05-07genGeneration — pipeline-v5 · with 3 morepipeline-v5
  37. 2026-05-07rungeneration run

The same entries, as forms: six forms.