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1Provenance card

the boundary, as counts

Sources

4015 with DOI

13 strong · 18 moderate · 9 weak

Compilations

12026-05-03T21:21:41.166Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

33last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:31:45.012Z

notice · info card · emergency

Searches

201 with no results

queries and counts on the build

Claims checked

7960 supported

60 supported · 19 not

Correspondence

0received

consent field ships in Phase 4

Edges

264

derivations recorded for this entity

Complete over 40 sources, 1 compilation, and 33 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/ephedrine/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-24srcEfficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis.
  3. 2026-09-24srcSpinal-induced hypotension: Incidence, mechanisms, prophylaxis, and management: Summarizing 20 years of research.
  4. 2026-09-24srcEphedrine induced thioredoxin-1 expression through β-adrenergic receptor/cyclic AMP/protein kinase A/dopamine- and cyclic AMP-regulated phosphoprotein signaling pathway.
  5. 2026-09-24srcEphedrae herba: A comprehensive review of its traditional uses, phytochemistry, pharmacology, and toxicology.
  6. 2026-09-24srcGlimpses of diagnostic tools and treatment of asthma in Sweden, Norway, and Finland from a medico-historical perspective.
  7. 2026-09-24srcPharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA).
  8. 2026-09-24srcOver a century since ephedrine discovery: an updated revisit to its pharmacological aspects, functionality and toxicity in comparison to its herbal extracts.
  9. 2026-09-24srcAdverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids.
  10. 2026-09-24srcUse of a prescribed ephedrine/caffeine combination and the risk of serious cardiovascular events: a registry-based case-crossover study.
  11. 2026-09-24srcRandomised double-blind comparison of bolus phenylephrine or ephedrine for treatment of hypotension in women with pre-eclampsia undergoing caesarean section.
  12. 2026-09-24srcEphedrine-induced acute myocardial infarction in a young athlete.
  13. 2026-09-24srcThe sympathomimetic actions of l-ephedrine and d-pseudoephedrine: direct receptor activation or norepinephrine release?
  14. 2026-09-24srcThe history of Ephedra (ma-huang).
  15. 2026-09-24srcComparative Effectiveness of Prophylactic Vasopressors During Elective Cesarean Delivery Under Neuraxial Anesthesia: A Systematic Review With Network-Based Quantitative Synthesis.
  16. 2026-09-24srcIntraoperative Hypotension After Neuraxial Anesthesia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials of Vasopressors for Cesarean Birth Stratified by Maternal Risk.
  17. 2026-09-24srcPsychiatric complications of Ma-huang.
  18. 2026-09-24srcAdverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine.
  19. 2026-09-24srcA quantitative, systematic review of randomized controlled trials of ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean delivery.
  20. 2026-09-24srcPossible case of mania associated with ma-huang.
  21. 2026-09-24srcThe effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet.
  22. 2026-09-24srcPharmacology of thermogenic drugs.
  23. 2026-09-24srcBiotransformation of D(-)-ephedrine and L(+)-ephedrine in the rabbit, in vivo and in vitro.
  24. 2026-09-24srcEffect of inhibition of nitric oxide synthase on the vasopressor response to ephedrine.
  25. 2026-09-24srcFinal rule declaring dietary supplements containing ephedrine alkaloids adulterated because they present an unreasonable risk.
  26. 2026-09-24srcEnhanced stimulant and metabolic effects of combined ephedrine and caffeine.
  27. 2026-09-24srcDilated cardiomyopathy and acute liver injury associated with combined use of ephedra, gamma-hydroxybutyrate, and anabolic steroids.
  28. 2026-09-24srcPressor responses to ephedrine are mediated by a direct mechanism in the rat.
  29. 2026-09-24srcPsychiatric effects of ephedra: addiction.
  30. 2026-09-24srcEffects of sympathomimetic agents on opiate analgesia, tolerance and dependence in mice.
  31. 2026-09-24srcMyocardial necrosis and severe biventricular dysfunction in the context of chronic ephedrine abuse.
  32. 2026-09-24srcClinical characteristics of cough mixture abusers referred to three substance abuse clinics in Hong Kong.
  33. 2026-09-24srcDoes ephedrine promote weight loss in low-energy-adapted obese women?
  34. 2026-09-24srcAlpha- and beta-adrenergic receptor subtypes: properties, distribution and regulation.
  35. 2026-09-24srcRenal excretion of pseudoephedrine.
  36. 2026-09-24srcFactors influencing the reinforcing and subjective effects of ephedrine in humans.
  37. 2026-09-24srcThe metabolism of (-)-ephedrine in man.
  38. 2026-09-24srcThe pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment.
  39. 2026-09-24srcFinal Rule Declaring Dietary Supplements Containing Ephedrine Alkaloids Adulterated (Federal Register Feb 11 2004)
  40. 2026-09-24srcEphedrine (StatPearls)
  41. 2026-09-24srcEphedrine (PIM 209) - IPCS/WHO International Programme on Chemical Safety
  42. 2026-09-04issueIssued emergency
  43. 2026-09-04issueIssued info_card
  44. 2026-09-04issueIssued notice
  45. 2026-06-04proposal31 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  46. 2026-06-04publicationPublication — backfill
  47. 2026-05-03revisionRevision 1
  48. 2026-05-03absenceSearched ClinicalTrials.gov for "ephedrine obesity weight loss" — no results
  49. 2026-05-03genGeneration — pipeline-v5pipeline-v5
  50. 2026-05-03rungeneration run

The same entries, as forms: six forms.