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1Provenance card

the boundary, as counts

Sources

3024 with DOI

1 strong · 26 moderate · 3 weak

Compilations

12026-05-03T12:16:34.243Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

31last ruled 2026-06-04

0 awaiting a ruling

Issued documents

52026-10-19T20:31:41.008Z

notice · info card · emergency

Searches

172 with no results

queries and counts on the build

Claims checked

5748 supported

48 supported · 9 not

Correspondence

0received

consent field ships in Phase 4

Edges

207

derivations recorded for this entity

Complete over 30 sources, 1 compilation, and 31 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/doi/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued emergency
  2. 2026-10-19issueIssued info_card
  3. 2026-09-24srcHead-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model
  4. 2026-09-24srcThe detection and prevention of unintentional consumption of DOx and 25x-NBOMe at Portugal's Boom Festival
  5. 2026-09-24srcIn Vitro Structure-Activity Relationship of 30 Psychedelic NPS by β-Arrestin 2 Recruitment to 5-HT2A Receptor
  6. 2026-09-24srcUse of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines
  7. 2026-09-24srcHallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
  8. 2026-09-24src5-HT2 receptor activation alleviates airway inflammation and structural remodeling in a chronic mouse asthma model
  9. 2026-09-24srcMetabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists
  10. 2026-09-24srcEffects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response
  11. 2026-09-24srcPharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds
  12. 2026-09-24srcCorrelation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species
  13. 2026-09-24srcDistinct 5-HT receptor subtypes regulate claustrum excitability by serotonin and the psychedelic, DOI
  14. 2026-09-24srcInvestigation of the 2,5-Dimethoxy Motif in Phenethylamine Serotonin 2A Receptor Agonists
  15. 2026-09-24srcTolerance and Cross-Tolerance among Psychedelic and Nonpsychedelic 5-HT2A Receptor Agonists in Mice
  16. 2026-09-24src1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI): From an Obscure to Pivotal Member of the DOX Family of Serotonergic Psychedelic Agents - A Review.
  17. 2026-09-24src5-HT2A and 5-HT2C receptors exert opposing effects on locomotor activity in mice
  18. 2026-09-24srcLasting dynamic effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) on cognitive flexibility
  19. 2026-09-24srcTowards an understanding of psychedelic-induced neuroplasticity
  20. 2026-09-24srcPsychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling
  21. 2026-09-24srcManganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia
  22. 2026-09-24srcThe Synthesis of Some Analogs of the Hallucinogen 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane (DOM).
  23. 2026-09-24srcPsychedelics and the human receptorome
  24. 2026-09-24srcSerotonin 5-HT2A receptor activation blocks TNF-α mediated inflammation in vivo
  25. 2026-09-24srcPsychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities
  26. 2026-09-24srcThe Hallucinogenic Serotonin2A Receptor Agonist, 2,5-Dimethoxy-4-Iodoamphetamine, Promotes cAMP Response Element Binding Protein-Dependent Gene Expression of Specific Plasticity-Associated Genes in the Rodent Neocortex
  27. 2026-09-24src5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells
  28. 2026-09-24srcDifferentiation of 5-hydroxytryptamine2 receptor subtypes using 125I-R-(-)2,5-dimethoxy-4-iodo-phenylisopropylamine and 3H-ketanserin.
  29. 2026-09-24srcIntegration of mitogen-activated protein kinase kinase activation in vascular 5-hydroxytryptamine2A receptor signal transduction
  30. 2026-09-24srcDOI - Psychedelic Science Review
  31. 2026-09-24srcDOI (2,5-Dimethoxy-4-iodoamphetamine) - Cayman Chemical product page
  32. 2026-09-24srcSchedules of Controlled Substances: Placement of 2,5-dimethoxy-4-iodoamphetamine (DOI) and 2,5-dimethoxy-4-chloroamphetamine (DOC) in Schedule I
  33. 2026-09-04issueIssued emergency
  34. 2026-09-04issueIssued info_card
  35. 2026-09-04issueIssued notice
  36. 2026-06-04proposal29 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  37. 2026-06-04publicationPublication — backfill
  38. 2026-05-03revisionRevision 1
  39. 2026-05-03absenceSearched Multiple for "Monoamine releasing agent classification verification" — no results
  40. 2026-05-03absenceSearched ClinicalTrials.gov for "DOI 2,5-dimethoxy-4-iodoamphetamine" — no results
  41. 2026-05-03genGeneration — pipeline-v5pipeline-v5
  42. 2026-05-03rungeneration run

The same entries, as forms: six forms.