DOI
2,5-dimethoxy-4-iodoamphetamine
1Provenance card
the boundary, as counts
Sources
3024 with DOI
1 strong · 26 moderate · 3 weak
Compilations
12026-05-03T12:16:34.243Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09
Decisions
31last ruled 2026-06-04
0 awaiting a ruling
Issued documents
52026-10-19T20:31:41.008Z
notice · info card · emergency
Searches
172 with no results
queries and counts on the build
Claims checked
5748 supported
48 supported · 9 not
Correspondence
0received
consent field ships in Phase 4
Edges
207
derivations recorded for this entity
Complete over 30 sources, 1 compilation, and 31 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/doi/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued emergency
- 2026-10-19issueIssued info_card
- 2026-09-24srcHead-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model
- 2026-09-24srcThe detection and prevention of unintentional consumption of DOx and 25x-NBOMe at Portugal's Boom Festival
- 2026-09-24srcIn Vitro Structure-Activity Relationship of 30 Psychedelic NPS by β-Arrestin 2 Recruitment to 5-HT2A Receptor
- 2026-09-24srcUse of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines
- 2026-09-24srcHallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
- 2026-09-24src5-HT2 receptor activation alleviates airway inflammation and structural remodeling in a chronic mouse asthma model
- 2026-09-24srcMetabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists
- 2026-09-24srcEffects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response
- 2026-09-24srcPharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds
- 2026-09-24srcCorrelation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species
- 2026-09-24srcDistinct 5-HT receptor subtypes regulate claustrum excitability by serotonin and the psychedelic, DOI
- 2026-09-24srcInvestigation of the 2,5-Dimethoxy Motif in Phenethylamine Serotonin 2A Receptor Agonists
- 2026-09-24srcTolerance and Cross-Tolerance among Psychedelic and Nonpsychedelic 5-HT2A Receptor Agonists in Mice
- 2026-09-24src1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI): From an Obscure to Pivotal Member of the DOX Family of Serotonergic Psychedelic Agents - A Review.
- 2026-09-24src5-HT2A and 5-HT2C receptors exert opposing effects on locomotor activity in mice
- 2026-09-24srcLasting dynamic effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) on cognitive flexibility
- 2026-09-24srcTowards an understanding of psychedelic-induced neuroplasticity
- 2026-09-24srcPsychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling
- 2026-09-24srcManganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia
- 2026-09-24srcThe Synthesis of Some Analogs of the Hallucinogen 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane (DOM).
- 2026-09-24srcPsychedelics and the human receptorome
- 2026-09-24srcSerotonin 5-HT2A receptor activation blocks TNF-α mediated inflammation in vivo
- 2026-09-24srcPsychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities
- 2026-09-24srcThe Hallucinogenic Serotonin2A Receptor Agonist, 2,5-Dimethoxy-4-Iodoamphetamine, Promotes cAMP Response Element Binding Protein-Dependent Gene Expression of Specific Plasticity-Associated Genes in the Rodent Neocortex
- 2026-09-24src5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells
- 2026-09-24srcDifferentiation of 5-hydroxytryptamine2 receptor subtypes using 125I-R-(-)2,5-dimethoxy-4-iodo-phenylisopropylamine and 3H-ketanserin.
- 2026-09-24srcIntegration of mitogen-activated protein kinase kinase activation in vascular 5-hydroxytryptamine2A receptor signal transduction
- 2026-09-24srcDOI - Psychedelic Science Review
- 2026-09-24srcDOI (2,5-Dimethoxy-4-iodoamphetamine) - Cayman Chemical product page
- 2026-09-24srcSchedules of Controlled Substances: Placement of 2,5-dimethoxy-4-iodoamphetamine (DOI) and 2,5-dimethoxy-4-chloroamphetamine (DOC) in Schedule I
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-06-04proposal29 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-05-03revisionRevision 1
- 2026-05-03absenceSearched Multiple for "Monoamine releasing agent classification verification" — no results
- 2026-05-03absenceSearched ClinicalTrials.gov for "DOI 2,5-dimethoxy-4-iodoamphetamine" — no results
- 2026-05-03genGeneration — pipeline-v5pipeline-v5
- 2026-05-03rungeneration run
The same entries, as forms: six forms.