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1Provenance card

the boundary, as counts

Sources

4015 with DOI

12 strong · 23 moderate · 5 weak

Compilations

12026-05-09T21:50:52.117Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

34last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:31:31.716Z

notice · info card · emergency

Searches

211 with no results

queries and counts on the build

Claims checked

9887 supported

87 supported · 11 not

Correspondence

0received

consent field ships in Phase 4

Edges

304

derivations recorded for this entity

Complete over 40 sources, 1 compilation, and 34 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/dihydrocodeine/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-07srcClinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy
  3. 2026-09-07srcThe management of dyspnea in cancer patients: a systematic review.
  4. 2026-09-07srcHighlighting the hidden dangers of a 'weak' opioid: Deaths following use of dihydrocodeine in England (2001-2020).
  5. 2026-09-07srcRelative toxicity of analgesics commonly used for intentional self-poisoning: A study of case fatality based on fatal and non-fatal overdoses
  6. 2026-09-07srcA randomized, double-blind, double-dummy comparison of short- and long-acting dihydrocodeine in chronic non-malignant pain.
  7. 2026-09-07srcComparative risk-benefit profiles of weak opioids in the treatment of osteoarthritis: a network meta-analysis.
  8. 2026-09-07srcDihydrocodeine Overdoses in a Neonate and in a 14-year-old Girl Who Were Both Genotyped as Cytochrome P450 2D6*1/*10-*36.
  9. 2026-09-07srcOpioid-induced inhibition of the human 5-HT and noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome
  10. 2026-09-07srcThe impact of tramadol and dihydrocodeine treatment on quality of life of patients with cancer pain.
  11. 2026-09-07srcComparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study.
  12. 2026-09-07srcA case report of inpatient detoxification after kratom dependence.
  13. 2026-09-07srcA systematic review of the use of opioid medication for those with moderate to severe cancer pain and renal impairment.
  14. 2026-09-07srcOpioid prescription patterns in Germany and the global opioid epidemic.
  15. 2026-09-07srcDihydrocodeine: safety concerns.
  16. 2026-09-07srcPharmacovigilance Signals of the Opioid Epidemic: Data Mining Methods in EudraVigilance and FAERS.
  17. 2026-09-07srcThe detection of dihydrocodeine and its main metabolites in cases of fatal overdose.
  18. 2026-09-07srcPharmacokinetics of opioids in liver disease.
  19. 2026-09-07srcPharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing.
  20. 2026-09-07srcSingle dose dihydrocodeine for acute postoperative pain.
  21. 2026-09-07srcDose-related effects of controlled release dihydrocodeine on oro-cecal transit and pupillary light reflex. A study in human volunteers.
  22. 2026-09-07srcA systematic review of the use of opioids in the management of dyspnoea.
  23. 2026-09-07srcAffinities of dihydrocodeine and its metabolites to opioid receptors
  24. 2026-09-07srcTherapy with opioids in liver or renal failure.
  25. 2026-09-07srcActivation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors.
  26. 2026-09-07srcDevelopment of a directly compressible poly(ethylene oxide) matrix for the sustained-release of dihydrocodeine bitartrate.
  27. 2026-09-07srcThe Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) project.
  28. 2026-09-07srcPain and pain treatments in European palliative care units. A cross sectional survey.
  29. 2026-09-07srcCodeine and dihydrocodeine as substitute and alternative drugs.
  30. 2026-09-07src'Weak' opioid analgesics. Codeine, dihydrocodeine and tramadol: no less risky than morphine
  31. 2026-09-07srcTwo assays for dihydrocodeine in plasma and in urine and their use to determine the bioavailability of a controlled-release product.
  32. 2026-09-07srcEffects of renal insufficiency on the pharmacokinetics and pharmacodynamics of opioid analgesics.
  33. 2026-09-07srcPharmacokinetics of intravenous and oral dihydrocodeine and its acid metabolites.
  34. 2026-09-07srcDrug substitution treatment of heroin dependent patients with codeine preparations — treatment effects from the viewpoint of the physicians and patients.
  35. 2026-09-07srcDihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans.
  36. 2026-09-07srcAffinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes.
  37. 2026-09-07srcA multiple dose comparison of ibuprofen and dihydrocodeine after third molar surgery.
  38. 2026-09-07srcPharmacokinetics of opioids in renal dysfunction.
  39. 2026-09-07srcCharacterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine.
  40. 2026-09-07srcFormation and clearance of active and inactive metabolites of opiates in humans.
  41. 2026-09-07srcDihydrocodeine - Wikipedia
  42. 2026-09-04issueIssued emergency
  43. 2026-09-04issueIssued info_card
  44. 2026-09-04issueIssued notice
  45. 2026-06-04proposal32 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  46. 2026-06-04publicationPublication — backfill
  47. 2026-05-09revisionRevision 1
  48. 2026-05-09absenceSearched WebFetch for "FPM dose equivalents opioids" — no results
  49. 2026-05-09genGeneration — pipeline-v5 · with 2 morepipeline-v5
  50. 2026-05-09rungeneration run

The same entries, as forms: six forms.