Diazepam
1Provenance card
the boundary, as counts
Sources
3720 with DOI
6 strong · 30 moderate · 1 weak
Compilations
12026-04-28T00:17:29.011Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09
Decisions
35last ruled 2026-06-04
1 awaiting a ruling
Issued documents
42026-10-19T20:31:28.840Z
notice · info card · emergency
Searches
262 with no results
queries and counts on the build
Claims checked
11575 supported
75 supported · 40 not
Correspondence
0received
consent field ships in Phase 4
Edges
340
derivations recorded for this entity
Complete over 37 sources, 1 compilation, and 35 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/diazepam/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued info_card
- 2026-10-02srcA reappraisal of acute doses of benzodiazepines as a model of anterograde amnesia
- 2026-10-02srcPotential role for histone deacetylation in chronic diazepam-induced downregulation of alpha1-GABAA receptor subunit expression.
- 2026-10-02srcBenzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability
- 2026-10-02srcBenzodiazepine-opioid co-prescribing in a national probability sample of ED encounters
- 2026-10-02srcRationalizing the binding and alpha subtype selectivity of synthesized imidazodiazepines and benzodiazepines at GABAA receptors by using molecular docking studies.
- 2026-10-02srcbetaCCT, an antagonist selective for alpha(1)GABA(A) receptors, reverses diazepam withdrawal-induced anxiety in rats
- 2026-10-02srcDiazepam Therapy and CYP2C19 Genotype
- 2026-10-02srcRescue Treatments for Seizure Clusters
- 2026-10-02srcBenzodiazepine exposure induces transcriptional down-regulation of GABAA receptor alpha1 subunit gene via L-type voltage-gated calcium channel activation.
- 2026-10-02srcProlonged exposure of cerebrocortical neurons to diazepam induces downregulation of surface α1-containing GABA-A receptors and uncoupling of GABA/benzodiazepine site interactions through different mechanisms.
- 2026-10-02srcGABAA receptor subtypes in the mouse brain: Regional mapping and diazepam receptor occupancy by in vivo [18F]flumazenil PET
- 2026-10-02srcBenzodiazepine use and risk of incident MCI and dementia in a community sample.
- 2026-10-02srcUrinary diazepam metabolite distribution in a chronic pain population
- 2026-10-02srcAdverse Events Associated with Flumazenil Treatment for the Management of Suspected Benzodiazepine Intoxication--A Systematic Review with Meta-Analyses.
- 2026-10-02srcHistory of Psychopharmacology
- 2026-10-02srcThe distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
- 2026-10-02srcImpaired Cognitive Function and Hippocampal Changes Following Chronic Diazepam Treatment in Middle-Aged Mice.
- 2026-10-02srcDiazepam Accelerates GABA-A receptor Synaptic Exchange and Alters Intracellular Trafficking.
- 2026-10-02srcAssociation Between Z Drugs Use and Risk of Cognitive Impairment in Middle-Aged and Older Patients With Chronic Insomnia
- 2026-10-02srcThe history of benzodiazepines
- 2026-10-02srcTreatment of benzodiazepine overdose with flumazenil: The Flumazenil in Benzodiazepine Intoxication Multicenter Study Group
- 2026-10-02srcSelective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513
- 2026-10-02srcPharmacologic aspects of benzodiazepine tolerance and dependence
- 2026-10-02srcDifferential contribution of GABAA receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands
- 2026-10-02srcGABAA receptor subtype-selective modulators. I. alpha2/alpha3-selective agonists as non-sedating anxiolytics
- 2026-10-02srcA clinical scale to assess benzodiazepine withdrawal
- 2026-10-02srcDetermining Efficacy of Intervention in the Limitation of Opioid and Benzodiazepine Co-Prescription
- 2026-10-02srcClinical pharmacokinetics of diazepam and its biologically active metabolites
- 2026-10-02srcEffects of buspirone and diazepam, alone and in combination with alcohol, on skilled performance and evoked potentials
- 2026-10-02srcPharmacodynamic interactions of diazepam and intravenous alcohol at pseudo steady state
- 2026-10-02srcThe effects of benzodiazepine use during pregnancy and lactation.
- 2026-10-02srcDiazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms
- 2026-10-02srcStudies on psychomotor performance in healthy volunteers after diazepam, propranolol and alcohol given alone or in combination
- 2026-10-02srcUse-dependent regulation of GABAA receptors.
- 2026-10-02srcBenzodiazepine receptor: demonstration in the central nervous system
- 2026-10-02srcA risk-benefit assessment of flumazenil in the management of benzodiazepine overdose
- 2026-10-02srcDiazepam pharmacokinetics - StatPearls/FDA label data
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-07-03proposaldependence · taper
- 2026-06-04proposal32 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-04-28revisionRevision 1
- 2026-04-28absenceSearched Multiple for "Verify seed data against confirmed sources" — no results
- 2026-04-28absenceSearched Multiple PubMed/OpenAlex sources for "Compile pharmacokinetics, receptor data, history, legal status" — no results
- 2026-04-28genGeneration — pipeline-v5pipeline-v5
- 2026-04-28rungeneration run
The same entries, as forms: six forms.