Cocaine
1Provenance card
the boundary, as counts
Sources
4324 with DOI
8 strong · 30 moderate · 5 weak
Compilations
12026-04-20T12:42:46.376Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09 · 1 other run
Decisions
76last ruled 2026-06-04
1 awaiting a ruling
Issued documents
42026-10-19T20:31:12.045Z
notice · info card · emergency
Searches
151 with no results
queries and counts on the build
Claims checked
12487 supported
87 supported · 37 not
Correspondence
0received
consent field ships in Phase 4
Edges
388
derivations recorded for this entity
Complete over 43 sources, 1 compilation, and 76 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/cocaine/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued info_card
- 2026-09-27runbrief run
- 2026-09-27revisionr1.a1
- 2026-09-24srcAssociation of Stimulant Use With Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-analysis
- 2026-09-24srcCocaine-induced midline destructive lesions (CIMDL): misdiagnosis as ANCA-associated vasculitis
- 2026-09-24srcPharmacokinetics and safety of l-tetrahydropalmatine in cocaine users with intranasal cocaine challenge
- 2026-09-24srcCardiac magnetic resonance in cocaine-induced myocardial damage
- 2026-09-24srcDrug abuse and stroke
- 2026-09-24srcBDNF serum levels in cocaine-dependent patients during early abstinence
- 2026-09-24srcRisk factors for cocaine-induced psychosis in cocaine-dependent patients
- 2026-09-24srcAlveolar hemorrhage and cocaine use: systematic literature review
- 2026-09-24srcPulmonary complications in cocaine users (systematic review)
- 2026-09-24srcNeurocircuitry of addiction
- 2026-09-24srcIntermittent intake of rapid cocaine injections promotes relapse risk and increases mesocorticolimbic BDNF
- 2026-09-24srcAddiction: beyond dopamine reward circuitry
- 2026-09-24srcAn international perspective and review of cocaine-induced psychosis
- 2026-09-24srcBioavailability and Pharmacokinetics of Oral Cocaine in Humans
- 2026-09-24srcSnorting the Brain Away: Cerebral Damage as Extension of Cocaine-Induced Midline Destructive Lesions
- 2026-09-24srcCarl Koller, cocaine, and local anesthesia: some less known and forgotten facts
- 2026-09-24srcCocaine use disorder: no FDA-approved treatments exist
- 2026-09-24srcAcute cocaine effects improved response inhibition in ERP investigation
- 2026-09-24srcAdaptive Increase in D3 Dopamine Receptors in Brain Reward Circuits of Human Cocaine Fatalities
- 2026-09-24srcCocaine self-administration produces long-lasting alterations in dopamine transporter responses to cocaine
- 2026-09-24srcCocaine in Pregnancy: Prenatal substance abuse and child outcomes
- 2026-09-24srcCocaine cardiotoxicity: a review of the pathophysiology, pathology, and treatment options
- 2026-09-24srcCocaine-induced rhabdomyolysis with acute kidney injury
- 2026-09-24srcFatal multiorgan dysfunction syndrome secondary to cocaine toxicity
- 2026-09-24srcThe effects of acute and chronic cocaine use on the heart
- 2026-09-24srcEffects of ethanol on cocaine metabolism: formation of cocaethylene and norcocaethylene
- 2026-09-24srcCocaine cardiovascular toxicity
- 2026-09-24srcNeural systems of reinforcement for drug addiction: from actions to habits to compulsion
- 2026-09-24srcComparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs
- 2026-09-24srcThe history of cocaine in medicine and its importance to the discovery of the different forms of anaesthesia
- 2026-09-24srcDrug addiction as a pathology of staged neuroplasticity
- 2026-09-24srcNeuropathological alterations in cocaine abuse
- 2026-09-24srcContribution of oxidative metabolism to cocaine-induced liver and kidney damage
- 2026-09-24srcRole of protein binding in cocaine-induced hepatic necrosis
- 2026-09-24srcIntranasal and oral cocaine kinetics
- 2026-09-24srcCocaine cardiotoxicity: toxic mechanisms of the heart
- 2026-09-24srcHyperthermia in psychostimulant overdose
- 2026-09-24srcOxygen free radical production mediated by cocaine and its ethanol-derived metabolite, cocaethylene, in rat hepatocytes
- 2026-09-24srcAcute systemic effects of cocaine in man: a controlled study by intranasal and intravenous routes
- 2026-09-24srcRegenerative changes in hepatic morphology and enhanced expression of CYP2B10 and CYP3A during daily administration of cocaine
- 2026-09-24srcCocaine disposition in saliva following intravenous, intranasal, and smoked administration
- 2026-09-24srcConcurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone
- 2026-09-24srcUNODC Global Report on Cocaine 2023
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-07-03proposaldependence · taper
- 2026-06-04proposal67 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-04-20proposaldose_tier · heavy
- 2026-04-20proposaldose_tier · strong
- 2026-04-20proposaldose_tier · common
- 2026-04-20proposaldose_tier · light
- 2026-04-20proposaldose_tier · threshold
- 2026-04-20revisionRevision 1
- 2026-04-20absenceSearched PubMed for "cocaine history discovery Carl Koller local anesthetic coca" — no results
- 2026-04-20genGeneration — pipeline-v5pipeline-v5
- 2026-04-20rungeneration run
The same entries, as forms: six forms.