Skip to main content

Coca Facts

Stimulant; Substituted tropane; Dopamine reuptake inhibitor

Description

Coca (Erythroxylum coca Lam., Erythroxylaceae) is a flowering shrub native to the Andes whose leaves contain the stimulant alkaloid cocaine. It blocks the brain's dopamine recycling system, flooding reward circuits and producing the plant's stimulant and euphoric effects.[1]

Subjective effects include stimulation, euphoria, appetite suppression, increased confidence, and local numbness in the mouth and throat. The experience varies enormously by preparation: leaf chewing produces mild, sustained alertness comparable to strong tea, while smoked cocaine delivers a brief, overwhelming rush followed by rapid craving.

Cocaine carries significant abuse liability and cardiovascular toxicity — including risk of heart attack, arrhythmia, and sudden cardiac death.[2] The illicit supply is heavily contaminated: levamisole adulterates an estimated 69–80% of US cocaine, causing blood disorders independent of cocaine's own effects,[3] and fentanyl contamination is increasingly common.

Dose and duration

No dose or duration recorded for any route.

Body and dependence

Acute toxicity
High
Chronic toxicity
Critical
Physical dependence
Low
Psychological dependence
High
Withdrawal
Moderate
Compulsive redosing
High

Tolerance

Builds
Rapid
Fully resets after
Not recorded
Carries over to
amphetamines

Effectslikely at a common dose

Body
Stimulation; Vasoconstriction; Wakefulness; +17 possible, including Heart rate perception changes, Insomnia, Muscle tension
Thinking
none likely · 11 possible, including Compulsive redosing urge
Feeling
Euphoria; +2 possible, including Anxiety
Self
none likely · 7 possible, including Craving, Ego inflation
Awareness
Sustained attention (vicara)

Who shouldn't take it

Absolute
Pre-existing cardiac conditions; Concurrent beta-blocker therapy; Uncontrolled hypertension; Hyperthyroidism / pheochromocytoma; Pregnancy; Prenatal exposure
Relative
Schizophrenia spectrum / psychosis vulnerability; Liver disease; Concurrent MAOI use; Concurrent tricyclic antidepressant use

Combinations61 recorded

Lethal (2)
Ibogaine; Opioids
Dangerous (39)
Amphetamines; Benzodiazepines, Barbiturates; Ephedrine, Pseudoephedrine; Local anesthetics; MAOIs; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); Nicotine; NRIs; SSRIs; Stimulants; 5-HTP, Tryptophan; Alpha-2 adrenergic receptor antagonist; Anticholinergics; Antihistamines; Antipsychotics; Atypical antipsychotics; Buspirone; Caffeine; Clonidine, Guanfacine; Dopamine agonists; DXM; GHB, Baclofen; and 15 more, see full page
Caution (17)
See full page: psychedex.org/substances/coca
Not graded (3)
Not listed never means safe.

Seek help immediately if

No emergency profile is recorded for this substance. Not recorded never means no risk.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r2 · Not medical advice

References

  1. [1]
    ^Heal DJ, Gosden J, Smith SL (2014) Dopamine reuptake transporter (DAT) 'inverse agonism' — a novel hypothesis to explain the enigmatic pharmacology of cocaine — Neuropharmacology doi:10.1016/j.neuropharm.2014.06.012
  2. [2]
    ^Lucyk SN (2022) Acute Cardiovascular Toxicity of Cocaine — The Canadian Journal of Cardiology doi:10.1016/j.cjca.2022.05.003
  3. [3]
    ^Buchanan JA, Lavonas EJ (2012) Agranulocytosis and other consequences due to use of illicit cocaine contaminated with levamisole — Current Opinion in Hematology doi:10.1097/moh.0b013e32834da9ef
Print version
Report an issue