Coca Facts
Stimulant;
Description
Coca (Erythroxylum coca Lam., Erythroxylaceae) is a flowering shrub native to the Andes whose leaves contain the stimulant alkaloid cocaine. It blocks the brain's dopamine recycling system, flooding reward circuits and producing the plant's stimulant and euphoric effects.[1]
Subjective effects include stimulation, euphoria, appetite suppression, increased confidence, and local numbness in the mouth and throat. The experience varies enormously by preparation: leaf chewing produces mild, sustained alertness comparable to strong tea, while smoked cocaine delivers a brief, overwhelming rush followed by rapid craving.
Cocaine carries significant abuse liability and cardiovascular toxicity — including risk of heart attack, arrhythmia, and sudden cardiac death.[2] The illicit supply is heavily contaminated: levamisole adulterates an estimated 69–80% of US cocaine, causing blood disorders independent of cocaine's own effects,[3] and fentanyl contamination is increasingly common.
Dose and duration
No dose or duration recorded for any route.
Body and dependence
- Acute toxicity
- High
- Chronic toxicity
- Critical
- Physical dependence
- Low
- Psychological dependence
- High
- Withdrawal
- Moderate
- Compulsive redosing
- High
Tolerance
- Builds
- Rapid
- Fully resets after
- Not recorded
- Carries over to
- amphetamines
Effectslikely at a common dose
- Perception
- none likely · 1 possible
- Body
- Stimulation;
Vasoconstriction; Wakefulness; +17 possible, including Heart rate perception changes, Insomnia, Muscle tension - Thinking
- none likely · 11 possible, including Compulsive redosing urge
- Feeling
- Euphoria;
+2 possible, including Anxiety - Self
- none likely · 7 possible, including Craving, Ego inflation
- Awareness
- Sustained attention (vicara)
Who shouldn't take it
Combinations61 recorded
Seek help immediately if
No emergency profile is recorded for this substance. Not recorded never means no risk.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^Heal DJ, Gosden J, Smith SL (2014) Dopamine reuptake transporter (DAT) 'inverse agonism' — a novel hypothesis to explain the enigmatic pharmacology of cocaine — Neuropharmacology doi:10.1016/j.neuropharm.2014.06.012
- [2]^Lucyk SN (2022) Acute Cardiovascular Toxicity of Cocaine — The Canadian Journal of Cardiology doi:10.1016/j.cjca.2022.05.003
- [3]^Buchanan JA, Lavonas EJ (2012) Agranulocytosis and other consequences due to use of illicit cocaine contaminated with levamisole — Current Opinion in Hematology doi:10.1097/moh.0b013e32834da9ef