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Clonidine Facts

Depressant; Sedative; Arylaminoimidazoline; Alpha-2 adrenergic receptor agonist

Dose and durationby route · individual sensitivity varies

Oral(μg)
Threshold< 25 μgLight50 – 75 μgCommon75 – 100 μgStrong100 – 300 μgHeavy300+ μg

Starts in 15 – 45 minLasts 6 – 8 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
None
Psychological dependence
None
Withdrawal
Not assessed
Compulsive redosing
Not assessed

Tolerance

Not recorded.

Effectslikely at a common dose

Perception
none likely · 1 possible
Body
none likely · 5 possible, including Dizziness
Thinking
none likely · 4 possible
Feeling
none likely · 2 possible

Who shouldn't take it

None recorded. Not listed never means safe to take.

Combinations60 recorded

Dangerous (22)
Alpha-2 adrenergic receptor antagonist; Benzodiazepines, Barbiturates; Gabapentin, Pregabalin; GHB, Baclofen; GHB, GBL; Opioids; Poppers (Alkyl nitrites); Poppers, Nitrates; Antipsychotics; Atypical antipsychotics; Benzodiazepines; DXM; Ibogaine; Ketamine, DXM, PCP; Local anesthetics; MAOIs; MDMA, MDA; NDRIs (Wellbutrin); SNRIs; SSRIs; Synthetic cannabinoids; Salvia, Ibogaine
Caution (27)
See full page: psychedex.org/substances/clonidine
Not graded (11)
Not listed never means safe.

Seek help immediately if

No emergency profile is recorded for this substance. Not recorded never means no risk.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice
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